KEGG   Monodelphis domestica (gray short-tailed opossum): 100018044
Entry
100018044         CDS       T01031                                 
Symbol
MAP2K2
Name
(RefSeq) mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo01521  EGFR tyrosine kinase inhibitor resistance
mdo01522  Endocrine resistance
mdo04010  MAPK signaling pathway
mdo04012  ErbB signaling pathway
mdo04014  Ras signaling pathway
mdo04015  Rap1 signaling pathway
mdo04022  cGMP-PKG signaling pathway
mdo04024  cAMP signaling pathway
mdo04066  HIF-1 signaling pathway
mdo04068  FoxO signaling pathway
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04140  Autophagy - animal
mdo04148  Efferocytosis
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04210  Apoptosis
mdo04218  Cellular senescence
mdo04270  Vascular smooth muscle contraction
mdo04370  VEGF signaling pathway
mdo04371  Apelin signaling pathway
mdo04540  Gap junction
mdo04550  Signaling pathways regulating pluripotency of stem cells
mdo04613  Neutrophil extracellular trap formation
mdo04620  Toll-like receptor signaling pathway
mdo04650  Natural killer cell mediated cytotoxicity
mdo04660  T cell receptor signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04664  Fc epsilon RI signaling pathway
mdo04720  Long-term potentiation
mdo04722  Neurotrophin signaling pathway
mdo04730  Long-term depression
mdo04810  Regulation of actin cytoskeleton
mdo04910  Insulin signaling pathway
mdo04912  GnRH signaling pathway
mdo04915  Estrogen signaling pathway
mdo04916  Melanogenesis
mdo04917  Prolactin signaling pathway
mdo04919  Thyroid hormone signaling pathway
mdo04921  Oxytocin signaling pathway
mdo04926  Relaxin signaling pathway
mdo04929  GnRH secretion
mdo04934  Cushing syndrome
mdo04935  Growth hormone synthesis, secretion and action
mdo05010  Alzheimer disease
mdo05022  Pathways of neurodegeneration - multiple diseases
mdo05132  Salmonella infection
mdo05135  Yersinia infection
mdo05160  Hepatitis C
mdo05161  Hepatitis B
mdo05163  Human cytomegalovirus infection
mdo05164  Influenza A
mdo05165  Human papillomavirus infection
mdo05166  Human T-cell leukemia virus 1 infection
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05170  Human immunodeficiency virus 1 infection
mdo05200  Pathways in cancer
mdo05205  Proteoglycans in cancer
mdo05206  MicroRNAs in cancer
mdo05207  Chemical carcinogenesis - receptor activation
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05210  Colorectal cancer
mdo05211  Renal cell carcinoma
mdo05213  Endometrial cancer
mdo05214  Glioma
mdo05215  Prostate cancer
mdo05216  Thyroid cancer
mdo05218  Melanoma
mdo05219  Bladder cancer
mdo05220  Chronic myeloid leukemia
mdo05221  Acute myeloid leukemia
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
mdo05226  Gastric cancer
mdo05230  Central carbon metabolism in cancer
mdo05231  Choline metabolism in cancer
mdo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100018044 (MAP2K2)
   04012 ErbB signaling pathway
    100018044 (MAP2K2)
   04014 Ras signaling pathway
    100018044 (MAP2K2)
   04015 Rap1 signaling pathway
    100018044 (MAP2K2)
   04370 VEGF signaling pathway
    100018044 (MAP2K2)
   04371 Apelin signaling pathway
    100018044 (MAP2K2)
   04066 HIF-1 signaling pathway
    100018044 (MAP2K2)
   04068 FoxO signaling pathway
    100018044 (MAP2K2)
   04072 Phospholipase D signaling pathway
    100018044 (MAP2K2)
   04071 Sphingolipid signaling pathway
    100018044 (MAP2K2)
   04024 cAMP signaling pathway
    100018044 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    100018044 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    100018044 (MAP2K2)
   04150 mTOR signaling pathway
    100018044 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100018044 (MAP2K2)
   04148 Efferocytosis
    100018044 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    100018044 (MAP2K2)
   04218 Cellular senescence
    100018044 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100018044 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100018044 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100018044 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100018044 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    100018044 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    100018044 (MAP2K2)
   04660 T cell receptor signaling pathway
    100018044 (MAP2K2)
   04662 B cell receptor signaling pathway
    100018044 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    100018044 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100018044 (MAP2K2)
   04929 GnRH secretion
    100018044 (MAP2K2)
   04912 GnRH signaling pathway
    100018044 (MAP2K2)
   04915 Estrogen signaling pathway
    100018044 (MAP2K2)
   04917 Prolactin signaling pathway
    100018044 (MAP2K2)
   04921 Oxytocin signaling pathway
    100018044 (MAP2K2)
   04926 Relaxin signaling pathway
    100018044 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    100018044 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    100018044 (MAP2K2)
   04916 Melanogenesis
    100018044 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100018044 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    100018044 (MAP2K2)
   04730 Long-term depression
    100018044 (MAP2K2)
   04722 Neurotrophin signaling pathway
    100018044 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100018044 (MAP2K2)
   05206 MicroRNAs in cancer
    100018044 (MAP2K2)
   05205 Proteoglycans in cancer
    100018044 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    100018044 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100018044 (MAP2K2)
   05230 Central carbon metabolism in cancer
    100018044 (MAP2K2)
   05231 Choline metabolism in cancer
    100018044 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100018044 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100018044 (MAP2K2)
   05225 Hepatocellular carcinoma
    100018044 (MAP2K2)
   05226 Gastric cancer
    100018044 (MAP2K2)
   05214 Glioma
    100018044 (MAP2K2)
   05216 Thyroid cancer
    100018044 (MAP2K2)
   05221 Acute myeloid leukemia
    100018044 (MAP2K2)
   05220 Chronic myeloid leukemia
    100018044 (MAP2K2)
   05218 Melanoma
    100018044 (MAP2K2)
   05211 Renal cell carcinoma
    100018044 (MAP2K2)
   05219 Bladder cancer
    100018044 (MAP2K2)
   05215 Prostate cancer
    100018044 (MAP2K2)
   05213 Endometrial cancer
    100018044 (MAP2K2)
   05224 Breast cancer
    100018044 (MAP2K2)
   05223 Non-small cell lung cancer
    100018044 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100018044 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    100018044 (MAP2K2)
   05161 Hepatitis B
    100018044 (MAP2K2)
   05160 Hepatitis C
    100018044 (MAP2K2)
   05164 Influenza A
    100018044 (MAP2K2)
   05163 Human cytomegalovirus infection
    100018044 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100018044 (MAP2K2)
   05165 Human papillomavirus infection
    100018044 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100018044 (MAP2K2)
   05135 Yersinia infection
    100018044 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100018044 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    100018044 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100018044 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100018044 (MAP2K2)
   01522 Endocrine resistance
    100018044 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mdo01001]
    100018044 (MAP2K2)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100018044 (MAP2K2)
Protein kinases [BR:mdo01001]
 Serine/threonine kinases: STE group
  STE7 family
   100018044 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Kdo CAMSAP_CC1 Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 100018044
NCBI-ProteinID: XP_001365472
Ensembl: ENSMODG00000000809
UniProt: F6S9S9
LinkDB
Position
3:complement(440554687..440590021)
AA seq 400 aa
MLAKRKPVLPALNITPTNAEGPSPTSEGASEANLADLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNTRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKELEAIFGRPMVDGAEGEPHSISPRPRP
PGRPISGHGIDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTHTAM
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggccaagaggaagccggtgctgccggcgctcaacatcacccccaccaacgccgag
ggcccgtccccgaccagcgagggcgcgtccgaggcaaacttggcagacctgcagaaaaaa
ttagaggaactagaacttgatgagcagcaaaagaagcgactggaagctttccttacccaa
aaggcaaaggtgggggaactgaaggatgatgactttgaaagaatctctgaactgggagct
ggcaatggtggggtggtcaccaaagtgcaacataggccctcaggcctcatcatggcccga
aagttgattcacctagagatcaaaccagcaatccggaaccagattatccgtgaactccag
gtcctacatgaatgcaactctccatacattgtgggtttctatggtgccttttatagtgat
ggagagattagcatctgcatggagcacatggatggcggttctctggatcaagtattgaaa
gaggccaagagaattcctgaagaaatcttggggaaggttagcattgcggttcttcggggt
ttggcttatctaagagagaaacaccagattatgcacagagatgtgaaaccttccaacatc
ttggtcaatactcggggagagatcaagctctgtgattttggggtgagcgggcaactcatc
gactctatggcaaattcctttgtaggaacccgatcctacatgtctccggagcgattgcaa
ggcacccactactcagtccagtcagatatctggagcatgggcttgtccctagtagagctg
tccattggaaggtacccgattcccccaccagactccaaggaactagaagcgatatttggt
cggcccatggtcgatggggcagagggagaacctcacagcatctcaccacggccacgaccc
ccaggacgtcccatcagtggtcatgggatagacagtcggcctgccatggccatctttgag
ctattggattatattgttaatgagcctccacctaagctgccgaatggtgttttcacacaa
gatttccaggagtttgtaaataaatgcttaattaaaaacccagccgagagggccgatctg
aagatgctgatgaatcacacttttatcaaacggtcagaagtggaagaagtggattttgca
ggctggttatgtaaaactctgaggttaaaccagcccagcactcccacacacactgccatg
tga

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