Entry Name Protein export - Mirounga leonina (Southern elephant seal)
Description The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class Genetic Information Processing; Folding, sorting and degradationBRITE hierarchy
Pathway map Other DBs Organism Mirounga leonina (Southern elephant seal) [GN:
mlx ]
Gene 117999268 GET4; Golgi to ER traffic protein 4 homolog isoform X1 [KO:K23387 ]
118001568 SEC63; translocation protein SEC63 homolog isoform X1 [KO:K09540 ]
118003360 SRP14; signal recognition particle 14 kDa protein isoform X1 [KO:K03104 ]
118003911 SPCS2; signal peptidase complex subunit 2 [KO:K12947 ] [EC:3.4.-.-]
118004893 SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
118005084 SPCS1; signal peptidase complex subunit 1 [KO:K12946 ] [EC:3.4.-.-]
118005537 SGTA; small glutamine-rich tetratricopeptide repeat-containing protein alpha [KO:K16365 ]
118010095 SPCS3; signal peptidase complex subunit 3 [KO:K12948 ] [EC:3.4.-.-]
118013381 SRPRA; signal recognition particle receptor subunit alpha [KO:K13431 ]
118015725 IMMP1L; mitochondrial inner membrane protease subunit 1 isoform X1 [KO:K09647 ] [EC:3.4.21.-]
118020983 IMMP2L; mitochondrial inner membrane protease subunit 2 isoform X1 [KO:K09648 ] [EC:3.4.21.-]
118021582 SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956 ]
118024534 SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342 ]
118026141 GET1; guided entry of tail-anchored proteins factor 1 isoform X1 [KO:K22384 ]
Reference Authors Dalbey RE, Robinson C.
Title Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal Reference Authors Berks BC, Sargent F, Palmer T.
Title The Tat protein export pathway.
Journal Reference Authors Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal Reference Authors Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal Reference Authors Rapoport TA
Title Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal Reference Authors Flower AM
Title The SecY translocation complex: convergence of genetics and structure.
Journal Reference Authors Osborne AR, Rapoport TA, van den Berg B
Title Protein translocation by the Sec61/SecY channel.
Journal Reference Authors Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title Signal peptidases.
Journal Reference Authors Paetzel M, Dalbey RE, Strynadka NC
Title The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal Reference Authors Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title Archaeal signal peptidases.
Journal Reference Authors Desvaux M, Hebraud M, Talon R, Henderson IR
Title Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal Reference Authors Nakatogawa H, Murakami A, Ito K
Title Control of SecA and SecM translation by protein secretion.
Journal KO pathway
