KEGG   Mirounga leonina (Southern elephant seal): 118008659
Entry
118008659         CDS       T07472                                 
Symbol
CDK4
Name
(RefSeq) cyclin-dependent kinase 4 isoform X1
  KO
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01522  Endocrine resistance
mlx04110  Cell cycle
mlx04115  p53 signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04218  Cellular senescence
mlx04530  Tight junction
mlx04660  T cell receptor signaling pathway
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04934  Cushing syndrome
mlx05160  Hepatitis C
mlx05162  Measles
mlx05163  Human cytomegalovirus infection
mlx05164  Influenza A
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05169  Epstein-Barr virus infection
mlx05200  Pathways in cancer
mlx05203  Viral carcinogenesis
mlx05212  Pancreatic cancer
mlx05214  Glioma
mlx05218  Melanoma
mlx05219  Bladder cancer
mlx05220  Chronic myeloid leukemia
mlx05222  Small cell lung cancer
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    118008659 (CDK4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    118008659 (CDK4)
   04115 p53 signaling pathway
    118008659 (CDK4)
   04218 Cellular senescence
    118008659 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    118008659 (CDK4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    118008659 (CDK4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118008659 (CDK4)
   05203 Viral carcinogenesis
    118008659 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    118008659 (CDK4)
   05225 Hepatocellular carcinoma
    118008659 (CDK4)
   05214 Glioma
    118008659 (CDK4)
   05220 Chronic myeloid leukemia
    118008659 (CDK4)
   05218 Melanoma
    118008659 (CDK4)
   05219 Bladder cancer
    118008659 (CDK4)
   05224 Breast cancer
    118008659 (CDK4)
   05222 Small cell lung cancer
    118008659 (CDK4)
   05223 Non-small cell lung cancer
    118008659 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118008659 (CDK4)
   05160 Hepatitis C
    118008659 (CDK4)
   05164 Influenza A
    118008659 (CDK4)
   05162 Measles
    118008659 (CDK4)
   05163 Human cytomegalovirus infection
    118008659 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118008659 (CDK4)
   05169 Epstein-Barr virus infection
    118008659 (CDK4)
   05165 Human papillomavirus infection
    118008659 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118008659 (CDK4)
   04934 Cushing syndrome
    118008659 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    118008659 (CDK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlx01001]
    118008659 (CDK4)
Enzymes [BR:mlx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     118008659 (CDK4)
Protein kinases [BR:mlx01001]
 Serine/threonine kinases: CMGC group
  CDK family
   118008659 (CDK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Kdo ABC1 Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 118008659
NCBI-ProteinID: XP_034858166
LinkDB
Position
Unknown
AA seq 303 aa
MATPRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFSPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLQKAEG
NPE
NT seq 912 nt   +upstreamnt  +downstreamnt
atggctactcctcgatatgagccagtggctgagattggtgttggtgcctatggaacagta
tacaaggcccgtgatccccacagtggccacttcgtggccctcaagagtgtgagagtccct
aatggaggaggtgctggagggggccttcccatcagcacagttcgtgaggtggccttactg
aggcggctggaggcttttgagcatcccaacgttgtccggctgatggacgtctgtgccacc
gcccgaactgaccgggagaccaaagtgaccctggtgtttgagcacgtggaccaagacctg
aggacctatctggacaaggcacccccaccaggtttgccagtggagaccatcaaggatctg
atgcgccagtttctaagaggcctagatttccttcatgccaactgcatcgttcaccgagac
ctgaagccagagaacattctggtgactagtggtgggacagtcaagctggctgactttggc
ctggccagaatctacagctaccagatggcacttacacctgtggttgttacactctggtac
cgtgctccagaagttcttctgcagtctacatacgcaacacccgtggacatgtggagcgtt
ggctgtatcttcgcagagatgtttcgtcgcaagcctctcttctgtggaaactctgaagct
gaccagttaggcaaaatctttgacctgatcgggctgcccccagaggatgactggccccga
gatgtgtctctcccccgaggagccttttccccccgagggccccgtccagtgcagtcagtg
gtacctgagatggaggaatctggagcacagctgctgctggagatgctgacttttaaccca
cacaagcgaatctctgccttccgagccctgcagcactcttatctacaaaaggcagaaggt
aacccagagtga

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