Mandrillus leucophaeus (drill): 105541159 Help Entry 105541159         CDS       T08763                                  Symbol INSR Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism mleu  Mandrillus leucophaeus (drill) Pathway mleu04010   MAPK signaling pathway mleu04014   Ras signaling pathway mleu04015   Rap1 signaling pathway mleu04022   cGMP-PKG signaling pathway mleu04066   HIF-1 signaling pathway mleu04068   FoxO signaling pathway mleu04072   Phospholipase D signaling pathway mleu04081   Hormone signaling mleu04150   mTOR signaling pathway mleu04151   PI3K-Akt signaling pathway mleu04152   AMPK signaling pathway mleu04211   Longevity regulating pathway mleu04213   Longevity regulating pathway - multiple species mleu04520   Adherens junction mleu04910   Insulin signaling pathway mleu04913   Ovarian steroidogenesis mleu04923   Regulation of lipolysis in adipocytes mleu04930   Type II diabetes mellitus mleu04931   Insulin resistance mleu04932   Non-alcoholic fatty liver disease mleu04960   Aldosterone-regulated sodium reabsorption mleu05010   Alzheimer disease mleu05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mleu00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     105541159 (INSR)    04014 Ras signaling pathway     105541159 (INSR)    04015 Rap1 signaling pathway     105541159 (INSR)    04066 HIF-1 signaling pathway     105541159 (INSR)    04068 FoxO signaling pathway     105541159 (INSR)    04072 Phospholipase D signaling pathway     105541159 (INSR)    04022 cGMP-PKG signaling pathway     105541159 (INSR)    04151 PI3K-Akt signaling pathway     105541159 (INSR)    04152 AMPK signaling pathway     105541159 (INSR)    04150 mTOR signaling pathway     105541159 (INSR)   09133 Signaling molecules and interaction    04081 Hormone signaling     105541159 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     105541159 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     105541159 (INSR)    04923 Regulation of lipolysis in adipocytes     105541159 (INSR)    04913 Ovarian steroidogenesis     105541159 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     105541159 (INSR)   09149 Aging    04211 Longevity regulating pathway     105541159 (INSR)    04213 Longevity regulating pathway - multiple species     105541159 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105541159 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     105541159 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     105541159 (INSR)    04932 Non-alcoholic fatty liver disease     105541159 (INSR)    04931 Insulin resistance     105541159 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mleu01001]     105541159 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:mleu04090]     105541159 (INSR) Enzymes [BR:mleu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      105541159 (INSR) Protein kinases [BR:mleu01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    105541159 (INSR) CD molecules [BR:mleu04090]  Proteins   105541159 (INSR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  105541159 NCBI-ProteinID:  XP_011837453 Ensembl:  ENSMLEG00000032885 LinkDB All DBs Position Unknown AA seq 1380 aa AA seqDB search MKTQGPSFTSMRPALPLILLTHPPCVCSPVFAFCSFSLLVCPGMDIRNNLTRLHELENCS VIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRL FFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL NKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLC CHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCK NSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSA QELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRL IRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSG TKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFY KEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK TLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITH YLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEHEDSAGECCSCPK TDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAV PTVAAFPNTSSTSTPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERC SVAAYVSARTMPEGGAAAPGICILAVNNALNCLWKLLVSLEWLSPPTFNPTLELHLCVSR KHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPL IFVFLFSIVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREK ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAE IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP ERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPENEELEMEFE DMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4143 nt NT seq  +upstreamnt  +downstreamnt atgaaaacacagggcccaagtttcacgtccatgaggccggctctgcccctgatccttctg acgcatccaccgtgtgtctgctcacctgtctttgctttctgttcattttctcttctagtg tgtcccggcatggatatccggaacaacctcaccaggttacacgagctggagaattgctct gtcatcgaaggacacttgcagatactcttgatgtttaaaacgaggcccgaagatttccgg gacctcagtttccccaaactcataatgatcactgattacttgctgctcttccgggtctat gggctcgagagcctgaaggacctgttccccaacctcacggtcatccggggatcacgactg ttctttaactacgcgctggtcatcttcgagatggttcacctcaaggaacttggcctctac aatctaatgaacatcacccggggttctgtccgcatcgagaagaacaacgagctctgttac ttggccactatcgactggtcccgcatcctggattccgtggaggataattacatcgtgttg aacaaagatgacaacgaggagtgtggagacatctgtccgggtacagcgaagggcaagacc aactgccccgccactgtcatcaatgggcagtttgtcgaacggtgttggactcatagtcac tgccagaaagtttgcccaaccatctgtaagtcacacggctgcactgccgaaggcctctgt tgccacagcgagtgcctgggcaactgttccgagcccgacgaccccaccaagtgcgtggcc tgccgcaacttctacctggacggcaggtgtgtggagacctgcccgcccccgtactaccac ttccaggactggcgctgtgtgaacttcagcttctgccaggacctgcaccacaaatgcaag aactcgcggaggcagggctgccaccagtacgtcattcataacaacaagtgcatccctgag tgtccctccgggtacacgatgaattccagcaacttgctgtgcaccccgtgcctgggtccc tgtcccaaggtatgccacctcctagaaggcgagaagaccatcgactcagtgacgtctgcc caggagctccgaggatgcaccgtcatcaacgggagtctgatcatcaacattcgaggaggc aataatctggcagctgagctagaagccaacctcggcctcattgaagaaatttcaggttat ctaaaaatccgccgatcctacgctctggtgtcactttccttcttccggaagttgcgtctg attcgaggagagacattggaaatcgggaactactccttctatgccttggacaaccagaac ctaaggcagctctgggactggagcaaacacaacctcaccatcactcaggggaaactcttc ttccactataaccccaaactctgcttgtcagaaatccacaagatggaagaagtttcagga accaaggggcgccaggagagaaatgacattgccctgaagacaaatggggaccaggcatcc tgtgaaaatgagttacttaaattttcttacattcggacatctttcgataagatcttgctg agatgggagccgtactggccccccgacttccgagacctcctggggttcatgctgttctac aaagaggccccttaccagaatgtgacggagtttgacgggcaggatgcgtgtggttccaac agttggacggtggtagacattgacccgcccctgaggtccaacgaccccaaatcacagaac cacccaggatggctaatgcggggtctcaagccctggacccagtatgccatctttgtgaag accctggtcaccttttcggatgaacgccggacctacggagccaagagcgacatcatttat gtccagacagatgccaccaacccctccgtgcctctggatccaatctcagtgtctaactca tcatcccagattattctgaagtggaaaccgccctccgaccccaacggcaacatcacccac tacctggtcttctgggagaggcaggcagaagacagtgagctgttcgagctggattattgc ctcaaagggctgaagctgccctcgaggacctggtctccaccgttcgagtctgaggattct cagaagcacaaccagagtgaacatgaggattcagccggtgaatgttgctcctgtccaaag acagactctcagatcctgaaggagctggaggagtcctcgtttaggaagacgtttgaggat tacctgcacaacgtggttttcgtccccagaaaaacctcttcaggcactggtgccgaggac cctaggccatctcggaaacgcaggtcccttggcgatgttgggaatgtgacggtggccgtg cccacggtggcagctttccccaacacttcctcgaccagcacgcccacgagtccggaggag cacaggccctttgagaaggtggtgaacaaggagtcgctggtcatctccggcttgcgacac ttcacgggctatcgcatcgagctgcaggcttgcaaccaagacacccctgaggaacggtgc agtgtggcagcctacgtcagcgccaggaccatgcctgaaggtggggctgctgccccggga atctgtatccttgctgtcaacaatgccctgaactgcctttggaagctgctcgtctccctt gagtggctctcacctcccaccttcaaccccaccctggagctgcatctctgtgtctcccgc aagcacttcgctctggaacggggctgcaggctgcgcgggctgtcgccggggaactacagc gtgcgagtccgggccacctccctcgcgggcaacggctcctggacggaacccacctatttc tacgtgacggactatttagatgtcccgtcaaatattgcaaaaattatcatcggccccctc atctttgtctttctcttcagtattgtgattggaagtatttatctattcctgagaaagagg cagccagatgggccactgggaccgctttacgcttcttcaaaccctgagtatctcagtgcc agtgatgtgtttccatgctctgtgtacgtgccggacgagtgggaggtgcctcgagagaag atcaccctccttcgagagctggggcagggctccttcggcatggtgtatgagggcaacgcc agggacatcatcaagggtgaggcagagacccgcgtggcagtgaagacggtcaacgagtca gccagtctccgagagcggattgagttcctcaatgaggcctcggtcatgaagggcttcacc tgccatcatgtggtgcgtctcctgggagtggtgtccaagggccagcccacgctggtggtg atggagctgatggctcacggagacctgaagagctacctccgttctctgcggccagaggct gagaataatcctggccgccctccccctaccctgcaagagatgattcagatggcggcggag attgctgacgggatggcctacctgaatgccaagaagttcgtgcatcgggacctggcagca agaaactgcatggtcgcccacgattttactgtcaaaattggagactttggaatgaccaga gacatctatgaaacggattactaccggaaaggaggcaagggtctgctccctgtacggtgg atggcgccggagtccctgaaggatggggtctttaccacttcttctgacatgtggtccttt ggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtctaat gaacaggtgttgaaatttgtcatggacggagggtatctggatcagcccgacaactgtcca gagagagtcactgacctcatgcgcatgtgctggcaattcaaccccaagatgaggccaacc ttcctggagatcgtcaacctgctcaaggacgacctgcaccccagctttccggaggtgtct ttctttcatagcgaggagaacaaggctcccgagaatgaggagctggagatggagtttgag gacatggagaacgtgcccctggaccgttcctcgcactgtcagagggaggaggcggggggc cgggatggagggtcctcgctgggtttcaagcggagctacgaggaacacatcccttacacc cacatgaacggaggcaagaaaaacgggcggattctgaccttgcctcggtccaatccttcc taa

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