KEGG   Mirounga leonina (Southern elephant seal): 118011488
Entry
118011488         CDS       T07472                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx00562  Inositol phosphate metabolism
mlx01100  Metabolic pathways
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04020  Calcium signaling pathway
mlx04062  Chemokine signaling pathway
mlx04064  NF-kappa B signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04070  Phosphatidylinositol signaling system
mlx04072  Phospholipase D signaling pathway
mlx04360  Axon guidance
mlx04370  VEGF signaling pathway
mlx04613  Neutrophil extracellular trap formation
mlx04650  Natural killer cell mediated cytotoxicity
mlx04658  Th1 and Th2 cell differentiation
mlx04659  Th17 cell differentiation
mlx04660  T cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04666  Fc gamma R-mediated phagocytosis
mlx04670  Leukocyte transendothelial migration
mlx04722  Neurotrophin signaling pathway
mlx04750  Inflammatory mediator regulation of TRP channels
mlx04919  Thyroid hormone signaling pathway
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04935  Growth hormone synthesis, secretion and action
mlx05012  Parkinson disease
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05135  Yersinia infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05171  Coronavirus disease - COVID-19
mlx05200  Pathways in cancer
mlx05205  Proteoglycans in cancer
mlx05206  MicroRNAs in cancer
mlx05214  Glioma
mlx05223  Non-small cell lung cancer
mlx05225  Hepatocellular carcinoma
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05417  Lipid and atherosclerosis
Module
mlx_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118011488 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118011488 (PLCG1)
   04014 Ras signaling pathway
    118011488 (PLCG1)
   04015 Rap1 signaling pathway
    118011488 (PLCG1)
   04370 VEGF signaling pathway
    118011488 (PLCG1)
   04064 NF-kappa B signaling pathway
    118011488 (PLCG1)
   04066 HIF-1 signaling pathway
    118011488 (PLCG1)
   04020 Calcium signaling pathway
    118011488 (PLCG1)
   04070 Phosphatidylinositol signaling system
    118011488 (PLCG1)
   04072 Phospholipase D signaling pathway
    118011488 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118011488 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    118011488 (PLCG1)
   04660 T cell receptor signaling pathway
    118011488 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    118011488 (PLCG1)
   04659 Th17 cell differentiation
    118011488 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    118011488 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    118011488 (PLCG1)
   04670 Leukocyte transendothelial migration
    118011488 (PLCG1)
   04062 Chemokine signaling pathway
    118011488 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    118011488 (PLCG1)
   04919 Thyroid hormone signaling pathway
    118011488 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    118011488 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118011488 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    118011488 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118011488 (PLCG1)
   05206 MicroRNAs in cancer
    118011488 (PLCG1)
   05205 Proteoglycans in cancer
    118011488 (PLCG1)
   05231 Choline metabolism in cancer
    118011488 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118011488 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    118011488 (PLCG1)
   05214 Glioma
    118011488 (PLCG1)
   05223 Non-small cell lung cancer
    118011488 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    118011488 (PLCG1)
   05171 Coronavirus disease - COVID-19
    118011488 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118011488 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118011488 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    118011488 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    118011488 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118011488 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118011488 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118011488 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlx04131]
    118011488 (PLCG1)
Enzymes [BR:mlx01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     118011488 (PLCG1)
Membrane trafficking [BR:mlx04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    118011488 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    118011488 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 118011488
NCBI-ProteinID: XP_034862211
LinkDB
Position
Unknown
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLQDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSTKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNSRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGRKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMREEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSVKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIDVFPAKQENGDLSPFGMSLRERGSDASGQLFHGRAREGSFEARYQQPFEDF
RISHEHLADQSDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgcagcgtccccctgtgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggaacgtaagaccttccaggtcaagctggagacgcggcagatc
acgtggagccgtggcgccgacaagatcgagggggccattgacattcgcgaaatcaaggag
atccgccctgggaaaacctcacgggattttgatcgctaccaagaagaccctgctttccga
ccagaccagtcacactgctttgtcatcctgtatgggatggaattccgcctaaagaccctg
agcctgcaagctacatctgaggatgaagtgaacatgtggatcaagggtttaacatggctg
atggaggacacattgcaggcagccacacctctgcagattgagaggtggctgcggaagcag
ttctactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagtgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttagaagccagtgccctgagggca
ggggagcggccggagctctgtcgtgtgtcccttcctgagttccaacagtttctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcaagaccccttgcgagaaattgaagaaccatacttcttcctggacgagtttgttacc
tttctgttctccaaagagaacagtgtgtggaactcgcagctggatgcagtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcccacaacacgtacctgacc
ggggaccaattctccagcgagtcctccctagaagcctacgctcgctgcctgcgaatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccagtcatttaccat
ggacacacccttaccaccaagatcaagttctcagacgttctgcacaccatcaaggagcat
gccttcgtggcctcagagtaccctgtcatcctgtccatcgaggaccactgcagcattgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacacactccttaccaag
cccgtggacattgccgcggacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagtgcctacgaagaggtgcctacatcagtgatg
tactctgagaatgatatcagcaactccatcaagaatggcatcctctacctggaagacccc
gtgaaccacgagtggtacccccactacttcgttctgaccagcaccaagatctactactct
gaagagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggccagcggc
agcacggagctgcactccagtgagaagtggttccatgggaagctcggggccggacgggat
ggacggcacatcgccgagcgcctgctcaccgagtattgcatcgagaccggggcccctgac
ggctccttcctcgtgcgggagagcgagaccttcgtgggcgactacacgctctctttctgg
aggaatgggaaagtccagcactgccggatccactcccggcaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcgctctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaacgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgctagcctgaccagagctcaggccgagcac
atgctgatgcgtgttccccgggacggggccttcctggtgagaaaacggaatgagcccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgtgtccagcaggag
ggccagacggtgatgctgggcaactcggagtttgacagcctcgtggacctcatcagctac
tatgagaagcatccgctgtaccgcaaaatgaagctgcgctatcccatcaacgaggaggcg
ctggagaagattggcaccgctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctacgtggaggcaaatcctatgcctactttcaagtgtgcggtcaaagccctcttt
gactacaaggcgcagagggaggacgagctgacgttcacgaagagcgccatcatccagaat
gtggagaagcaagacggcggctggtggcggggggactatggggggaagaagcagctgtgg
ttcccgtccaactacgtggaggagatggtcagccctgcagccctggagcctgagagggag
cacttggatgagaacagccccctgggggacttgctccggggggtcttggatgtgccggct
tgtcagatcgccatccgtcccgagggcaagaacagccggctcttcgtcttctccatcagc
atggcttcggtggcacactggtccctggacgtcgctgctgactcccaggaggagctgcag
gactgggtgaagaagatccgagaggtggcccagacggcagacgccaggctcacggagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgt
cggcccgttcccttcgacgaagagaagattggcacggaacgtgcctgctaccgggacatg
tcgtcctttccggagacgaaggcggagaaatacgtgaacaaggccaaaggcaggaagttc
ctccaatacaaccggctgcagctctcccgcatctaccccaagggccagcggctggactcc
tccaactacgaccccttgcccatgtggatctgcggcagtcagctcgtggccctcaacttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggccggcggccactgc
ggctacgtgctgcagccgagcaccatgcgggaggaggccttcgatccctttgacaagagc
agcctccggggtctggagccatgtgccatctgcattgaggtgctgggggcccggcacctg
ccaaagaacggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcagag
tacgacagcgtcaagcagaagacagagtttgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagcaacccggaattcgcctttctgcgctttgtg
gtgtatgaggaagacatgttcagtgaccagaacttcctggctcaggctaccttcccagtg
aaaggcctgaagacaggatacagagccgtgcctttgaagaacaactacagcgaggacctg
gagctggcctccctgctcgtcaagatcgatgttttccctgccaagcaggagaacggggac
ctcagtcccttcggtatgtctctgcgggagcggggctccgatgcctcgggccagctcttt
cacggccgggcccgggaaggttccttcgaagcccgctaccagcagccgtttgaggacttc
cgtatctcccacgagcatctggcagaccagtctgacagtcgggaacggagggccccacgt
cggactcgggtcaacggagacaaccgcctctag

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