KEGG   Mycobacterium lacus: MLAC_21270
Entry
MLAC_21270        CDS       T07377                                 
Symbol
metH
Name
(GenBank) methionine synthase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
mlj  Mycobacterium lacus
Pathway
mlj00270  Cysteine and methionine metabolism
mlj00450  Selenocompound metabolism
mlj00670  One carbon pool by folate
mlj01100  Metabolic pathways
mlj01110  Biosynthesis of secondary metabolites
mlj01230  Biosynthesis of amino acids
mlj04980  Cobalamin transport and metabolism
mlj04981  Folate transport and metabolism
Module
mlj_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:mlj00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    MLAC_21270 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    MLAC_21270 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    MLAC_21270 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    MLAC_21270 (metH)
   04980 Cobalamin transport and metabolism
    MLAC_21270 (metH)
Enzymes [BR:mlj01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     MLAC_21270 (metH)
SSDB
Motif
Pfam: S-methyl_trans Pterin_bind Met_synt_B12 B12-binding_2 B12-binding MOV-10_beta-barrel
Other DBs
NCBI-ProteinID: BBX96833
UniProt: A0A1X1YE00
LinkDB
Position
complement(2259188..2262766)
AA seq 1192 aa
MTAANEHHYDTDLLDVLSRRVVVGDGAMGTQLQGADLTLDDFRGLEGCNEILNETRPDVL
EAIHRNYFEAGADAVETNTFGCNLSNLGDYDIADKIRDLSEKGTAIARRVADEMATPDRR
RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG
SRRAMKRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE
HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALSGFIAEFGLSLVGGCCGT
TPAHIREVAAAVADVNRPERHVTSEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE
AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST
ETPVLRAGLEHLGGRCAINSVNYEDGDGPESRFAKTMELVAEHGAAVVALTIDEEGQART
AEKKVEIAERLIADITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKRRH
PNVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPINRIPEEQRNV
ALDLIYDRRRDGYDPLQELMRLFEGVSAASSKESRAAELAKLPLFERLAQRIVDGERNGL
EADLDEAMTQKPPLEIINENLLAGMKTVGELFGSGQMQLPFVLQSAEVMKTAVAYLEPHM
EKAEGDAGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIANILEVAEDKS
ADVVGMSGLLVKSTVVMKENLEEMNTRGVAERFPVLLGGAALTRSYVENDLAEVYEGEVH
YARDAFEGLKLMDTIMSAKRGEAPDTDSPEAIAARKKEAERKARHERSKRIAAQRKAAEE
PVEVPERSDVAADVEVPVPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGVRGGQGP
AYEDLVETEGRPRLRHWLDQLSTDGILAHAAVVYGYFPAVSEGDDVVVLTEPKADARERF
RFTFPRQQRGRFLCIADFIRSRELASERGEVDVLPFQLVTMGQPIADFANKLFASNSYRD
YLEVHGIGVQFTEALAEYWHRRIREELKFSGDRAMAADDPDAVEDYFKLGYRGARFAFGY
GACPDLEDRAKMMELLQPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV
NT seq 3579 nt   +upstreamnt  +downstreamnt
gtgactgcagcaaacgaacaccactacgacaccgatctcctcgacgttttgtcgcggcgc
gtggtggtgggcgacggcgccatgggcacccagttgcagggcgcggacctcacgctcgac
gacttccgcggcctggaaggctgcaacgagatcctcaacgagacccgccccgacgtgctg
gaagccatccaccgcaactacttcgaggcgggtgccgacgccgtcgagacgaacacgttc
ggctgcaacctgtccaacctcggcgactacgacatcgccgacaagatccgcgacctgtcg
gagaagggcaccgcgatcgcccgccgggtcgccgacgagatggccacaccggaccgcaga
cgctacgtgctggggtcgatggggccgggcaccaagctgccgacgctgggccacaccgag
tacgcggtcatccgtgacgcctacaccgaggccgccctcggcatgctcgacggcggcgcc
gacgccatcctggtggaaacctgccaggacctgctgcagctcaaggcggcggtgctgggg
tcgcgtcgcgcgatgaagcgggccgggcggcacattccggtgttcgcgcacgtcaccgtg
gagaccaccggcacgatgctgttgggcagcgagatcggcgcggcgctgacggccgtcgag
ccgctcggcgtggacatgatcggtttgaattgcgcgaccgggcccgccgagatgagcgag
cacctgcggcacctgtcgcggcacgcccgcatcccggtgtcggtgatgcccaacgccggg
ttgccggtgctgggcgcgaaaggcgctgaatatccgctgctgccagacgaattggcggag
gcgctgtccggtttcatcgccgagttcggactgtcgctggtcggcggctgttgtggtacc
accccggcccacatccgggaggtggccgccgcagtcgctgacgtcaaccgccccgagcgc
cacgtcacctccgagccgtcggtgtcgtcgctgtacaccgccatcccgttcgcgcaggac
gcctcggtcctggtgatcggcgagcggacaaatgccaacggctccaagggctttcgtgag
gcgatgatcgccgaggactaccagaagtgtctggacatcgccaaggaccagacccgcgac
ggcgcacacctgctggatctatgtgtcgactacgtgggccgcgacggcgtggccgacatg
aaggcactggccagccggctggccacgtcgtcgacgctgccgatcatgctggactccacc
gaaaccccggtgctgcgagccggtttggagcatctgggtggccgctgcgccatcaactcg
gtcaactacgaggacggcgacggcccggagtcgcgcttcgccaagaccatggagctggtc
gccgagcacggcgcggcggtggtcgcgctgaccatcgacgaagagggtcaggcccgcacc
gcggagaagaaggtcgagatcgccgagcggctgatcgccgacatcaccggcaactggggc
gtcgacgaatcctccatcctcatcgacactttgacattcaccatcgccaccgggcaggag
gagtcgcgccgcgacggcatcgagaccatcgaggcgatccgcgagctcaagcggcgtcac
cccaacgtgcagaccacgctgggcttgtccaacatctcgttcggcctcaatcccgctgcg
cgccaagtgctcaactcggtgttcttgcacgaatgccaggaggcggggctggactcggcg
atcgtgcacgcgtcgaagatcctgcccatcaaccgcatacccgaagaacaacgcaacgtc
gcgctggacctgatctacgaccgccgccgcgacggctatgacccgctgcaggagctgatg
cgcctgttcgagggcgtgtcggcggcgtcgtcaaaagaatcccgggccgccgaactggcg
aaactgcccctgttcgagcggctggcgcaacgcatcgtcgacggcgaacgcaacggcctc
gaggcagacctcgacgaggcgatgacgcagaagccgccgctggagatcatcaacgagaac
ctgttggccggcatgaagaccgtcggcgagctgttcggctccggccagatgcagctgccg
ttcgtgttgcagtccgccgaggtgatgaaaaccgcggtcgcctacctggagccgcacatg
gaaaaggccgaaggtgacgccggcaagggacggatcgtgctcgccaccgtcaagggcgac
gtgcacgacatcggcaagaacctcgtcgacatcatcttgagcaacaacggctacgaggtg
gtcaacatcggcatcaagcagccgattgccaacattctcgaggtcgccgaggacaagagc
gccgacgtggtcggcatgtcgggcctgctggtgaagtcgaccgtggtgatgaaggaaaac
ctcgaggagatgaacacccggggagtcgccgaaaggttcccggtgctgctcggcggcgcg
gcgctgacgcgcagttatgtggagaacgacctggccgaagtctacgagggcgaagtgcat
tacgcgcgagacgcttttgagggcctgaagctgatggacaccatcatgagcgccaagcgg
ggcgaggcgccggacaccgacagcccggaggcaatcgcggcccgcaagaaggaagccgag
cgcaaggcccgtcacgagcggtccaaacgcattgcggcgcaacgcaaagcggccgaagag
ccggtcgaagtgcccgaacgctccgatgtcgcggccgatgtcgaggtccccgttccgccg
ttctggggatcgcggatcgtcaagggcctagcggtggccgactacaccggcctgctcgac
gagcgagcgttgttcttgggccagtggggtttacgcggtgtgcgcggcggacagggaccg
gcgtacgaggacctcgtcgagaccgaaggccggccccggctgcggcactggctcgaccag
ttgtccaccgacggcatcctggcgcacgccgccgtggtgtacggctacttcccggcggtc
tccgagggcgacgacgtcgtggtgctcaccgagccgaaagccgatgcgcgggagcggttc
cggttcaccttcccgcgccagcaacgcggccggttcctgtgcatcgccgacttcatccgg
tcgcgagagctggccagcgagcgcggcgaggttgacgtgctgccattccaactggtgacc
atgggccaacccatcgccgacttcgccaacaagctgttcgcgtccaattcctatcgcgat
tacctcgaagtgcacgggatcggcgtgcaattcaccgaggcgcttgccgaatactggcac
cggcgtatccgcgaggagctcaagttttccggggaccgggcgatggccgctgacgatccc
gatgccgtcgaggactatttcaagctcggctaccgtggtgcccggttcgccttcggttac
ggcgcatgcccggacctcgaggaccgggccaagatgatggagctgctgcagcccgaacgc
atcggcgtgacgttgtccgaggagttgcagctgcatcccgagcagtcgaccgacgcgttc
gtcctgcaccatcccgaggccaagtacttcaacgtgtga

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