KEGG   Monodelphis domestica (gray short-tailed opossum): 100019317
Entry
100019317         CDS       T01031                                 
Symbol
PIK3R1
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo01521  EGFR tyrosine kinase inhibitor resistance
mdo01522  Endocrine resistance
mdo01524  Platinum drug resistance
mdo04012  ErbB signaling pathway
mdo04014  Ras signaling pathway
mdo04015  Rap1 signaling pathway
mdo04024  cAMP signaling pathway
mdo04062  Chemokine signaling pathway
mdo04066  HIF-1 signaling pathway
mdo04068  FoxO signaling pathway
mdo04070  Phosphatidylinositol signaling system
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04081  Hormone signaling
mdo04140  Autophagy - animal
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04152  AMPK signaling pathway
mdo04210  Apoptosis
mdo04211  Longevity regulating pathway
mdo04213  Longevity regulating pathway - multiple species
mdo04218  Cellular senescence
mdo04360  Axon guidance
mdo04370  VEGF signaling pathway
mdo04380  Osteoclast differentiation
mdo04510  Focal adhesion
mdo04550  Signaling pathways regulating pluripotency of stem cells
mdo04611  Platelet activation
mdo04613  Neutrophil extracellular trap formation
mdo04620  Toll-like receptor signaling pathway
mdo04625  C-type lectin receptor signaling pathway
mdo04630  JAK-STAT signaling pathway
mdo04650  Natural killer cell mediated cytotoxicity
mdo04660  T cell receptor signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04664  Fc epsilon RI signaling pathway
mdo04666  Fc gamma R-mediated phagocytosis
mdo04668  TNF signaling pathway
mdo04670  Leukocyte transendothelial migration
mdo04722  Neurotrophin signaling pathway
mdo04725  Cholinergic synapse
mdo04750  Inflammatory mediator regulation of TRP channels
mdo04810  Regulation of actin cytoskeleton
mdo04910  Insulin signaling pathway
mdo04914  Progesterone-mediated oocyte maturation
mdo04915  Estrogen signaling pathway
mdo04917  Prolactin signaling pathway
mdo04919  Thyroid hormone signaling pathway
mdo04923  Regulation of lipolysis in adipocytes
mdo04926  Relaxin signaling pathway
mdo04929  GnRH secretion
mdo04930  Type II diabetes mellitus
mdo04931  Insulin resistance
mdo04932  Non-alcoholic fatty liver disease
mdo04933  AGE-RAGE signaling pathway in diabetic complications
mdo04935  Growth hormone synthesis, secretion and action
mdo04960  Aldosterone-regulated sodium reabsorption
mdo04973  Carbohydrate digestion and absorption
mdo05010  Alzheimer disease
mdo05017  Spinocerebellar ataxia
mdo05020  Prion disease
mdo05100  Bacterial invasion of epithelial cells
mdo05135  Yersinia infection
mdo05142  Chagas disease
mdo05146  Amoebiasis
mdo05160  Hepatitis C
mdo05161  Hepatitis B
mdo05162  Measles
mdo05163  Human cytomegalovirus infection
mdo05164  Influenza A
mdo05165  Human papillomavirus infection
mdo05166  Human T-cell leukemia virus 1 infection
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05168  Herpes simplex virus 1 infection
mdo05169  Epstein-Barr virus infection
mdo05170  Human immunodeficiency virus 1 infection
mdo05171  Coronavirus disease - COVID-19
mdo05200  Pathways in cancer
mdo05203  Viral carcinogenesis
mdo05205  Proteoglycans in cancer
mdo05206  MicroRNAs in cancer
mdo05207  Chemical carcinogenesis - receptor activation
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05210  Colorectal cancer
mdo05211  Renal cell carcinoma
mdo05212  Pancreatic cancer
mdo05213  Endometrial cancer
mdo05214  Glioma
mdo05215  Prostate cancer
mdo05218  Melanoma
mdo05220  Chronic myeloid leukemia
mdo05221  Acute myeloid leukemia
mdo05222  Small cell lung cancer
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
mdo05226  Gastric cancer
mdo05230  Central carbon metabolism in cancer
mdo05231  Choline metabolism in cancer
mdo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mdo05415  Diabetic cardiomyopathy
mdo05417  Lipid and atherosclerosis
mdo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100019317 (PIK3R1)
   04014 Ras signaling pathway
    100019317 (PIK3R1)
   04015 Rap1 signaling pathway
    100019317 (PIK3R1)
   04370 VEGF signaling pathway
    100019317 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100019317 (PIK3R1)
   04668 TNF signaling pathway
    100019317 (PIK3R1)
   04066 HIF-1 signaling pathway
    100019317 (PIK3R1)
   04068 FoxO signaling pathway
    100019317 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100019317 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100019317 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100019317 (PIK3R1)
   04024 cAMP signaling pathway
    100019317 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100019317 (PIK3R1)
   04152 AMPK signaling pathway
    100019317 (PIK3R1)
   04150 mTOR signaling pathway
    100019317 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100019317 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100019317 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    100019317 (PIK3R1)
   04218 Cellular senescence
    100019317 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100019317 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100019317 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100019317 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100019317 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    100019317 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100019317 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    100019317 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100019317 (PIK3R1)
   04660 T cell receptor signaling pathway
    100019317 (PIK3R1)
   04662 B cell receptor signaling pathway
    100019317 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100019317 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    100019317 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100019317 (PIK3R1)
   04062 Chemokine signaling pathway
    100019317 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100019317 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    100019317 (PIK3R1)
   04929 GnRH secretion
    100019317 (PIK3R1)
   04915 Estrogen signaling pathway
    100019317 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    100019317 (PIK3R1)
   04917 Prolactin signaling pathway
    100019317 (PIK3R1)
   04926 Relaxin signaling pathway
    100019317 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100019317 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100019317 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100019317 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100019317 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100019317 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100019317 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100019317 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100019317 (PIK3R1)
   04380 Osteoclast differentiation
    100019317 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100019317 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100019317 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100019317 (PIK3R1)
   05206 MicroRNAs in cancer
    100019317 (PIK3R1)
   05205 Proteoglycans in cancer
    100019317 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    100019317 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100019317 (PIK3R1)
   05203 Viral carcinogenesis
    100019317 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100019317 (PIK3R1)
   05231 Choline metabolism in cancer
    100019317 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100019317 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100019317 (PIK3R1)
   05212 Pancreatic cancer
    100019317 (PIK3R1)
   05225 Hepatocellular carcinoma
    100019317 (PIK3R1)
   05226 Gastric cancer
    100019317 (PIK3R1)
   05214 Glioma
    100019317 (PIK3R1)
   05221 Acute myeloid leukemia
    100019317 (PIK3R1)
   05220 Chronic myeloid leukemia
    100019317 (PIK3R1)
   05218 Melanoma
    100019317 (PIK3R1)
   05211 Renal cell carcinoma
    100019317 (PIK3R1)
   05215 Prostate cancer
    100019317 (PIK3R1)
   05213 Endometrial cancer
    100019317 (PIK3R1)
   05224 Breast cancer
    100019317 (PIK3R1)
   05222 Small cell lung cancer
    100019317 (PIK3R1)
   05223 Non-small cell lung cancer
    100019317 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100019317 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100019317 (PIK3R1)
   05161 Hepatitis B
    100019317 (PIK3R1)
   05160 Hepatitis C
    100019317 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    100019317 (PIK3R1)
   05164 Influenza A
    100019317 (PIK3R1)
   05162 Measles
    100019317 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    100019317 (PIK3R1)
   05163 Human cytomegalovirus infection
    100019317 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100019317 (PIK3R1)
   05169 Epstein-Barr virus infection
    100019317 (PIK3R1)
   05165 Human papillomavirus infection
    100019317 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100019317 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100019317 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100019317 (PIK3R1)
   05142 Chagas disease
    100019317 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100019317 (PIK3R1)
   05017 Spinocerebellar ataxia
    100019317 (PIK3R1)
   05020 Prion disease
    100019317 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100019317 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    100019317 (PIK3R1)
   05415 Diabetic cardiomyopathy
    100019317 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100019317 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100019317 (PIK3R1)
   04931 Insulin resistance
    100019317 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100019317 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100019317 (PIK3R1)
   01524 Platinum drug resistance
    100019317 (PIK3R1)
   01522 Endocrine resistance
    100019317 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdo04131]
    100019317 (PIK3R1)
Membrane trafficking [BR:mdo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100019317 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 SH3_1 SH3_2 SH3_9 Laminin_I CCDC113_CCDC96_CC
Other DBs
NCBI-GeneID: 100019317
NCBI-ProteinID: XP_001367149
Ensembl: ENSMODG00000019685
UniProt: F6TD14
LinkDB
Position
3:34135415..34229028
AA seq 731 aa
MVTLAKMSAEGYQYRALYEYKKEREEDIDLHVGDVLTVNKGSLVALGFSEGEEAKPDEIG
WLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKLETDNEQQGFT
LLDLTEQFSSPAVAPPILIKLVEAIEKKGLECPTLYRTQSSSSLAELRQLLDCDASSVDL
DVIDVQVLSDAFKRYLLDLPNPVIPGTIYSEMISVAQELQNSEENVQMLKKLMRTPHIPH
QHGLTLQYLLKHFFKLCQASSKNLLNARSLSEIFSPVLFRFPNTGSDNAEHLIKTIELLI
SSEWNERQPAPALPPKPPKPTTVTANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADG
TFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESL
AQYNPKLDVKLLYPVSKYQQDQVVKEDSIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRT
SQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKS
RISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKK
LNEWLGNENTEDQYSMVEDDEDLPHHDERTWNVGSSNRSKAENLLRGKRDGTFLVRESSK
QGCFACSVVVDGEVKHCVINKTPTGYGFAEPYNLYNSLKELVLHYQHTSLVQHNDSLNVT
LAYPVNAQQRR
NT seq 2196 nt   +upstreamnt  +downstreamnt
atggtcacgttggcaaaaatgagtgctgaaggatatcagtatcgagccttatatgagtat
aaaaaagaacgagaagaagatattgacttgcatgtgggggacgtgttaactgtgaataaa
gggtccttagtagcacttggattcagtgagggggaagaagcaaagcctgatgaaattggt
tggttaaatggctataatgaaaccacaggagaaagaggcgactttccaggaacttatgta
gaatatattggaaggaaaagaatttcacctcctaccccaaagcctcggccaccccgaccc
cttcctgtagctccaggctcttcaaaactggaaacagataatgaacaacaaggttttaca
cttctagatctcacagagcaattttcctctcctgctgttgctccaccaatccttatcaaa
ttagtggaagctattgagaagaaaggtctggaatgcccaactttgtacagaacccagagc
tcaagcagcttagctgaactccggcagcttcttgattgtgatgcctcttcagtggatttg
gatgtgattgatgtgcaggtcctatcagatgctttcaagagatatctcttggacctgcca
aatcccgtcattcctgggacgatttacagtgaaatgatttctgtagcacaagaactgcag
aactcagaagagaacgtccagatgctaaagaagcttatgaggactcctcacatacctcat
cagcatgggctcacgcttcagtatttgctaaaacatttcttcaaactctgccaggcctcc
agcaaaaatcttttgaatgcaaggtctctctctgaaattttcagccctgtgcttttcaga
tttccaaacacaggctctgataatgccgaacacctcataaaaactatagaacttttaatc
tcaagtgaatggaatgagcgacagcctgcaccagcactgcctcctaagccacccaaaccc
actactgtaacagctaacaacggtatgaataacaatatgtccttacaagatgccgaatgg
tactggggagacatctcaagggaagaagtcaatgaaaagctgcgtgatacagcagatggc
acctttttggtacgagatgcatccaccaaaatgcatggggactatactcttacacttagg
aaaggaggaaataacaaattaatcaaaatatttcaccgagatgggaaatatggcttctct
gacccattgactttcaactctgtggttgaactgataaaccactaccggaatgaatctcta
gctcagtataatcctaaactggatgtgaaattactttatccagtttccaagtaccaacag
gatcaagttgtaaaagaggatagtattgaagctgtaggaaagaaattacatgaatataac
actcaattccaagaaaaaagcagagaatatgacagactatatgaagattatacccgtaca
tctcaggaaatccaaatgaaaagaacagcaattgaagcatttaatgaaacaataaagata
tttgaagaacaatgccaaacccaggaacggtacagcaaagaatatatagaaaagtttaaa
cgtgaaggaaatgaaaaagaaatacaaaggattatgcataattatgaaaagttaaagtct
cgaatcagtgaaatcgtggacagtagacgaaggttggaggaggatttgaaaaagcaagca
gccgagtatcgagagattgacaagcggatgaacagcatcaagccagatctcattcagttg
aggaagacaagggaccaatacttgatgtggttgactcaaaaaggtgtccgacaaaagaag
ttgaatgaatggctgggcaacgaaaatacggaagaccaatattcaatggtggaagatgac
gaggatttgccgcaccatgacgagaggacatggaatgtgggaagcagcaacagaagcaaa
gcagagaacctcttgcggggcaaacgagatggcactttcctggttcgagagagcagcaaa
cagggttgctttgcttgctctgtagtggtggatggtgaagtaaagcactgtgtgataaac
aaaaccccaacggggtatggatttgcagagccatataacttgtacaactctttgaaagag
ctggtgctacattaccaacacacgtcccttgtccagcacaacgactctctcaatgtcacc
ctagcctacccagtcaatgcacagcagaggcgatga

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