KEGG   Macaca fascicularis (crab-eating macaque): 102138726
Entry
102138726         CDS       T02918                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf00562  Inositol phosphate metabolism
mcf01100  Metabolic pathways
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf04012  ErbB signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04062  Chemokine signaling pathway
mcf04064  NF-kappa B signaling pathway
mcf04066  HIF-1 signaling pathway
mcf04070  Phosphatidylinositol signaling system
mcf04072  Phospholipase D signaling pathway
mcf04360  Axon guidance
mcf04370  VEGF signaling pathway
mcf04613  Neutrophil extracellular trap formation
mcf04650  Natural killer cell mediated cytotoxicity
mcf04658  Th1 and Th2 cell differentiation
mcf04659  Th17 cell differentiation
mcf04660  T cell receptor signaling pathway
mcf04664  Fc epsilon RI signaling pathway
mcf04666  Fc gamma R-mediated phagocytosis
mcf04670  Leukocyte transendothelial migration
mcf04722  Neurotrophin signaling pathway
mcf04750  Inflammatory mediator regulation of TRP channels
mcf04919  Thyroid hormone signaling pathway
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf04935  Growth hormone synthesis, secretion and action
mcf05012  Parkinson disease
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05135  Yersinia infection
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05170  Human immunodeficiency virus 1 infection
mcf05171  Coronavirus disease - COVID-19
mcf05200  Pathways in cancer
mcf05205  Proteoglycans in cancer
mcf05206  MicroRNAs in cancer
mcf05214  Glioma
mcf05223  Non-small cell lung cancer
mcf05225  Hepatocellular carcinoma
mcf05231  Choline metabolism in cancer
mcf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcf05417  Lipid and atherosclerosis
Module
mcf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102138726 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102138726 (PLCG1)
   04014 Ras signaling pathway
    102138726 (PLCG1)
   04015 Rap1 signaling pathway
    102138726 (PLCG1)
   04370 VEGF signaling pathway
    102138726 (PLCG1)
   04064 NF-kappa B signaling pathway
    102138726 (PLCG1)
   04066 HIF-1 signaling pathway
    102138726 (PLCG1)
   04020 Calcium signaling pathway
    102138726 (PLCG1)
   04070 Phosphatidylinositol signaling system
    102138726 (PLCG1)
   04072 Phospholipase D signaling pathway
    102138726 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102138726 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    102138726 (PLCG1)
   04660 T cell receptor signaling pathway
    102138726 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    102138726 (PLCG1)
   04659 Th17 cell differentiation
    102138726 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    102138726 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    102138726 (PLCG1)
   04670 Leukocyte transendothelial migration
    102138726 (PLCG1)
   04062 Chemokine signaling pathway
    102138726 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    102138726 (PLCG1)
   04919 Thyroid hormone signaling pathway
    102138726 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102138726 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102138726 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    102138726 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102138726 (PLCG1)
   05206 MicroRNAs in cancer
    102138726 (PLCG1)
   05205 Proteoglycans in cancer
    102138726 (PLCG1)
   05231 Choline metabolism in cancer
    102138726 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102138726 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102138726 (PLCG1)
   05214 Glioma
    102138726 (PLCG1)
   05223 Non-small cell lung cancer
    102138726 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102138726 (PLCG1)
   05171 Coronavirus disease - COVID-19
    102138726 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102138726 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102138726 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    102138726 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    102138726 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102138726 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102138726 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102138726 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    102138726 (PLCG1)
Enzymes [BR:mcf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102138726 (PLCG1)
Membrane trafficking [BR:mcf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102138726 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102138726 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 102138726
NCBI-ProteinID: XP_005569061
Ensembl: ENSMFAG00000000283
LinkDB
Position
10:join(97244397..97244613,97266622..97266774,97266886..97266979,97267123..97267170,97269444..97269528,97269634..97269717,97269951..97269985,97270196..97270268,97270372..97270473,97270709..97270827,97270910..97270995,97271070..97271190,97271909..97272077,97272222..97272344,97272427..97272528,97272615..97272802,97273139..97273339,97273416..97273535,97273619..97273799,97274832..97274909,97275753..97275856,97276065..97276161,97276439..97276508,97277087..97277244,97279154..97279250,97279382..97279606,97279690..97279838,97280359..97280473,97280578..97280739,97280846..97280934,97281047..97281234,97281403..97281445)
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLQTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRVSQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcatccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatagagggggccattgatattcgagaaatcaaggag
attcgcccagggaagacctcacgagactttgatcgctatcaagaggaccccgctttccgg
ccggaccagtcacactgctttgtcattctctatggaatggaattccgtctgaagacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctaaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaatagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccccctttcccactattggatctcctcctcacacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcaaaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcggcacatcgctgagcgcctgctcactgagtactgcatcgagaccggggcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcacggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgactttcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctgatgcgtgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgaaggcaagatcaagcattgccgtgtccagcaagag
ggccagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaagcacccgctataccgcaagatgaagctgcgctacccaatcaatgaggaggcg
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagggaggatgagctgaccttcaccaagagtgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccagagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagatcgccctggagctctctgaacttgttgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggctctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctgttgaggtgctgggtgcccgacatttg
ccaaagaatggccgaggcattgtgtgcccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccggccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcgtctcccaggagcatcttgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag

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