Mycolicibacterium frederiksbergense: EXE63_23215
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Entry
EXE63_23215 CDS
T10436
Name
(GenBank) multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
mfre Mycolicibacterium frederiksbergense
Pathway
mfre00020
Citrate cycle (TCA cycle)
mfre00630
Glyoxylate and dicarboxylate metabolism
mfre00785
Lipoic acid metabolism
mfre01100
Metabolic pathways
mfre01110
Biosynthesis of secondary metabolites
mfre01120
Microbial metabolism in diverse environments
mfre01200
Carbon metabolism
mfre01210
2-Oxocarboxylic acid metabolism
Module
mfre_M00009
Citrate cycle (TCA cycle, Krebs cycle)
mfre_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
mfre00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
EXE63_23215
00630 Glyoxylate and dicarboxylate metabolism
EXE63_23215
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
EXE63_23215
Enzymes [BR:
mfre01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
EXE63_23215
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
EXE63_23215
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
EXE63_23215
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
EXE63_23215
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Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
OxoGdeHyase_C
Transket_pyr
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
QIV83472
UniProt:
A0A6H0S796
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Position
complement(4136158..4139934)
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AA seq
1258 aa
AA seq
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MSSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYAPESMDTPAQKSEPAAAKPS
APAKAAPAPSAPAKAEAKTEAKAETTTEAKAAPKAAPKAEAATPKAAAPATKAEPAPKKP
APAAPAAEGDENTVLRGASAAVVKNMNASLDVPTATSVRAIPAKAMIDNRVVINNHLKRT
RGGKISFTHLLGYAIVQAVKKFPNMNRHFAEVDGKPNVVTPAHTNLGLAIDLAGKDGNRS
LVVAAIKKCETMAFGQFIAAYEDIVRRARDGKLTAEDFAGVTISLTNPGTIGTVHSVPRL
MRGQGAIIGAGAMEYPAEFQGASEERIAELGVGKLITLTSTYDHRIIQGAESGDFLRTIH
TLLLDDEFYDEIFRELGIPHEPVRWRTDNPDSIYDKNARIIELIAAYRNRGHLMADIDPL
RLDKGRFRSHPDLDVLTHGLTLWDLDREFKVDGFAGAEYKKLRDVLSVLRDAYCRHVGVE
YTHILEPEQQRWIQERVETKHDKPTVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEG
AETVIPMMDAAIDQAAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFGEFEGNLNPSQA
HGSGDVKYHLGATGTYLQMFGDNDIAVSLVANPSHLEAVDPVLEGLVRAKQDIIDFTSPE
GHAAFSVVPMMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIIVNNQIGFTTSPHDSR
SSEYCTDVAKMVGAPIFHVNGDDPEACVWVAKLAIDFRQKFNKDVVIDMLCYRRRGHNEG
DDPSMTQPGMYDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVREL
EKHEIEPSESVEADQQTPKGLNTAVDKSVLARIGDAHLAVPENFNVHPRVQPVLDKRREM
AYEGKVDWAMGELLALGSLVSEGKTVRLTGQDVRRGTFTQRHAVIIDRKTGAEFTPLDLL
TADTDGNPTGGRFMVYDSALSEFAAVGFEYGYSVGNPGAIVLWEAQFGDFVNGAQSIIDE
FISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQVCAEGSMTVAMPSTPANYFH
LLRRHALDGIHRPLIVFTPKSMLRNKAAVSEVKDFTEIKFRSVLEEPTYEEGIGERSKVK
RVLLTSGKIYYELVARKAKEKRDDVAIIRIEQLYPLPRRRLNATLDEYPNVSQYFWVQEE
PANQGAWPTFGLSLPELLPEKLTGIKRISRRAMSAPSSGSSKVHAVEQQEIIDEAFAP
NT seq
3777 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagttcaccatcaccatttggacagaacgagtggctcgtcgaagagatgtatcgc
aagttccgcgaggatccttcgtcggtggatccgagttggcacgagttcctggtggactac
gcccccgagtcgatggacaccccggcccagaaatccgagcccgccgcggccaagccgtcg
gcgcccgcaaaggccgcccccgccccgtctgccccggcaaaggctgaggcgaagacggaa
gcaaaggcggagaccacgacggaggccaaggccgctccgaaggccgctccgaaggccgag
gccgcgacgccgaaggccgccgccccggccacgaaggcggagccggcccccaagaagccc
gcacccgccgcccccgcggccgagggcgatgagaacaccgtgctgcgtggcgcgtcggcc
gccgtcgtcaagaacatgaacgcctcactggacgtgcccacggccaccagcgtgcgggcc
atcccggccaaggcgatgatcgacaaccgggtggtcatcaacaaccacctcaagcgcacc
cgcggcggcaagatcagcttcacccacctgctcggctacgccatcgtgcaggcggtcaag
aagttcccgaacatgaaccggcacttcgccgaggtcgacggcaagcccaatgtcgtgacc
ccggcgcacaccaatctgggtctggccatcgacctggccggtaaggacggcaaccgatcg
ctggtcgtggccgccatcaagaagtgcgagacgatggcgttcggtcagttcatcgccgcg
tatgaggacatcgtccggcgcgcgcgcgacggcaagctcaccgccgaggacttcgccggt
gtcaccatctcgctgaccaacccgggcaccatcggcaccgtgcactcggtgccgcgactg
atgcgcggtcagggcgcgatcatcggcgccggcgccatggagtaccccgccgagttccag
ggcgcctccgaggagcgcatcgccgaactgggtgtcggcaagctgatcaccctgacgtcg
acgtatgaccaccgcatcatccagggtgcggagtccggtgacttcctgcgcaccatccac
accctgttgctcgacgacgagttctacgacgagatcttccgcgaactgggcatcccgcac
gagccggtgcgctggcggaccgacaacccggactccatctacgacaagaacgcccggatc
atcgaactgatcgcggcgtaccgcaaccgcggtcacctgatggccgatatcgacccgctg
cgactggacaagggccgcttccgcagccaccccgacctcgacgtgctgacccacggcctg
acgctgtgggatctggaccgcgagttcaaggtcgacggtttcgccggcgccgaatacaag
aagctgcgcgatgtgctctcggtgctgcgcgacgcctattgccgccacgtcggcgtggag
tacacccacatcctggaacccgagcagcagcgctggatccaggagcgcgtcgagaccaag
cacgacaagccgaccgtcgccgagcagaagtacatcctgagcaagctcaacgcggccgag
gcgttcgagacgttcctgcagaccaagtacgtcgggcagaagcgcttctcgctcgaaggc
gccgagaccgtcatcccgatgatggacgccgcgatcgaccaggccgccgagcacggtctc
gacgaggtcgtcatcggcatgccgcaccgcggccggctcaacgtgctggccaatatcgtc
ggcaagccctacagccagatcttcggcgagttcgagggcaacctgaacccgagtcaggcg
cacggctccggtgacgtcaagtaccacctcggcgcgaccggcacctacctgcagatgttc
ggcgacaacgatattgcggtgtcgctggtggccaacccgagccacctcgaggccgtcgac
ccggtgctcgaaggcctggtccgtgccaagcaggacatcatcgacttcacctccccggag
gggcatgccgccttctcggtggtgccgatgatgctgcacggtgacgccgcgttcgccggt
cagggtgtggtggccgagacgctgaacctggcgctgctgcggggttaccgcaccggcggc
accatccacatcatcgtgaacaaccagatcggcttcaccacctcgccgcacgattcgcgc
tccagcgagtactgcaccgatgtcgccaagatggtcggcgcgccgatcttccacgtcaac
ggcgacgatcccgaggcgtgtgtgtgggtggccaagctggccatcgacttccggcagaag
ttcaacaaggacgtcgtcatcgacatgctgtgctaccgccgccgcgggcacaacgagggc
gacgacccgtcgatgacgcagcccggcatgtacgacgtgatcgacaccaagcgtggtgtc
cgcaagtcctacaccgaggcgctgatcggccgcggcgacatctcgatgaaggaggccgag
gacgcgctgcgcgactaccagggccaactggagcgggtgttcaacgaggtccgcgagctg
gagaagcacgagatcgagccgagcgaatcggtcgaggccgaccagcagacaccaaagggc
ctcaacaccgccgtcgacaagtcggtgctggcgcggatcggtgatgcgcacctggccgtg
ccggagaacttcaacgtgcatccgcgcgtgcagccggtgctcgacaagcgtcgcgagatg
gcctacgagggcaaggtggactgggccatgggcgagctgctggccctcggatcgcttgtc
tccgaaggcaagacggtccgcctgaccggccaggacgtccggcgcggcacgttcacccag
cgtcacgcggtgatcatcgaccgcaagaccggcgccgagttcacccccctggacctgctg
accgccgataccgacggcaacccgaccggtggccgcttcatggtgtacgactcggcactg
tccgagttcgcggcggtaggcttcgaatacggctactcggtgggcaaccccggggcaatc
gtgttgtgggaggcccagttcggcgatttcgtcaacggcgcgcagtcgatcatcgacgag
ttcatctcctctggcgaggccaagtggggccagctctccgatgtcgtgttgctgctgcca
cacggtcacgagggccagggtcccgaccacacgtcgggccgtatcgagcgcttcctgcag
gtgtgcgccgagggctcgatgaccgtggcaatgccctcgaccccggcgaactacttccac
ctgctgcgcaggcacgccctcgacggtatccaccggccgctgatcgtcttcaccccgaag
tcgatgctgcgcaacaaggccgcggtcagcgaggtcaaggacttcaccgagatcaagttc
cgctcggtgctggaagagcccacctacgaagagggcatcggcgagcggtcgaaggtcaag
cgagtgctgctcaccagcggcaagatctactacgagctggtggcccgcaaggccaaggag
aagcgtgatgatgtggcgatcatccgcatcgagcagctctacccgctgccgcggcgccgg
cttaacgcgaccctcgacgagtaccccaatgtgtcgcagtacttctgggtgcaggaggag
ccggccaaccagggtgcctggccgacgttcgggctttccctgccggagttgttgccggag
aagctgaccgggatcaagcgcatctcccggcgcgccatgtcggctccgtcctcgggttcc
tcgaaggtgcacgcggtcgagcagcaggagatcatcgacgaagcgttcgcgccgtag
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