Manis javanica (Malayan pangolin): 108397189 Help Entry 108397189         CDS       T06054                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv04022   cGMP-PKG signaling pathway mjv04068   FoxO signaling pathway mjv04081   Hormone signaling mjv04140   Autophagy - animal mjv04150   mTOR signaling pathway mjv04151   PI3K-Akt signaling pathway mjv04152   AMPK signaling pathway mjv04211   Longevity regulating pathway mjv04213   Longevity regulating pathway - multiple species mjv04722   Neurotrophin signaling pathway mjv04910   Insulin signaling pathway mjv04920   Adipocytokine signaling pathway mjv04923   Regulation of lipolysis in adipocytes mjv04930   Type II diabetes mellitus mjv04931   Insulin resistance mjv04932   Non-alcoholic fatty liver disease mjv04935   Growth hormone synthesis, secretion and action mjv04960   Aldosterone-regulated sodium reabsorption mjv05010   Alzheimer disease mjv05206   MicroRNAs in cancer mjv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mjv00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     108397189 (IRS1)    04022 cGMP-PKG signaling pathway     108397189 (IRS1)    04151 PI3K-Akt signaling pathway     108397189 (IRS1)    04152 AMPK signaling pathway     108397189 (IRS1)    04150 mTOR signaling pathway     108397189 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     108397189 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     108397189 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     108397189 (IRS1)    04923 Regulation of lipolysis in adipocytes     108397189 (IRS1)    04920 Adipocytokine signaling pathway     108397189 (IRS1)    04935 Growth hormone synthesis, secretion and action     108397189 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     108397189 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     108397189 (IRS1)   09149 Aging    04211 Longevity regulating pathway     108397189 (IRS1)    04213 Longevity regulating pathway - multiple species     108397189 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     108397189 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     108397189 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     108397189 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     108397189 (IRS1)    04932 Non-alcoholic fatty liver disease     108397189 (IRS1)    04931 Insulin resistance     108397189 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  108397189 NCBI-ProteinID:  XP_036853618 LinkDB All DBs Position 12:10765183..10831239 Genome browser AA seq 1227 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGVGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKHGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGTSTLTAPN GNYILPRGSNGPRYLPGGGLGMSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDTSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSSSSAAPSGSSYGKLWTNGAGGHHSHALPHPKLPMESSSG KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKSVLSYYSLPRSFKHTQRPGELEDS ARPQHLRLSSSSGRLLYAATEDSSSSTSSDSLGGGYCGARPEPGLSHLHHQVLQPYLPRK VDTAAQTNSRLARPTRLSLGDPKASTLPRAREQPPPLLHPPEPKSPGEYVNIEFGSDQPG YLSGPVASHSSPSVRCPPQLQPAPREEEAGTEEYMNMDLGPGRRAAWQESAGGQLGRVGP APPGAASVCRPTRAVPSSRADYMTMQMGCPHQSYVDTLPVAPVSYADMRTGIVMEEVSLP EATAATPSSSSAAASAAPQGTGELTARSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVIR ADPQGCRRRHSSETFSSKPSATRAGNAVPFGGGAAVGGSSSTEDVKRHSSASFENVWLRT GELGAASKESAQVCGAAGGLENGLNYIDLDLVKDLKQRPLEHPPQPQPPPPPHRPLGSNE SSSTSLSSEDVSSYASISFQKQPEDLQ NT seq 3684 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagaccgacggcttttcggacgtgcgcaaggtgggctacctgcga aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc ccagcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaatatcaacaagcgggccgactccaagaac aagcacctggtggccctctacacccgggacgagcactttgccatagcggcggacagcgag gcggagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggagccgcggcccttggggtgggaggtggcgggggcagctgcagcggcagctca ggccttggcgaggctggggaggacttgagctacggggatgtgcccccaggacccgcgttc aaagaggtctggcaggtgatcctgaagcctaagggcctggggcagacaaagaaccttatt ggtatctaccgcctctgtctgaccagcaagaccatcagcttcgtgaagttgaactcagag gcggcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc ttcttcatcgaagtaggccgttccgcagtgacaggacctggggagttctggatgcaggta gatgactctgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg agcgatgagttccgtcctcgaagcaagagccagtcctcctccaactgctccaaccccatc agtgtcccgctgcgtaggcatcacctcaacaaccccccgcccagccaggtggggctgact cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggttggggggaag cacggctctttccgtgtccgagcctccagcgacggtgaaggcaccatgtcccgcccggcc tcggtggacggcagccccgtgagtcctagcaccaacaggacccacgcccaccggcatcgg ggcagctcgcgactgcaccctcctctcaaccacagccgctccatccccatgccttcctct cgctgctcaccttctgccaccagcccggtcagtctctcgtccagcagcaccagtggccat ggctccacctctgactgtctcttcccacggcggtctagtgcctctgtgtctggttccccg agtgatggcggtttcatctcctccgatgagtatggctccagtccctgtgacttccgaagt tctttccgcagtgtcaccccggattccctgggccacaccccaccagcccgcggtgaggag gagctgagcaactatatctgcatgggaggcaaggggacctctaccctcaccgcccccaat ggcaactacattttgcctcggggtagcaatggtccccgttacctcccaggaggtggtttg ggcatgagtccagccctggctggggatgaagcagccagtgctgcagatctggataatcgg ttccgaaaacggactcactctgcaggcacatcccctaccatttctcaccagaagacccca tcccagtcctctgtggcttccattgaggaatatacagagatgatgcctgcctatccacca ggaggtggcagtggaggccgactgcccggataccggcactccgcgttcgtgcccacccac tcctaccctgaggagggtctggaaatgcatcctttggagaggcgtgggggccaccaccgc ccagacacttccaccctccacactgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagcagccgaaagggcagtggggactacatgcccatgagccccaagagtgtg tctgccccacagcagatcatcaaccccatcagacgtcatccccagagagtggaccccaat ggctacatgatgatgtccccaagtggcagctgctcccctgacattggaggtggtcccagc agcagcagcagtgctgccccttccgggagcagctatggcaagctgtggacaaacggggcg gggggccaccactctcatgccctgccgcaccccaaactacccatggagagcagtagtggc aagctcttgtcctgtacaggtgactacatgaacatgtcaccagtgggggactccaatacc agcagcccctccgactgctactatggccctgaggacccccagcacaagtcagtcctttcc tactactcattgccaaggtccttcaagcatacccagcgcccaggggagctggaggacagc gcccggccccagcacctccgcctttcctccagctcaggtcgtctgctctatgcagcgaca gaagattcctcctcctctaccagcagcgacagcctgggaggtggatactgtggggctagg cctgagcccggcctctcacatctccaccatcaggtcctgcagccctatctgcctcgaaag gtggacacggctgcccagaccaatagccgcctggctcggcccacgaggctgtccctgggg gatcccaaggccagcaccttacctcgggcgcgagagcagccgcctcccctgctgcaccct ccggagcccaagagcccaggggagtatgtgaatattgaatttgggagtgatcagcctggt tacttgtctggccctgtggcttcccacagctcaccttctgtcaggtgtccgccccagctc cagccagctcccagagaggaggaggctggcactgaagagtacatgaacatggacctgggg ccaggccggagagcagcctggcaggagagtgctgggggccagctgggcagggtgggtcct gcgcctcctggggctgctagcgtgtgcaggcctacccgggcagtgcccagcagccgggct gactacatgaccatgcagatgggttgtcctcatcagagctacgtggacaccttgccagtt gcccctgtcagctatgctgacatgcggacgggcattgtcatggaggaggtgagccttccg gaggccacagcagccactccctcctcctcctctgcagcagcttctgctgcaccccaagga acaggggagctgactgcccgctcttccctgctggggggcccacagggccctgggggcatg agcgccttcacccgggtgaacctcagtcccaaccgcaaccagagtgccaaagtgatccgt gcggacccgcaagggtgccggaggaggcatagctctgagaccttctcttccaagccgagt gccacccgggcgggcaacgctgtgccctttggagggggtgctgctgtagggggcagcagc agcactgaggatgtgaaacgccacagctctgcttcctttgagaatgtgtggctgaggact ggggagctcggggcagcctccaaggagtcagcccaggtgtgcggggcggctgggggtttg gagaatggtctcaactacatagacctggatttggtcaaggacctcaaacagcgcccgctg gagcacccccctcaaccacagccacccccaccccctcatcggcctctgggcagcaacgag agcagctccaccagtctctccagtgaggatgtaagctcctatgccagcatcagtttccag aagcagccagaggacctccaatag

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