KEGG   Manis javanica (Malayan pangolin): 108383561
Entry
108383561         CDS       T06054                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv01524  Platinum drug resistance
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04024  cAMP signaling pathway
mjv04062  Chemokine signaling pathway
mjv04066  HIF-1 signaling pathway
mjv04068  FoxO signaling pathway
mjv04070  Phosphatidylinositol signaling system
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04081  Hormone signaling
mjv04140  Autophagy - animal
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04152  AMPK signaling pathway
mjv04210  Apoptosis
mjv04211  Longevity regulating pathway
mjv04213  Longevity regulating pathway - multiple species
mjv04218  Cellular senescence
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04380  Osteoclast differentiation
mjv04510  Focal adhesion
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04611  Platelet activation
mjv04613  Neutrophil extracellular trap formation
mjv04620  Toll-like receptor signaling pathway
mjv04625  C-type lectin receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04666  Fc gamma R-mediated phagocytosis
mjv04668  TNF signaling pathway
mjv04670  Leukocyte transendothelial migration
mjv04722  Neurotrophin signaling pathway
mjv04725  Cholinergic synapse
mjv04750  Inflammatory mediator regulation of TRP channels
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04923  Regulation of lipolysis in adipocytes
mjv04926  Relaxin signaling pathway
mjv04929  GnRH secretion
mjv04930  Type II diabetes mellitus
mjv04931  Insulin resistance
mjv04932  Non-alcoholic fatty liver disease
mjv04933  AGE-RAGE signaling pathway in diabetic complications
mjv04935  Growth hormone synthesis, secretion and action
mjv04960  Aldosterone-regulated sodium reabsorption
mjv04973  Carbohydrate digestion and absorption
mjv05010  Alzheimer disease
mjv05017  Spinocerebellar ataxia
mjv05020  Prion disease
mjv05100  Bacterial invasion of epithelial cells
mjv05135  Yersinia infection
mjv05142  Chagas disease
mjv05146  Amoebiasis
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05162  Measles
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05166  Human T-cell leukemia virus 1 infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05168  Herpes simplex virus 1 infection
mjv05169  Epstein-Barr virus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05171  Coronavirus disease - COVID-19
mjv05200  Pathways in cancer
mjv05203  Viral carcinogenesis
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05207  Chemical carcinogenesis - receptor activation
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05218  Melanoma
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05222  Small cell lung cancer
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mjv05415  Diabetic cardiomyopathy
mjv05417  Lipid and atherosclerosis
mjv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    108383561 (PIK3R2)
   04014 Ras signaling pathway
    108383561 (PIK3R2)
   04015 Rap1 signaling pathway
    108383561 (PIK3R2)
   04370 VEGF signaling pathway
    108383561 (PIK3R2)
   04630 JAK-STAT signaling pathway
    108383561 (PIK3R2)
   04668 TNF signaling pathway
    108383561 (PIK3R2)
   04066 HIF-1 signaling pathway
    108383561 (PIK3R2)
   04068 FoxO signaling pathway
    108383561 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    108383561 (PIK3R2)
   04072 Phospholipase D signaling pathway
    108383561 (PIK3R2)
   04071 Sphingolipid signaling pathway
    108383561 (PIK3R2)
   04024 cAMP signaling pathway
    108383561 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    108383561 (PIK3R2)
   04152 AMPK signaling pathway
    108383561 (PIK3R2)
   04150 mTOR signaling pathway
    108383561 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    108383561 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108383561 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    108383561 (PIK3R2)
   04218 Cellular senescence
    108383561 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108383561 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    108383561 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108383561 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    108383561 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    108383561 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    108383561 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    108383561 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    108383561 (PIK3R2)
   04660 T cell receptor signaling pathway
    108383561 (PIK3R2)
   04662 B cell receptor signaling pathway
    108383561 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    108383561 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    108383561 (PIK3R2)
   04670 Leukocyte transendothelial migration
    108383561 (PIK3R2)
   04062 Chemokine signaling pathway
    108383561 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108383561 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    108383561 (PIK3R2)
   04929 GnRH secretion
    108383561 (PIK3R2)
   04915 Estrogen signaling pathway
    108383561 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    108383561 (PIK3R2)
   04917 Prolactin signaling pathway
    108383561 (PIK3R2)
   04926 Relaxin signaling pathway
    108383561 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    108383561 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    108383561 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    108383561 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    108383561 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    108383561 (PIK3R2)
   04722 Neurotrophin signaling pathway
    108383561 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    108383561 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    108383561 (PIK3R2)
   04380 Osteoclast differentiation
    108383561 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    108383561 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    108383561 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108383561 (PIK3R2)
   05206 MicroRNAs in cancer
    108383561 (PIK3R2)
   05205 Proteoglycans in cancer
    108383561 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    108383561 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    108383561 (PIK3R2)
   05203 Viral carcinogenesis
    108383561 (PIK3R2)
   05230 Central carbon metabolism in cancer
    108383561 (PIK3R2)
   05231 Choline metabolism in cancer
    108383561 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108383561 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108383561 (PIK3R2)
   05212 Pancreatic cancer
    108383561 (PIK3R2)
   05225 Hepatocellular carcinoma
    108383561 (PIK3R2)
   05226 Gastric cancer
    108383561 (PIK3R2)
   05214 Glioma
    108383561 (PIK3R2)
   05221 Acute myeloid leukemia
    108383561 (PIK3R2)
   05220 Chronic myeloid leukemia
    108383561 (PIK3R2)
   05218 Melanoma
    108383561 (PIK3R2)
   05211 Renal cell carcinoma
    108383561 (PIK3R2)
   05215 Prostate cancer
    108383561 (PIK3R2)
   05213 Endometrial cancer
    108383561 (PIK3R2)
   05224 Breast cancer
    108383561 (PIK3R2)
   05222 Small cell lung cancer
    108383561 (PIK3R2)
   05223 Non-small cell lung cancer
    108383561 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    108383561 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    108383561 (PIK3R2)
   05161 Hepatitis B
    108383561 (PIK3R2)
   05160 Hepatitis C
    108383561 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    108383561 (PIK3R2)
   05164 Influenza A
    108383561 (PIK3R2)
   05162 Measles
    108383561 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    108383561 (PIK3R2)
   05163 Human cytomegalovirus infection
    108383561 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108383561 (PIK3R2)
   05169 Epstein-Barr virus infection
    108383561 (PIK3R2)
   05165 Human papillomavirus infection
    108383561 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    108383561 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    108383561 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    108383561 (PIK3R2)
   05142 Chagas disease
    108383561 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108383561 (PIK3R2)
   05017 Spinocerebellar ataxia
    108383561 (PIK3R2)
   05020 Prion disease
    108383561 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    108383561 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    108383561 (PIK3R2)
   05415 Diabetic cardiomyopathy
    108383561 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    108383561 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    108383561 (PIK3R2)
   04931 Insulin resistance
    108383561 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    108383561 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108383561 (PIK3R2)
   01524 Platinum drug resistance
    108383561 (PIK3R2)
   01522 Endocrine resistance
    108383561 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mjv04131]
    108383561 (PIK3R2)
Membrane trafficking [BR:mjv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    108383561 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 SH3_9 Ribosomal_L22e ATG11
Other DBs
NCBI-GeneID: 108383561
NCBI-ProteinID: XP_036878427
LinkDB
Position
Unknown
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGSERCPQNVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPREGPPEPGLTLPDLPEQFSP
PDVAPPVLVKLVEAIERTGPDSESLYRPEPPATRTDWSLSDVEQWDAAALSDGVKGFLLA
LPAPLVTPEAAAEARRALREAAEPVGPTLEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
LAVRALSATFGPLVLHAPPPSPPPGGAPDGTEPNPDFPVLLVEKLLQEHLEEQEVAPPAL
PPKPPKAKLAPVGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPASAR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggctggtgctgaaggcttccagtatcgtgctctgtacccatttcgccgggagcgacca
gaggacctggagctgctgccaggtgatgtgctggtggtgagccgggcagccctgcaggtg
ttgggagtggccgagggcagcgaacgctgcccacagaatgtaggctggatgcctggcctc
aacgagcgcacgcggcagcgaggtgacttccccggcacctatgttgagttcctggggcca
gtggccctggcccgaccaggccctcgcccacgtggtccccgcccactgcctgccaggccc
cgagaggggccccccgagccaggcctcacgctccctgacctgcctgagcagttctctccg
cctgacgtggctcccccagtcctggtgaagcttgtggaggccattgagcggacaggccca
gacagcgaatccctctacaggcctgagccgccggcaacgcgcacagactggtccctgagt
gacgtggagcagtgggacgctgcagccctgtcggacggcgtcaagggcttcctgctggcg
ctgcccgcgcccctcgtaacgcccgaggccgcagccgaggcgcgccgggccctgcgggag
gccgcggagcccgtggggccgacgctggagcccccgacgctgccgcttcaccgcgcgctc
acgctgcgcttcctgctccagcacctgggccgggtggcccggcgcgcacccgcccctggt
ctcgcggtgcgggccctgagcgccacctttgggccgctggtgctccacgcgccaccgccc
tcgccgccgccagggggcgcgcccgacgggactgagcccaaccccgacttccctgtactg
ctggtggagaagttgcttcaagaacatctggaggaacaggaggtggcacccccagcactg
ccgcctaaaccccccaaggccaagctagcccctgtaggcctggccaatgggggcagtcca
ccctccttgcaggatgctgagtggtactggggtgacatctccagggaggaggtgaatgag
aaacttcgggacacacctgatggcacctttctggtccgagatgcatccagcaagatccag
ggggaatacacgctgaccctcaggaaaggcgggaacaacaagctgatcaaggtcttccac
cgggacgggcactatggcttctcagagccgctcaccttctgctcagtcgttgacctcatc
acccactaccgccatgagtcgctggcccagtacaacgccaaattggacactcggctcctt
taccctgtgtccaagtaccagcaggaccagatcgtcaaggaggacagtgtggaggcagtg
ggagcgcaactcaaagtctaccaccagcagtaccaggacaagagccgcgagtatgaccag
ctctacgaggagtacacacgcacctcccaggaactacaaatgaagcgcacagcaattgag
gccttcaatgagaccatcaaaatcttcgaagagcagggtcaaacacaagagaagtgtagc
aaggaatatctggagcgcttccggcgtgaaggcaatgagaaagagatgcaaaggatcctg
ctgaactcagaacgactcaaatctcgcattgcggagatccacgagagccgcacaaagctg
gagcaggagctgcgagcccaggcctcagacaaccgggagatagacaagcgcatgaacagc
ctcaagccagatctgatgcagctgcgcaagattcgagaccagtatcttgtctggcttact
cagaaaggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaggatgaggacgacctcccccaccacgaagaacgcacatgg
tatgtgggcaagatcaaccgcacacaggctgaggaaatgctgagcggcaagcgggatggc
accttcctcatccgcgagagcagccagcggggctgctatgcctgctctgtggtggtggac
ggcgacaccaagcactgtgttatctatcgcacggccacaggctttggcttcgcggagccc
tacaacctgtacgggtcactgaaggagctggtgctgcactaccagcacgcctcgctggta
cagcacaatgatgcgctcacggtcaccctcgcccatcccgtgcgggccccgggccctggg
ccccctgcctctgcccgctga

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