Mycobacterium sp. MCS: Mmcs_3362
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Entry
Mmcs_3362 CDS
T00367
Name
(GenBank) 2-oxo-acid dehydrogenase E1 component, homodimeric type
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
mmc
Mycobacterium sp. MCS
Pathway
mmc00010
Glycolysis / Gluconeogenesis
mmc00020
Citrate cycle (TCA cycle)
mmc00620
Pyruvate metabolism
mmc00785
Lipoic acid metabolism
mmc01100
Metabolic pathways
mmc01110
Biosynthesis of secondary metabolites
mmc01120
Microbial metabolism in diverse environments
mmc01200
Carbon metabolism
mmc01210
2-Oxocarboxylic acid metabolism
Module
mmc_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mmc00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
Mmcs_3362
00020 Citrate cycle (TCA cycle)
Mmcs_3362
00620 Pyruvate metabolism
Mmcs_3362
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
Mmcs_3362
Enzymes [BR:
mmc01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
Mmcs_3362
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
ABG09469
UniProt:
A0A5Q5BM75
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Position
3560921..3563695
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AA seq
924 aa
AA seq
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MRQDLAQNSSTAAEHDRVRVIREGVASYLPDIDPDETSEWLESFDQLLERSGPARARYLL
LRLLERSGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQ
RPGVGVGGHISTYASSAALYEVGFNHFFRGKSHSGGGDQVFIQGHASPGIYARAYLEGRL
TADQLDGFRQEHSHPGGGIPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRG
IKDTTDQHVWAFLGDGEMDEPESRGLIHVAALEALDNLTFVVNCNLQRLDGPVRGNGKII
QELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRD
HFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVYAAYRAAMEHKGQPTVILAKTIKGYT
LGKHFEGRNATHQMKKLALQDLKDFRDAQRIPIGDAQLEENPYLPPYYHPGPEAPEIRYM
LDRRRALGGFVPERRTKSKALALPSSDAYKALKKGSGKQEVATTMATVRTFKEILRDKQI
GHRIVPIIPDEARTFGMDSWFPNLKIYNRNGQLYTSVDAELMLAYRESEVGQILHEGINE
AGSVGTFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGATAGRT
TLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEIAYIIESGLHRMYGENPENVYFYLTI
YNEPYVQPAEPENLDVEGLLRGIYRYRAAAEKKSNTAQILVSGVAMPSALKAAEMLAEEW
DVAADVWSVTSWNELNRDGVQVEKDLLRHPDRPAGTPYITTALADAAGPVVAVSDWMRAV
PEQIRPWVPGTYITLGTDGFGFSDTRPAARRFYNTDAESITVAVLEGLARDGNIDISVAV
EAARRYEIDDVLAAPEQTSDPGVA
NT seq
2775 nt
NT seq
+upstream
nt +downstream
nt
gtgcgccaggatctggcccaaaactcctccaccgcagccgaacacgatcgtgtccgggtg
atccgtgagggtgttgcatcgtatctgcccgacatcgatcccgatgagacgagcgaatgg
ctggagtcgttcgaccagctgctcgaacgctccggaccggcgagagcccgctacctgctg
ttgcggctgctcgaacgctccggggagcagcgggtggccatccccgcgctcacctcgacc
gactacgtgaacacgatcccgaccgaactcgagccgtggttccccggcgacgaggacgtc
gaacgccgctaccgggcctggatccggtggaacgccgcgatcatggtgcaccgcgcgcag
cgtccgggagtcggtgtgggcggccacatctcgacgtacgcgtcgtcggccgcgctctac
gaggtgggcttcaaccacttcttccgcggtaagagccactccggcggcggcgaccaggtg
ttcatccagggccacgcctcccccgggatctacgcgcgcgcctatctcgagggcaggctg
accgccgaccaactcgacgggttccgccaggagcacagccaccccggcggcggtatcccg
tcgtacccgcatccgcggctgatgcccgacttctgggagttccccacggtctcgatgggc
ctgggcccgatgaacgcgatctaccaggcccggttcaaccactacctgcacgaccgcggc
atcaaggacaccaccgaccagcatgtgtgggcgttcctcggcgacggcgagatggacgaa
ccggagagccgggggctcatccacgtggccgccctcgaggcgctggacaacctgacgttc
gtcgtcaactgcaacctgcagcgcctcgacggcccggtgcgcggcaacggcaagatcatc
caggaactggagtcgttcttccgcggcgccggctggaacgtcatcaaggtggtgtggggc
cgcgaatgggatgcgctgctgcacgccgaccgcgacggcgcactggtcaacctgatgaac
accacccccgacggcgactaccagacctacaaggccaacgacggcggctacgtacgcgac
cacttcttcggccgtgacccgcgcaccaaggcgctggtggaaccgatgaccgacgccgag
atctggaacctcaagcgcggcgggcacgactaccgcaaggtctacgccgcgtaccgcgcg
gcgatggagcacaagggccagccgacggtcatcctcgccaagaccatcaagggctacacc
ctgggtaagcacttcgagggccgcaacgccacccatcagatgaaaaagcttgcgctgcaa
gacctcaaggacttccgcgacgcccagcgcatcccgatcggcgatgcccagctcgaggag
aacccctacctgccgccgtactaccaccccggccccgaggcgcccgagatccgctacatg
ctcgaccgcaggcgcgcgctcggcggtttcgtgccggagcgtcgcacgaagtccaaggca
ctcgcgctgccgagcagcgatgcctacaaggcgctgaagaagggctccggcaagcaggag
gtcgccaccacgatggcgacagtccgcaccttcaaggagatcctgcgcgacaagcagatc
ggccatcgcatcgtgccgatcatccccgacgaggcgcgcacgttcgggatggactcctgg
ttcccgaacctcaagatctacaaccgcaacgggcagctctacacctccgtcgacgccgag
ctgatgctggcgtaccgggagagcgaggtcgggcagatcctgcacgaggggatcaacgag
gccggttcggtgggcacgttcatcgctgcgggcacgtcgtacgccacgcacaacgagccg
atgatcccgatctacatcttctattcgatgttcgggttccagcgcaccggtgacagcttc
tgggcggccgccgaccagatggcccgtggattcgtgctgggcgcgacggccgggcgcacc
acgctggtcggtgaggggttgcagcacgccgacggccactcactgctgctggcgtcgacc
aaccccgcggtggtggcctacgacccggcgttcgcctacgagatcgcctacatcatcgaa
tccgggctgcaccggatgtacggggagaacccggagaacgtctacttctatctgacgatc
tacaacgagccctacgtccagccggcggaaccggagaacctcgacgtcgagggtctgttg
cgcgggatctaccggtaccgggccgcggcggagaagaaatccaacaccgcccagatcctg
gtgtccggcgtggcgatgccctcggcgctcaaggccgccgagatgctggccgaggagtgg
gacgtggccgccgacgtgtggtcggtgaccagctggaacgagctcaaccgcgacggcgtc
caggtcgagaaggacctgctgcgccatccggaccggccggcgggcaccccgtacatcacc
acggcgctcgccgacgcggccggaccggtcgtggcggtctcggactggatgcgcgcggtg
cccgagcagatccggccgtgggtacccggtacgtacatcacgctcggcacggacggtttc
ggattctccgacacccggcccgccgcgcggcggttctacaacaccgacgccgagtcgatc
accgtggcggtgctcgaagggctggcccgcgacggcaacatcgacatctcggtggccgtc
gaggcggcccgccgctacgagatcgacgacgtgctggcggcgccggagcagacctccgat
cccggggtggcctga
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