Monodelphis domestica (gray short-tailed opossum): 100021838
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Entry
100021838 CDS
T01031
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
mdo
Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo04022
cGMP-PKG signaling pathway
mdo04068
FoxO signaling pathway
mdo04081
Hormone signaling
mdo04140
Autophagy - animal
mdo04150
mTOR signaling pathway
mdo04151
PI3K-Akt signaling pathway
mdo04152
AMPK signaling pathway
mdo04211
Longevity regulating pathway
mdo04213
Longevity regulating pathway - multiple species
mdo04722
Neurotrophin signaling pathway
mdo04910
Insulin signaling pathway
mdo04920
Adipocytokine signaling pathway
mdo04923
Regulation of lipolysis in adipocytes
mdo04930
Type II diabetes mellitus
mdo04931
Insulin resistance
mdo04932
Non-alcoholic fatty liver disease
mdo04935
Growth hormone synthesis, secretion and action
mdo04960
Aldosterone-regulated sodium reabsorption
mdo05010
Alzheimer disease
mdo05206
MicroRNAs in cancer
mdo05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
mdo00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
100021838 (IRS1)
04022 cGMP-PKG signaling pathway
100021838 (IRS1)
04151 PI3K-Akt signaling pathway
100021838 (IRS1)
04152 AMPK signaling pathway
100021838 (IRS1)
04150 mTOR signaling pathway
100021838 (IRS1)
09133 Signaling molecules and interaction
04081 Hormone signaling
100021838 (IRS1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100021838 (IRS1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
100021838 (IRS1)
04923 Regulation of lipolysis in adipocytes
100021838 (IRS1)
04920 Adipocytokine signaling pathway
100021838 (IRS1)
04935 Growth hormone synthesis, secretion and action
100021838 (IRS1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
100021838 (IRS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
100021838 (IRS1)
09149 Aging
04211 Longevity regulating pathway
100021838 (IRS1)
04213 Longevity regulating pathway - multiple species
100021838 (IRS1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
100021838 (IRS1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100021838 (IRS1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
100021838 (IRS1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100021838 (IRS1)
04932 Non-alcoholic fatty liver disease
100021838 (IRS1)
04931 Insulin resistance
100021838 (IRS1)
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Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
100021838
NCBI-ProteinID:
XP_001373872
Ensembl:
ENSMODG00000021208
UniProt:
F7B223
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Position
7:222317019..222391635
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AA seq
1243 aa
AA seq
DB search
MASPPEGDGCFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSGA
PKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSESEQESWYQALLQLHNRAKG
HHLHHSHHEAAAFGVGGGGGGGSCSGSSGLGEGGEDSSYGEMAPGPAFKEVWQVILKPKG
LGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTG
PGEFWMQVDDSVVAQNMHETILEAMRAMSEEFRPRSKSQSSSNCSNPISVPLRRHHLNNP
PPSQVGLTRRSRTESVTATSPASVVGGKPCSFRVRASSDGEGTMSRPASVDGSPVSPSTN
RTHSHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRS
SASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEDLSNYICMGGKN
TPNLMAPNGHYNLSRGGNGHRYTPGAGPSPATVGEEAATAADLEKSFRKRTHSAGTSPTI
SHQKTPSQSSVASIEEYTEMMPSYPPCSSAGTGNRMQAYRHSAFVPTHSYPEECLEIHPL
EERGGHHHRGDTPGLHTDDGYMPMSPGVAPVPSSRKSGGDYMPMSPKSVSAPQQIINPGR
RHSQRVDPNGYMMMSPSGSCSPDGAGGSGNGNAATPGNSYGKLWTNGVGGHHHHHHGHPK
LSMESSDGKLPCSSDYINMSPAGDSATSSPSEGYYGPDDPQGKAIYSYYSLPRSFKHTQQ
QQRRGEPEDGGRLHHLRLSASSGRLLYATAAEDSSSSASSDSLGGGGGGQEGVHGHLHHQ
ALHQHLPRKMDLVAQTKSRLTRPTRLSLDGPKASTLPRAREQPQQPLLPPEPKSPGEYVN
IEFVGEQPSYPHGSAISLCSPTVRCPAPRQPAPREEDPGSEEYMNMDLRPPRRPACQEGF
GSKAGRACPLPTGVGGVCRPSRALPNSQDYVTMQVGGPCSGCADASLSYVVMQTSRASEE
SSVPGAASAAPSPAFTAATPSLPQHPGQAELASRPSLLGGPKGPGGISAFTRVNLSPSRN
QSAKVIRADPQGCRRRHSSETFSSTPSAARGSNVAVPFGAAGAGGSGTSGGGSSEDVKRH
SSASFENVWLKPGDVGGPPSRKETPQMSGGAPAGAAAGLENGLNYIDLDLVKDFNHRPQE
CPPLLQPPHQPCGSGGGSGSGCSSEDLSAYASISFQKQPEDLP
NT seq
3732 nt
NT seq
+upstream
nt +downstream
nt
atggcgagtccaccggagggggacggctgcttctcagatgtgcggaaggtgggctacctc
cgcaaacccaagagcatgcacaaacgcttcttcgtcctgcgggcagctagtgaggccggg
ggtccagcccgcctggagtactacgagaacgaaaagaagtggaggcacaaatcgggtgcc
cccaagcgctctatcccgctagagagctgcttcaacatcaacaagcgggctgactccaag
aacaaacacctggtagccctctacacccgggatgagcattttgccattgccgcggacagc
gagtcggagcaggagagctggtaccaggcgctcctgcagctccacaaccgggccaagggg
catcacttgcaccattcccaccacgaggctgcagcttttggagtgggagggggaggagga
ggagggagctgcagcggcagctctggcctgggagaagggggtgaggacagtagctatggt
gaaatggccccaggacccgcattcaaggaggtttggcaagtgatcctgaagcctaagggc
ttggggcagacaaagaacctgattggtatctaccggctctgcttgaccagtaagaccatc
agctttgtgaagctcaactcagaggcagccgcagtggtcctccaattgatgaacattcgc
aggtgtggccactcggaaaacttcttttttattgaggtggggcgctctgccgtgactggg
cctggggagttctggatgcaagtggatgactctgtagttgcccaaaatatgcatgagact
atcctggaagccatgcgggccatgagtgaggagttccggcctcggagcaagagccaatcg
tcctctaactgctccaaccccatcagtgtccctcttcgcaggcatcacctcaataacccc
ccacccagccaagtggggctcactcggaggtcccggactgagagtgtcactgccacatcc
ccagctagtgtggttggtgggaagccctgctctttccgtgtccgggcttctagtgatgga
gaaggcaccatgtcccggccagcttcagtggacgggagccctgtgagtcccagtaccaac
cggacccattcacaccgacatcggggcagctcccggttgcatccccctcttaaccacagc
cgctccatccccatgccctcctcccgatgttccccttcagccacaagtccagtcagcttg
tcatccagcagcaccagtggccatggatcaacttcagactgcctcttccctaggaggtcc
agtgcctctgtgtctggctcccccagtgatgggggcttcatctcttccgatgaatatggc
tccagcccttgtgacttccgaagttctttccggagtgtcacccctgattccttgggtcat
accccaccagctaggggcgaggaagacctgagcaactatatctgcatgggaggcaaaaac
acacctaacttgatggcccccaatggccactataacctctccaggggtggcaatgggcac
cggtatacccccggagctggccccagccctgctacagttggagaggaggcagccactgct
gcagacctggagaaaagtttcagaaagagaactcactcagcaggtacttctcccaccatt
tcccaccagaagaccccctcacaatcctccgttgcctccattgaggagtacacagagatg
atgccttcctacccaccctgttcctcagcgggcaccgggaaccggatgcaagcctaccgg
cactcagcctttgtgcccacccattcctatcccgaggagtgtctggaaatccatccctta
gaggagcggggaggccaccatcaccggggggacactcccgggctacacaccgatgatggc
tacatgcccatgtctcctggggtagccccagtgcccagcagccgaaagagtgggggagat
tacatgcccatgagccccaagagcgtgtctgccccgcagcagatcattaaccctggccgg
aggcattcccaaagggtagatcccaatggctacatgatgatgtcccccagtggcagctgt
tccccggatggcgcagggggctcaggcaatggcaatgcggccacccctgggaacagctat
ggcaagttatggacaaacggggttggtggccaccatcaccatcaccacgggcaccccaag
ctctccatggagagcagtgatgggaagctgccctgcagcagcgactacattaacatgtcc
ccagccggagactcggccaccagcagcccctccgagggctactatggaccagatgacccg
cagggcaaggccatctactcctactactcactgcctcgctccttcaagcacacccagcag
cagcagcgtcgaggggagcccgaagatggcggccggctccaccacctgcgcctctctgcc
agctccggccgccttctctacgccacagcggcggaggactcgtcttcttccgccagcagt
gacagcctgggaggaggtggaggtggccaggaaggggtgcacggccacctccaccatcag
gccctacaccagcacctgccccgaaagatggatctagttgcccagaccaagagccgcctg
actcggcccacaagactctctctggatggccccaaggccagcaccttacccagggctcgg
gagcagccccagcagcctcttcttcctccagagcccaagagcccgggagaatacgtgaat
attgagtttgtaggtgagcagcccagctacccgcatggctcagccatctccctctgctct
cccaccgtcaggtgcccagccccgcgccagccggcccccagagaggaggaccctggctcc
gaggaatatatgaacatggacttgaggcctcccaggaggccggcctgccaggaaggcttt
gggtcgaaggcgggaagagcctgccccctgcccaccggggtaggtggtgtgtgcaggccc
agccgggcactgccaaacagccaggattacgtgaccatgcaggtgggtgggccctgctca
ggctgtgccgatgcttctctcagctatgtggtgatgcagacaagcagggcttccgaggag
tccagcgtcccaggcgctgcctctgccgccccttccccagcttttactgccgccaccccc
tccctcccccagcacccaggccaggcagagctggctagccgcccctccctgctaggaggt
ccaaagggacccggagggattagcgccttcactcgagtgaacctcagccctagccgcaac
cagagtgccaaagtgatccgggctgacccccaaggatgccggaggcggcacagctccgag
actttttcctccacccccagtgctgcccggggcagtaacgttgcagtgccctttggggcg
gctggcgcaggtggctctgggaccagcggcggcggcagcagcgaagatgttaaacgccac
agttctgcctcctttgaaaatgtctggctaaagcctggggatgtagggggcccacccagc
aggaaggagaccccccagatgagtgggggtgcccccgcgggagcagcggccggtttggag
aacggactcaactacatcgacctggatttggtcaaggattttaatcaccggccccaggag
tgcccccctctgctgcagcctcctcatcagccctgtggcagtggtgggggcagtggcagc
ggctgttccagtgaggatctaagcgcctatgctagcatcagctttcagaagcagccagag
gaccttccatag
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