KEGG   Myotis lucifugus (little brown bat): 102427890
Entry
102427890         CDS       T07795                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mlf  Myotis lucifugus (little brown bat)
Pathway
mlf01521  EGFR tyrosine kinase inhibitor resistance
mlf01522  Endocrine resistance
mlf01524  Platinum drug resistance
mlf04012  ErbB signaling pathway
mlf04014  Ras signaling pathway
mlf04015  Rap1 signaling pathway
mlf04024  cAMP signaling pathway
mlf04062  Chemokine signaling pathway
mlf04066  HIF-1 signaling pathway
mlf04068  FoxO signaling pathway
mlf04070  Phosphatidylinositol signaling system
mlf04071  Sphingolipid signaling pathway
mlf04072  Phospholipase D signaling pathway
mlf04081  Hormone signaling
mlf04140  Autophagy - animal
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04152  AMPK signaling pathway
mlf04210  Apoptosis
mlf04211  Longevity regulating pathway
mlf04213  Longevity regulating pathway - multiple species
mlf04218  Cellular senescence
mlf04360  Axon guidance
mlf04370  VEGF signaling pathway
mlf04380  Osteoclast differentiation
mlf04510  Focal adhesion
mlf04550  Signaling pathways regulating pluripotency of stem cells
mlf04611  Platelet activation
mlf04613  Neutrophil extracellular trap formation
mlf04620  Toll-like receptor signaling pathway
mlf04625  C-type lectin receptor signaling pathway
mlf04630  JAK-STAT signaling pathway
mlf04650  Natural killer cell mediated cytotoxicity
mlf04660  T cell receptor signaling pathway
mlf04662  B cell receptor signaling pathway
mlf04664  Fc epsilon RI signaling pathway
mlf04666  Fc gamma R-mediated phagocytosis
mlf04668  TNF signaling pathway
mlf04670  Leukocyte transendothelial migration
mlf04722  Neurotrophin signaling pathway
mlf04725  Cholinergic synapse
mlf04750  Inflammatory mediator regulation of TRP channels
mlf04810  Regulation of actin cytoskeleton
mlf04910  Insulin signaling pathway
mlf04914  Progesterone-mediated oocyte maturation
mlf04915  Estrogen signaling pathway
mlf04917  Prolactin signaling pathway
mlf04919  Thyroid hormone signaling pathway
mlf04923  Regulation of lipolysis in adipocytes
mlf04926  Relaxin signaling pathway
mlf04929  GnRH secretion
mlf04930  Type II diabetes mellitus
mlf04931  Insulin resistance
mlf04932  Non-alcoholic fatty liver disease
mlf04933  AGE-RAGE signaling pathway in diabetic complications
mlf04935  Growth hormone synthesis, secretion and action
mlf04960  Aldosterone-regulated sodium reabsorption
mlf04973  Carbohydrate digestion and absorption
mlf05010  Alzheimer disease
mlf05017  Spinocerebellar ataxia
mlf05020  Prion disease
mlf05100  Bacterial invasion of epithelial cells
mlf05135  Yersinia infection
mlf05142  Chagas disease
mlf05146  Amoebiasis
mlf05160  Hepatitis C
mlf05161  Hepatitis B
mlf05162  Measles
mlf05163  Human cytomegalovirus infection
mlf05164  Influenza A
mlf05165  Human papillomavirus infection
mlf05166  Human T-cell leukemia virus 1 infection
mlf05167  Kaposi sarcoma-associated herpesvirus infection
mlf05168  Herpes simplex virus 1 infection
mlf05169  Epstein-Barr virus infection
mlf05170  Human immunodeficiency virus 1 infection
mlf05171  Coronavirus disease - COVID-19
mlf05200  Pathways in cancer
mlf05203  Viral carcinogenesis
mlf05205  Proteoglycans in cancer
mlf05206  MicroRNAs in cancer
mlf05207  Chemical carcinogenesis - receptor activation
mlf05208  Chemical carcinogenesis - reactive oxygen species
mlf05210  Colorectal cancer
mlf05211  Renal cell carcinoma
mlf05212  Pancreatic cancer
mlf05213  Endometrial cancer
mlf05214  Glioma
mlf05215  Prostate cancer
mlf05218  Melanoma
mlf05220  Chronic myeloid leukemia
mlf05221  Acute myeloid leukemia
mlf05222  Small cell lung cancer
mlf05223  Non-small cell lung cancer
mlf05224  Breast cancer
mlf05225  Hepatocellular carcinoma
mlf05226  Gastric cancer
mlf05230  Central carbon metabolism in cancer
mlf05231  Choline metabolism in cancer
mlf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlf05415  Diabetic cardiomyopathy
mlf05417  Lipid and atherosclerosis
mlf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102427890 (PIK3R1)
   04015 Rap1 signaling pathway
    102427890 (PIK3R1)
   04630 JAK-STAT signaling pathway
    102427890 (PIK3R1)
   04668 TNF signaling pathway
    102427890 (PIK3R1)
   04066 HIF-1 signaling pathway
    102427890 (PIK3R1)
   04068 FoxO signaling pathway
    102427890 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    102427890 (PIK3R1)
   04072 Phospholipase D signaling pathway
    102427890 (PIK3R1)
   04071 Sphingolipid signaling pathway
    102427890 (PIK3R1)
   04024 cAMP signaling pathway
    102427890 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    102427890 (PIK3R1)
   04152 AMPK signaling pathway
    102427890 (PIK3R1)
   04150 mTOR signaling pathway
    102427890 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102427890 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102427890 (PIK3R1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102427890 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102427890 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    102427890 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    102427890 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    102427890 (PIK3R1)
   04660 T cell receptor signaling pathway
    102427890 (PIK3R1)
   04662 B cell receptor signaling pathway
    102427890 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    102427890 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    102427890 (PIK3R1)
   04670 Leukocyte transendothelial migration
    102427890 (PIK3R1)
   04062 Chemokine signaling pathway
    102427890 (PIK3R1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    102427890 (PIK3R1)
   04929 GnRH secretion
    102427890 (PIK3R1)
   04915 Estrogen signaling pathway
    102427890 (PIK3R1)
   04917 Prolactin signaling pathway
    102427890 (PIK3R1)
   04926 Relaxin signaling pathway
    102427890 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    102427890 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    102427890 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102427890 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102427890 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    102427890 (PIK3R1)
   04722 Neurotrophin signaling pathway
    102427890 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102427890 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    102427890 (PIK3R1)
   04380 Osteoclast differentiation
    102427890 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    102427890 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    102427890 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102427890 (PIK3R1)
   05206 MicroRNAs in cancer
    102427890 (PIK3R1)
   05205 Proteoglycans in cancer
    102427890 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    102427890 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102427890 (PIK3R1)
   05203 Viral carcinogenesis
    102427890 (PIK3R1)
   05230 Central carbon metabolism in cancer
    102427890 (PIK3R1)
   05231 Choline metabolism in cancer
    102427890 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102427890 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102427890 (PIK3R1)
   05212 Pancreatic cancer
    102427890 (PIK3R1)
   05225 Hepatocellular carcinoma
    102427890 (PIK3R1)
   05226 Gastric cancer
    102427890 (PIK3R1)
   05214 Glioma
    102427890 (PIK3R1)
   05221 Acute myeloid leukemia
    102427890 (PIK3R1)
   05220 Chronic myeloid leukemia
    102427890 (PIK3R1)
   05218 Melanoma
    102427890 (PIK3R1)
   05211 Renal cell carcinoma
    102427890 (PIK3R1)
   05215 Prostate cancer
    102427890 (PIK3R1)
   05213 Endometrial cancer
    102427890 (PIK3R1)
   05224 Breast cancer
    102427890 (PIK3R1)
   05222 Small cell lung cancer
    102427890 (PIK3R1)
   05223 Non-small cell lung cancer
    102427890 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102427890 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    102427890 (PIK3R1)
   05161 Hepatitis B
    102427890 (PIK3R1)
   05160 Hepatitis C
    102427890 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    102427890 (PIK3R1)
   05164 Influenza A
    102427890 (PIK3R1)
   05162 Measles
    102427890 (PIK3R1)
   05163 Human cytomegalovirus infection
    102427890 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102427890 (PIK3R1)
   05169 Epstein-Barr virus infection
    102427890 (PIK3R1)
   05165 Human papillomavirus infection
    102427890 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102427890 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    102427890 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102427890 (PIK3R1)
   05142 Chagas disease
    102427890 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102427890 (PIK3R1)
   05017 Spinocerebellar ataxia
    102427890 (PIK3R1)
   05020 Prion disease
    102427890 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102427890 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    102427890 (PIK3R1)
   05415 Diabetic cardiomyopathy
    102427890 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102427890 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    102427890 (PIK3R1)
   04931 Insulin resistance
    102427890 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102427890 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102427890 (PIK3R1)
   01524 Platinum drug resistance
    102427890 (PIK3R1)
   01522 Endocrine resistance
    102427890 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlf04131]
    102427890 (PIK3R1)
Membrane trafficking [BR:mlf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102427890 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 AAA_13 SH3_1 SH3_2 Laminin_I CCDC113_CCDC96_CC SH3_9 ACDC
Other DBs
NCBI-GeneID: 102427890
NCBI-ProteinID: XP_006081444
Ensembl: ENSMLUG00000015409
UniProt: G1PSA4
LinkDB
Position
Unknown
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLDDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEAETEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRAQSSSNPAELRQLLDCDAASMDLETVDVQ
VLADAFKRYLSDLPNPVIPVAVYNEMISLAQEVQSSEDYLQLLKKLIRSPNIPHQYWLTL
QYLLKHFFKLSQSSSKNLLTAGVLSELFSPLLFRFPAASSENAEPLRKVIEILISTEWSE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtacagagcactctatgattataaaaaggaacgagaagaa
gatattgacttgcacttggatgacatattgactgtgaataaagggtccttagtagctctt
ggatttagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacgggggagagaggggactttccaggaacttacgtagaatatattgggaggaaa
aaaatctcacctcccaccccaaagccccggccacctcgaccccttcctgttgcaccaggt
tcttcgaaaactgaagcagaaactgagcagcaagctttgacccttccggatcttgcagaa
cagtttgcccctcctgacatcgctccacctcttcttatcaagctagtagaagccattgaa
aagaaaggtctggaatgttcaactctgtacagagcacagagctccagcaacccagcagaa
ttacgacagcttcttgattgtgatgctgcctccatggacttggaaacagttgatgttcaa
gttttagcagacgctttcaaacgctatctctcggacctaccgaatcctgtcattccagta
gctgtttacaatgaaatgatttctttagcccaagaagtacaaagctccgaagactatctc
cagctgttgaagaagctcattagatcacctaacatacctcatcagtattggcttacgctt
cagtatttgctcaaacatttcttcaagctctcccaaagctccagcaagaacctcttgact
gcaggagtgctctcggaacttttcagccctctgcttttcagattccctgcagccagctct
gagaatgctgaacccctccgaaaagttatagaaattttaatctcaacggaatggagcgag
cgacagccagcaccagcactgcctcctaaaccaccaaaacctactactgtggccaacaac
ggtatgaataacaatatgtccttacaagatgctgagtggtactggggagatatctcgagg
gaggaagtgaatgaaaaactccgagatacagctgacggaacctttttggtacgagatgca
tctactaaaatgcatggagattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatacggcttctcggacccattaaccttcaactct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtacaatcccaagctg
gatgtgaagttactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtaggaaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaggactatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaaca
caggagcgctacagtaaagagtacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgaaaagttaaagtctcggatcagtgaaattgtggac
agcagaagacgactggaggaagacttgaagaaacaggcagctgagtatcgggagattgac
aagcgcatgaacagcattaagcccgacctcatccaactgagaaagacaagagaccagtac
ttgatgtggttgactcagaaaggtgttcggcagaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcgctggtagaggatgatgaggatctgccccaccatgac
gagaagacctggaatgtcggaagcagcaaccgaaacaaggctgagaacctactacgaggg
aagcgagacggcactttcctggtccgggaaagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaggtaaagcattgtgtcataaacaaaaccgcaaccggctatggc
tttgccgagccctataacctgtacagctccctcaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtatatgca
cagcagaggcgatga

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