KEGG   Mirounga leonina (Southern elephant seal): 118004882
Entry
118004882         CDS       T07472                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx01522  Endocrine resistance
mlx04010  MAPK signaling pathway
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04024  cAMP signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04068  FoxO signaling pathway
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04140  Autophagy - animal
mlx04148  Efferocytosis
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04218  Cellular senescence
mlx04270  Vascular smooth muscle contraction
mlx04370  VEGF signaling pathway
mlx04371  Apelin signaling pathway
mlx04540  Gap junction
mlx04550  Signaling pathways regulating pluripotency of stem cells
mlx04613  Neutrophil extracellular trap formation
mlx04620  Toll-like receptor signaling pathway
mlx04650  Natural killer cell mediated cytotoxicity
mlx04660  T cell receptor signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04720  Long-term potentiation
mlx04722  Neurotrophin signaling pathway
mlx04730  Long-term depression
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
mlx04912  GnRH signaling pathway
mlx04915  Estrogen signaling pathway
mlx04916  Melanogenesis
mlx04917  Prolactin signaling pathway
mlx04919  Thyroid hormone signaling pathway
mlx04921  Oxytocin signaling pathway
mlx04926  Relaxin signaling pathway
mlx04929  GnRH secretion
mlx04934  Cushing syndrome
mlx04935  Growth hormone synthesis, secretion and action
mlx05010  Alzheimer disease
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05132  Salmonella infection
mlx05135  Yersinia infection
mlx05160  Hepatitis C
mlx05161  Hepatitis B
mlx05163  Human cytomegalovirus infection
mlx05164  Influenza A
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05200  Pathways in cancer
mlx05205  Proteoglycans in cancer
mlx05206  MicroRNAs in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05210  Colorectal cancer
mlx05211  Renal cell carcinoma
mlx05213  Endometrial cancer
mlx05214  Glioma
mlx05215  Prostate cancer
mlx05216  Thyroid cancer
mlx05218  Melanoma
mlx05219  Bladder cancer
mlx05220  Chronic myeloid leukemia
mlx05221  Acute myeloid leukemia
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
mlx05226  Gastric cancer
mlx05230  Central carbon metabolism in cancer
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118004882 (MAP2K2)
   04012 ErbB signaling pathway
    118004882 (MAP2K2)
   04014 Ras signaling pathway
    118004882 (MAP2K2)
   04015 Rap1 signaling pathway
    118004882 (MAP2K2)
   04370 VEGF signaling pathway
    118004882 (MAP2K2)
   04371 Apelin signaling pathway
    118004882 (MAP2K2)
   04066 HIF-1 signaling pathway
    118004882 (MAP2K2)
   04068 FoxO signaling pathway
    118004882 (MAP2K2)
   04072 Phospholipase D signaling pathway
    118004882 (MAP2K2)
   04071 Sphingolipid signaling pathway
    118004882 (MAP2K2)
   04024 cAMP signaling pathway
    118004882 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    118004882 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    118004882 (MAP2K2)
   04150 mTOR signaling pathway
    118004882 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118004882 (MAP2K2)
   04148 Efferocytosis
    118004882 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    118004882 (MAP2K2)
   04218 Cellular senescence
    118004882 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    118004882 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    118004882 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118004882 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118004882 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    118004882 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    118004882 (MAP2K2)
   04660 T cell receptor signaling pathway
    118004882 (MAP2K2)
   04662 B cell receptor signaling pathway
    118004882 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    118004882 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118004882 (MAP2K2)
   04929 GnRH secretion
    118004882 (MAP2K2)
   04912 GnRH signaling pathway
    118004882 (MAP2K2)
   04915 Estrogen signaling pathway
    118004882 (MAP2K2)
   04917 Prolactin signaling pathway
    118004882 (MAP2K2)
   04921 Oxytocin signaling pathway
    118004882 (MAP2K2)
   04926 Relaxin signaling pathway
    118004882 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    118004882 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    118004882 (MAP2K2)
   04916 Melanogenesis
    118004882 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    118004882 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    118004882 (MAP2K2)
   04730 Long-term depression
    118004882 (MAP2K2)
   04722 Neurotrophin signaling pathway
    118004882 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118004882 (MAP2K2)
   05206 MicroRNAs in cancer
    118004882 (MAP2K2)
   05205 Proteoglycans in cancer
    118004882 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    118004882 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    118004882 (MAP2K2)
   05230 Central carbon metabolism in cancer
    118004882 (MAP2K2)
   05231 Choline metabolism in cancer
    118004882 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118004882 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118004882 (MAP2K2)
   05225 Hepatocellular carcinoma
    118004882 (MAP2K2)
   05226 Gastric cancer
    118004882 (MAP2K2)
   05214 Glioma
    118004882 (MAP2K2)
   05216 Thyroid cancer
    118004882 (MAP2K2)
   05221 Acute myeloid leukemia
    118004882 (MAP2K2)
   05220 Chronic myeloid leukemia
    118004882 (MAP2K2)
   05218 Melanoma
    118004882 (MAP2K2)
   05211 Renal cell carcinoma
    118004882 (MAP2K2)
   05219 Bladder cancer
    118004882 (MAP2K2)
   05215 Prostate cancer
    118004882 (MAP2K2)
   05213 Endometrial cancer
    118004882 (MAP2K2)
   05224 Breast cancer
    118004882 (MAP2K2)
   05223 Non-small cell lung cancer
    118004882 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118004882 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    118004882 (MAP2K2)
   05161 Hepatitis B
    118004882 (MAP2K2)
   05160 Hepatitis C
    118004882 (MAP2K2)
   05164 Influenza A
    118004882 (MAP2K2)
   05163 Human cytomegalovirus infection
    118004882 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118004882 (MAP2K2)
   05165 Human papillomavirus infection
    118004882 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118004882 (MAP2K2)
   05135 Yersinia infection
    118004882 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118004882 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    118004882 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118004882 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118004882 (MAP2K2)
   01522 Endocrine resistance
    118004882 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlx01001]
    118004882 (MAP2K2)
Enzymes [BR:mlx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118004882 (MAP2K2)
Protein kinases [BR:mlx01001]
 Serine/threonine kinases: STE group
  STE7 family
   118004882 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 118004882
NCBI-ProteinID: XP_034852293
LinkDB
Position
Unknown
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGAEGEPHSISPRPKP
PGRPVSGHGTDSRPAMAIFELLDYIVNEPPPKLPSGIFTQDFQEFVNKCLIKNPAERADL
KMLMSHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctagcggagctagaactcgacgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggaactcaaggacgatgactttgaaagaatctcggagctgggagcc
gggaacggtggggtggtcaccaaggtccagcacagaccttccggcctcatcatggcgaga
aagctaatccacctggaaatcaagccggccatccggaaccagatcatccgtgagctgcag
gtgctgcacgagtgtaactctccgtacatcgtgggcttctacggggccttctacagcgac
ggtgagatcagcatctgcatggagcacatggatggcggctctctggatcaggtgttaaaa
gaagccaagagaattcccgaggagatcttggggaaggtcagcattgcggttcttcggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagacgtgaaaccttccaacatc
ctcgtcaactcccgaggggagattaagctgtgcgattttggggtgagcgggcagctcatc
gactccatggccaactcctttgtgggaactcggtcctacatgtctccagagcggctgcag
ggcacgcactactccgtgcagtcggacatctggagcatgggcctgtccctggtggagctg
tccatcggaaggtaccccatccccccaccagatgccaaggagctagaggccatatttggc
cggcccgtggtggacggggcagaaggagagcctcacagcatctcgccacggccgaaaccc
cctggacgccccgtcagcggtcacgggacggacagccggccggccatggccatcttcgag
ctgctggactatattgtgaacgagccacctcccaagctgcccagcggcatcttcacccag
gacttccaggagtttgtaaataaatgcctaataaagaacccagcagagcgagctgatctg
aagatgctcatgagccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaacgctgcggctgaaccagcccagcacacccacgcgcaccgccgtg
tga

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