KEGG   Mandrillus leucophaeus (drill): 105543389
Entry
105543389         CDS       T08763                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mleu  Mandrillus leucophaeus (drill)
Pathway
mleu01521  EGFR tyrosine kinase inhibitor resistance
mleu01522  Endocrine resistance
mleu01524  Platinum drug resistance
mleu04012  ErbB signaling pathway
mleu04014  Ras signaling pathway
mleu04015  Rap1 signaling pathway
mleu04024  cAMP signaling pathway
mleu04062  Chemokine signaling pathway
mleu04066  HIF-1 signaling pathway
mleu04068  FoxO signaling pathway
mleu04070  Phosphatidylinositol signaling system
mleu04071  Sphingolipid signaling pathway
mleu04072  Phospholipase D signaling pathway
mleu04081  Hormone signaling
mleu04140  Autophagy - animal
mleu04150  mTOR signaling pathway
mleu04151  PI3K-Akt signaling pathway
mleu04152  AMPK signaling pathway
mleu04210  Apoptosis
mleu04211  Longevity regulating pathway
mleu04213  Longevity regulating pathway - multiple species
mleu04218  Cellular senescence
mleu04360  Axon guidance
mleu04370  VEGF signaling pathway
mleu04380  Osteoclast differentiation
mleu04510  Focal adhesion
mleu04550  Signaling pathways regulating pluripotency of stem cells
mleu04611  Platelet activation
mleu04613  Neutrophil extracellular trap formation
mleu04620  Toll-like receptor signaling pathway
mleu04625  C-type lectin receptor signaling pathway
mleu04630  JAK-STAT signaling pathway
mleu04650  Natural killer cell mediated cytotoxicity
mleu04660  T cell receptor signaling pathway
mleu04662  B cell receptor signaling pathway
mleu04664  Fc epsilon RI signaling pathway
mleu04666  Fc gamma R-mediated phagocytosis
mleu04668  TNF signaling pathway
mleu04670  Leukocyte transendothelial migration
mleu04722  Neurotrophin signaling pathway
mleu04725  Cholinergic synapse
mleu04750  Inflammatory mediator regulation of TRP channels
mleu04810  Regulation of actin cytoskeleton
mleu04910  Insulin signaling pathway
mleu04914  Progesterone-mediated oocyte maturation
mleu04915  Estrogen signaling pathway
mleu04917  Prolactin signaling pathway
mleu04919  Thyroid hormone signaling pathway
mleu04923  Regulation of lipolysis in adipocytes
mleu04926  Relaxin signaling pathway
mleu04929  GnRH secretion
mleu04930  Type II diabetes mellitus
mleu04931  Insulin resistance
mleu04932  Non-alcoholic fatty liver disease
mleu04933  AGE-RAGE signaling pathway in diabetic complications
mleu04935  Growth hormone synthesis, secretion and action
mleu04960  Aldosterone-regulated sodium reabsorption
mleu04973  Carbohydrate digestion and absorption
mleu05010  Alzheimer disease
mleu05017  Spinocerebellar ataxia
mleu05020  Prion disease
mleu05100  Bacterial invasion of epithelial cells
mleu05135  Yersinia infection
mleu05142  Chagas disease
mleu05146  Amoebiasis
mleu05160  Hepatitis C
mleu05161  Hepatitis B
mleu05162  Measles
mleu05163  Human cytomegalovirus infection
mleu05164  Influenza A
mleu05165  Human papillomavirus infection
mleu05166  Human T-cell leukemia virus 1 infection
mleu05167  Kaposi sarcoma-associated herpesvirus infection
mleu05168  Herpes simplex virus 1 infection
mleu05169  Epstein-Barr virus infection
mleu05170  Human immunodeficiency virus 1 infection
mleu05171  Coronavirus disease - COVID-19
mleu05200  Pathways in cancer
mleu05203  Viral carcinogenesis
mleu05205  Proteoglycans in cancer
mleu05206  MicroRNAs in cancer
mleu05207  Chemical carcinogenesis - receptor activation
mleu05208  Chemical carcinogenesis - reactive oxygen species
mleu05210  Colorectal cancer
mleu05211  Renal cell carcinoma
mleu05212  Pancreatic cancer
mleu05213  Endometrial cancer
mleu05214  Glioma
mleu05215  Prostate cancer
mleu05218  Melanoma
mleu05220  Chronic myeloid leukemia
mleu05221  Acute myeloid leukemia
mleu05222  Small cell lung cancer
mleu05223  Non-small cell lung cancer
mleu05224  Breast cancer
mleu05225  Hepatocellular carcinoma
mleu05226  Gastric cancer
mleu05230  Central carbon metabolism in cancer
mleu05231  Choline metabolism in cancer
mleu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mleu05415  Diabetic cardiomyopathy
mleu05417  Lipid and atherosclerosis
mleu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mleu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105543389 (PIK3R1)
   04014 Ras signaling pathway
    105543389 (PIK3R1)
   04015 Rap1 signaling pathway
    105543389 (PIK3R1)
   04370 VEGF signaling pathway
    105543389 (PIK3R1)
   04630 JAK-STAT signaling pathway
    105543389 (PIK3R1)
   04668 TNF signaling pathway
    105543389 (PIK3R1)
   04066 HIF-1 signaling pathway
    105543389 (PIK3R1)
   04068 FoxO signaling pathway
    105543389 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    105543389 (PIK3R1)
   04072 Phospholipase D signaling pathway
    105543389 (PIK3R1)
   04071 Sphingolipid signaling pathway
    105543389 (PIK3R1)
   04024 cAMP signaling pathway
    105543389 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    105543389 (PIK3R1)
   04152 AMPK signaling pathway
    105543389 (PIK3R1)
   04150 mTOR signaling pathway
    105543389 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105543389 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105543389 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    105543389 (PIK3R1)
   04218 Cellular senescence
    105543389 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105543389 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105543389 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105543389 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105543389 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    105543389 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    105543389 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    105543389 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    105543389 (PIK3R1)
   04660 T cell receptor signaling pathway
    105543389 (PIK3R1)
   04662 B cell receptor signaling pathway
    105543389 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    105543389 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    105543389 (PIK3R1)
   04670 Leukocyte transendothelial migration
    105543389 (PIK3R1)
   04062 Chemokine signaling pathway
    105543389 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105543389 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    105543389 (PIK3R1)
   04929 GnRH secretion
    105543389 (PIK3R1)
   04915 Estrogen signaling pathway
    105543389 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    105543389 (PIK3R1)
   04917 Prolactin signaling pathway
    105543389 (PIK3R1)
   04926 Relaxin signaling pathway
    105543389 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    105543389 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    105543389 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105543389 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105543389 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    105543389 (PIK3R1)
   04722 Neurotrophin signaling pathway
    105543389 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105543389 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    105543389 (PIK3R1)
   04380 Osteoclast differentiation
    105543389 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    105543389 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    105543389 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105543389 (PIK3R1)
   05206 MicroRNAs in cancer
    105543389 (PIK3R1)
   05205 Proteoglycans in cancer
    105543389 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    105543389 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105543389 (PIK3R1)
   05203 Viral carcinogenesis
    105543389 (PIK3R1)
   05230 Central carbon metabolism in cancer
    105543389 (PIK3R1)
   05231 Choline metabolism in cancer
    105543389 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105543389 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105543389 (PIK3R1)
   05212 Pancreatic cancer
    105543389 (PIK3R1)
   05225 Hepatocellular carcinoma
    105543389 (PIK3R1)
   05226 Gastric cancer
    105543389 (PIK3R1)
   05214 Glioma
    105543389 (PIK3R1)
   05221 Acute myeloid leukemia
    105543389 (PIK3R1)
   05220 Chronic myeloid leukemia
    105543389 (PIK3R1)
   05218 Melanoma
    105543389 (PIK3R1)
   05211 Renal cell carcinoma
    105543389 (PIK3R1)
   05215 Prostate cancer
    105543389 (PIK3R1)
   05213 Endometrial cancer
    105543389 (PIK3R1)
   05224 Breast cancer
    105543389 (PIK3R1)
   05222 Small cell lung cancer
    105543389 (PIK3R1)
   05223 Non-small cell lung cancer
    105543389 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105543389 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    105543389 (PIK3R1)
   05161 Hepatitis B
    105543389 (PIK3R1)
   05160 Hepatitis C
    105543389 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    105543389 (PIK3R1)
   05164 Influenza A
    105543389 (PIK3R1)
   05162 Measles
    105543389 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    105543389 (PIK3R1)
   05163 Human cytomegalovirus infection
    105543389 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105543389 (PIK3R1)
   05169 Epstein-Barr virus infection
    105543389 (PIK3R1)
   05165 Human papillomavirus infection
    105543389 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105543389 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    105543389 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105543389 (PIK3R1)
   05142 Chagas disease
    105543389 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105543389 (PIK3R1)
   05017 Spinocerebellar ataxia
    105543389 (PIK3R1)
   05020 Prion disease
    105543389 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105543389 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    105543389 (PIK3R1)
   05415 Diabetic cardiomyopathy
    105543389 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105543389 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    105543389 (PIK3R1)
   04931 Insulin resistance
    105543389 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105543389 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105543389 (PIK3R1)
   01524 Platinum drug resistance
    105543389 (PIK3R1)
   01522 Endocrine resistance
    105543389 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mleu04131]
    105543389 (PIK3R1)
Membrane trafficking [BR:mleu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105543389 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 Laminin_I SH3_9 FANCI_S2 FWWh Exonuc_VII_L
Other DBs
NCBI-GeneID: 105543389
NCBI-ProteinID: XP_011840669
Ensembl: ENSMLEG00000041078
UniProt: A0A2K6A179
LinkDB
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSGNLAELRQLLDCDTASVDLEMIDVH
ILADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagggcgctgtatgattataaaaaagaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacgccaaagccccggccgcctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacgttgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccggcaacctggcggaa
ttacgacagcttcttgattgtgatacagcctctgtggacttggaaatgatcgatgtgcac
attttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctactgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtaaatgaaaaacttcgagatacagcagatgggacctttttggtacgagatgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaagctg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
agagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccagacc
caggagcgctacagcaaagaatacatagaaaagtttaaacgtgagggcaatgagaaagaa
atacaaaggattatgcataattatgataagttgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtggaagatgatgaagatttaccccatcatgat
gagaagacgtggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctatgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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