KEGG   Alexandromys fortis (reed vole): 126491758
Entry
126491758         CDS       T08493                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mfot  Alexandromys fortis (reed vole)
Pathway
mfot01521  EGFR tyrosine kinase inhibitor resistance
mfot01522  Endocrine resistance
mfot01524  Platinum drug resistance
mfot04012  ErbB signaling pathway
mfot04014  Ras signaling pathway
mfot04015  Rap1 signaling pathway
mfot04024  cAMP signaling pathway
mfot04062  Chemokine signaling pathway
mfot04066  HIF-1 signaling pathway
mfot04068  FoxO signaling pathway
mfot04070  Phosphatidylinositol signaling system
mfot04071  Sphingolipid signaling pathway
mfot04072  Phospholipase D signaling pathway
mfot04081  Hormone signaling
mfot04140  Autophagy - animal
mfot04150  mTOR signaling pathway
mfot04151  PI3K-Akt signaling pathway
mfot04152  AMPK signaling pathway
mfot04210  Apoptosis
mfot04211  Longevity regulating pathway
mfot04213  Longevity regulating pathway - multiple species
mfot04218  Cellular senescence
mfot04360  Axon guidance
mfot04370  VEGF signaling pathway
mfot04380  Osteoclast differentiation
mfot04510  Focal adhesion
mfot04550  Signaling pathways regulating pluripotency of stem cells
mfot04611  Platelet activation
mfot04613  Neutrophil extracellular trap formation
mfot04620  Toll-like receptor signaling pathway
mfot04625  C-type lectin receptor signaling pathway
mfot04630  JAK-STAT signaling pathway
mfot04650  Natural killer cell mediated cytotoxicity
mfot04660  T cell receptor signaling pathway
mfot04662  B cell receptor signaling pathway
mfot04664  Fc epsilon RI signaling pathway
mfot04666  Fc gamma R-mediated phagocytosis
mfot04668  TNF signaling pathway
mfot04670  Leukocyte transendothelial migration
mfot04722  Neurotrophin signaling pathway
mfot04725  Cholinergic synapse
mfot04750  Inflammatory mediator regulation of TRP channels
mfot04810  Regulation of actin cytoskeleton
mfot04910  Insulin signaling pathway
mfot04914  Progesterone-mediated oocyte maturation
mfot04915  Estrogen signaling pathway
mfot04917  Prolactin signaling pathway
mfot04919  Thyroid hormone signaling pathway
mfot04923  Regulation of lipolysis in adipocytes
mfot04926  Relaxin signaling pathway
mfot04929  GnRH secretion
mfot04930  Type II diabetes mellitus
mfot04931  Insulin resistance
mfot04932  Non-alcoholic fatty liver disease
mfot04933  AGE-RAGE signaling pathway in diabetic complications
mfot04935  Growth hormone synthesis, secretion and action
mfot04960  Aldosterone-regulated sodium reabsorption
mfot04973  Carbohydrate digestion and absorption
mfot05010  Alzheimer disease
mfot05017  Spinocerebellar ataxia
mfot05020  Prion disease
mfot05100  Bacterial invasion of epithelial cells
mfot05135  Yersinia infection
mfot05142  Chagas disease
mfot05146  Amoebiasis
mfot05160  Hepatitis C
mfot05161  Hepatitis B
mfot05162  Measles
mfot05163  Human cytomegalovirus infection
mfot05164  Influenza A
mfot05165  Human papillomavirus infection
mfot05166  Human T-cell leukemia virus 1 infection
mfot05167  Kaposi sarcoma-associated herpesvirus infection
mfot05168  Herpes simplex virus 1 infection
mfot05169  Epstein-Barr virus infection
mfot05170  Human immunodeficiency virus 1 infection
mfot05171  Coronavirus disease - COVID-19
mfot05200  Pathways in cancer
mfot05203  Viral carcinogenesis
mfot05205  Proteoglycans in cancer
mfot05206  MicroRNAs in cancer
mfot05207  Chemical carcinogenesis - receptor activation
mfot05208  Chemical carcinogenesis - reactive oxygen species
mfot05210  Colorectal cancer
mfot05211  Renal cell carcinoma
mfot05212  Pancreatic cancer
mfot05213  Endometrial cancer
mfot05214  Glioma
mfot05215  Prostate cancer
mfot05218  Melanoma
mfot05220  Chronic myeloid leukemia
mfot05221  Acute myeloid leukemia
mfot05222  Small cell lung cancer
mfot05223  Non-small cell lung cancer
mfot05224  Breast cancer
mfot05225  Hepatocellular carcinoma
mfot05226  Gastric cancer
mfot05230  Central carbon metabolism in cancer
mfot05231  Choline metabolism in cancer
mfot05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mfot05415  Diabetic cardiomyopathy
mfot05417  Lipid and atherosclerosis
mfot05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mfot00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    126491758
   04014 Ras signaling pathway
    126491758
   04015 Rap1 signaling pathway
    126491758
   04370 VEGF signaling pathway
    126491758
   04630 JAK-STAT signaling pathway
    126491758
   04668 TNF signaling pathway
    126491758
   04066 HIF-1 signaling pathway
    126491758
   04068 FoxO signaling pathway
    126491758
   04070 Phosphatidylinositol signaling system
    126491758
   04072 Phospholipase D signaling pathway
    126491758
   04071 Sphingolipid signaling pathway
    126491758
   04024 cAMP signaling pathway
    126491758
   04151 PI3K-Akt signaling pathway
    126491758
   04152 AMPK signaling pathway
    126491758
   04150 mTOR signaling pathway
    126491758
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    126491758
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    126491758
  09143 Cell growth and death
   04210 Apoptosis
    126491758
   04218 Cellular senescence
    126491758
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    126491758
   04550 Signaling pathways regulating pluripotency of stem cells
    126491758
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    126491758
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    126491758
   04613 Neutrophil extracellular trap formation
    126491758
   04620 Toll-like receptor signaling pathway
    126491758
   04625 C-type lectin receptor signaling pathway
    126491758
   04650 Natural killer cell mediated cytotoxicity
    126491758
   04660 T cell receptor signaling pathway
    126491758
   04662 B cell receptor signaling pathway
    126491758
   04664 Fc epsilon RI signaling pathway
    126491758
   04666 Fc gamma R-mediated phagocytosis
    126491758
   04670 Leukocyte transendothelial migration
    126491758
   04062 Chemokine signaling pathway
    126491758
  09152 Endocrine system
   04910 Insulin signaling pathway
    126491758
   04923 Regulation of lipolysis in adipocytes
    126491758
   04929 GnRH secretion
    126491758
   04915 Estrogen signaling pathway
    126491758
   04914 Progesterone-mediated oocyte maturation
    126491758
   04917 Prolactin signaling pathway
    126491758
   04926 Relaxin signaling pathway
    126491758
   04935 Growth hormone synthesis, secretion and action
    126491758
   04919 Thyroid hormone signaling pathway
    126491758
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    126491758
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    126491758
  09156 Nervous system
   04725 Cholinergic synapse
    126491758
   04722 Neurotrophin signaling pathway
    126491758
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    126491758
  09158 Development and regeneration
   04360 Axon guidance
    126491758
   04380 Osteoclast differentiation
    126491758
  09149 Aging
   04211 Longevity regulating pathway
    126491758
   04213 Longevity regulating pathway - multiple species
    126491758
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    126491758
   05206 MicroRNAs in cancer
    126491758
   05205 Proteoglycans in cancer
    126491758
   05207 Chemical carcinogenesis - receptor activation
    126491758
   05208 Chemical carcinogenesis - reactive oxygen species
    126491758
   05203 Viral carcinogenesis
    126491758
   05230 Central carbon metabolism in cancer
    126491758
   05231 Choline metabolism in cancer
    126491758
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    126491758
  09162 Cancer: specific types
   05210 Colorectal cancer
    126491758
   05212 Pancreatic cancer
    126491758
   05225 Hepatocellular carcinoma
    126491758
   05226 Gastric cancer
    126491758
   05214 Glioma
    126491758
   05221 Acute myeloid leukemia
    126491758
   05220 Chronic myeloid leukemia
    126491758
   05218 Melanoma
    126491758
   05211 Renal cell carcinoma
    126491758
   05215 Prostate cancer
    126491758
   05213 Endometrial cancer
    126491758
   05224 Breast cancer
    126491758
   05222 Small cell lung cancer
    126491758
   05223 Non-small cell lung cancer
    126491758
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    126491758
   05170 Human immunodeficiency virus 1 infection
    126491758
   05161 Hepatitis B
    126491758
   05160 Hepatitis C
    126491758
   05171 Coronavirus disease - COVID-19
    126491758
   05164 Influenza A
    126491758
   05162 Measles
    126491758
   05168 Herpes simplex virus 1 infection
    126491758
   05163 Human cytomegalovirus infection
    126491758
   05167 Kaposi sarcoma-associated herpesvirus infection
    126491758
   05169 Epstein-Barr virus infection
    126491758
   05165 Human papillomavirus infection
    126491758
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    126491758
   05100 Bacterial invasion of epithelial cells
    126491758
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    126491758
   05142 Chagas disease
    126491758
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    126491758
   05017 Spinocerebellar ataxia
    126491758
   05020 Prion disease
    126491758
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    126491758
   05418 Fluid shear stress and atherosclerosis
    126491758
   05415 Diabetic cardiomyopathy
    126491758
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    126491758
   04932 Non-alcoholic fatty liver disease
    126491758
   04931 Insulin resistance
    126491758
   04933 AGE-RAGE signaling pathway in diabetic complications
    126491758
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    126491758
   01524 Platinum drug resistance
    126491758
   01522 Endocrine resistance
    126491758
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mfot04131]
    126491758
Membrane trafficking [BR:mfot04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    126491758
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 Ribosomal_L22e SH3_9 SH3_1 ATG11
Other DBs
NCBI-GeneID: 126491758
NCBI-ProteinID: XP_049983544
LinkDB
Position
Unknown
AA seq 721 aa
MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRGALQALGVVDGGERCPHNVGWMPGF
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSESGVALADLAEQFSP
PEPAPPILVKLIEAVEQAGLDSECYSRPELPAPRTDWSLSDVEQWDRTTLCDAVKGFLLA
LPTAVVTPEAAAEAHRALQEAAGPVGPVLEPPTLPLHQALTLRFLLQHLGRVARRAPAQA
AAIHSLASAFGPLLLRTPPPGSDIDGSELGPDFPGLLLGRLLQEHVDEQDAAPPALPPKP
SKAKPAPTALANGGNPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYT
LTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVS
KYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNE
TIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDL
RAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYS
LMEDEDTLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTK
HCVIYRTATGFGFAEPYNLYASLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPTA
R
NT seq 2166 nt   +upstreamnt  +downstreamnt
atggcgggcgctgagggcttccagtacagggctgtgtacccattccgccgggagcggccc
gaggacctggagctattgcctggagacctactggtggtgagccggggggccctacaagcc
ctgggcgtggtggatggaggggagcgctgcccacacaacgtgggctggatgcctggcttc
aatgagcgtacccggcagcgaggggacttccctggaacatatgtggagttcctaggacct
gtcgctctggctcgaccaggacctcgcccacgaggcccccgtccattgcctgccaggccc
ttggatgggccctccgagtcaggtgttgcactggcagacctggcagagcagttctcccca
cctgagcctgctccgcccattctggtcaagctgatagaggccgttgagcaagcagggctg
gacagtgagtgctacagtagaccagagctgcctgcacctcggacagactggtccttgagt
gacgtggagcagtgggaccgcaccaccttgtgtgatgccgtgaagggcttcctgctggca
ttgcctacagctgttgtgactcctgaggctgcggcagaggcgcaccgggcactgcaggag
gctgcagggcccgtggggccggtgctggaacccccaacactaccgctgcaccaggcactc
acgctgcggttcctgctgcagcacctgggccgtgtggcccgcagagctcccgcacaggcc
gcagccatccactctctcgctagcgcctttgggccactgttactgcgtacacctccgcca
gggagtgacattgatgggagtgagcttgggcctgacttcccagggctgctgttggggagg
ctgctgcaggaacacgtggacgagcaggatgctgcccccccagcactgccacccaagccc
tctaaggccaagccggcccccacagccctggccaacggaggaaacccaccgtcgcttcag
gatgcagagtggtactggggagacatctccagggaagaggtgaatgagaggctccgggac
acgcctgatggcaccttcttggtccgggatgcatccagcaagatccaaggagagtacacg
ctcaccctcaggaaaggcgggaacaacaagctgatcaaagtcttccaccgggatggtcac
tacggcttctcggagcccctcaccttctgctccgtggtagagctcatctctcactaccgc
cacgagtcgctggcccagtataacgccaagctggacacgcgcctgctctaccctgtgtcc
aagtaccagcaggaccaggtggtgaaggaggacagcgtggaggctgtgggcgcgcagctc
aaagtctaccaccagcagtaccaggacaagagccgcgagtacgaccagctgtatgaggaa
tacacacgaacttcccaggagcttcagatgaagcgcacagccatagaggccttcaatgag
accatcaagatcttcgaagaacagggccagacgcaggaaaagtgcagcaaggagtatttg
gagcgcttccggcgtgagggcaatgagaaggagatgcagaggatcttgctgaactcagag
cgactcaagtctcgcattgcggagatccatgagagtcgcacgaagctggaacaggacctg
cgagcacaggcctcggacaaccgagagatcgacaagcgcatgaacagcctcaaacccgat
ctcatgcagctacgcaagatccgggaccagtaccttgtgtggctcacccagaaaggtgcc
cgacagaggaagatcaacgagtggctgggaatcaagaacgagactgaggaccagtattca
ctgatggaggatgaggacaccctcccccaccacgaggaacgcacgtggtacgtgggcaag
atcaaccgcacacaggcagaggagatgctgagtggcaaaagggacgggaccttcctcatc
cgggagagcagccagcgtggctgttacgcatgctccgtggtggtggacggcgataccaag
cactgcgtcatctaccgcacggccacaggcttcggcttcgcggaaccctacaacctgtat
gcgtccctgaaggagctggtgctgcactaccagcacgcgtcgcttgtgcagcacaacgac
gcactcaccgtcacccttgcgcacccggtgcgcgcacccgggcctggcccgcctacggcc
cgctga

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