KEGG   Monodelphis domestica (gray short-tailed opossum): 100025395
Entry
100025395         CDS       T01031                                 
Symbol
IRS4
Name
(RefSeq) insulin receptor substrate 4
  KO
K07187  insulin receptor substrate 2
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo04022  cGMP-PKG signaling pathway
mdo04068  FoxO signaling pathway
mdo04081  Hormone signaling
mdo04140  Autophagy - animal
mdo04152  AMPK signaling pathway
mdo04211  Longevity regulating pathway
mdo04213  Longevity regulating pathway - multiple species
mdo04910  Insulin signaling pathway
mdo04920  Adipocytokine signaling pathway
mdo04923  Regulation of lipolysis in adipocytes
mdo04930  Type II diabetes mellitus
mdo04931  Insulin resistance
mdo04932  Non-alcoholic fatty liver disease
mdo04935  Growth hormone synthesis, secretion and action
mdo05010  Alzheimer disease
mdo05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100025395 (IRS4)
   04022 cGMP-PKG signaling pathway
    100025395 (IRS4)
   04152 AMPK signaling pathway
    100025395 (IRS4)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100025395 (IRS4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100025395 (IRS4)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    100025395 (IRS4)
   04923 Regulation of lipolysis in adipocytes
    100025395 (IRS4)
   04920 Adipocytokine signaling pathway
    100025395 (IRS4)
   04935 Growth hormone synthesis, secretion and action
    100025395 (IRS4)
  09149 Aging
   04211 Longevity regulating pathway
    100025395 (IRS4)
   04213 Longevity regulating pathway - multiple species
    100025395 (IRS4)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    100025395 (IRS4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100025395 (IRS4)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100025395 (IRS4)
   04932 Non-alcoholic fatty liver disease
    100025395 (IRS4)
   04931 Insulin resistance
    100025395 (IRS4)
SSDB
Motif
Pfam: IRS PH PH_11
Other DBs
NCBI-GeneID: 100025395
NCBI-ProteinID: XP_007506999
LinkDB
Position
X:6593049..6620665
AA seq 1094 aa
MWRGAEDGARCCSPDRGDPGLTQLLQAAGDDVRKCGYLRKQKHGHKRYFVLRTASRLAPA
RLEYYESEKKFRNSLRAAAAAAAAAGGPSAGAAASVPPAVQPKRVIPLYQCFTVSRRADA
KYRHLIALYTKDDYFAMVAENEEEQESWYQALSLLMGQSKTRSSGDGGEDDDDTNGGGGG
GGGSGGGGGGGGGGGTRIAVGEMVEDGSAFREVWQVHVKPKGLGQTRNMSGIYRLCLSSK
EVHLVRLNSDAPTIQLQLLSIRRCGHSEHFFFLEVGRSSSIGPGEIWMQVDDSVVAQHMH
ETFLETMKALKAFADFRPRSKSQSSCSNPISFLSTRRHLGYLQPCLGMSRRSRTDSVAST
PPSCKGNTYRFRASSEGDGTMDRPFRTVTGSLMQLNPGRMNPARPESGRYVRAAFNGCCH
SHSTSLPVSPFPSGSSPAPGTSTRPSSSMCGNPGDGGAASSDDYGSSPGGMRYLRVRNGT
PDSVGNTPPIREERAFTKYVAPNKQRAKDGARGNHMEPEKCCKRKTFSLAKPPAVTTQQK
TTQTSALDIESPGNSRLLLPSSQSVRSRETPKLEHGENGSNRNQSRNSKAEDEGYMSMMP
GVAGPLKGNSDYLPMAPKGASASKPTSSSSSSQKDSRGYMMMFPRASSVSPGRHARGAFS
SRGASHKEEDNEYMDMSPGQPLAPRQSHEGNSLHLPSSFSKSLSSLFSLPKSFRTITEHS
DDSDYVPMASPGRLLSTVPEKGRSGSVPPRDIPRAPPTSKASDGGLPPRKASRPTKLPLG
TRGSSVPRVFQRGLRAESPAEYVNMDFSRNASSTPRCLSAECSPSSLGSCRDHTQSPFSD
CMGFAMDVNSPKAAKELANTLKLSGSKLPRNQLTRDSARRPLGAAARISTPTNDDDDDYT
EMNFNPAASAAAAPSAVRSKEPVKIDSPSAAVNRLRIADDSSEGRTFSLRDPRPPPAVIP
RAVRAEPQGRRRHSSETFSRAGAAATPSSPFSDSGRQSSVSFDSVWSSSGQGAPDPEETR
MSRVTSAGFQNGLNFIAVSVRDAAAPTAPPRRRVSSTAPSAQRGNGASDLDSGTYVTIDF
SKDDIFQRTSSRKD
NT seq 3285 nt   +upstreamnt  +downstreamnt
atgtggaggggcgcagaggacggcgcccgctgctgctccccggatcgcggggacccgggc
ctaacgcagctgctgcaggcggccggagacgatgtccgcaaatgtggctacctgcggaaa
cagaagcacggccacaagcgctacttcgtgcttcgaacggccagccgcctggccccggcg
cgcctagagtactacgagagcgaaaagaagttccgcaacagtctccgcgccgctgccgcc
gccgccgcggcagctggaggcccctccgcgggcgcagcggcgagtgtgccccccgcggtg
cagcccaagcgcgttatccccctgtatcagtgcttcacggtgagccgccgcgcagatgcc
aagtaccgccacctcatcgccctctacactaaggacgactacttcgccatggtggccgag
aatgaggaggagcaggagagctggtaccaagcgctgagtctcctgatgggtcagagcaag
acgcgaagctccggcgacgggggcgaagatgacgatgacaccaacggtggcggcggcggc
ggcggcggcagcggcggcggcggcggcggcggcggcggtggcggcaccagaatcgctgtg
ggtgagatggtagaggacgggagcgccttcagggaggtgtggcaggtgcatgtgaaaccc
aaggggctgggccagaccaggaacatgagcggcatctatcgcctgtgcctgtccagcaag
gaggtgcacctggtgcgtctgaactcggatgcgcccaccattcagctgcagctgctcagc
atccgtcgctgcggccactcggagcacttcttcttcctcgaggtgggcaggtcatcgtcc
attggccctggggagatctggatgcaggtggacgactcagtggtggctcagcacatgcac
gagaccttcctggaaaccatgaaagccctcaaggcctttgccgacttcaggccccggagc
aagagccagtcgtcctgctccaaccccatctcgttcctctccaccaggaggcacctgggc
tacctgcagccctgtctgggtatgtcccgcaggtcccgcaccgacagcgtagccagcacc
ccgccctcctgcaagggcaacacttaccgattccgcgcctccagcgagggcgacggcacc
atggacagacccttccgaacggtcaccggaagcctgatgcagttgaaccccggccgcatg
aacccggcccgcccggaaagtggcaggtacgttcgcgccgctttcaatggttgctgtcac
tctcactctacctccttgccagtgtctccctttccctccgggtccagcccagccccagga
acctcgaccaggccttcgagctccatgtgtggaaacccgggtgatggtggcgcagcctcc
tccgatgattacggctccagcccgggaggaatgaggtatttacgagtgagaaacgggacc
ccggactccgtgggaaacaccccacccatccgagaagaacgcgccttcacgaagtacgtg
gcgccgaataaacagcgcgccaaagacggtgccagaggcaatcatatggaacccgaaaag
tgctgtaagagaaaaactttctccctggctaagccaccggctgtaaccacgcaacaaaaa
acaacacagacctccgctttggatatcgagtctcctggaaactccaggctgctgctcccc
tcctcccagtcggtgcgatcgagagagacccccaagctggagcacggtgagaatgggtcc
aatcgcaaccaaagcagaaacagcaaagctgaggatgaaggttacatgtccatgatgcca
ggagtggccggccccctcaaaggaaacagcgattacttgccgatggctcctaaaggtgct
tctgcctccaaacccaccagttcctcgtcatcctcacagaaagactcccgcggctacatg
atgatgtttccaagagctagcagcgtctcaccgggccgccatgctcgtggcgccttctcc
tccaggggggcgagtcataaggaagaagataatgaatacatggatatgtccccgggccaa
cccctggctccccggcagtctcacgagggcaattctctgcacctcccctcctccttttcc
aaaagtttgagttcgctcttctccctgccaaaaagtttccgcacgataaccgagcatagt
gacgacagcgactacgtcccgatggcatcacctggaagactcctgagcaccgtcccggaa
aagggccgaagcggaagcgtgccccccagggacattcctagagctcctccaacttcgaaa
gcttccgacgggggactcccaccaaggaaggcttcgagacctaccaaactccctctcggc
acaagaggaagcagtgttccgcgagtctttcagcgtggcctgagagcagagagccctgcg
gagtacgtcaacatggactttagcaggaacgcaagcagtacaccccgctgcctctcagcc
gaatgctccccctcgtctttgggctcctgccgtgaccacacacagtcacccttttccgac
tgcatgggttttgccatggatgttaactcgcccaaagctgccaaggagctcgccaatacc
ttaaagctgtcgggttccaagctgccccgaaaccagctaactcgggactctgctagacgt
ccacttggtgctgctgcccgcattagtacccccactaacgacgatgatgatgactacacc
gagatgaatttcaacccagcggcgtccgcagcagccgcgccttctgctgtccggagcaag
gagcctgtcaaaatcgatagcccttcagccgctgtgaaccggctccgcattgccgacgac
tcttccgagggccgcactttctccctccgcgatccccggccgccgccagccgttattccc
cgggcggtccgagccgagccgcagggcagaagacgccacagttcggaaactttctctcgc
gctggagccgcagccacaccttcctccccgttctccgatagcggaaggcagtcttctgtc
tccttcgacagcgtctggtccagctccggccagggcgctcccgatcccgaggagacgagg
atgtcccgggtcacctcggctggctttcagaatggcctcaacttcatcgccgtcagcgtc
cgcgacgccgctgctcccactgctccccccagaaggagggtcagctcgaccgctcccagt
gcccagcgggggaatggtgcttccgatctggacagtggcacttacgtaaccatcgacttc
tccaaagatgacatcttccagcgcacttcttcgagaaaagactga

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