Mycobacterium sp. KMS: Mkms_3424
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Entry
Mkms_3424 CDS
T00442
Name
(GenBank) 2-oxo-acid dehydrogenase E1 subunit, homodimeric type
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
mkm
Mycobacterium sp. KMS
Pathway
mkm00010
Glycolysis / Gluconeogenesis
mkm00020
Citrate cycle (TCA cycle)
mkm00620
Pyruvate metabolism
mkm00785
Lipoic acid metabolism
mkm01100
Metabolic pathways
mkm01110
Biosynthesis of secondary metabolites
mkm01120
Microbial metabolism in diverse environments
mkm01200
Carbon metabolism
mkm01210
2-Oxocarboxylic acid metabolism
Module
mkm_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mkm00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
Mkms_3424
00020 Citrate cycle (TCA cycle)
Mkms_3424
00620 Pyruvate metabolism
Mkms_3424
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
Mkms_3424
Enzymes [BR:
mkm01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
Mkms_3424
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GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
ABL92618
UniProt:
A1UIG0
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Position
3589188..3591977
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AA seq
929 aa
AA seq
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MTTEFVRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPAR
ARYLLLRLLERSGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSGGGDQVFIQGHASPGIYARAY
LEGRLTADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHY
LHDRGIKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRG
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
GYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVYAAYRAAMEHKGQPTVILAKT
IKGYTLGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAP
EIRYMLDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEIL
RDKQIGHRIVPIIPDEARTFGMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILH
EGINEAGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGA
TAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVY
FYLTIYNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEM
LAEEWDVAADVWSVTSWNELNRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSD
WMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNTDAESITVAVLEGLARDGNID
ISVAVEAARRYEIDDVLAAPEQTSDPGVA
NT seq
2790 nt
NT seq
+upstream
nt +downstream
nt
ttgaccaccgagttcgtgcgccaggatctggcccaaaactcctccaccgcagccgaacac
gatcgtgtccgggtgatccgtgagggtgttgcatcgtatctgcccgacatcgatcccgat
gagacgagcgaatggctggagtcgttcgaccagctgctcgaacgctccggaccggcgaga
gcccgctacctgctgttgcggctgctcgaacgctccggggagcagcgggtggccatcccc
gcgctcacctcgaccgactacgtgaacacgatcccgaccgaactcgagccgtggttcccc
ggcgacgaggacgtcgaacgccgctaccgggcctggatccggtggaacgccgcgatcatg
gtgcaccgcgcgcagcgtccgggagtcggtgtgggcggccacatctcgacgtacgcgtcg
tcggccgcgctctacgaggtgggcttcaaccacttcttccgcggtaagagccactccggc
ggcggcgaccaggtgttcatccagggccacgcctcccccgggatctacgcgcgcgcctat
ctcgagggcaggctgaccgccgaccaactcgacgggttccgccaggagcacagccacccc
ggcggcggtatcccgtcgtacccgcatccgcggctgatgcccgacttctgggagttcccc
acggtctcgatgggcctgggcccgatgaacgcgatctaccaggcccggttcaaccactac
ctgcacgaccgcggcatcaaggacaccaccgaccagcatgtgtgggcgttcctcggcgac
ggcgagatggacgaaccggagagccgggggctcatccacgtggccgccctcgaggcgctg
gacaacctgacgttcgtcgtcaactgcaacctgcagcgcctcgacggcccggtgcgcggc
aacggcaagatcatccaggaactggagtcgttcttccgcggcgccggctggaacgtcatc
aaggtggtgtggggccgcgaatgggatgcgctgctgcacgccgaccgcgacggcgcactg
gtcaacctgatgaacaccacccccgacggcgactaccagacctacaaggccaacgacggc
ggctacgtacgcgaccacttcttcggccgtgacccgcgcaccaaggcgctggtggaaccg
atgaccgacgccgagatctggaacctcaagcgcggcgggcacgactaccgcaaggtctac
gccgcgtaccgcgcggcgatggagcacaagggccagccgacggtcatcctcgccaagacc
atcaagggctacaccctgggtaagcacttcgagggccgcaacgccacccatcagatgaaa
aagcttgcgctgcaagacctcaaggacttccgcgacgcccagcgcatcccgatcggcgat
gcccagctcgaggagaacccctacctgccgccgtactaccaccccggccccgaggcgccc
gagatccgctacatgctcgaccgcaggcgcgcgctcggcggtttcgtgccggagcgtcgc
acgaagtccaaggcactcgcgctgccgagcagcgatgcctacaaggcgctgaagaagggc
tccggcaagcaggaggtcgccaccacgatggcgacagtccgcaccttcaaggagatcctg
cgcgacaagcagatcggccatcgcatcgtgccgatcatccccgacgaggcgcgcacgttc
gggatggactcctggttcccgaacctcaagatctacaaccgcaacgggcagctctacacc
tccgtcgacgccgagctgatgctggcgtaccgggagagcgaggtcgggcagatcctgcac
gaggggatcaacgaggccggttcggtgggcacgttcatcgctgcgggcacgtcgtacgcc
acgcacaacgagccgatgatcccgatctacatcttctattcgatgttcgggttccagcgc
accggtgacagcttctgggcggccgccgaccagatggcccgtggattcgtgctgggcgcg
acggccgggcgcaccacgctggtcggtgaggggttgcagcacgccgacggccactcactg
ctgctggcgtcgaccaaccccgcggtggtggcctacgacccggcgttcgcctacgagatc
gcctacatcatcgaatccgggctgcaccggatgtacggggagaacccggagaacgtctac
ttctatctgacgatctacaacgagccctacgtccagccggcggaaccggagaacctcgac
gtcgagggtctgttgcgcgggatctaccggtaccgggccgcggcggagaagaaatccaac
accgcccagatcctggtgtccggcgtggcgatgccctcggcgctcaaggccgccgagatg
ctggccgaggagtgggacgtggccgccgacgtgtggtcggtgaccagctggaacgagctc
aaccgcgacggcgtccaggtcgagaaggacctgctgcgccatccggaccggccggcgggc
accccgtacatcaccacggcgctcgccgacgcggccggaccggtcgtggcggtctcggac
tggatgcgcgcggtgcccgagcagatccggccgtgggtacccggtacgtacatcacgctc
ggcacggacggtttcggattctccgacacccggcccgccgcgcggcggttctacaacacc
gacgccgagtcgatcaccgtggcggtgctcgaagggctggcccgcgacggcaacatcgac
atctcggtggccgtcgaggcggcccgccgctacgagatcgacgacgtgctggcggcgccg
gagcagacctccgatcccggggtggcctga
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