Entry Name ABC transporters - Methylorubrum extorquens AM1
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Methylorubrum extorquens AM1 [GN:
mea ]
Gene Mex_1p0226 ssuC; alkanesulfonate transporter subunit; membrane component of ABC superfamily [KO:K15554 ]
Mex_1p0390 cysA; putative sulfate/thiosulfate transporter subunit; ATP-binding component of ABC superfamily [KO:K02010 ] [EC:7.2.2.7 ]
Mex_1p0391 fbpA; ABC transporter, periplasmic protein precursor, putative iron transporter [KO:K02012 ]
Mex_1p0392 fpbB; ABC transporter, permease precursor, putative iron transporter [KO:K02011 ]
Mex_1p0403 cysP; ABC transporter, periplasmic protein, putative sulfate/thiosulfate transporter [KO:K23163 ]
Mex_1p0404 cysU; ABC transporter, permease, putative sulfate/thiosulfate transporter [KO:K02046 ]
Mex_1p0405 cysW; ABC transporter, permease, putative sulfate/thiosulfate transporter [KO:K02047 ]
Mex_1p0835 lolD; outer membrane-specific lipoprotein transporter subunit; ATP-binding component of ABC superfamily [KO:K09810 ] [EC:7.6.2.-]
Mex_1p0920 nrtA; nitrate ABC transporter component precursor (substrate-binding protein) (tat pathway signal) [KO:K15576 ]
Mex_1p0948 ssuA; ABC transporter, substrate-binding protein, aliphatic sulphonates [KO:K15553 ]
Mex_1p1807 yejF; oligopeptide transport protein (ABC superfamily, atp_bind) [KO:K13896 ]
Mex_1p2481 yejE; putative oligopeptide transporter subunit; permease component of ABC superfamily transporter [KO:K13895 ]
Mex_1p2732 ccmC; heme exporter protein, cytochrome c-type biogenesis protein; ABC transporter, permease [KO:K02195 ]
Mex_1p2733 ccmD; heme exporter protein D (cytochrome c-type biogenesis protein cycX) [KO:K02196 ]
Mex_1p2825 ccmB; heme exporter subunit; membrane component of ABC superfamily [KO:K02194 ]
Mex_1p3067 ftsE; transporter subunit: ATP-binding component of ABC superfamily [KO:K09812 ]
Mex_1p3560 ssuA; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily (tat pathway signal) [KO:K15553 ]
Mex_1p3564 ssuB; ATP-binding component of ABC superfamily; putative alkanesulfonate transporter subunit [KO:K15555 ] [EC:7.6.2.14 ]
Mex_1p3633 ssuA; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily [KO:K15553 ]
Mex_1p3638 ssuA; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily [KO:K15553 ]
Mex_1p3639 ssuA; alkanesulfonate transport protein, periplasmic-binding subunit, ABC superfamily [KO:K15553 ]
Mex_1p3723 livG; Branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995 ]
Mex_1p3727 livF; leucine/isoleucine/valine transporter subunit; ATP-binding component of ABC superfamily [KO:K01996 ]
Mex_1p3890 modB; molybdate transporter, membrane component of ABC transporter [KO:K02018 ]
Mex_1p4103 proV; glycine/betaine/proline transporter, ATP-binding component of ABC transporter [KO:K02000 ] [EC:7.6.2.9 ]
Mex_1p4104 opuAB; glycine/betaine/proline transporter, membrane component of ABC transporter [KO:K02001 ]
Mex_1p4105 proX; glycine/betaine/proline transporter, Substrate-binding periplasmic component of ABC transporter [KO:K02002 ]
Mex_1p4346 gltI; glutamate and aspartate transporter subunit; periplasmic-binding component of ABC superfamily [KO:K10001 ]
Mex_1p4347 gltJ; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10003 ]
Mex_1p4348 gltK; glutamate and aspartate transporter subunit; membrane component of ABC superfamily [KO:K10002 ]
Mex_1p4349 gltL; glutamate and aspartate transporter subunit; ATP-binding component of ABC superfamily [KO:K10004 ] [EC:7.4.2.1 ]
Mex_1p4583 potI; putrescine transporter, membrane component of ABC transporter [KO:K11074 ]
Mex_1p4584 potH; putrescine transporter, membrane component of ABC transporter [KO:K11075 ]
Mex_1p4669 oppB; oligopeptide transporter subunit; membrane component of ABC superfamily [KO:K15581 ]
Mex_1p4822 ssuB; alkanesulfonate transporter subunit; ATP-binding component of ABC superfamily [KO:K15555 ] [EC:7.6.2.14 ]
Mex_1p4922 modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020 ]
Mex_1p5164 pstS; phosphate ABC transporter, periplasmic phosphate binding protein [KO:K02040 ]
Mex_2p0357 phnC; phosphonate/organophosphate ester transporter subunit; ATP-binding component of ABC superfamily [KO:K02041 ] [EC:7.3.2.2 ]
Mex_2p0358 ptxB; putative phosphonate transport system substrate-binding protein [KO:K02044 ]
Mex_2p0359 ptxC; putative phosphate permease component of ATP-dependent phosphate uptake system [KO:K02042 ]
Mex_2p1231 ptxB; putative phosphonate transport system substrate-binding protein [KO:K02044 ]
Mex_2p1232 ptxC; putative phosphate permease component of ATP-dependent phosphate uptake system [KO:K02042 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
