KEGG   Myotis daubentonii (Daubenton's bat): 132233575
Entry
132233575         CDS       T10294                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mdt  Myotis daubentonii (Daubenton's bat)
Pathway
mdt01521  EGFR tyrosine kinase inhibitor resistance
mdt01522  Endocrine resistance
mdt01524  Platinum drug resistance
mdt04012  ErbB signaling pathway
mdt04014  Ras signaling pathway
mdt04015  Rap1 signaling pathway
mdt04024  cAMP signaling pathway
mdt04062  Chemokine signaling pathway
mdt04066  HIF-1 signaling pathway
mdt04068  FoxO signaling pathway
mdt04070  Phosphatidylinositol signaling system
mdt04071  Sphingolipid signaling pathway
mdt04072  Phospholipase D signaling pathway
mdt04081  Hormone signaling
mdt04140  Autophagy - animal
mdt04150  mTOR signaling pathway
mdt04151  PI3K-Akt signaling pathway
mdt04152  AMPK signaling pathway
mdt04210  Apoptosis
mdt04211  Longevity regulating pathway
mdt04213  Longevity regulating pathway - multiple species
mdt04218  Cellular senescence
mdt04360  Axon guidance
mdt04370  VEGF signaling pathway
mdt04380  Osteoclast differentiation
mdt04510  Focal adhesion
mdt04550  Signaling pathways regulating pluripotency of stem cells
mdt04611  Platelet activation
mdt04613  Neutrophil extracellular trap formation
mdt04620  Toll-like receptor signaling pathway
mdt04625  C-type lectin receptor signaling pathway
mdt04630  JAK-STAT signaling pathway
mdt04650  Natural killer cell mediated cytotoxicity
mdt04660  T cell receptor signaling pathway
mdt04662  B cell receptor signaling pathway
mdt04664  Fc epsilon RI signaling pathway
mdt04666  Fc gamma R-mediated phagocytosis
mdt04668  TNF signaling pathway
mdt04670  Leukocyte transendothelial migration
mdt04722  Neurotrophin signaling pathway
mdt04725  Cholinergic synapse
mdt04750  Inflammatory mediator regulation of TRP channels
mdt04810  Regulation of actin cytoskeleton
mdt04910  Insulin signaling pathway
mdt04914  Progesterone-mediated oocyte maturation
mdt04915  Estrogen signaling pathway
mdt04917  Prolactin signaling pathway
mdt04919  Thyroid hormone signaling pathway
mdt04923  Regulation of lipolysis in adipocytes
mdt04926  Relaxin signaling pathway
mdt04929  GnRH secretion
mdt04930  Type II diabetes mellitus
mdt04931  Insulin resistance
mdt04932  Non-alcoholic fatty liver disease
mdt04933  AGE-RAGE signaling pathway in diabetic complications
mdt04935  Growth hormone synthesis, secretion and action
mdt04960  Aldosterone-regulated sodium reabsorption
mdt04973  Carbohydrate digestion and absorption
mdt05010  Alzheimer disease
mdt05017  Spinocerebellar ataxia
mdt05020  Prion disease
mdt05100  Bacterial invasion of epithelial cells
mdt05135  Yersinia infection
mdt05142  Chagas disease
mdt05146  Amoebiasis
mdt05160  Hepatitis C
mdt05161  Hepatitis B
mdt05162  Measles
mdt05163  Human cytomegalovirus infection
mdt05164  Influenza A
mdt05165  Human papillomavirus infection
mdt05166  Human T-cell leukemia virus 1 infection
mdt05167  Kaposi sarcoma-associated herpesvirus infection
mdt05168  Herpes simplex virus 1 infection
mdt05169  Epstein-Barr virus infection
mdt05170  Human immunodeficiency virus 1 infection
mdt05171  Coronavirus disease - COVID-19
mdt05200  Pathways in cancer
mdt05203  Viral carcinogenesis
mdt05205  Proteoglycans in cancer
mdt05206  MicroRNAs in cancer
mdt05207  Chemical carcinogenesis - receptor activation
mdt05208  Chemical carcinogenesis - reactive oxygen species
mdt05210  Colorectal cancer
mdt05211  Renal cell carcinoma
mdt05212  Pancreatic cancer
mdt05213  Endometrial cancer
mdt05214  Glioma
mdt05215  Prostate cancer
mdt05218  Melanoma
mdt05220  Chronic myeloid leukemia
mdt05221  Acute myeloid leukemia
mdt05222  Small cell lung cancer
mdt05223  Non-small cell lung cancer
mdt05224  Breast cancer
mdt05225  Hepatocellular carcinoma
mdt05226  Gastric cancer
mdt05230  Central carbon metabolism in cancer
mdt05231  Choline metabolism in cancer
mdt05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mdt05415  Diabetic cardiomyopathy
mdt05417  Lipid and atherosclerosis
mdt05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mdt00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    132233575 (PIK3R1)
   04014 Ras signaling pathway
    132233575 (PIK3R1)
   04015 Rap1 signaling pathway
    132233575 (PIK3R1)
   04370 VEGF signaling pathway
    132233575 (PIK3R1)
   04630 JAK-STAT signaling pathway
    132233575 (PIK3R1)
   04668 TNF signaling pathway
    132233575 (PIK3R1)
   04066 HIF-1 signaling pathway
    132233575 (PIK3R1)
   04068 FoxO signaling pathway
    132233575 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    132233575 (PIK3R1)
   04072 Phospholipase D signaling pathway
    132233575 (PIK3R1)
   04071 Sphingolipid signaling pathway
    132233575 (PIK3R1)
   04024 cAMP signaling pathway
    132233575 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    132233575 (PIK3R1)
   04152 AMPK signaling pathway
    132233575 (PIK3R1)
   04150 mTOR signaling pathway
    132233575 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    132233575 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    132233575 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    132233575 (PIK3R1)
   04218 Cellular senescence
    132233575 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    132233575 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    132233575 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    132233575 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132233575 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    132233575 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    132233575 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    132233575 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    132233575 (PIK3R1)
   04660 T cell receptor signaling pathway
    132233575 (PIK3R1)
   04662 B cell receptor signaling pathway
    132233575 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    132233575 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    132233575 (PIK3R1)
   04670 Leukocyte transendothelial migration
    132233575 (PIK3R1)
   04062 Chemokine signaling pathway
    132233575 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132233575 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    132233575 (PIK3R1)
   04929 GnRH secretion
    132233575 (PIK3R1)
   04915 Estrogen signaling pathway
    132233575 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    132233575 (PIK3R1)
   04917 Prolactin signaling pathway
    132233575 (PIK3R1)
   04926 Relaxin signaling pathway
    132233575 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    132233575 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    132233575 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    132233575 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    132233575 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    132233575 (PIK3R1)
   04722 Neurotrophin signaling pathway
    132233575 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    132233575 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    132233575 (PIK3R1)
   04380 Osteoclast differentiation
    132233575 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    132233575 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    132233575 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132233575 (PIK3R1)
   05206 MicroRNAs in cancer
    132233575 (PIK3R1)
   05205 Proteoglycans in cancer
    132233575 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    132233575 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    132233575 (PIK3R1)
   05203 Viral carcinogenesis
    132233575 (PIK3R1)
   05230 Central carbon metabolism in cancer
    132233575 (PIK3R1)
   05231 Choline metabolism in cancer
    132233575 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132233575 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    132233575 (PIK3R1)
   05212 Pancreatic cancer
    132233575 (PIK3R1)
   05225 Hepatocellular carcinoma
    132233575 (PIK3R1)
   05226 Gastric cancer
    132233575 (PIK3R1)
   05214 Glioma
    132233575 (PIK3R1)
   05221 Acute myeloid leukemia
    132233575 (PIK3R1)
   05220 Chronic myeloid leukemia
    132233575 (PIK3R1)
   05218 Melanoma
    132233575 (PIK3R1)
   05211 Renal cell carcinoma
    132233575 (PIK3R1)
   05215 Prostate cancer
    132233575 (PIK3R1)
   05213 Endometrial cancer
    132233575 (PIK3R1)
   05224 Breast cancer
    132233575 (PIK3R1)
   05222 Small cell lung cancer
    132233575 (PIK3R1)
   05223 Non-small cell lung cancer
    132233575 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    132233575 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    132233575 (PIK3R1)
   05161 Hepatitis B
    132233575 (PIK3R1)
   05160 Hepatitis C
    132233575 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    132233575 (PIK3R1)
   05164 Influenza A
    132233575 (PIK3R1)
   05162 Measles
    132233575 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    132233575 (PIK3R1)
   05163 Human cytomegalovirus infection
    132233575 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132233575 (PIK3R1)
   05169 Epstein-Barr virus infection
    132233575 (PIK3R1)
   05165 Human papillomavirus infection
    132233575 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    132233575 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    132233575 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132233575 (PIK3R1)
   05142 Chagas disease
    132233575 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132233575 (PIK3R1)
   05017 Spinocerebellar ataxia
    132233575 (PIK3R1)
   05020 Prion disease
    132233575 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132233575 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    132233575 (PIK3R1)
   05415 Diabetic cardiomyopathy
    132233575 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    132233575 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    132233575 (PIK3R1)
   04931 Insulin resistance
    132233575 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    132233575 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    132233575 (PIK3R1)
   01524 Platinum drug resistance
    132233575 (PIK3R1)
   01522 Endocrine resistance
    132233575 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdt04131]
    132233575 (PIK3R1)
Membrane trafficking [BR:mdt04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    132233575 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 Laminin_I SH3_9 CCDC113_CCDC96_CC FANCI_S2
Other DBs
NCBI-GeneID: 132233575
NCBI-ProteinID: XP_059550425
LinkDB
Position
4:complement(80364592..80448666)
AA seq 744 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEAETEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRAQSSSNPAELRQLLDCGEWHGATDTDGKD
SAYLSVLDAASVDLETVDVQVLADAFKRYLSDLPNPVIPVAVYNEMISLAQEVQSSEDYI
QLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQSSSKNLLTAGVLSELFSPLLFRFPAASS
ENAEPLRKVIEILISTEWSERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISR
EEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNS
VVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKS
REYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKE
IQRIMHNYEKLKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQY
LMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRG
KRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQH
TSLVQHNDSLNVTLAYPVYAQQRR
NT seq 2235 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcactctatgattataaaaaggaacgagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggatttagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacgggggagagaggggactttccaggaacttacgtagaatatattgggaggaaa
aaaatctcacctcccaccccaaagccccggccacctcgaccccttcctgttgcaccaggc
tcttcgaaaactgaagcagaaactgagcagcaagctttgacccttccggatcttgcagaa
cagtttgcccctcctgacatcgctccacctcttcttatcaagctagtagaagccattgaa
aagaaaggtctggaatgttcaactctatacagagcacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtggtgagtggcatggagctacggatacagatggcaaagac
agtgcttacctttctgttttggatgctgcctccgtggacttggaaacagttgatgttcaa
gttttagcagatgctttcaaacgctatctctcggacctaccgaatcctgtcattccagta
gctgtttacaatgaaatgatttctttagcccaagaagtacaaagctccgaagactatatc
cagctgttgaagaagctcattaggtcacctaacatacctcatcagtattggcttacgctc
cagtatttgctcaaacatttcttcaagctctcccaaagctccagcaagaacctcttgact
gcaggagtgctctcggaacttttcagccctctgcttttcagattccctgcagccagctct
gagaatgccgaacccctccgaaaagttatagaaattttaatctcaacggaatggagcgag
cgacagccagcaccagcactgcctcctaaaccaccaaaacctactactgtggccaacaac
ggtatgaataacaatatgtccttacaagatgctgagtggtactggggagatatctcgagg
gaggaagtgaatgaaaaactgcgagatacagctgacggaacctttttggtacgagatgca
tctactaaaatgcacggagattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatacggcttctcggacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaagttactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtaggaaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggactatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaaca
caggagcgctacagtaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgaaaagttgaagtctcggatcagtgaaattgtggac
agcagaagaagactggaggaagacttgaagaaacaggcagctgagtatcgggagattgac
aagcgcatgaacagcattaagcccgacctcatccaactgagaaagacgagagaccagtac
ttgatgtggttgactcagaaaggtgttcggcagaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcattggtggaggatgatgaggatctgccccaccatgac
gagaagacctggaatgtcggaagcagcaaccgaaacaaggctgagaacctactacgaggg
aagcgagacggcactttcctggtccgggaaagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaggtaaagcattgtgtcataaacaaaaccgcaactggctatggc
tttgccgagccctataacctgtacagctccctcaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtatatgca
cagcagaggcgatga

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