Manis javanica (Malayan pangolin): 108403511 Help Entry 108403511         CDS       T06054                                  Symbol ADCY1 Name (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism mjv  Manis javanica (Malayan pangolin) Pathway mjv00230   Purine metabolism mjv01100   Metabolic pathways mjv01522   Endocrine resistance mjv04015   Rap1 signaling pathway mjv04020   Calcium signaling pathway mjv04022   cGMP-PKG signaling pathway mjv04024   cAMP signaling pathway mjv04062   Chemokine signaling pathway mjv04072   Phospholipase D signaling pathway mjv04081   Hormone signaling mjv04082   Neuroactive ligand signaling mjv04114   Oocyte meiosis mjv04211   Longevity regulating pathway mjv04213   Longevity regulating pathway - multiple species mjv04261   Adrenergic signaling in cardiomyocytes mjv04270   Vascular smooth muscle contraction mjv04371   Apelin signaling pathway mjv04540   Gap junction mjv04611   Platelet activation mjv04713   Circadian entrainment mjv04714   Thermogenesis mjv04720   Long-term potentiation mjv04723   Retrograde endocannabinoid signaling mjv04724   Glutamatergic synapse mjv04725   Cholinergic synapse mjv04727   GABAergic synapse mjv04750   Inflammatory mediator regulation of TRP channels mjv04911   Insulin secretion mjv04912   GnRH signaling pathway mjv04913   Ovarian steroidogenesis mjv04914   Progesterone-mediated oocyte maturation mjv04915   Estrogen signaling pathway mjv04916   Melanogenesis mjv04918   Thyroid hormone synthesis mjv04921   Oxytocin signaling pathway mjv04923   Regulation of lipolysis in adipocytes mjv04925   Aldosterone synthesis and secretion mjv04926   Relaxin signaling pathway mjv04927   Cortisol synthesis and secretion mjv04928   Parathyroid hormone synthesis, secretion and action mjv04934   Cushing syndrome mjv04935   Growth hormone synthesis, secretion and action mjv04970   Salivary secretion mjv04971   Gastric acid secretion mjv04972   Pancreatic secretion mjv04976   Bile secretion mjv05032   Morphine addiction mjv05142   Chagas disease mjv05146   Amoebiasis mjv05163   Human cytomegalovirus infection mjv05166   Human T-cell leukemia virus 1 infection mjv05200   Pathways in cancer mjv05207   Chemical carcinogenesis - receptor activation mjv05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:mjv00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     108403511 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     108403511 (ADCY1)    04371 Apelin signaling pathway     108403511 (ADCY1)    04020 Calcium signaling pathway     108403511 (ADCY1)    04072 Phospholipase D signaling pathway     108403511 (ADCY1)    04024 cAMP signaling pathway     108403511 (ADCY1)    04022 cGMP-PKG signaling pathway     108403511 (ADCY1)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     108403511 (ADCY1)    04081 Hormone signaling     108403511 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     108403511 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     108403511 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     108403511 (ADCY1)    04062 Chemokine signaling pathway     108403511 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     108403511 (ADCY1)    04923 Regulation of lipolysis in adipocytes     108403511 (ADCY1)    04912 GnRH signaling pathway     108403511 (ADCY1)    04913 Ovarian steroidogenesis     108403511 (ADCY1)    04915 Estrogen signaling pathway     108403511 (ADCY1)    04914 Progesterone-mediated oocyte maturation     108403511 (ADCY1)    04921 Oxytocin signaling pathway     108403511 (ADCY1)    04926 Relaxin signaling pathway     108403511 (ADCY1)    04935 Growth hormone synthesis, secretion and action     108403511 (ADCY1)    04918 Thyroid hormone synthesis     108403511 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     108403511 (ADCY1)    04916 Melanogenesis     108403511 (ADCY1)    04925 Aldosterone synthesis and secretion     108403511 (ADCY1)    04927 Cortisol synthesis and secretion     108403511 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     108403511 (ADCY1)    04270 Vascular smooth muscle contraction     108403511 (ADCY1)   09154 Digestive system    04970 Salivary secretion     108403511 (ADCY1)    04971 Gastric acid secretion     108403511 (ADCY1)    04972 Pancreatic secretion     108403511 (ADCY1)    04976 Bile secretion     108403511 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     108403511 (ADCY1)    04727 GABAergic synapse     108403511 (ADCY1)    04725 Cholinergic synapse     108403511 (ADCY1)    04720 Long-term potentiation     108403511 (ADCY1)    04723 Retrograde endocannabinoid signaling     108403511 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     108403511 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     108403511 (ADCY1)    04213 Longevity regulating pathway - multiple species     108403511 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     108403511 (ADCY1)    04714 Thermogenesis     108403511 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     108403511 (ADCY1)    05207 Chemical carcinogenesis - receptor activation     108403511 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     108403511 (ADCY1)    05163 Human cytomegalovirus infection     108403511 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     108403511 (ADCY1)    05142 Chagas disease     108403511 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     108403511 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     108403511 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     108403511 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     108403511 (ADCY1) Enzymes [BR:mjv01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      108403511 (ADCY1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom Motif Other DBs NCBI-GeneID:  108403511 NCBI-ProteinID:  XP_036859058 LinkDB All DBs Position Unknown AA seq 1102 aa AA seqDB search MLDTYKKSLKPLMPASLGCTEDTQGGHCPITGPVSPVQERLLMSLLPRNVAMEMKEDFLK PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCR RIKILGDCYYCVSGLTQPKADHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVL CGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGCGHERNSF LRAHSIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS NVMTCEDDDKRPHPVGEDLCICGRRAMSWSQGEARCHKTRRSFEPCHPVLGLWDLEAVSR RALRTASEKLRNRLSFSTNVVYTTPGTRVNRYIGRLLEARQTELEMADLNFFTLKYKQAE RERKYHQLQDEYFTSAVVLALILAASFGLVYLLIIPQSVAVLLLLVFCICFLVSCVLYLH ITRIQCFPGCLTIQIRTVLCIFIVVLIYSVAQGYVVGCLPWAWGSSPNGSLVVLTSRGWS PALPTMPCESAPHALLCGLVGTLPLAIFLRVSSLPKMILLCMLTTSYILVLELSGYTQAM GGGAMSRRSFEPIMAILLFSCTLALHARQVDVKLRLDYLWAAQAEEEREDMEKVKLDNKR ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFDDFYIELDGNNMGVECLR LLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLVPTAGTKGPLASSPAPEHWCSAW LLGAGLMLKAEEEREDMEKVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGV MFASIPNFDDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAA VGLVPTAGTKAKKCISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVI GARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEDVHRLLCRGAYHFVCRGKVSVKGKGEM LTYFLEGRIDGNNSQTRAIDAKRKLCPYGRGSLQSQVAMGRPPVSPAAGLPVRAGLGALQ GSGLAPPTPSQHLPPGAAGKEA NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt atgttggacacgtataagaagagtctgaagcctctcatgccagcttcactggggtgtacc gaggacacgcagggagggcactgccctatcacagggcctgtttctcctgtccaggagagg ctgctcatgagcctcctgccccggaacgttgctatggagatgaaggaggacttcctgaag ccccctgagagaatttttcacaagatttacatccagcggcatgacaacgtaagcatcctg tttgctgacatcgtgggcttcacaggcctggcttcgcagtgcacggcccaggagctggtg aaactcctcaacgagctcttcggcaagtttgatgaattggccacggagaaccactgccgt cgcataaagatcctgggcgattgctactactgtgtgtcgggcctgacgcagcccaaggcc gaccatgcccactgctgtgtggagatgggcctggacatgattgacaccatcacgtcggtg gccgaggccactgaggtggacctgaacatgcgtgtggggctgcacaccggcagggttctc tgtggggtcctgggcctgcgcaagtggcaatatgatgtatggtctaacgatgtgaccctg gccaatgtcatggaggccgctggcctgccagggaaggtccacatcaccaagacaaccctg gcatgcttgaatggtgactacgaggtggagccaggttgtgggcatgagaggaacagcttt ctgagggcccacagcattgagaccttcttcatcgtgccatcacaccggcggaagattttc ccaggactgattctctcagacataaaaccagccaagaggatgaagttcaagaccgtgtgc tacctgctcgtgcagctcatgcactgccgcaagatgttcaaggcggagatccccttctcc aacgtcatgacctgcgaggatgacgacaagagaccccatcctgtaggggaagatctctgc atctgtggcaggagggccatgtcctggagccagggtgaagccaggtgccacaagacccgc aggagctttgagccgtgccatcctgttcttggcctctgggacctagaggctgtttcccgg agagcattgagaacagcctcagaaaaactcagaaaccgcttgtctttctctacaaatgtc gtctacaccaccccgggcactcgcgtgaacaggtacatcggccgcctcctagaagctcgc cagacagagctggagatggcagacctgaacttcttcacactgaagtacaagcaggctgag cgagagcgaaagtaccaccagcttcaggatgagtactttaccagcgctgtcgtgcttgcc ctcatcctggcagcctcatttggccttgtctacctgctgataatcccacagagtgtggct gtcctgctcctgctggtgttctgcatctgcttcctggtgtcctgtgtcctgtatctgcac atcactcggatccagtgttttccagggtgcctgaccattcagatccgcaccgtcttgtgt attttcattgtggtcttaatctactctgtggcccaaggatatgtggtgggctgcctgccc tgggcctggggctccagtcccaatgggtccctggtggtcctgacatcccggggctggagt ccggcactacccaccatgccctgcgagtctgcaccccatgccctgctctgtggactcgtg ggcaccctcccgctagccatattcttgcgggtctcctccttgccaaagatgattctgctg tgcatgctcaccacatcctacatcctggtcttggagctcagcgggtacacccaggctatg gggggtggtgccatgtccaggcgcagcttcgagccaatcatggccatcctgctgttctca tgcacgctggccctgcacgcccggcaggtggatgtcaagctgcggctggactacctctgg gcagcacaggcagaggaggagcgagaggacatggagaaggtgaaactggacaacaagagg atcctgttcaacctgctgccagcccatgttgcccagcacttcctcatgtccaacccccgg aacatggacctgtactaccagtcatactcacaggtgggggtcatgttcgcctccatccct aactttgatgacttctacatcgagctggatggcaacaacatgggtgtcgagtgtctgcgc ctcctcaatgagatcattgctgactttgatgagctcatggacaaagacttttacaaggac ctggagaagatcaagaccattgggagcacctacatggctgctgtggggctggtgcccaca gccggaaccaagggtcccctagcctcgtcccctgctccagagcattggtgctcagcctgg ctccttggtgctggactcatgctgaaggcagaggaggagcgagaggacatggagaaggtg aaactggacaacaagaggatcctgttcaacctgctgccagcccatgttgcccagcacttc ctcatgtccaacccccggaacatggacctgtactaccagtcatactcacaggtgggggtc atgttcgcctccatccctaactttgatgacttctacatcgagctggatggcaacaacatg ggtgtcgagtgtctgcgcctcctcaatgagatcattgctgactttgatgagctcatggac aaagacttttacaaggacctggagaagatcaagaccattgggagcacctacatggctgct gtggggctggtgcccacagccggaaccaaggctaagaagtgcatctcctcccacctcagc acgctggcggactttgctattgagatgtttgacgtcctggatgagatcaactaccagtcc tacaacgactttgtgctccgtgtgggcatcaatgttggacccgtggtggctggggtgatc ggggctcgcaggccacagtatgacatctggggaaacacagtcaacgtcgccagtcggatg gacagcactggagtccagggcagaatccaggtgactgaggacgtccaccggctgctgtgc agaggggcataccacttcgtgtgccgggggaaagtcagtgtcaagggcaagggcgagatg ctgacctacttcctggagggcaggatcgacgggaacaactcccaaaccagggccattgac gccaagcggaaactgtgtccttacggaagaggcagcctccagtcccaagtggccatgggc cggcccccagtgtcccctgcagctggccttccagtcagagctggcctgggggctctgcag ggctcagggcttgctcccccaacccccagccagcacctaccccctggagcagctggaaag gaggcttag

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