KEGG PATHWAY: mis00966

PATHWAY: mis00966

Entry

mis00966                    Pathway

Name

Glucosinolate biosynthesis - Micromonas commoda

Description

Glucosinolates are biologically active secondary metabolites found in Brassicaceae (mustard family) and related families.These compounds are genetically variable within plant species and used as natural pesticides, such as against insect herbivores. All glucosinolates share a common structure consisting of a beta-thioglucose moiety, a sulfonated oxime moiety, and a variable aglycone side chain derived from an alpha-amino acid. Genes encoding glucosinolate biosynthetic enzymes have been identified in Arabidopsis thaliana by genetic polymorphisms and loss-of-function mutations. This map shows examples of side chain elongation in methionine-derived glucosinolates and the core pathway for biosynthesis of glucosinolates from amino acids.

Class

Metabolism; Biosynthesis of other secondary metabolites

Pathway map

mis00966

Glucosinolate biosynthesis

Other DBs

GO:

0019761

Organism

Micromonas commoda [GN:mis]

Gene

MICPUN_106230

predicted protein [KO:K00826] [EC:2.6.1.42]

Compound

C00073

L-Methionine

C00078

L-Tryptophan

C00079

L-Phenylalanine

C00082

L-Tyrosine

C00123

L-Leucine

C00141

3-Methyl-2-oxobutanoic acid

C00183

L-Valine

C00233

4-Methyl-2-oxopentanoate

C00407

L-Isoleucine

C00671

(S)-3-Methyl-2-oxopentanoic acid

C01069

Desulfoglucotropeolin

C01180

4-Methylthio-2-oxobutanoic acid

C02153

Glucotropaeolin

C02937

Indole-3-acetaldehyde oxime

C03219

(E)-2-Methylpropanal oxime

C03719

Phenylacetothiohydroximate

C04350

(E)-4-Hydroxyphenylacetaldehyde oxime

C05837

Glucobrassicin

C08401

Glucoberteroin

C08407

Glucocochlearin

C08409

Glucoerucin

C08412

Glucoiberverin

C08417

Gluconasturtiin

C08418

Glucoputranjivin

C08426

Sinalbin

C16516

Indolylmethylthiohydroximate

C16517

Indolylmethyl-desulfoglucosinolate

C16518

S-(Indolylmethylthiohydroximoyl)-L-cysteine

C17210

2-(2'-Methylthio)ethylmalic acid

C17211

2-Oxo-5-methylthiopentanoic acid

C17212

3-(2'-Methylthio)ethylmalic acid

C17213

Homomethionine

C17214

2-(3'-Methylthio)propylmalic acid

C17215

3-(3'-Methylthio)propylmalic acid

C17216

2-Oxo-6-methylthiohexanoic acid

C17217

Dihomomethionine

C17218

2-(4'-Methylthio)butylmalic acid

C17219

3-(4'-Methylthio)butylmalic acid

C17220

2-Oxo-7-methylthioheptanoic acid

C17221

Trihomomethionine

C17222

2-(5'-Methylthio)pentylmalic acid

C17223

3-(5'-Methylthio)pentylmalic acid

C17224

2-Oxo-8-methylthiooctanoic acid

C17225

Tetrahomomethionine

C17226

2-(6'-Methylthio)hexylmalic acid

C17227

3-(6'-Methylthio)hexylmalic acid

C17228

2-Oxo-9-methylthiononanoic acid

C17229

Pentahomomethionine

C17230

2-(7'-Methylthio)heptylmalic acid

C17231

3-(7'-Methylthio)heptylmalic acid

C17232

2-Oxo-10-methylthiodecanoic acid

C17233

Hexahomomethionine

C17235

L-Homophenylalanine

C17236

3-Phenylpropionaldoxim

C17237

S-(Phenylacetothiohydroximoyl)-L-cysteine

C17238

S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine

C17239

p-Hydroxyphenylacetothiohydroximate

C17240

p-Hydroxybenzyldesulphoglucosinolate

C17241

4-Methylthiobutanaldoxime

C17242

S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine

C17243

4-Methylthiobutylthiohydroximate

C17244

3-Methylthiopropyl-desulfoglucosinolate

C17245

5-Methylthiopentanaldoxime

C17246

6-Methylthiohexanaldoxime

C17248

4-Methylthiobutyl-desulfoglucosinolate

C17249

7-Methylthioheptanaldoxime

C17250

Glucolesquerellin

C17251

8-Methylthiooctanaldoxime

C17252

7-Methylthioheptyl glucosinolate

C17253

9-Methylthiononanaldoxime

C17254

8-Methylthiooctyl glucosinolate

C17255

3-Methylbutyraldehyde oxime

C17256

2-Methylpropyl glucosinolate

C19491

(E)-2-Methylbutanal oxime

C19714

(E)-Phenylacetaldoxime

C21650

7-Methylthioheptyl-desulfoglucosinolate

C21746

8-Methylthiooctyl-desulfoglucosinolate

Reference

PMID:12049923

Authors

Wittstock U, Halkier BA

Title

Glucosinolate research in the Arabidopsis era.

Journal

Trends Plant Sci 7:263-70 (2002)
DOI:10.1016/S1360-1385(02)02273-2

Reference

PMID:15913672

Authors

Windsor AJ, Reichelt M, Figuth A, Svatos A, Kroymann J, Kliebenstein DJ, Gershenzon J, Mitchell-Olds T

Title

Geographic and evolutionary diversification of glucosinolates among near relatives of Arabidopsis thaliana (Brassicaceae).

Journal

Phytochemistry 66:1321-33 (2005)
DOI:10.1016/j.phytochem.2005.04.016

Reference

PMID:14740211

Authors

Textor S, Bartram S, Kroymann J, Falk KL, Hick A, Pickett JA, Gershenzon J

Title

Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain-elongation cycle.

Journal

Planta 218:1026-35 (2004)
DOI:10.1007/s00425-003-1184-3

Reference

PMID:15358770

Authors

Piotrowski M, Schemenewitz A, Lopukhina A, Muller A, Janowitz T, Weiler EW, Oecking C

Title

Desulfoglucosinolate sulfotransferases from Arabidopsis thaliana catalyze the final step in the biosynthesis of the glucosinolate core structure.

Journal

J Biol Chem 279:50717-25 (2004)
DOI:10.1074/jbc.M407681200

Reference

PMID:12586901