KEGG   Mustela lutreola (European mink): 131823754
Entry
131823754         CDS       T09578                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk01521  EGFR tyrosine kinase inhibitor resistance
mlk01522  Endocrine resistance
mlk01524  Platinum drug resistance
mlk04012  ErbB signaling pathway
mlk04014  Ras signaling pathway
mlk04015  Rap1 signaling pathway
mlk04024  cAMP signaling pathway
mlk04062  Chemokine signaling pathway
mlk04066  HIF-1 signaling pathway
mlk04068  FoxO signaling pathway
mlk04070  Phosphatidylinositol signaling system
mlk04071  Sphingolipid signaling pathway
mlk04072  Phospholipase D signaling pathway
mlk04081  Hormone signaling
mlk04140  Autophagy - animal
mlk04150  mTOR signaling pathway
mlk04151  PI3K-Akt signaling pathway
mlk04152  AMPK signaling pathway
mlk04210  Apoptosis
mlk04211  Longevity regulating pathway
mlk04213  Longevity regulating pathway - multiple species
mlk04218  Cellular senescence
mlk04360  Axon guidance
mlk04370  VEGF signaling pathway
mlk04380  Osteoclast differentiation
mlk04510  Focal adhesion
mlk04517  IgSF CAM signaling
mlk04518  Integrin signaling
mlk04550  Signaling pathways regulating pluripotency of stem cells
mlk04611  Platelet activation
mlk04613  Neutrophil extracellular trap formation
mlk04620  Toll-like receptor signaling pathway
mlk04625  C-type lectin receptor signaling pathway
mlk04630  JAK-STAT signaling pathway
mlk04650  Natural killer cell mediated cytotoxicity
mlk04660  T cell receptor signaling pathway
mlk04662  B cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04666  Fc gamma R-mediated phagocytosis
mlk04668  TNF signaling pathway
mlk04670  Leukocyte transendothelial migration
mlk04722  Neurotrophin signaling pathway
mlk04725  Cholinergic synapse
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04810  Regulation of actin cytoskeleton
mlk04910  Insulin signaling pathway
mlk04914  Progesterone-mediated oocyte maturation
mlk04915  Estrogen signaling pathway
mlk04917  Prolactin signaling pathway
mlk04919  Thyroid hormone signaling pathway
mlk04923  Regulation of lipolysis in adipocytes
mlk04926  Relaxin signaling pathway
mlk04929  GnRH secretion
mlk04930  Type II diabetes mellitus
mlk04931  Insulin resistance
mlk04932  Non-alcoholic fatty liver disease
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04935  Growth hormone synthesis, secretion and action
mlk04960  Aldosterone-regulated sodium reabsorption
mlk04973  Carbohydrate digestion and absorption
mlk05010  Alzheimer disease
mlk05017  Spinocerebellar ataxia
mlk05020  Prion disease
mlk05100  Bacterial invasion of epithelial cells
mlk05135  Yersinia infection
mlk05142  Chagas disease
mlk05146  Amoebiasis
mlk05160  Hepatitis C
mlk05161  Hepatitis B
mlk05162  Measles
mlk05163  Human cytomegalovirus infection
mlk05164  Influenza A
mlk05165  Human papillomavirus infection
mlk05166  Human T-cell leukemia virus 1 infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05168  Herpes simplex virus 1 infection
mlk05169  Epstein-Barr virus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05171  Coronavirus disease - COVID-19
mlk05200  Pathways in cancer
mlk05203  Viral carcinogenesis
mlk05205  Proteoglycans in cancer
mlk05206  MicroRNAs in cancer
mlk05207  Chemical carcinogenesis - receptor activation
mlk05208  Chemical carcinogenesis - reactive oxygen species
mlk05210  Colorectal cancer
mlk05211  Renal cell carcinoma
mlk05212  Pancreatic cancer
mlk05213  Endometrial cancer
mlk05214  Glioma
mlk05215  Prostate cancer
mlk05218  Melanoma
mlk05220  Chronic myeloid leukemia
mlk05221  Acute myeloid leukemia
mlk05222  Small cell lung cancer
mlk05223  Non-small cell lung cancer
mlk05224  Breast cancer
mlk05225  Hepatocellular carcinoma
mlk05226  Gastric cancer
mlk05230  Central carbon metabolism in cancer
mlk05231  Choline metabolism in cancer
mlk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
mlk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    131823754 (PIK3R2)
   04014 Ras signaling pathway
    131823754 (PIK3R2)
   04015 Rap1 signaling pathway
    131823754 (PIK3R2)
   04370 VEGF signaling pathway
    131823754 (PIK3R2)
   04630 JAK-STAT signaling pathway
    131823754 (PIK3R2)
   04668 TNF signaling pathway
    131823754 (PIK3R2)
   04066 HIF-1 signaling pathway
    131823754 (PIK3R2)
   04068 FoxO signaling pathway
    131823754 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    131823754 (PIK3R2)
   04072 Phospholipase D signaling pathway
    131823754 (PIK3R2)
   04071 Sphingolipid signaling pathway
    131823754 (PIK3R2)
   04024 cAMP signaling pathway
    131823754 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    131823754 (PIK3R2)
   04152 AMPK signaling pathway
    131823754 (PIK3R2)
   04150 mTOR signaling pathway
    131823754 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    131823754 (PIK3R2)
   04517 IgSF CAM signaling
    131823754 (PIK3R2)
   04518 Integrin signaling
    131823754 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    131823754 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    131823754 (PIK3R2)
   04218 Cellular senescence
    131823754 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131823754 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    131823754 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    131823754 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131823754 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    131823754 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    131823754 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    131823754 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    131823754 (PIK3R2)
   04660 T cell receptor signaling pathway
    131823754 (PIK3R2)
   04662 B cell receptor signaling pathway
    131823754 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    131823754 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    131823754 (PIK3R2)
   04670 Leukocyte transendothelial migration
    131823754 (PIK3R2)
   04062 Chemokine signaling pathway
    131823754 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    131823754 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    131823754 (PIK3R2)
   04929 GnRH secretion
    131823754 (PIK3R2)
   04915 Estrogen signaling pathway
    131823754 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    131823754 (PIK3R2)
   04917 Prolactin signaling pathway
    131823754 (PIK3R2)
   04926 Relaxin signaling pathway
    131823754 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    131823754 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    131823754 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    131823754 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    131823754 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    131823754 (PIK3R2)
   04722 Neurotrophin signaling pathway
    131823754 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    131823754 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    131823754 (PIK3R2)
   04380 Osteoclast differentiation
    131823754 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    131823754 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    131823754 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131823754 (PIK3R2)
   05206 MicroRNAs in cancer
    131823754 (PIK3R2)
   05205 Proteoglycans in cancer
    131823754 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    131823754 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    131823754 (PIK3R2)
   05203 Viral carcinogenesis
    131823754 (PIK3R2)
   05230 Central carbon metabolism in cancer
    131823754 (PIK3R2)
   05231 Choline metabolism in cancer
    131823754 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131823754 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    131823754 (PIK3R2)
   05212 Pancreatic cancer
    131823754 (PIK3R2)
   05225 Hepatocellular carcinoma
    131823754 (PIK3R2)
   05226 Gastric cancer
    131823754 (PIK3R2)
   05214 Glioma
    131823754 (PIK3R2)
   05221 Acute myeloid leukemia
    131823754 (PIK3R2)
   05220 Chronic myeloid leukemia
    131823754 (PIK3R2)
   05218 Melanoma
    131823754 (PIK3R2)
   05211 Renal cell carcinoma
    131823754 (PIK3R2)
   05215 Prostate cancer
    131823754 (PIK3R2)
   05213 Endometrial cancer
    131823754 (PIK3R2)
   05224 Breast cancer
    131823754 (PIK3R2)
   05222 Small cell lung cancer
    131823754 (PIK3R2)
   05223 Non-small cell lung cancer
    131823754 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    131823754 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    131823754 (PIK3R2)
   05161 Hepatitis B
    131823754 (PIK3R2)
   05160 Hepatitis C
    131823754 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    131823754 (PIK3R2)
   05164 Influenza A
    131823754 (PIK3R2)
   05162 Measles
    131823754 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    131823754 (PIK3R2)
   05163 Human cytomegalovirus infection
    131823754 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131823754 (PIK3R2)
   05169 Epstein-Barr virus infection
    131823754 (PIK3R2)
   05165 Human papillomavirus infection
    131823754 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    131823754 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    131823754 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    131823754 (PIK3R2)
   05142 Chagas disease
    131823754 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131823754 (PIK3R2)
   05017 Spinocerebellar ataxia
    131823754 (PIK3R2)
   05020 Prion disease
    131823754 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131823754 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    131823754 (PIK3R2)
   05415 Diabetic cardiomyopathy
    131823754 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    131823754 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    131823754 (PIK3R2)
   04931 Insulin resistance
    131823754 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    131823754 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    131823754 (PIK3R2)
   01524 Platinum drug resistance
    131823754 (PIK3R2)
   01522 Endocrine resistance
    131823754 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlk04131]
    131823754 (PIK3R2)
Membrane trafficking [BR:mlk04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    131823754 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e ATG11 SH3_9
Other DBs
NCBI-GeneID: 131823754
NCBI-ProteinID: XP_059016495
LinkDB
Position
2:14245225..14257677
AA seq 726 aa
MAGAEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQVLGVAEGNERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGPPEPGLTLPDLPEQFSP
PDVAPPILVKLVEAIERTGLDSESLYRPELPAPRTDWSLSDVEQWDSAALTDGVKGFLLA
LPAPLVTPEAVAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPAPG
PAVRALGATFGPLLLRAPPPSPPPGGAPDGTESSPDFPVLLVEKLLQEHLEEQEVAPPAL
PPKPPKAKPAPAGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQ
GEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLITHYRHESLAQYNAKLDTRLL
YPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIE
AFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKL
EQELRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETE
DQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVD
GDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPG
PPPPAR
NT seq 2181 nt   +upstreamnt  +downstreamnt
atggccggtgccgagggcttccagtaccgtgcactgtacccgttccgccgggagcggccg
gaggacctggagctgctgccgggcgacgtgctggtggtgagccgggcagccctgcaggtg
ctgggcgtggctgagggcaacgagcgctgcccacagagcgtgggctggatgcctggcctc
aatgagcgcacgcggcaacgaggtgacttccctggcacctacgtcgagttcctgggtcct
gtagccctggcccggcctggccctcgtccacgtggcccccgcccactgcccgccaggccc
cgggatgggccccctgagccaggcctcactctccccgacctgccagagcagttctcccca
cctgatgtggctcccccgatcctggtgaagctggtggaggccattgagcggacaggttta
gacagtgaatccctctacaggcctgaactgcctgccccgcgcacagactggtccctgagc
gacgtggagcagtgggactccgcagccctgacagacggtgtcaagggcttcctgctggcg
ctgcccgcgcccctcgtgactcccgaggccgtggccgaggcacgccgggccctgcgggag
gccgcggggccagtggggcctgcgctggagcccccgacgctgccactgcaccgcgcgctc
accctacggttcctgcttcagcacctgggccgggtggcccgacgcgccccagctccgggc
cccgccgtgcgagccctgggcgccaccttcgggccgctgctgctgcgggcgcctcctccc
tcgccgccgccagggggcgcgcccgacgggactgagtccagccctgacttcccggtgctg
ctggtggagaagttgcttcaggaacatctggaggagcaggaggttgcgcccccagcgctg
cctcctaaaccccccaaagcaaagcctgcccctgcaggcctggccaatgggggaagccca
ccctccctgcaggacgcggagtggtactggggtgacatctccagggaggaggtgaacgag
aagctccgggacacgcctgatggcacctttctggtccgagatgcatctagcaagatccaa
ggggagtacacgctgaccctcaggaaaggcgggaacaacaagctgatcaaagtcttccac
cgcgacgggcactacggcttctcggagcctctcaccttctgctctgttgtggacctcatc
acccactaccgccatgagtcgctggcccagtacaatgccaagctggacacccggctcctc
taccccgtgtccaagtaccagcaggaccagattgtcaaggaggacagtgtggaggcggtg
ggtgcccagctcaaagtctaccaccagcagtaccaggacaagagccgcgagtacgaccag
ctctatgaggagtacacccgcacctcccaggagctgcagatgaagcgcacagctatcgag
gccttcaatgagaccatcaagatctttgaagagcagggccagacacaagagaagtgtagc
aaggaatatctggagcgcttccgacgtgagggcaatgagaaggagatgcagaggatcctg
ctgaactcagagcggctcaagtctcgcatcgccgagatccacgagagccgcacaaagctg
gagcaggagctgcgggcgcaggcctcagacaaccgggagatcgacaagcgcatgaacagc
ctcaagccagacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctcact
cagaaaggcgcccggcagaagaaaatcaacgagtggttggggatcaaaaatgagactgag
gaccagtatgcgctgatggaggatgaggacgacctgccccaccatgaggaacgcacgtgg
tatgtgggcaagatcaaccggacacaggctgaggaaatgctgagcggcaagcgggatggc
accttcctcatccgcgagagcagccagcgtggctgctacgcctgctccgtggtggtggac
ggcgacaccaagcactgcgtcatctaccgcacggccacaggcttcggcttcgcggagccc
tacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctcgtg
cagcacaacgacgcgctcacggtcacgctcgcccacccggtgcgcgcccccggccctggg
cccccgccccctgcccgctga

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