Mycolicibacterium flavescens: NCTC10271_02069
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Entry
NCTC10271_02069 CDS
T07767
Symbol
metH
Name
(GenBank) B12-dependent methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
mflv
Mycolicibacterium flavescens
Pathway
mflv00270
Cysteine and methionine metabolism
mflv00450
Selenocompound metabolism
mflv00670
One carbon pool by folate
mflv01100
Metabolic pathways
mflv01110
Biosynthesis of secondary metabolites
mflv01230
Biosynthesis of amino acids
mflv04980
Cobalamin transport and metabolism
mflv04981
Folate transport and metabolism
Module
mflv_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
mflv00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
NCTC10271_02069 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
NCTC10271_02069 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
NCTC10271_02069 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
NCTC10271_02069 (metH)
04980 Cobalamin transport and metabolism
NCTC10271_02069 (metH)
Enzymes [BR:
mflv01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
NCTC10271_02069 (metH)
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SSDB
Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
CdhD
Motif
Other DBs
NCBI-ProteinID:
VEG40722
LinkDB
All DBs
Position
1:2155862..2159611
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AA seq
1249 aa
AA seq
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MTAVESNTLTPDIRPDCTDELTATLGQRIMVIDGAMGTAIQRDRPDEAGYRGERFKDWPS
DVQGNNDLLNLTQPQIIEAIHREYLDAGADIIETNTFNANAISLSDYGMEELSYEVNYAG
AALARKACDEVGTGDRPRYVAGALGPTTRTASISPDVNDPGARNITYDRLVDAYLEAANG
LVDGGADIILVETIFDTLNAKAAVFAIETLFEERGRRWPVVISGTITDASGRTLSGQVTE
AFWNSVRHARPLAIGLNCALGAPEMRPYIAEMSRIADTFVSCYPNAGLPNAFAEYDETPE
RQAGYVADFAEAGFVNLVGGCCGTTPAHIAKIAEAVEGKPPRQVPEVPVATRLSGLEPLN
IDDDTLFVNIGERTNITGSARFRNLIKAEDYDTALSVALQQVEVGAQVIDINMDEGMIDG
VAAMDRFTRLIASEPDISRVPVMIDSSKWEVIEAGLKNVQGKPIVNSISLKEGEEKFIRE
ARLCRKYGAAVVVMAFDEEGQADNLERRKEICGRAYRVLTEEVGFPAEDIIFDPNCFALA
TGIEEHATYGIDFIEACAWIKENLPGVHLSGGISNVSFSFRGNNPVREAIHAVFLFHAIK
AGLDMGIVNAGALVPYDSIDAELRERIEDVVLNRREDAAERLLEIAERFNTKDKADDPAA
AEWRSLPVRERITHALVKGIDAHVEDDTEELRVEIADAGGRPIEVIEGPLMDGMNVVGDL
FGSGKMFLPQVVKSARVMKKAVAYLLPFIEAEKEESGTTGSKDTNGTIVMATVKGDVHDI
GKNIVGVVLQCNNFEVIDLGVMVPAQKILDAVKEHDADIVGLSGLITPSLDEMSNFAVEM
ERAGLEIPLLIGGATTSRAHTAVKISPRRSGPVVWVKDASRSVPVAAALLDDKQRPGLLE
ATEKDYASLRERHAQKNDRPMLTLEKARANRTPIDWDGYTPPVPAQGLGVREFVDYDLAE
LREYIDWQPFFNAWEMKGRFPDILNNPATGEAARKLYDDAQEMLDTAIKEKWLTANGVIG
FFAANAVGDDVEVYTDDTRTEVLTTLHNLRQQGEHREGIPNRSLGDFVAPKDTGLADYVG
GFAVTAGLGSQDKIMEFKAALDDYSAILLESVADRLAEAFAERMHQRVRKEFWGYQPDEQ
LDNDALIGEKYVGIRPAPGYPACPEHTEKATLFNLLDVTKRTGIELTDSMAMWPGAAVSG
WYFSHPQSQYFVVGRLAQDQVADYAKRKGWTLKEAERWLAPNLGYNPED
NT seq
3750 nt
NT seq
+upstream
nt +downstream
nt
atgactgccgttgagtcgaacactctcacgccggacatccgccccgactgcaccgacgaa
ctgaccgcgacactgggtcagcggatcatggtgatcgacggcgcgatgggcacggcgatc
cagcgggaccggcccgacgaggccggataccgcggcgaacggttcaaggactggccgagc
gacgtccagggcaacaacgacctgctcaacctgacccagccgcagatcatcgaggcgatt
caccgcgaatacctcgacgccggcgccgacatcattgagaccaacacgttcaacgcgaac
gcgatctcgctctccgactacggcatggaagagctcagctacgaggtgaactacgccggc
gcggcgctggcgcggaaggcctgcgacgaggtcggcaccggtgaccggccccgctacgtc
gccggagcgctgggaccgaccacgcggaccgcctcgatctcgccggacgtcaacgatccc
ggcgcccgcaacatcacctacgaccggttggtcgacgcctacctcgaagccgccaacggc
ctggtcgacggtggtgccgacatcatcctggtcgagacgatcttcgacacgctcaacgcc
aaggccgccgtgttcgcgatcgagacgctgttcgaggaacgcggccgccgctggcccgtc
gtcatctcgggcaccatcaccgacgcttccgggcggacgctgtccggccaggtcaccgag
gcgttctggaactcggtcaggcacgccaggccgctcgcgatcggcctcaactgcgcgctc
ggtgcaccggagatgaggccttacatcgccgagatgtcgcgaatcgcggacacgttcgtc
tcctgctacccgaacgccgggctgcccaacgcgttcgccgagtacgacgaaacccccgag
cgtcaggccggctacgtcgcggacttcgccgaggcgggcttcgtcaacctggtcggtggt
tgctgtggaacgacgcccgcgcacatcgccaagatcgccgaggccgtcgagggcaagcca
ccgcgccaggtgcctgaggtcccggtggccacccggctgtcgggcctggaaccgctcaac
atcgacgacgacaccttgttcgtcaacatcggtgagcgcaccaacatcaccggctcggcc
cggttccgcaacctcatcaaggccgaggactacgacaccgcgctgtcggtggccctgcag
caggtggaggtcggtgcgcaggtcatcgacatcaacatggacgagggcatgatcgacggc
gtcgccgcgatggaccggttcacccggctgatcgcgtccgaacccgacatcagccgcgtg
ccggtgatgatcgactcctccaagtgggaggtcatcgaggccggcctgaagaacgtgcag
ggcaagccgatcgtcaactcgatctccctgaaggagggcgaggagaagttcatccgcgag
gctcggttgtgccgcaagtacggcgccgccgtcgtcgtgatggccttcgacgaggagggg
caggccgacaacctggagcgccgcaaggagatctgcggtcgcgcctaccgggtcctgacc
gaagaggtcggcttccccgccgaggacatcatcttcgacccgaactgcttcgcgctggcc
accggcatcgaggagcatgcgacctacgggatcgacttcatcgaggcgtgcgcctggatc
aaggagaacctgcccggggtgcacctctccggcggcatctcgaacgtgtcgttctcgttc
cgcggcaacaacccggtccgcgaggcgatccacgcggtattcctcttccacgccatcaag
gcgggcctggacatgggcatcgtcaacgcaggcgcgctggtgccctacgactcgatcgac
gccgaactacgggagcgcatcgaggacgtcgtgctgaaccgtcgcgaggatgcggccgaa
cggctgctcgagatcgccgagcgcttcaacaccaaggacaaggccgacgacccggcggca
gcggagtggcggtccctaccggtccgcgagcggatcacgcacgcgctggtcaagggcatc
gacgcccacgtcgaggacgacaccgaggaactgcgggtcgagatcgccgacgcgggcggg
cgaccgatcgaggtgatcgagggtccgctgatggacggtatgaacgtcgtcggcgacctg
ttcggctcgggcaagatgtttttgccccaggtcgtgaagtcggcccgggtgatgaagaag
gccgtcgcatacctgcttccgttcatcgaggcggagaaggaggagtccggcacgacgggt
tccaaagacaccaacggcacgatcgtgatggcgaccgtcaagggcgacgtccacgacatc
ggcaagaacatcgtcggggttgtcctgcagtgcaacaacttcgaagtgatcgacctcggg
gtgatggtgcccgcgcagaagatcctggacgcggtgaaggagcacgacgccgacatcgtc
gggctgtccggcctgatcaccccgtcgctggacgagatgtccaacttcgccgtcgagatg
gaacgcgcagggctggagatcccactgctcatcggcggtgcgaccacctcgcgcgcgcac
acggcggtgaagatctcgccgcgccgcagcggtccggtggtctgggtcaaggacgcgtcc
cgctcggttccggtggccgccgcgctgctcgacgacaaacagcggccgggactgctggag
gccaccgagaaggactacgcatccctgcgcgagcggcacgcccagaagaacgaccggccg
atgctgaccctggagaaggcccgcgcgaaccggacgccgatcgactgggacggctacacg
ccgccggtgcccgctcaggggctcggcgtgcgcgagttcgttgactacgacctcgccgaa
ttgcgcgagtacatcgactggcagccgttcttcaacgcctgggagatgaagggccgattc
cccgacatcctcaacaacccggccacgggggaggccgcccgcaagctctacgacgacgcg
caggagatgctcgacacggcgatcaaggagaaatggctgaccgcgaacggggtgatcggt
ttcttcgcggccaacgccgtcggtgacgacgtcgaggtctacaccgacgacacccgcacc
gaggtgctgaccacactgcacaacctgcgccagcagggcgagcaccgcgagggcatcccg
aaccggtcgctcggcgacttcgtcgcacccaaagacaccggtctggccgactacgtcggc
ggtttcgccgtcaccgcggggctcggcagccaggacaagatcatggagttcaaggcagcg
ctggacgattacagcgccatcctgttggagtcggtcgccgaccggctcgccgaggcgttc
gccgaacggatgcaccaacgggtccgcaaggagttctggggataccagcccgacgagcag
ctggacaacgacgcgctcattggcgagaaatacgtgggcatccgtcccgcgccgggttat
ccggcatgcccggagcacaccgagaaggcgacgctgttcaacctgctggacgtcacgaag
cgcaccggcatcgagctgaccgattcgatggcgatgtggccgggggccgcggtcagcggc
tggtacttctcgcacccgcagtcccagtacttcgtggtcggccggttggcccaggaccag
gtcgccgactacgccaagcgcaagggttggacgctgaaggaggccgagcgctggctcgcg
cccaacctcggctacaacccggaggactga
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