KEGG   Manis javanica (Malayan pangolin): 108390800
Entry
108390800         CDS       T06054                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase-like
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv00140  Steroid hormone biosynthesis
mjv01100  Metabolic pathways
mjv04913  Ovarian steroidogenesis
mjv04925  Aldosterone synthesis and secretion
mjv04927  Cortisol synthesis and secretion
mjv04934  Cushing syndrome
Module
mjv_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mjv_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mjv_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mjv_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    108390800
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    108390800
   04925 Aldosterone synthesis and secretion
    108390800
   04927 Cortisol synthesis and secretion
    108390800
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    108390800
Enzymes [BR:mjv01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     108390800
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     108390800
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind NmrA KR GSIII_N
Other DBs
NCBI-GeneID: 108390800
NCBI-ProteinID: XP_017505550
LinkDB
Position
Unknown
AA seq 373 aa
MAGFSCLVTGAGGFLGQRIVRLLLEEKELQEIRALDKVFSPELQEEFSKPQSRIKLTLLQ
GDILDEQCLKRACQGISAVIHTASIIDVTSAAHRETLMNVNLKGTQLLLEACTQASVPIF
IYTSSIEVAGPNSYKEVIQNGHEEQDLETTWNSPYPYSKKLAEKAVLAANGWALQNGGTL
YTCALRPMYTFGEGSQFLYYHVTTALKNNGILSHENKLSIANPVYVGNIAWAHILALRTL
QDPKKAPGIGGQFYYISDDTPHQSYDDLNYNLCREWGFSLDSRMSLPVSVKYWLAFLLEM
VSFLLSPIYRYNPSLNRHLVTLSNSVFTFSYKKAQRDLGYKPLFSWEEAKKKTTEWIGFL
VKQHKETLKEKAH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctggattcagctgccttgtaacaggagcaggaggatttttgggccagaggatcgtc
cgcttgttgttggaggagaaggagctgcaggaaatacgtgccctagacaaagtcttcagt
ccggaattgcaggaggaattttctaagccccagagcaggatcaagctaaccctgctgcaa
ggagacattctggatgagcagtgcctgaagagagcctgccagggcatctcggctgtcatt
cacaccgcctccatcattgacgtcacaagtgccgctcaccgagagactctgatgaatgtc
aatctgaaaggtacccagctccttctggaggcctgtacccaggcaagtgtgccaatcttc
atctacaccagcagcatagaggtggcagggcctaactcctacaaggaggtcatccagaat
ggccatgaagaacaggatctcgaaacaacatggaacagtccatacccatatagcaaaaag
cttgctgagaaggctgtgctagctgctaacgggtgggctcttcaaaatggtggcaccctg
tatacttgtgccttaaggcctatgtatacatttggggaaggaagccaattcctttattac
catgtgaccacggccctgaagaacaatggcatcctgtcacacgagaacaagctctccatc
gccaacccagtctatgttggcaatatagcctgggcccacattctggccctgaggaccctg
caggaccctaagaaggctcctggcattggaggtcagttctactatatctcagatgacaca
cctcatcaaagttatgatgacctcaattacaatttgtgccgagaatggggcttctccctt
gattccagaatgagccttcctgtatctgtgaagtactggcttgccttcctgctggaaatg
gtgagcttcctgctcagtccgatttatagatataacccctccctcaaccgccacttagtg
acattatcaaatagtgtgtttaccttctcctataagaaagcccagcgagatctggggtat
aagcccctctttagctgggaggaagccaagaagaaaaccacggagtggattggcttcctg
gtgaaacagcacaaggagaccctgaaagaaaaggctcactga

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