KEGG T02918: 101925768

Macaca fascicularis (crab-eating macaque): 101925768

Entry

101925768         CDS       T02918

Symbol

ITCH

Name

(RefSeq) E3 ubiquitin-protein ligase Itchy homolog isoform X1

K05632

E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]

Organism

mcf Macaca fascicularis (crab-eating macaque)

Pathway

mcf04120

Ubiquitin mediated proteolysis

mcf04144

Endocytosis

mcf04330

Notch signaling pathway

mcf04668

TNF signaling pathway

mcf04932

Non-alcoholic fatty liver disease

Brite

KEGG Orthology (KO) [BR:mcf00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    101925768 (ITCH)
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    101925768 (ITCH)
   04668 TNF signaling pathway
    101925768 (ITCH)
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    101925768 (ITCH)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    101925768 (ITCH)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    101925768 (ITCH)
   04121 Ubiquitin system [BR:mcf04121]
    101925768 (ITCH)
Enzymes [BR:mcf01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     101925768 (ITCH)
Membrane trafficking [BR:mcf04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    101925768 (ITCH)
Ubiquitin system [BR:mcf04121]
Ubiquitin ligases (E3)
  HECT type E3
   101925768 (ITCH)

SSDB

Motif

Pfam:

HECT WW C2 PQQ_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

Ensembl:

UniProt:

LinkDB

Position

10:join(90442453..90442522,90456786..90456927,90461270..90461394,90462799..90462936,90470747..90470792,90484159..90484316,90486537..90486726,90488743..90488838,90492155..90492329,90496260..90496329,90504357..90504441,90509916..90510044,90517586..90517658,90518970..90519041,90522033..90522121,90524169..90524328,90525127..90525260,90525591..90525731,90533982..90534102,90534544..90534648,90537036..90537132,90542750..90542822,90545995..90546094)

AA seq 862 aa
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLGGDREPTETVGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRLSTNGS
DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD
GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR
VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ
LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT
RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIAYFVDHNRRTTTYIDPRTGKSALDNGPQ
IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSLSPQDLRRRLWVIF
PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI
GRFIAMALFHGKIIDTSFSLPFYKRILSKPVGLKDLESIDPEFYNSLIWVKENNIEECGL
EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF
NEILPQQYVQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDN
EKRMRLLQFVTGTCRLPLGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE

NT seq 2589 nt +upstreamnt +downstreamnt
atgtctgacagtggatcacaacttggttcaatgggtagcctcaccatgaaatcacagctt
cagatcactgtcatctcagcaaaacttaaggaaaataagaagaattggtttggaccaagt
ccttatgtagaggtcacagtagatggacagtcaaagaagacagaaaaatgcaacaacaca
aacagtcctaagtggaagcaaccccttacagttatcgttacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttgtgactttg
cagcttggaggtgacagagagccaacagagacagtaggagacttatcaatttgtcttgat
gggctacagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaagtgct
tctcagaatgacgatggctccagatccaaggatgaaacaagactgagcacaaatggatca
gatgatcccgaagatgcaggagctggtgaaaataggagagtcagtgggaataattctcca
tcactctcaaatggcggttttaaaccttctagacctccaagaccttcacgaccaccacca
cccaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagtgat
gggtctagtacaggctctctgccaccgacaaatacaaatacaaatacatctgaaggagca
acatctggattaataattcctcttactatatctggaggctcaggccctaggccattaaat
cctgtaactcaagctcccttgccacctggttgggagcagagagtggaccagcacggacga
gtttactatgtagatcatgttgagaaaagaacaacatgggatagaccagaacctctacct
cctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcaca
agaacaacaacgtggcagaggccaacactggaatctgtccggaactatgaacaatggcag
ctacagcgtagtcagcttcaaggagcaatgcagcagtttaaccagagattcatttatggg
aatcaagatttatttgctacatcacaaagtaaagaatttgatcctcttggtccattgcca
cctggatgggagaagagaacagacagcaatggcagagtatatttcgtcaaccacaacact
cgaattacacaatgggaagaccccagaagtcaaggtcaattaaatgaaaagcccttacct
gaaggttgggaaatgagattcacagtggatggaattgcatattttgtggaccacaataga
agaactaccacctatatagatccccgcacaggaaaatctgccctagacaatggacctcag
atagcctatgttcgggacttcaaagcaaaggttcagtatttccgattctggtgtcagcaa
ctggccatgccacagcacataaagattacagtgacaaggaaaacattgtttgaggattcc
tttcaacagataatgagcctcagtccccaagatctgcgaagacgtttgtgggtgattttt
ccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtca
catgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgc
ttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgttttatt
ggcagatttattgccatggctctgttccatgggaaaatcatagacacaagtttttctcta
ccattctataagcgtatcttgagcaaaccagttggactcaaggatttagaatctattgat
ccagaattttacaattctctcatctgggttaaagaaaacaatattgaggaatgtggtttg
gaaatgtacttctccgttgacaaagaaattctaggtgaaattaagagtcatgatctgaaa
cctaatggtggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatggta
gctgaatggaggttgtctcgaggtgttgaagaacagacacaagctttctttgagggcttt
aatgaaattcttccccagcaatatgtgcaatactttgatgcaaaggaattagaggtcctt
ttatgtggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcat
tatacgaggaccagcaaacaaatcatgtggttttggcagtttgttaaagaaattgataat
gagaagagaatgagacttctacagtttgttactggaacctgccgattgccactaggagga
tttgctgatctcatggggagcaatggaccacagaaattctgcattgaaaaagttgggaaa
gaaaattggctacccagaagtcatacctgttttaatcgcctggaccttccaccatacaag
agctatgagcaactgaaggaaaagctgttgtttgccatagaagaaacagaaggatttgga
caagagtaa

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