Mycobacterium kubicae: I2456_15250
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Entry
I2456_15250 CDS
T07774
Symbol
metH
Name
(GenBank) methionine synthase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
mku
Mycobacterium kubicae
Pathway
mku00270
Cysteine and methionine metabolism
mku00450
Selenocompound metabolism
mku00670
One carbon pool by folate
mku01100
Metabolic pathways
mku01110
Biosynthesis of secondary metabolites
mku01230
Biosynthesis of amino acids
mku04980
Cobalamin transport and metabolism
mku04981
Folate transport and metabolism
Module
mku_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
mku00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
I2456_15250 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
I2456_15250 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
I2456_15250 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
I2456_15250 (metH)
04980 Cobalamin transport and metabolism
I2456_15250 (metH)
Enzymes [BR:
mku01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
I2456_15250 (metH)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
S-methyl_trans
Pterin_bind
Met_synt_B12
B12-binding_2
B12-binding
MOV-10_beta-barrel
Motif
Other DBs
NCBI-ProteinID:
QPI35944
UniProt:
A0AAX1J3A9
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All DBs
Position
complement(3243212..3246811)
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AA seq
1199 aa
AA seq
DB search
MTSANKPHYDTDLLDVLSQRVVVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL
ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSERGTAIARRVADELASPDRK
RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG
SRRAMKQAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE
HLRYLSRHARIPVSVMPNAGLPVLGAKGAEYPLQPDELAEALATFISEFGLSLVGGCCGT
TPAHIREVAAAVASFNDGTKQRGERQVSFEPSVSSLYTAVPFEQESSVLVIGERTNANGS
KGFREAMIAEDYQKCLDIAKDQTRDGAHMLDLCVDYVGRDGAADMKALASRLATSSTLPI
MLDSTETPVLLAGLEHLGGRCAVNSVNYEDGDGPESRFHKTMELVAEHGAAVVALTIDEE
GQARTAEKKVQIAERLIDDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRQ
LKQRHPQVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPD
EQRQVALDLIYDRRRPEDEYDPLQELMRLFEGVSAASSKESRAAELAKLPLFERLAQRIV
DGERNGLDADLDEAMTQKPPLAIINENLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAV
AYLEPHMEKAEDDAGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATIL
EVAEDKSADVVGMSGLLVKSTVVMKENLEEMNARGVAEKFPVVLGGAALTRSYVENDLAE
VYEGEVHYARDAFEGLKLMDTIMSAKRGEGPDPDSPEAVAARKKEAERKARHERSKRIAA
QRKAAEEPVQVPERSDVAADIEVPTPPFWGSRIVKGLAMAEYTGLLDERALFLGQWGLRG
QRGGEGPSYEELVETEGRPRLRYWLDRLSTDGILAHAAVVYGYYPAVSEGDDVVVLASPE
PDAQERYRFTFPRQQRGRFLCIADFIRSRKLATERGQVDVLPFQLVTMGRPIADFANELF
AANAYRDYLEVHGIGVQLTEALAEYWHKRIREELKFSGDRAVAADDPESVEDYFKLEYRG
ARFAFGYGACPNLEDRAKMMELLDPGRIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV
NT seq
3600 nt
NT seq
+upstream
nt +downstream
nt
gtgacttccgctaacaagccccactacgacaccgatctgctcgacgttttgtcgcagcga
gtagtggtgggcgacggcgcgatgggcacccagttgcaggccgcggacctcactctcgat
gacttccgcggcctcgagggctgcaacgagatcctcaacgaaacccgccctgacgtgctg
gaaaccatccaccgcaactatttcgaggccggcgcggacgccgtcgagaccaacacgttc
ggctgcaacctgtccaacctcggcgactacgacatcgccgaccggatcagggacctctcc
gagcgcggcaccgccatcgcgcgccgggtcgccgacgagctggccagccccgaccgtaag
cgctatgtgttgggctcgatgggtccgggcaccaagctgcccaccctcgggcacaccgag
tacgcggtgatccgcgacgcctacaccgaggccgccctcggcatgctcgacggcggcgcc
gacgccatcctcgtcgagacctgccaggacctgctacaactcaaggccgcggtcctgggc
tcgcggcgggcgatgaagcaggccggccgccacatcccggtgttcgcccacgtcaccgtg
gaaaccaccggcaccatgctgctgggcagtgaaatcggtgcggcgttgaccgccgttgag
ccgctcggcgtcgacatgatcggcctcaactgcgcgaccggccccgccgagatgagcgag
cacctgcgctacctgtctcggcacgcccgcatcccggtgtcggtgatgcccaacgccgga
ctgccggtgctgggcgccaagggcgcggagtatccgctgcagcccgacgaacttgccgag
gcgctggccaccttcatctccgagttcgggctgtcactggtcggcggctgctgtggcacc
acccccgcccacatccgcgaggtcgccgccgccgtcgcctccttcaacgacggcaccaaa
cagcgcggcgagcggcaggtcagcttcgagccgtcggtgtcctcgctgtacaccgccgtt
ccgttcgagcaggaatcttcggtgctggtcatcggcgagcgcacgaacgccaacggctcc
aagggattccgtgaggcgatgatcgccgaggactaccagaagtgcctcgacatcgccaag
gaccagacccgcgacggcgcccacatgctcgacctgtgcgtcgactacgtgggccgcgac
ggcgccgccgacatgaaagcgctggccagccggctggcgacgtcgtcgacactgccgatc
atgctggactcgaccgaaacccccgtgctgctagccggattggagcacctgggtggccgc
tgcgcggtcaactcggtgaactacgaggacggcgacggcccggaatcgcggttccacaag
accatggaactggtcgccgagcacggtgccgcggtggtcgcgctgaccatcgacgaagag
gggcaggcccgcaccgccgagaagaaggtgcagatcgccgaacggctgatcgacgacatc
accggcaactggggcgtcgacgaatcctccatcctcatcgacactttgacgttcaccatc
gccaccggccaggaagagtcacgtcgcgacggcatcgaaacgatcgaagccatccggcaa
ctcaagcagcgccatcctcaggtgcaaaccacgctcgggttgtccaacatctcgttcggc
ttgaatcccgctgcgcgccaagtgctcaactcggtgtttctgcacgaatgccaggaagcg
ggactggactccgcgatcgtgcacgcgtcgaagatcctgccgatgaaccggattcccgac
gagcagcgacaggtcgccctggatctgatctatgaccgccgccgccccgaggacgagtac
gacccgctgcaggagctcatgcggctgttcgagggcgtctcggcggcctcgtcgaaggaa
tcgcgcgccgccgaactggccaaactgccgctgttcgaacggcttgcgcaacgcattgtc
gacggcgaacgcaacggcctggacgccgacctcgacgaggcgatgacacagaagcccccg
ctggcgatcatcaacgagaacctgctggccggcatgaaaaccgttggcgaactgttcggt
tcgggtcagatgcagctgcccttcgtgttgcagtccgccgaggtgatgaaagccgcggtc
gcctacctggaaccgcacatggagaaggcggaggacgacgccggcaaggggcgcatcgtg
ctggccaccgtcaagggcgacgtccatgacatcggcaagaacctcgtcgacatcatcttg
agcaacaacggctacgaggtggtcaacatcggcatcaagcagccgatcgccaccatcctg
gaagtcgccgaagacaaaagcgccgacgtggtgggcatgtcgggtctgctggtgaaatcc
accgtggtgatgaaagaaaacctcgaggagatgaacgctcggggcgtcgccgagaagttt
ccggtcgtgctcggcggtgcggcgttgacccgcagctacgtcgagaacgacctggccgag
gtctacgagggcgaagtgcattatgcgcgcgacgctttcgagggcttgaagctgatggac
accatcatgagcgccaagcgcggtgagggtccggatcccgacagcccggaggccgtcgcc
gcccgcaagaaagaagccgaacgcaaggcgcgccacgagcggtccaaacgcattgctgcc
caacgcaaagccgccgaagagccggtccaggtgccggaacgttccgacgtcgccgccgat
atcgaggtaccgacgccgccgttctggggctcgcggatcgtcaagggtctggcgatggcc
gaatacaccggcctgctcgacgagcgcgccttgttcctggggcagtggggattacgcggg
cagcgtggcggagaggggccgtcgtacgaggagctggtggagaccgaaggccggccgcgg
ctgcggtactggctggaccggttgtccaccgacggcatcctggcgcacgcggcagtggtg
tacggctactacccggcggtgtccgagggcgacgacgtggtggtcctggccagccccgaa
cccgacgcgcaggagcgctaccggttcactttcccgcgccagcagcgcggccggttcttg
tgcatcgccgacttcattcggtcacgcaagctggcgaccgaacgcgggcaggtcgacgtg
ctgcccttccagttggtgacgatgggccggcccatcgccgacttcgccaacgagttgttc
gcggcgaacgcataccgcgattacctcgaagtgcacggcatcggcgtgcagctgaccgaa
gcgctggccgagtactggcacaaacgcatccgcgaagagctcaagttctccggcgatcgg
gcggtggccgccgacgacccggaatccgtcgaagactacttcaagctggagtaccgcggt
gcccgcttcgccttcggttacggcgcctgccccaacctggaggaccgggcgaagatgatg
gagctgctcgaccccggccgcatcggcgtgaccctgtccgaggaactgcagttgcatccc
gagcaatccaccgacgcgttcgtgctgcaccaccccgaggccaagtacttcaacgtgtag
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