KEGG   Myotis lucifugus (little brown bat): 102421330
Entry
102421330         CDS       T07795                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mlf  Myotis lucifugus (little brown bat)
Pathway
mlf00562  Inositol phosphate metabolism
mlf01100  Metabolic pathways
mlf01521  EGFR tyrosine kinase inhibitor resistance
mlf04012  ErbB signaling pathway
mlf04014  Ras signaling pathway
mlf04015  Rap1 signaling pathway
mlf04020  Calcium signaling pathway
mlf04062  Chemokine signaling pathway
mlf04064  NF-kappa B signaling pathway
mlf04066  HIF-1 signaling pathway
mlf04070  Phosphatidylinositol signaling system
mlf04072  Phospholipase D signaling pathway
mlf04360  Axon guidance
mlf04370  VEGF signaling pathway
mlf04613  Neutrophil extracellular trap formation
mlf04650  Natural killer cell mediated cytotoxicity
mlf04658  Th1 and Th2 cell differentiation
mlf04659  Th17 cell differentiation
mlf04660  T cell receptor signaling pathway
mlf04664  Fc epsilon RI signaling pathway
mlf04666  Fc gamma R-mediated phagocytosis
mlf04670  Leukocyte transendothelial migration
mlf04722  Neurotrophin signaling pathway
mlf04750  Inflammatory mediator regulation of TRP channels
mlf04919  Thyroid hormone signaling pathway
mlf04933  AGE-RAGE signaling pathway in diabetic complications
mlf04935  Growth hormone synthesis, secretion and action
mlf05012  Parkinson disease
mlf05022  Pathways of neurodegeneration - multiple diseases
mlf05135  Yersinia infection
mlf05167  Kaposi sarcoma-associated herpesvirus infection
mlf05170  Human immunodeficiency virus 1 infection
mlf05171  Coronavirus disease - COVID-19
mlf05200  Pathways in cancer
mlf05205  Proteoglycans in cancer
mlf05206  MicroRNAs in cancer
mlf05214  Glioma
mlf05223  Non-small cell lung cancer
mlf05225  Hepatocellular carcinoma
mlf05231  Choline metabolism in cancer
mlf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlf05417  Lipid and atherosclerosis
Module
mlf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102421330 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102421330 (PLCG1)
   04014 Ras signaling pathway
    102421330 (PLCG1)
   04015 Rap1 signaling pathway
    102421330 (PLCG1)
   04370 VEGF signaling pathway
    102421330 (PLCG1)
   04064 NF-kappa B signaling pathway
    102421330 (PLCG1)
   04066 HIF-1 signaling pathway
    102421330 (PLCG1)
   04020 Calcium signaling pathway
    102421330 (PLCG1)
   04070 Phosphatidylinositol signaling system
    102421330 (PLCG1)
   04072 Phospholipase D signaling pathway
    102421330 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102421330 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    102421330 (PLCG1)
   04660 T cell receptor signaling pathway
    102421330 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    102421330 (PLCG1)
   04659 Th17 cell differentiation
    102421330 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    102421330 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    102421330 (PLCG1)
   04670 Leukocyte transendothelial migration
    102421330 (PLCG1)
   04062 Chemokine signaling pathway
    102421330 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    102421330 (PLCG1)
   04919 Thyroid hormone signaling pathway
    102421330 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102421330 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102421330 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    102421330 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102421330 (PLCG1)
   05206 MicroRNAs in cancer
    102421330 (PLCG1)
   05205 Proteoglycans in cancer
    102421330 (PLCG1)
   05231 Choline metabolism in cancer
    102421330 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102421330 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102421330 (PLCG1)
   05214 Glioma
    102421330 (PLCG1)
   05223 Non-small cell lung cancer
    102421330 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102421330 (PLCG1)
   05171 Coronavirus disease - COVID-19
    102421330 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102421330 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102421330 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    102421330 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    102421330 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102421330 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102421330 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102421330 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlf04131]
    102421330 (PLCG1)
Enzymes [BR:mlf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102421330 (PLCG1)
Membrane trafficking [BR:mlf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102421330 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102421330 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 PH SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD PH_9 EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 102421330
NCBI-ProteinID: XP_006085241
Ensembl: ENSMLUG00000010166
LinkDB
Position
Unknown
AA seq 1249 aa
MREVRGTRCANRSLGDLDAWPGAALCLPVLVDIREIKEIRPGKTSRDFDRYQEDPAFRPD
QSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFY
SVDRNREDRISAKDLKNMLSQVNYRVPNMRSLRERLTDLELRSSDITYGQFAQVYRSLMY
SDQKTMDLPFLEACAPRAGERPELCRMSLPEFQQFLLEYQAELWAVDRLQVQEFMLDFLR
DPLREIEEPYFSLDEFVTFLFSKENSVWNSQLDVVCPDTMNNPLSHYWISSSHNTYLTGD
QFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAF
VASEYPVILSIEDHCSIAQQRNMAQHFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIK
HKKLAEGSAYEEVPSSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEE
TSSDQGNEDEEEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGS
FLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQV
PLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSY
AISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALE
KIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQRDDELTFTKSAIIQNVE
KQDGGWWRGDYGGKKQLWFPSNYVEEMVSPAVLEPEREHLDENSPLGDLLRGVLDVPACQ
IAIRPEGKNNRPFVFSISMASVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKM
MERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQ
YNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGGHCGY
VLQPSTMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYD
NNKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKG
LKTGYRAVPLKNNYSEDLELASLLVKVDIFPAKQENGDLSPFSGTSLRERGSDASGQLFH
GRAREGSFEARYQQPFEDFRISQEHLPDHFDSRERRAPRRTRVNGDNRL
NT seq 3750 nt   +upstreamnt  +downstreamnt
atgagggaagtacgagggaccagatgtgccaacaggagcttgggagacttggacgcctgg
cctggagctgctctgtgcctacctgtcttggttgacattcgagaaatcaaggagatccgc
ccagggaagacttcacgggactttgatcgctatcaagaggaccctgctttccgaccagac
cagtcacattgctttgtcatcctgtatgggatggaattccgcctgaagaccctgagtctg
caagctacatctgaggatgaagtgaacatgtggatcaagggcttgacttggctgatggag
gacacattgcaggcagccacacccctgcagattgagaggtggctgcggaagcagttctac
tcggtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaatatgctgtcc
caggttaactaccgggtccccaacatgcgctccctccgagagcggctgacggacctggag
ctgcgcagcagcgatatcacctatgggcagtttgctcaggtgtaccgcagcctcatgtac
agcgaccagaagacgatggacctccccttcttggaagcctgcgccccaagggcaggggag
cggccggagctctgccgaatgtcccttccggagttccagcagttcctcctcgagtaccag
gcggagctgtgggctgtcgaccgactccaggtgcaggagttcatgctcgacttcctccga
gaccccttgagagagattgaggagccatacttctccctggatgagtttgtcaccttcctg
ttctctaaggagaacagtgtgtggaactcgcagctggatgtggtgtgcccggacaccatg
aacaaccctctctcccactactggatctcctcctcgcacaacacgtacctaaccggggac
cagttctccagcgagtcctccttggaagcctatgctcgctgcctgcgcatgggctgtcgc
tgtattgagttggactgctgggacggcccagacgggatgccagtcatttaccatggacac
acccttacaaccaagatcaagttctcagacgtcctgcacaccatcaaggagcatgccttc
gtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgctcagcag
aggaacatggcccagcactttaagaaggtgctcggggacacactcctcaccaagcccgtg
gacattgccgccgacgggctcccttcccccaaccagctcaagaggaagatccttatcaag
cacaaaaagctggctgagggcagtgcctatgaggaggtgccttcgtctgtgatgtactct
gagaacgacatcagcaactccatcaagaatggcatcctctacctggaagaccccgtgaac
catgagtggtatccccactactttgttctgaccagcagcaagatctactactctgaggag
accagcagtgaccagggcaatgaggatgaggaagagcccaaggaggccagtggcagcacc
gagctgcactccaatgagaagtggttccatgggaagcttggggcaggacgggacgggagg
cacatcgccgagcgcctgctgactgagtactgcattgagaccggggcccctgatggttcc
ttcctagtgcgcgagagcgagaccttcgttggcgactacaccctttctttctggcggaac
gggaaggtccaacactgccggatccactcccggcaggatgctgggacccccaagttcttc
ttgacagacaaccttgtatttgactcactctatgacctcatcacgcactaccagcaggtg
cccctgcgctgcaatgaatttgagatgcgcctctcggagcctgtcccccagaccaatgcc
cacgaaagcaaagaatggtaccacgcgagcctgaccagagcgcaggctgagcacatgctg
atgcgcgtcccccgtgatggggccttcctggtgcggaaacggaatgagcccaactcctac
gccatctccttccgggctgaaggcaagatcaagcattgccgcgtccagcaggagggccag
acggtgatgctgggcaactcggagtttgacagccttgtcgacctcatcagttactacgag
aagcatccattgtatcgaaagatgaagctgcgctatcccatcaatgaggaggcactggag
aagataggcacagctgagcctgactatggggccttgtatgagggacgcaaccctggcttt
tatgtggaggcaaaccctatgccaacttttaagtgtgcagtcaaagccctctttgactac
aaggcccagagagacgacgagctgactttcaccaagagcgccatcatccagaatgtggag
aagcaggacggaggctggtggcggggagactatggtgggaagaagcaactctggttcccg
tcaaactacgtggaggagatggtcagcccagcagtcctggagcctgagagggagcacttg
gacgagaacagccccctgggggacttgctgcggggggtcttggatgttccagcttgtcag
attgccatccgtcctgagggcaagaacaatcggccattcgtcttctccatcagtatggca
tcggtggcgcagtggtccctggatgttgctgctgactcacaggaggagctgcaggactgg
gtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaggggaagatg
atggagcggaggaagaagatcgcccttgaactctccgagcttgtcgtctactgccggcct
gttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggatatgtcgtcc
ttcccggaaaccaaggcggagaagtatgtgaacaaggccaaaggcaagaagttcctgcag
tacaaccggctgcagctctcccgcatctaccccaagggccagcggctagactcctccaat
tatgaccccttgcccatgtggatctgtggcagtcagctggtggccctcaacttccagacc
ccagacaagcccatgcagatgaaccaggccctcttcatgaccggcgggcactgcggctat
gtgctgcagcccagcaccatgcgggacgaggccttcgacccctttgacaagagcagcctc
cgcgggctggagccatgtgccatctgcatcgaggtgctgggcgcccggcatctaccaaag
aatggccgaggcattgtgtgtccctttgtggagattgaggttgctggagctgagtatgac
aacaacaagcagaagacagagtttgtggtggacaatggcctcaaccccgtgtggccggcc
aagcccttccacttccaaatcagtaaccctgaattcgcttttctgcgctttgtggtgtat
gaggaagacatgtttagtgaccagaacttcctggctcaggctactttcccggtgaaaggc
ctgaagacagggtacagagcagtgcctttgaagaacaactacagtgaggacctggagttg
gcttccctgctggtcaaggtcgacattttccctgccaagcaggagaacggtgacctcagt
cccttcagtggtacgtccctgcgggagcggggctccgatgcctcgggccagctgttccat
ggccgggcccgcgaaggctcctttgaagcgcgctaccagcagccatttgaagactttcgc
atctcccaggagcatctcccagaccattttgacagccgggagagaagggccccacgaagg
actcgggtcaacggagacaatcgcctctag

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