KEGG   Micromonospora sp. L5: ML5_4402
Entry
ML5_4402          CDS       T01379                                 
Name
(GenBank) Beta-ketoacyl synthase
  KO
K05551  minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Organism
mil  Micromonospora sp. L5
Pathway
mil00253  Tetracycline biosynthesis
mil01056  Biosynthesis of type II polyketide backbone
mil01100  Metabolic pathways
mil01110  Biosynthesis of secondary metabolites
Module
mil_M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:mil00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    ML5_4402
   00253 Tetracycline biosynthesis
    ML5_4402
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins [BR:mil01004]
    ML5_4402
   01008 Polyketide biosynthesis proteins [BR:mil01008]
    ML5_4402
Enzymes [BR:mil01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     ML5_4402
    2.3.1.260  tetracycline polyketide synthase
     ML5_4402
Lipid biosynthesis proteins [BR:mil01004]
 Polyketide synthase
  Component type
   ML5_4402
Polyketide biosynthesis proteins [BR:mil01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Octaketide PKS
     ML5_4402
    Nonaketide PKS
     ML5_4402
    Decaketide PKS
     ML5_4402
SSDB
Motif
Pfam: ketoacyl-synt Ketoacyl-synt_C Thiolase_N
Other DBs
NCBI-ProteinID: ADU09879
LinkDB
Position
4679020..4680291
AA seq 423 aa
MSQRRVVITGIGVVAPGGLGAKAFWERIVAGTPMTRLITAFDSTDFRSRIAAECDFDPFQ
YGFSEHDIGRLDRAALFALTATREAMSDSGLVVDRDDAHRVGVSLGTAVGATLRLEERYR
AVSHEGRDWLVDHRLAGPDLYDYFVPSSMAAEVAWAAGAEGPNAVVSAGCTSGIDAVGHA
WDLIRDGSVDMMIAGATDAPIAPITVACFDAIKATSNTNDDPGTAARPFDRTRNGFVLGE
GSAVLVLEELQSARRRDAHIYAEIRGYASRGNAFHMTGLRPDGQEMAAAIRAALDTARIP
ATAVDYVNAHGTATRQNDRHETQALKRGLGMHAYDVPISSIKPVIGHSLGAVGAIEVAAS
AMAIEFDVVPPTANLHHPDAELDLDYVPREARQRKLSTVLTVGSGFGGFQSAMVLSAPEA
VAA
NT seq 1272 nt   +upstreamnt  +downstreamnt
gtgagtcaacgtcgggtcgtcatcaccgggatcggcgtcgtcgcgcccggcgggttggga
gcgaaggccttctgggaacgcatcgtggcgggcaccccgatgacccgcctgatcaccgcc
ttcgactccaccgacttccggtcgcggatcgctgccgagtgtgacttcgatccgttccag
tacggcttcagcgagcacgacatcgggcgcttggaccgggccgccctgttcgcgctcacc
gccacgcgggaggcgatgagcgacagcggcctcgtcgtcgaccgcgacgacgcgcaccgg
gtcggggtgagtctcggtaccgccgttggcgccacgctgcggttggaggagcgctaccgc
gcggtcagccacgaagggcgcgactggctcgtcgaccaccggctcgccggccccgacctg
tacgactacttcgtgcccagctcgatggcggccgaggtggcctgggccgccggcgcggaa
ggacccaacgccgtcgtgtcggccgggtgcacctccggcatcgacgcggtgggacacgcc
tgggacctcatccgcgacggatcggtcgatatgatgatcgccggcgccaccgacgcgccg
atcgcgccgatcacggttgcctgcttcgacgccatcaaggccacgtccaacaccaacgac
gatccaggcaccgccgcgcggccgttcgaccgtacgcgtaacgggttcgtgctcggcgag
ggctcggcggtcctggtcttggaggaactgcagagcgcgcgccgccgcgacgcgcacatc
tacgccgagatccgcgggtacgcctcccgtggcaacgccttccacatgaccggcctgcgg
cccgacgggcaggagatggccgcggcgatccgcgccgccctcgacaccgcccgcatcccg
gccaccgccgtcgactacgtcaatgcgcacggcaccgcgaccagacagaacgaccgccac
gagacccaggcgctcaagcggggcctcggcatgcacgcctacgacgtgccgatcagctcc
atcaagccggtcatcggacactcgctcggcgccgtcggagcgatcgaggtcgccgccagc
gcgatggcgatcgagttcgacgtcgtgccaccgacggccaacctccaccaccccgacgcg
gagctggacctggactacgtgccacgcgaggccaggcagcgcaagctctccacagtgctg
accgtgggcagcggcttcggcggattccaaagcgcgatggtgctctccgcgcccgaggcg
gtggcagcatga

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