KEGG   Mustela lutreola (European mink): 131807620
Entry
131807620         CDS       T09578                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk00562  Inositol phosphate metabolism
mlk01100  Metabolic pathways
mlk01521  EGFR tyrosine kinase inhibitor resistance
mlk04012  ErbB signaling pathway
mlk04014  Ras signaling pathway
mlk04015  Rap1 signaling pathway
mlk04020  Calcium signaling pathway
mlk04062  Chemokine signaling pathway
mlk04064  NF-kappa B signaling pathway
mlk04066  HIF-1 signaling pathway
mlk04070  Phosphatidylinositol signaling system
mlk04072  Phospholipase D signaling pathway
mlk04360  Axon guidance
mlk04370  VEGF signaling pathway
mlk04613  Neutrophil extracellular trap formation
mlk04650  Natural killer cell mediated cytotoxicity
mlk04658  Th1 and Th2 cell differentiation
mlk04659  Th17 cell differentiation
mlk04660  T cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04666  Fc gamma R-mediated phagocytosis
mlk04670  Leukocyte transendothelial migration
mlk04722  Neurotrophin signaling pathway
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04919  Thyroid hormone signaling pathway
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04935  Growth hormone synthesis, secretion and action
mlk05012  Parkinson disease
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05135  Yersinia infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05171  Coronavirus disease - COVID-19
mlk05200  Pathways in cancer
mlk05205  Proteoglycans in cancer
mlk05206  MicroRNAs in cancer
mlk05214  Glioma
mlk05223  Non-small cell lung cancer
mlk05225  Hepatocellular carcinoma
mlk05231  Choline metabolism in cancer
mlk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlk05417  Lipid and atherosclerosis
Module
mlk_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    131807620 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    131807620 (PLCG1)
   04014 Ras signaling pathway
    131807620 (PLCG1)
   04015 Rap1 signaling pathway
    131807620 (PLCG1)
   04370 VEGF signaling pathway
    131807620 (PLCG1)
   04064 NF-kappa B signaling pathway
    131807620 (PLCG1)
   04066 HIF-1 signaling pathway
    131807620 (PLCG1)
   04020 Calcium signaling pathway
    131807620 (PLCG1)
   04070 Phosphatidylinositol signaling system
    131807620 (PLCG1)
   04072 Phospholipase D signaling pathway
    131807620 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    131807620 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    131807620 (PLCG1)
   04660 T cell receptor signaling pathway
    131807620 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    131807620 (PLCG1)
   04659 Th17 cell differentiation
    131807620 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    131807620 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    131807620 (PLCG1)
   04670 Leukocyte transendothelial migration
    131807620 (PLCG1)
   04062 Chemokine signaling pathway
    131807620 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    131807620 (PLCG1)
   04919 Thyroid hormone signaling pathway
    131807620 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    131807620 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    131807620 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    131807620 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131807620 (PLCG1)
   05206 MicroRNAs in cancer
    131807620 (PLCG1)
   05205 Proteoglycans in cancer
    131807620 (PLCG1)
   05231 Choline metabolism in cancer
    131807620 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131807620 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    131807620 (PLCG1)
   05214 Glioma
    131807620 (PLCG1)
   05223 Non-small cell lung cancer
    131807620 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    131807620 (PLCG1)
   05171 Coronavirus disease - COVID-19
    131807620 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131807620 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    131807620 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    131807620 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    131807620 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131807620 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    131807620 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    131807620 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlk04131]
    131807620 (PLCG1)
Enzymes [BR:mlk01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     131807620 (PLCG1)
Membrane trafficking [BR:mlk04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    131807620 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    131807620 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 131807620
NCBI-ProteinID: XP_058989128
LinkDB
Position
9:complement(18322496..18359089)
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKNAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAAESQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAVCIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSVKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIELFPAKQENGDLSPFGMSLRERGSDASGPLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgaccggagcggaagaccttccaggtcaagctggaaacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattagggaaatcaaggag
atccgcccagggaagacgtcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgctttgtcatcttgtacggaatggagttccgcctgaagaccctg
agcctacaggctacatctgaggatgaagtgaacatgtggatcaagggtttaacgtggctg
atggaggacaccctgcaggcggccacgcctctgcagatcgagaggtggctgcggaagcag
ttctactccgtggatcggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggcg
ggggagcggccggagctctgtcgagtatcccttcccgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgggaaatcgaagagccatacttcttcctggacgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggatgccgtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcccacaacacgtacctgacc
ggggaccagttctccagcgagtcctccctagaagcctacgcccgctgcctgcgaatgggc
tgtcgctgcattgagttggactgctgggatggcccagacgggatgccggtcatttaccac
ggacacacccttaccaccaagattaagttctcagatgttctgcacaccatcaaggagcac
gccttcgtggcctcagagtacccggtcatcctgtccatcgaggaccactgcagcattgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacaccctccttaccaag
cccgtggacatcgctgcagacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagcgcttatgaagaggtgcccacgtcggtgatg
tactccgagaacgacatcagcaactccatcaagaacggcatcctctacctggaggacccc
gtgaaccatgagtggtacccgcactacttcgttctgaccagcagcaagatctactactcc
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacggagctgcactccagtgagaagtggttccatgggaagcttggcgcgggccgggac
ggacggcacatcgccgagcgcctgctcaccgagtactgcatcgagaccggggcccctgac
ggctccttccttgtgcgggagagcgagaccttcgtgggcgactacaccctctccttctgg
aggaacgggaaagtccagcactgccggatccactcccgccaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggccgagcac
atgctgatgcgtgtcccccgggacggggccttcctggtgagaaaacggaacgaacccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgtgtccagcaggag
ggtcagacggtgatgctgggcaactcggagtttgacagccttgtggacctgatcagctac
tacgagaagcacccactgtaccgcaaaatgaagctgcgctaccccatcaacgaggaggcg
ctggagaagatcggcactgctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctacgtggaggcgaatcctatgccaactttcaagtgcgccgtcaaggccctcttt
gactacaaggcccagagggaggacgagctgacgttcacgaagaatgccatcatccagaac
gtggagaagcaggacggcggctggtggcggggagactacggggggaagaagcagctgtgg
ttcccgtcaaactatgtggaggagatggtcagccccgcagccctggagcctgagagggag
cacttggacgagaacagccccctgggagacttgctccggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgaaggcaagaacaaccggctcttcgtcttctccatcagc
atggcttcggtggcgcactggtccttggatgtcgctgccgaatcgcaggaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagatgccaggctcacagagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaaattc
ctccagtacaaccggctgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctcgtggccctcaacttc
cagaccccagacaagccgatgcagatgaaccaggccctgttcatggcgggtggccactgc
ggctacgtactgcagccaagtaccatgcgggatgaggccttcgatcccttcgacaagagc
agcctccggggcctggagccgtatgccgtctgcattgaggtactgggggcccggcacctg
ccaaagaacggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcggag
tatgacagcgtcaagcagaagacagagttcgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaaccctgaattcgcctttctgcgcttcgtg
gtgtatgaggaagacatgttcagtgaccagaacttcctggctcaggctaccttcccggtg
aaaggcctgaagacagggtacagagccgtgcctttgaagaacaactacagcgaggacctg
gagctggcctccctgctcgtcaagatcgagcttttccctgccaagcaggagaacggggac
ctcagtcccttcggcatgtctctgcgggagcggggctctgatgcctcaggcccgctgttc
catggccgggcccgggaaggttcctttgaagcccgctatcagcagccatttgaggacttt
cgtatctcccaggagcatctggcagaccattttgacagtcgggaacggagggccccacga
aggactcgggtcaacggagacaaccgcctctag

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