KEGG   Macaca fascicularis (crab-eating macaque): 101866246
Entry
101866246         CDS       T02918                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf01522  Endocrine resistance
mcf01524  Platinum drug resistance
mcf04012  ErbB signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04024  cAMP signaling pathway
mcf04062  Chemokine signaling pathway
mcf04066  HIF-1 signaling pathway
mcf04068  FoxO signaling pathway
mcf04070  Phosphatidylinositol signaling system
mcf04071  Sphingolipid signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04081  Hormone signaling
mcf04140  Autophagy - animal
mcf04150  mTOR signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04152  AMPK signaling pathway
mcf04210  Apoptosis
mcf04211  Longevity regulating pathway
mcf04213  Longevity regulating pathway - multiple species
mcf04218  Cellular senescence
mcf04360  Axon guidance
mcf04370  VEGF signaling pathway
mcf04380  Osteoclast differentiation
mcf04510  Focal adhesion
mcf04550  Signaling pathways regulating pluripotency of stem cells
mcf04611  Platelet activation
mcf04613  Neutrophil extracellular trap formation
mcf04620  Toll-like receptor signaling pathway
mcf04625  C-type lectin receptor signaling pathway
mcf04630  JAK-STAT signaling pathway
mcf04650  Natural killer cell mediated cytotoxicity
mcf04660  T cell receptor signaling pathway
mcf04662  B cell receptor signaling pathway
mcf04664  Fc epsilon RI signaling pathway
mcf04666  Fc gamma R-mediated phagocytosis
mcf04668  TNF signaling pathway
mcf04670  Leukocyte transendothelial migration
mcf04722  Neurotrophin signaling pathway
mcf04725  Cholinergic synapse
mcf04750  Inflammatory mediator regulation of TRP channels
mcf04810  Regulation of actin cytoskeleton
mcf04910  Insulin signaling pathway
mcf04914  Progesterone-mediated oocyte maturation
mcf04915  Estrogen signaling pathway
mcf04917  Prolactin signaling pathway
mcf04919  Thyroid hormone signaling pathway
mcf04923  Regulation of lipolysis in adipocytes
mcf04926  Relaxin signaling pathway
mcf04929  GnRH secretion
mcf04930  Type II diabetes mellitus
mcf04931  Insulin resistance
mcf04932  Non-alcoholic fatty liver disease
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf04935  Growth hormone synthesis, secretion and action
mcf04960  Aldosterone-regulated sodium reabsorption
mcf04973  Carbohydrate digestion and absorption
mcf05010  Alzheimer disease
mcf05017  Spinocerebellar ataxia
mcf05020  Prion disease
mcf05100  Bacterial invasion of epithelial cells
mcf05135  Yersinia infection
mcf05142  Chagas disease
mcf05146  Amoebiasis
mcf05160  Hepatitis C
mcf05161  Hepatitis B
mcf05162  Measles
mcf05163  Human cytomegalovirus infection
mcf05164  Influenza A
mcf05165  Human papillomavirus infection
mcf05166  Human T-cell leukemia virus 1 infection
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05168  Herpes simplex virus 1 infection
mcf05169  Epstein-Barr virus infection
mcf05170  Human immunodeficiency virus 1 infection
mcf05171  Coronavirus disease - COVID-19
mcf05200  Pathways in cancer
mcf05203  Viral carcinogenesis
mcf05205  Proteoglycans in cancer
mcf05206  MicroRNAs in cancer
mcf05207  Chemical carcinogenesis - receptor activation
mcf05208  Chemical carcinogenesis - reactive oxygen species
mcf05210  Colorectal cancer
mcf05211  Renal cell carcinoma
mcf05212  Pancreatic cancer
mcf05213  Endometrial cancer
mcf05214  Glioma
mcf05215  Prostate cancer
mcf05218  Melanoma
mcf05220  Chronic myeloid leukemia
mcf05221  Acute myeloid leukemia
mcf05222  Small cell lung cancer
mcf05223  Non-small cell lung cancer
mcf05224  Breast cancer
mcf05225  Hepatocellular carcinoma
mcf05226  Gastric cancer
mcf05230  Central carbon metabolism in cancer
mcf05231  Choline metabolism in cancer
mcf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcf05415  Diabetic cardiomyopathy
mcf05417  Lipid and atherosclerosis
mcf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101866246 (PIK3R1)
   04014 Ras signaling pathway
    101866246 (PIK3R1)
   04015 Rap1 signaling pathway
    101866246 (PIK3R1)
   04370 VEGF signaling pathway
    101866246 (PIK3R1)
   04630 JAK-STAT signaling pathway
    101866246 (PIK3R1)
   04668 TNF signaling pathway
    101866246 (PIK3R1)
   04066 HIF-1 signaling pathway
    101866246 (PIK3R1)
   04068 FoxO signaling pathway
    101866246 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    101866246 (PIK3R1)
   04072 Phospholipase D signaling pathway
    101866246 (PIK3R1)
   04071 Sphingolipid signaling pathway
    101866246 (PIK3R1)
   04024 cAMP signaling pathway
    101866246 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    101866246 (PIK3R1)
   04152 AMPK signaling pathway
    101866246 (PIK3R1)
   04150 mTOR signaling pathway
    101866246 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101866246 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101866246 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    101866246 (PIK3R1)
   04218 Cellular senescence
    101866246 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101866246 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101866246 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101866246 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101866246 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    101866246 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    101866246 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    101866246 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    101866246 (PIK3R1)
   04660 T cell receptor signaling pathway
    101866246 (PIK3R1)
   04662 B cell receptor signaling pathway
    101866246 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    101866246 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    101866246 (PIK3R1)
   04670 Leukocyte transendothelial migration
    101866246 (PIK3R1)
   04062 Chemokine signaling pathway
    101866246 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101866246 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    101866246 (PIK3R1)
   04929 GnRH secretion
    101866246 (PIK3R1)
   04915 Estrogen signaling pathway
    101866246 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    101866246 (PIK3R1)
   04917 Prolactin signaling pathway
    101866246 (PIK3R1)
   04926 Relaxin signaling pathway
    101866246 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    101866246 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    101866246 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101866246 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101866246 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    101866246 (PIK3R1)
   04722 Neurotrophin signaling pathway
    101866246 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101866246 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    101866246 (PIK3R1)
   04380 Osteoclast differentiation
    101866246 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    101866246 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    101866246 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101866246 (PIK3R1)
   05206 MicroRNAs in cancer
    101866246 (PIK3R1)
   05205 Proteoglycans in cancer
    101866246 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    101866246 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101866246 (PIK3R1)
   05203 Viral carcinogenesis
    101866246 (PIK3R1)
   05230 Central carbon metabolism in cancer
    101866246 (PIK3R1)
   05231 Choline metabolism in cancer
    101866246 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101866246 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101866246 (PIK3R1)
   05212 Pancreatic cancer
    101866246 (PIK3R1)
   05225 Hepatocellular carcinoma
    101866246 (PIK3R1)
   05226 Gastric cancer
    101866246 (PIK3R1)
   05214 Glioma
    101866246 (PIK3R1)
   05221 Acute myeloid leukemia
    101866246 (PIK3R1)
   05220 Chronic myeloid leukemia
    101866246 (PIK3R1)
   05218 Melanoma
    101866246 (PIK3R1)
   05211 Renal cell carcinoma
    101866246 (PIK3R1)
   05215 Prostate cancer
    101866246 (PIK3R1)
   05213 Endometrial cancer
    101866246 (PIK3R1)
   05224 Breast cancer
    101866246 (PIK3R1)
   05222 Small cell lung cancer
    101866246 (PIK3R1)
   05223 Non-small cell lung cancer
    101866246 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101866246 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    101866246 (PIK3R1)
   05161 Hepatitis B
    101866246 (PIK3R1)
   05160 Hepatitis C
    101866246 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    101866246 (PIK3R1)
   05164 Influenza A
    101866246 (PIK3R1)
   05162 Measles
    101866246 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    101866246 (PIK3R1)
   05163 Human cytomegalovirus infection
    101866246 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101866246 (PIK3R1)
   05169 Epstein-Barr virus infection
    101866246 (PIK3R1)
   05165 Human papillomavirus infection
    101866246 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101866246 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    101866246 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101866246 (PIK3R1)
   05142 Chagas disease
    101866246 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101866246 (PIK3R1)
   05017 Spinocerebellar ataxia
    101866246 (PIK3R1)
   05020 Prion disease
    101866246 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101866246 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    101866246 (PIK3R1)
   05415 Diabetic cardiomyopathy
    101866246 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101866246 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    101866246 (PIK3R1)
   04931 Insulin resistance
    101866246 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101866246 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101866246 (PIK3R1)
   01524 Platinum drug resistance
    101866246 (PIK3R1)
   01522 Endocrine resistance
    101866246 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    101866246 (PIK3R1)
Membrane trafficking [BR:mcf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101866246 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Laminin_I PI_PP_I Bap31_Bap29_C Exonuc_VII_L Transcrip_act
Other DBs
NCBI-GeneID: 101866246
NCBI-ProteinID: XP_005557120
Ensembl: ENSMFAG00000045395
UniProt: A0A7N9CVN4
LinkDB
Position
6:join(73947396..73947501,73948934..73949036,73949740..73949838,73949942..73950122,73950348..73950473,73951171..73951313,73951549..73951725,73951821..73951889,73952569..73952739,73953849..73954038)
AA seq 454 aa
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTVANNGMNNNMSLQD
AEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY
GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE
KFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL
IQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSN
RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSS
LKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgtacaatactgtttggaatatggaagacctggatttagaatatgccaagacagatata
aattgtggcacagacttgatgttttatatagaaatggacccaccagcactgcctcctaaa
ccaccaaaacccactactgtagccaacaacggtatgaataacaatatgtccttacaagat
gctgaatggtactggggagatatctcgagggaagaagtgaatgaaaaacttcgagataca
gcagatgggacctttttggtacgagatgcgtctactaaaatgcatggtgattatactctt
acactaaggaaagggggaaataacaaattaatcaaaatatttcatcgagatgggaaatat
ggcttctctgacccattaaccttcaattctgtggttgaattaataaaccactaccggaat
gaatctctagctcagtataatcccaagctggatgtgaaattactttatccagtatccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtagggaaaaaattacat
gaatataacactcagtttcaagaaaaaagtagagaatatgatagattatatgaagaatat
acccgtacatcccaggaaatccaaatgaaaaggacagctattgaagcatttaatgaaacc
ataaaaatatttgaagaacagtgccagacccaggagcgctacagcaaagaatacatagaa
aagtttaaacgtgagggcaatgagaaagaaatacaaaggattatgcataattatgataag
ttgaagtctcgaatcagtgaaattattgacagtagaagaagattggaagaagacttgaag
aagcaggcagctgagtatcgagaaattgacaaacgtatgaacagcattaaaccagacctt
atccagctgagaaagacgagagaccaatacttgatgtggttgactcaaaaaggtgttcgg
caaaagaagttgaacgagtggttgggcaatgaaaacactgaagaccaatattcgctggtg
gaagatgatgaagatttaccccatcatgatgagaagacgtggaatgttggaagcagcaac
cgaaacaaagctgaaaacctgttgcgagggaagcgagatggcacttttcttgtccgggag
agcagtaaacagggctgctacgcctgctctgtagtggtggacggcgaagtaaagcattgt
gtcataaacaaaacagcgactggctatggctttgccgagccctataacttgtacagctct
ctgaaagaactggtgctacattaccaacacacctccctcgtgcagcacaacgactccctc
aatgtcacactagcctacccagtatatgcacagcagaggcgatga

DBGET integrated database retrieval system