KEGG   Mastomys coucha (southern multimammate mouse): 116091317
Entry
116091317         CDS       T07224                                 
Symbol
Plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mcoc  Mastomys coucha (southern multimammate mouse)
Pathway
mcoc00562  Inositol phosphate metabolism
mcoc01100  Metabolic pathways
mcoc01521  EGFR tyrosine kinase inhibitor resistance
mcoc04012  ErbB signaling pathway
mcoc04014  Ras signaling pathway
mcoc04015  Rap1 signaling pathway
mcoc04020  Calcium signaling pathway
mcoc04062  Chemokine signaling pathway
mcoc04064  NF-kappa B signaling pathway
mcoc04066  HIF-1 signaling pathway
mcoc04070  Phosphatidylinositol signaling system
mcoc04072  Phospholipase D signaling pathway
mcoc04360  Axon guidance
mcoc04370  VEGF signaling pathway
mcoc04613  Neutrophil extracellular trap formation
mcoc04650  Natural killer cell mediated cytotoxicity
mcoc04658  Th1 and Th2 cell differentiation
mcoc04659  Th17 cell differentiation
mcoc04660  T cell receptor signaling pathway
mcoc04664  Fc epsilon RI signaling pathway
mcoc04666  Fc gamma R-mediated phagocytosis
mcoc04670  Leukocyte transendothelial migration
mcoc04722  Neurotrophin signaling pathway
mcoc04750  Inflammatory mediator regulation of TRP channels
mcoc04919  Thyroid hormone signaling pathway
mcoc04933  AGE-RAGE signaling pathway in diabetic complications
mcoc04935  Growth hormone synthesis, secretion and action
mcoc05012  Parkinson disease
mcoc05022  Pathways of neurodegeneration - multiple diseases
mcoc05135  Yersinia infection
mcoc05167  Kaposi sarcoma-associated herpesvirus infection
mcoc05170  Human immunodeficiency virus 1 infection
mcoc05171  Coronavirus disease - COVID-19
mcoc05200  Pathways in cancer
mcoc05205  Proteoglycans in cancer
mcoc05206  MicroRNAs in cancer
mcoc05214  Glioma
mcoc05223  Non-small cell lung cancer
mcoc05225  Hepatocellular carcinoma
mcoc05231  Choline metabolism in cancer
mcoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcoc05417  Lipid and atherosclerosis
Module
mcoc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcoc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    116091317 (Plcg1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    116091317 (Plcg1)
   04014 Ras signaling pathway
    116091317 (Plcg1)
   04015 Rap1 signaling pathway
    116091317 (Plcg1)
   04370 VEGF signaling pathway
    116091317 (Plcg1)
   04064 NF-kappa B signaling pathway
    116091317 (Plcg1)
   04066 HIF-1 signaling pathway
    116091317 (Plcg1)
   04020 Calcium signaling pathway
    116091317 (Plcg1)
   04070 Phosphatidylinositol signaling system
    116091317 (Plcg1)
   04072 Phospholipase D signaling pathway
    116091317 (Plcg1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    116091317 (Plcg1)
   04650 Natural killer cell mediated cytotoxicity
    116091317 (Plcg1)
   04660 T cell receptor signaling pathway
    116091317 (Plcg1)
   04658 Th1 and Th2 cell differentiation
    116091317 (Plcg1)
   04659 Th17 cell differentiation
    116091317 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    116091317 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    116091317 (Plcg1)
   04670 Leukocyte transendothelial migration
    116091317 (Plcg1)
   04062 Chemokine signaling pathway
    116091317 (Plcg1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    116091317 (Plcg1)
   04919 Thyroid hormone signaling pathway
    116091317 (Plcg1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    116091317 (Plcg1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    116091317 (Plcg1)
  09158 Development and regeneration
   04360 Axon guidance
    116091317 (Plcg1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116091317 (Plcg1)
   05206 MicroRNAs in cancer
    116091317 (Plcg1)
   05205 Proteoglycans in cancer
    116091317 (Plcg1)
   05231 Choline metabolism in cancer
    116091317 (Plcg1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116091317 (Plcg1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    116091317 (Plcg1)
   05214 Glioma
    116091317 (Plcg1)
   05223 Non-small cell lung cancer
    116091317 (Plcg1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    116091317 (Plcg1)
   05171 Coronavirus disease - COVID-19
    116091317 (Plcg1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116091317 (Plcg1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    116091317 (Plcg1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    116091317 (Plcg1)
   05022 Pathways of neurodegeneration - multiple diseases
    116091317 (Plcg1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116091317 (Plcg1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    116091317 (Plcg1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116091317 (Plcg1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcoc04131]
    116091317 (Plcg1)
Enzymes [BR:mcoc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     116091317 (Plcg1)
Membrane trafficking [BR:mcoc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    116091317 (Plcg1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    116091317 (Plcg1)
SSDB
Motif
Pfam: SH2 PI-PLC-Y PI-PLC-X EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 116091317
NCBI-ProteinID: XP_031228460
LinkDB
Position
Unknown
AA seq 1260 aa
MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSVDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRT
GERPEHCQVSLSEFQGFLLEYQSELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIECTLGLRFGEGRYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLP
SPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYF
VLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLT
EYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFD
SLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGA
FLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKM
KLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDEL
TFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVLEPEREHLDENSPLGD
LLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVA
QTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEK
YVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMN
QALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLDPCVIYIEVLGARHLPKNGRGIVCP
FVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPTKPFHFQISNPEFAFLRFVVYEEDMFSDQ
NFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIISAKENGDLSPFSGISLRE
RASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRVRRRTRVNGDNRL
NT seq 3783 nt   +upstreamnt  +downstreamnt
atggcgggcgtcgcgaccccctgcgccaacggctgcgggcccggcgcgccctccgaagcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggagcggaagaccttccaggtcaagttggagacgcgccagatc
acgtggagccgcggcgcggacaaaatcgaggggtccgttgatatccgtgaaatcaaggag
atccgcccagggaagacttccagggactttgaccgctaccaagaagacccggccttccgg
ccagatcagtcacactgctttgtcatcctctatggaatggaattccgcctgaagaccttg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacactgcaagcagccacaccgctgcaaattgagaggtggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaggacttgaagaatatg
ctgtcacaggttaactaccgggtccccaatatgcgcttcctccgagagcggctgacggac
ctcgaacagcgcagcggggacatcacctacggacagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggaccttcccttcctggaagccagcactttgaggact
ggagagcggccagagcattgccaggtgtccctttctgagttccagggcttccttcttgaa
taccagtcggagctgtgggctgtcgaccggctgcaggtgcaggaatttatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
tttctgttctccaaagagaacagtgtgtggaactcacagctggatgctgtgtgcccagat
accatgaacaacccactctctcactattggatctcttcctcacataatacgtacctgacc
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcctaaggatgggc
tgtcgctgcattgagtgtacgttgggtctaaggtttggagagggaaggtacccagtcatc
ctgtccattgaggaccactgcagcattgcccagcagagaaacatggctcagcacttcaga
aaggtgcttggcgacacactccttaccaagcctgtggatattgctgctgatgggcttcct
tctcccaaccagctcaagaggaagatccttattaagcacaagaagctggctgagggcagt
gcctatgaggaggtgcctacatctgtgatgtactcagagaatgacatcagtaactccatc
aagaatggtatcctctacttggaggaccccgtgaatcatgagtggtatccccactacttt
gttctgactagcagcaagatctactactctgaggagaccagcagtgaccagggcaatgag
gatgaagaggagccaaaggaggccagcggcagcacagagctgcactcgagtgagaagtgg
ttccatgggaagctcggggctgggcgcgatgggcggcacattgccgagcgcctgctcact
gagtactgcatagagactggggctcctgatggctccttcctggtgcgagaaagtgagacc
ttcgtgggtgactacacgctatctttctggcggaatgggaaagtccagcactgccgtatc
cactcccggcaggatgctgggactcctaagttcttcttgacagataaccttgtctttgac
tctctctatgacctcatcacacattatcagcaagtacccctgcgctgcaatgagtttgag
atgcgcctttcagagcctgttccacagacgaatgcccatgagagcaaagagtggtaccac
gcaagcctgactagagctcaggctgaacatatgctgatgcgagtgcccagggatggggcc
ttcctggtgcggaaacgcaacgagcctaactcatatgccatctctttccgggctgaggga
aagatcaagcactgccgagtacagcaggaaggccagactgtgatgctggggaactctgag
tttgacagccttgttgacctcatcagctactatgagaagcaccccctgtaccgcaaaatg
aagctgcgctaccccatcaatgaggaggcactggagaagattgggacagctgaacctgat
tatggggcactgtacgagggccgcaaccctggtttctatgtggaggcaaaccctatgcca
actttcaagtgtgcagttaaagccctctttgactacaaggcccagagagaggatgaactg
acctttaccaagagtgccattatccagaatgtggaaaagcaagatggtggctggtggcga
ggggattatggtgggaagaagcagctgtggttcccctcaaactatgtggaagagatgatc
aatccagcagtcctagagccagagagggagcacctggatgagaacagccctctgggggac
ttgctgcgaggggtcttagacgtgccagcctgccagatcgccattcgtcctgagggcaaa
aacaaccggctcttcgtcttctccatcagcatgccgtcagtggctcagtggtccctagat
gttgcagctgactcacaggaggagctgcaggactgggtgaaaaagatccgagaagttgcc
cagactgcagatgccaggcttactgaggggaagatgatggagaggaggaagaagatcgcc
ttggagctttctgagcttgtggtctactgccggcctgttccctttgatgaagagaagatt
ggcacagaacgtgcttgttaccgggacatgtcctcctttccggaaacaaaggctgagaag
tatgtgaacaaggccaaaggcaagaagttcctccagtacaaccggctgcagctctctcga
atctaccctaagggccaaaggctggactcctccaattatgatcctctgcccatgtggatc
tgcggcagccagcttgtagcactcaattttcagaccccagacaagcctatgcagatgaac
caggccctcttcatggctggtgggcattgtggctatgtgctgcagccaagcaccatgaga
gacgaagcctttgacccctttgataagagcagtctccgaggtctggatccctgtgtcatt
tacattgaggtgctgggggccaggcatctgccgaagaacggccggggtattgtgtgtcct
tttgtggagattgaggtggctggggctgagtacgacagcaccaagcaaaagacagagttt
gtagtggacaacggactgaaccctgtgtggcccactaagcccttccacttccagatcagt
aacccagagtttgcctttctgcgctttgtggtgtatgaggaagacatgtttagtgaccag
aacttcttggctcaggctactttcccagtaaaaggcctgaagacaggatacagagccgtg
cctttgaagaacaactacagtgaggatctggagttggcctccctgctcatcaagattgac
attatctctgctaaggagaatggtgacctcagtcctttcagtggcatatccctaagggaa
cgggcctcagatgcctccagccagctgttccatgtccgggcccgggaagggtcctttgaa
gccagataccagcagccatttgaagatttccgcatctcgcaggagcatcttgcagaccat
tttgacagtcgggaacgaagggtccgaagaaggactcgggtcaatggagacaaccgcctc
tag

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