Mycobacterium leprae TN: ML1307
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Entry
ML1307 CDS
T00047
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate-homocysteine methyltransferase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
mle
Mycobacterium leprae TN
Pathway
mle00270
Cysteine and methionine metabolism
mle00450
Selenocompound metabolism
mle00670
One carbon pool by folate
mle01100
Metabolic pathways
mle01110
Biosynthesis of secondary metabolites
mle01230
Biosynthesis of amino acids
mle04980
Cobalamin transport and metabolism
mle04981
Folate transport and metabolism
Module
mle_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
mle00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
ML1307 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
ML1307 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
ML1307 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
ML1307 (metH)
04980 Cobalamin transport and metabolism
ML1307 (metH)
Enzymes [BR:
mle01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
ML1307 (metH)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
S-methyl_trans
Pterin_bind
Met_synt_B12
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAC31688
Pasteur:
ML1307
UniProt:
Q49775
A0AAD0P4W5
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All DBs
Position
1556851..1560471
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AA seq
1206 aa
AA seq
DB search
MRVTAANQHQYDTDLLETLAQRVMVGDGAMGTQLQDAELTLDDFRGLEGCNEILNETRPD
VLETIHRRYFEAGADLVETNTFGCNLSNLGDYDIADKIRDLSQRGTVIARRVADELTTPD
HKRYVLGSMGPGTKLPTLGHTEYRVVRDAYTESALGMLDGGADAVLVETCQDLLQLKAAV
LGSRRAMTQAGRHIPVFVHVTVETTGTMLLGSEIGAALAAVEPLGVDMIGLNCATGPAEM
SEHLRHLSKHARIPVSVMPNAGLPVLGAKGAEYPLQPDELAEALAGFIAEFGLSLVGGCC
GTTPDHIREVAAAVARCNDGTVPRGERHVTYEPSVSSLYTAIPFAQKPSVLMIGERTNAN
GSKVFREAMIAEDYQKCLDIAKDQTRGGAHLLDLCVDYVGRNGVADMKALAGRLATVSTL
PIMLDSTEIPVLQAGLEHLGGRCVINSVNYEDGDGPESRFVKTMELVAEHGAAVVALTID
EQGQARTVEKKVEVAERLINDITSNWGVDKSAILIDCLTFTIATGQEESRKDGIETIDAI
RELKKRHPAVQTTLGLSNISFGLNPSARQVLNSVFLHECQEAGLDSAIVHASKILPINRI
PEEQRQAALDLVYDRRREGYDPLQKLMWLFKGVSSPSSKETREAELAKLPLFDRLAQRIV
DGERNGLDVDLDEAMTQKPPLAIINENLLDGMKTVGELFGSGQMQLPFVLQSAEVMKAAV
AYLEPHMEKSDCDFGKGLAKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNLGIKQPI
TNILEVAEDKSADVVGMSGLLVKSTVIMKENLEEMNTRGVAEKFPVLLGGAALTRSYVEN
DLAEVYEGEVHYARDAFEGLKLMDTIMSAKRGEALAPGSPESLAAEADRNKETERKARHE
RSKRIAVQRKAAEEPVEVPERSDVPSDVEVPAPPFWGSRIIKGLAVADYTGFLDERALFL
GQWGLRGVRGGAGPSYEDLVQTEGRPRLRYWLDRLSTYGVLAYAAVVYGYFPAVSEDNDI
VVLAEPRPDAEQRYRFTFPRQQRGRFLCIADFIRSRDLATERSEVDVLPFQLVTMGQPIA
DFVGELFVSNSYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGNRTMSADDPEAVEDY
FKLGYRGARFAFGYGACPDLEDRIKMMELLQPERIGVTISEELQLHPEQSTDAFVLHHPA
AKYFNV
NT seq
3621 nt
NT seq
+upstream
nt +downstream
nt
atgcgtgtaactgccgctaaccaacatcagtacgacaccgatctcctcgagactttggcg
cagcgtgtgatggtgggtgacggcgcaatgggtactcagctccaggacgcggaacttacg
ttagatgatttccgcggcctggagggctgcaacgagattctcaacgaaacgcgtcctgac
gtgctggaaaccatccaccgacgctacttcgaggcaggtgcggacctcgtcgagaccaac
actttcggctgcaacctgtccaaccttggtgactacgacatcgccgacaagatcagggac
ttgtcgcagcggggcaccgtgattgcgcgacgggtcgccgacgagctgaccacccccgac
cacaagcgatacgtgctggggtcgatgggaccaggcaccaagttgcccaccctgggccac
accgagtaccgggtcgttcgagacgcctacaccgagtcggcgttaggcatgctggacggt
ggcgctgacgccgtactggttgaaacctgtcaggacttgctgcagctcaaggctgcggtg
ctgggctcgcggcgcgcgatgacacaggccggtcggcacattccggtcttcgtccacgtg
actgtcgagacgaccggaacgatgctgctgggaagtgagatcggcgctgcactggctgcc
gtcgagccgctcggtgtcgacatgatcggtttgaactgcgcaacgggccccgctgagatg
agtgagcatctgcggcacttgtccaagcatgcccgcatcccggtgtcggtgatgcccaac
gccgggctgccggtgctgggtgccaagggagctgaatacccgctgcagcccgacgaattg
gccgaagctttggctgggttcatcgctgaatttggtctttcgttggtaggtggctgctgt
ggtaccaccccggaccacatccgggaagtggccgcagcggtagccagatgcaacgacggg
acagtgccacgcggtgagcgtcatgtgacctatgagccgtcggtatcgtcgctgtataca
gccattccattcgcccaaaaaccctcggttctgatgatcggtgagcgtacgaatgccaac
ggctccaaggtttttcgtgaggcaatgatcgccgaggactatcaaaagtgtctagatatc
gccaaggaccaaacccgtggcggcgcacacctgctggatctgtgtgtcgattacgtcggc
cgcaacggtgtggccgacatgaaggcgttggccggtcggcttgcaacggtgtcgacattg
ccgatcatgctggactctaccgaaataccggtgctgcaggcaggtttggagcacctgggc
gggcgctgcgtgatcaattccgtcaactacgaggacggtgacggtcccgagtcacggttt
gtcaagaccatggagctggtcgccgagcacggagcggcggtggttgcgctgaccatcgac
gaacagggtcaggcccgcaccgttgagaagaaggtcgaagtcgcggagcggcttatcaat
gacattacgagtaactggggcgttgataaatcggcgattctcatcgattgcttgactttt
actattgccactggccaggaggagtcacgcaaagacggcattgagaccatcgacgcgatt
cgtgagctgaagaagcggcacccagcggtgcagactacgctggggttgtccaacatctcc
ttcggtctcaatccttctgcacgccaagttcttaactctgtttttctacatgaatgtcag
gaagcaggactggattcggcgattgtgcacgcttcaaagatattgcccatcaaccggata
cccgaagaacagcgccaggctgcgctggatctagtgtatgaccgccgtcgcgaaggctac
gacccattgcagaagctgatgtggttattcaaaggtgtgtcgtcgccatcgtcgaaggaa
acacgggaggcagaactcgctaagctgccgttgttcgaccggttagcacagcggatcgtc
gacggcgagcgcaacgggttagatgttgatctcgacgaggcaatgacccagaaaccgccg
ttggcgatcatcaacgagaacctgctggacggcatgaagacagtcggtgaattgttcggc
tctgggcagatgcagctgcctttcgtgttgcagtcggccgaggttatgaaagcagcggtg
gcttatctagaaccgcacatggagaaatccgactgtgacttcggtaaggggttagccaaa
ggacggattgtgctggctaccgtcaaaggagatgtgcacgatattggcaaaaacctcgtc
gatatcattctgagcaacaacggctacgaagtggtaaacctcggcatcaagcagccgatt
accaacattctcgaggtggccgaggacaaaagcgccgacgtagtcgggatgtcgggcttg
ctggtgaaatcgactgtgatcatgaaggaaaacctcgaggagatgaacactcgcggagtc
gctgagaaattcccagtgctgctcggcggcgcggcgttgacccgcagctatgtggaaaac
gacctggccgaagtctatgagggcgaagtgcattacgcacgagacgctttcgagggtttg
aagttgatggacaccattatgagcgccaagcgcggcgaggcgcttgcgccggggagcccg
gagtccttagctgcagaagcagaccgcaataaggaaactgagcgcaaggcacgtcatgag
cggtccaaacgcattgcagtgcagcgtaaggctgccgaagagccagttgaggttcccgaa
cgctccgatgttccgagtgatgtcgaggttccggcgccgccgttctggggttcgcggatc
atcaagggtctggcggtggccgactataccgggttcctcgacgagcgcgcgttgttcttg
ggtcagtggggattacgtggtgtgcgcggcggtgcggggccctcgtacgaggatttggtg
cagaccgagggccggccgcggttgcgctactggctagaccgattgtccacctacggcgtc
ttggcgtacgccgccgtggtgtacggttacttcccggcggtgtccgaagacaacgatatt
gtcgtgctcgctgagccgagaccggacgccgagcagcggtaccggttcaccttcccgcgt
cagcaacgcggtcggttcctgtgcattgccgattttattcgatcccgggatctggcgacc
gagcggagtgaggtggatgttttgccgttccagctggtgaccatgggtcaacccattgct
gacttcgttggcgagttgttcgtgtccaattcctatcgtgattatcttgaagtgcatggc
atcggtgtgcagctaaccgaggcgctggccgaatactggcaccggcgcattcgtgaagag
ctgaaattctccggaaaccggacgatgtcggctgacgatcccgaggccgtcgaggactat
ttcaagctcggctaccgaggtgcccgcttcgcgttcgggtatggagcatgcccggacctg
gaggaccggatcaagatgatggagctgcttcaacccgaacgcatcggtgtaacgatatct
gaagagttgcagttacatcccgagcaatcgactgatgcgttcgtgctgcaccatccggcg
gctaagtacttcaacgtctga
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