Entry |
|
Symbol |
PLCG1
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
|
KO |
|
Organism |
mlk Mustela lutreola (European mink)
|
Pathway |
mlk01521 | EGFR tyrosine kinase inhibitor resistance |
mlk04070 | Phosphatidylinositol signaling system |
mlk04072 | Phospholipase D signaling pathway |
mlk04613 | Neutrophil extracellular trap formation |
mlk04650 | Natural killer cell mediated cytotoxicity |
mlk04658 | Th1 and Th2 cell differentiation |
mlk04660 | T cell receptor signaling pathway |
mlk04664 | Fc epsilon RI signaling pathway |
mlk04666 | Fc gamma R-mediated phagocytosis |
mlk04670 | Leukocyte transendothelial migration |
mlk04750 | Inflammatory mediator regulation of TRP channels |
mlk04919 | Thyroid hormone signaling pathway |
mlk04933 | AGE-RAGE signaling pathway in diabetic complications |
mlk04935 | Growth hormone synthesis, secretion and action |
mlk05022 | Pathways of neurodegeneration - multiple diseases |
mlk05167 | Kaposi sarcoma-associated herpesvirus infection |
mlk05170 | Human immunodeficiency virus 1 infection |
mlk05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Module |
mlk_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mlk00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
131807620 (PLCG1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
131807620 (PLCG1)
04014 Ras signaling pathway
131807620 (PLCG1)
04015 Rap1 signaling pathway
131807620 (PLCG1)
04370 VEGF signaling pathway
131807620 (PLCG1)
04064 NF-kappa B signaling pathway
131807620 (PLCG1)
04066 HIF-1 signaling pathway
131807620 (PLCG1)
04020 Calcium signaling pathway
131807620 (PLCG1)
04070 Phosphatidylinositol signaling system
131807620 (PLCG1)
04072 Phospholipase D signaling pathway
131807620 (PLCG1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
131807620 (PLCG1)
04650 Natural killer cell mediated cytotoxicity
131807620 (PLCG1)
04660 T cell receptor signaling pathway
131807620 (PLCG1)
04658 Th1 and Th2 cell differentiation
131807620 (PLCG1)
04659 Th17 cell differentiation
131807620 (PLCG1)
04664 Fc epsilon RI signaling pathway
131807620 (PLCG1)
04666 Fc gamma R-mediated phagocytosis
131807620 (PLCG1)
04670 Leukocyte transendothelial migration
131807620 (PLCG1)
04062 Chemokine signaling pathway
131807620 (PLCG1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
131807620 (PLCG1)
04919 Thyroid hormone signaling pathway
131807620 (PLCG1)
09156 Nervous system
04722 Neurotrophin signaling pathway
131807620 (PLCG1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
131807620 (PLCG1)
09158 Development and regeneration
04360 Axon guidance
131807620 (PLCG1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
131807620 (PLCG1)
05206 MicroRNAs in cancer
131807620 (PLCG1)
05205 Proteoglycans in cancer
131807620 (PLCG1)
05231 Choline metabolism in cancer
131807620 (PLCG1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
131807620 (PLCG1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
131807620 (PLCG1)
05214 Glioma
131807620 (PLCG1)
05223 Non-small cell lung cancer
131807620 (PLCG1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
131807620 (PLCG1)
05171 Coronavirus disease - COVID-19
131807620 (PLCG1)
05167 Kaposi sarcoma-associated herpesvirus infection
131807620 (PLCG1)
09171 Infectious disease: bacterial
05135 Yersinia infection
131807620 (PLCG1)
09164 Neurodegenerative disease
05012 Parkinson disease
131807620 (PLCG1)
05022 Pathways of neurodegeneration - multiple diseases
131807620 (PLCG1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
131807620 (PLCG1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
131807620 (PLCG1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
131807620 (PLCG1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mlk04131]
131807620 (PLCG1)
Enzymes [BR:mlk01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
131807620 (PLCG1)
Membrane trafficking [BR:mlk04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
131807620 (PLCG1)
Endocytosis
Macropinocytosis
Phospholipase C
131807620 (PLCG1)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
9:complement(18322496..18359089)
|
AA seq |
1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKNAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAAESQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAVCIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSVKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIELFPAKQENGDLSPFGMSLRERGSDASGPLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL |
NT seq |
3873 nt +upstreamnt +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgaccggagcggaagaccttccaggtcaagctggaaacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattagggaaatcaaggag
atccgcccagggaagacgtcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgctttgtcatcttgtacggaatggagttccgcctgaagaccctg
agcctacaggctacatctgaggatgaagtgaacatgtggatcaagggtttaacgtggctg
atggaggacaccctgcaggcggccacgcctctgcagatcgagaggtggctgcggaagcag
ttctactccgtggatcggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggcg
ggggagcggccggagctctgtcgagtatcccttcccgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgggaaatcgaagagccatacttcttcctggacgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggatgccgtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcccacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctagaagcctacgcccgctgcctgcgaatgggc
tgtcgctgcattgagttggactgctgggatggcccagacgggatgccggtcatttaccac
ggacacacccttaccaccaagattaagttctcagatgttctgcacaccatcaaggagcac
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacaccctccttaccaag
cccgtggacatcgctgcagacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagcgcttatgaagaggtgcccacgtcggtgatg
tactccgagaacgacatcagcaactccatcaagaacggcatcctctacctggaggacccc
gtgaaccatgagtggtacccgcactacttcgttctgaccagcagcaagatctactactcc
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacggagctgcactccagtgagaagtggttccatgggaagcttggcgcgggccgggac
ggacggcacatcgccgagcgcctgctcaccgagtactgcatcgagaccggggcccctgac
ggctccttccttgtgcgggagagcgagaccttcgtgggcgactacaccctctccttctgg
aggaacgggaaagtccagcactgccggatccactcccgccaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggccgagcac
atgctgatgcgtgtcccccgggacggggccttcctggtgagaaaacggaacgaacccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgtgtccagcaggag
ggtcagacggtgatgctgggcaactcggagtttgacagccttgtggacctgatcagctac
tacgagaagcacccactgtaccgcaaaatgaagctgcgctaccccatcaacgaggaggcg
ctggagaagatcggcactgctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctacgtggaggcgaatcctatgccaactttcaagtgcgccgtcaaggccctcttt
gactacaaggcccagagggaggacgagctgacgttcacgaagaatgccatcatccagaac
gtggagaagcaggacggcggctggtggcggggagactacggggggaagaagcagctgtgg
ttcccgtcaaactatgtggaggagatggtcagccccgcagccctggagcctgagagggag
cacttggacgagaacagccccctgggagacttgctccggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgaaggcaagaacaaccggctcttcgtcttctccatcagc
atggcttcggtggcgcactggtccttggatgtcgctgccgaatcgcaggaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagatgccaggctcacagagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaaattc
ctccagtacaaccggctgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctcgtggccctcaacttc
cagaccccagacaagccgatgcagatgaaccaggccctgttcatggcgggtggccactgc
ggctacgtactgcagccaagtaccatgcgggatgaggccttcgatcccttcgacaagagc
agcctccggggcctggagccgtatgccgtctgcattgaggtactgggggcccggcacctg
ccaaagaacggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcggag
tatgacagcgtcaagcagaagacagagttcgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaaccctgaattcgcctttctgcgcttcgtg
gtgtatgaggaagacatgttcagtgaccagaacttcctggctcaggctaccttcccggtg
aaaggcctgaagacagggtacagagccgtgcctttgaagaacaactacagcgaggacctg
gagctggcctccctgctcgtcaagatcgagcttttccctgccaagcaggagaacggggac
ctcagtcccttcggcatgtctctgcgggagcggggctctgatgcctcaggcccgctgttc
catggccgggcccgggaaggttcctttgaagcccgctatcagcagccatttgaggacttt
cgtatctcccaggagcatctggcagaccattttgacagtcgggaacggagggccccacga
aggactcgggtcaacggagacaaccgcctctag |