KEGG   Marmota marmota marmota (Alpine marmot): 107138082
Entry
107138082         CDS       T09644                                 
Symbol
Plcg1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mmma  Marmota marmota marmota (Alpine marmot)
Pathway
mmma00562  Inositol phosphate metabolism
mmma01100  Metabolic pathways
mmma01521  EGFR tyrosine kinase inhibitor resistance
mmma04012  ErbB signaling pathway
mmma04014  Ras signaling pathway
mmma04015  Rap1 signaling pathway
mmma04020  Calcium signaling pathway
mmma04062  Chemokine signaling pathway
mmma04064  NF-kappa B signaling pathway
mmma04066  HIF-1 signaling pathway
mmma04070  Phosphatidylinositol signaling system
mmma04072  Phospholipase D signaling pathway
mmma04360  Axon guidance
mmma04370  VEGF signaling pathway
mmma04613  Neutrophil extracellular trap formation
mmma04650  Natural killer cell mediated cytotoxicity
mmma04658  Th1 and Th2 cell differentiation
mmma04659  Th17 cell differentiation
mmma04660  T cell receptor signaling pathway
mmma04664  Fc epsilon RI signaling pathway
mmma04666  Fc gamma R-mediated phagocytosis
mmma04670  Leukocyte transendothelial migration
mmma04722  Neurotrophin signaling pathway
mmma04750  Inflammatory mediator regulation of TRP channels
mmma04919  Thyroid hormone signaling pathway
mmma04933  AGE-RAGE signaling pathway in diabetic complications
mmma04935  Growth hormone synthesis, secretion and action
mmma05012  Parkinson disease
mmma05022  Pathways of neurodegeneration - multiple diseases
mmma05135  Yersinia infection
mmma05167  Kaposi sarcoma-associated herpesvirus infection
mmma05170  Human immunodeficiency virus 1 infection
mmma05171  Coronavirus disease - COVID-19
mmma05200  Pathways in cancer
mmma05205  Proteoglycans in cancer
mmma05206  MicroRNAs in cancer
mmma05214  Glioma
mmma05223  Non-small cell lung cancer
mmma05225  Hepatocellular carcinoma
mmma05231  Choline metabolism in cancer
mmma05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmma05417  Lipid and atherosclerosis
Module
mmma_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmma00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    107138082 (Plcg1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    107138082 (Plcg1)
   04014 Ras signaling pathway
    107138082 (Plcg1)
   04015 Rap1 signaling pathway
    107138082 (Plcg1)
   04370 VEGF signaling pathway
    107138082 (Plcg1)
   04064 NF-kappa B signaling pathway
    107138082 (Plcg1)
   04066 HIF-1 signaling pathway
    107138082 (Plcg1)
   04020 Calcium signaling pathway
    107138082 (Plcg1)
   04070 Phosphatidylinositol signaling system
    107138082 (Plcg1)
   04072 Phospholipase D signaling pathway
    107138082 (Plcg1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    107138082 (Plcg1)
   04650 Natural killer cell mediated cytotoxicity
    107138082 (Plcg1)
   04660 T cell receptor signaling pathway
    107138082 (Plcg1)
   04658 Th1 and Th2 cell differentiation
    107138082 (Plcg1)
   04659 Th17 cell differentiation
    107138082 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    107138082 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    107138082 (Plcg1)
   04670 Leukocyte transendothelial migration
    107138082 (Plcg1)
   04062 Chemokine signaling pathway
    107138082 (Plcg1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    107138082 (Plcg1)
   04919 Thyroid hormone signaling pathway
    107138082 (Plcg1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    107138082 (Plcg1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    107138082 (Plcg1)
  09158 Development and regeneration
   04360 Axon guidance
    107138082 (Plcg1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107138082 (Plcg1)
   05206 MicroRNAs in cancer
    107138082 (Plcg1)
   05205 Proteoglycans in cancer
    107138082 (Plcg1)
   05231 Choline metabolism in cancer
    107138082 (Plcg1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107138082 (Plcg1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    107138082 (Plcg1)
   05214 Glioma
    107138082 (Plcg1)
   05223 Non-small cell lung cancer
    107138082 (Plcg1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    107138082 (Plcg1)
   05171 Coronavirus disease - COVID-19
    107138082 (Plcg1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    107138082 (Plcg1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    107138082 (Plcg1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    107138082 (Plcg1)
   05022 Pathways of neurodegeneration - multiple diseases
    107138082 (Plcg1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107138082 (Plcg1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    107138082 (Plcg1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107138082 (Plcg1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmma04131]
    107138082 (Plcg1)
Enzymes [BR:mmma01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     107138082 (Plcg1)
Membrane trafficking [BR:mmma04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    107138082 (Plcg1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    107138082 (Plcg1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 PH EF-hand_PLCG1 SH3_9 SH3_2 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 107138082
NCBI-ProteinID: XP_015336127
Ensembl: ENSMMMG00000014529
LinkDB
Position
Unknown
AA seq 1178 aa
MEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLKAATPLQIERWLRKQFYSVDRNREDRI
SAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRTGDITYGQFAQLYRSLMYSAQKTMDLPF
LDSSTLRTGERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPY
FFLDEFVTFLFSKENSVWNSQLDAVSPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEA
YARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILS
IEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDITADGLPSPNQLKRKILIKHKKLAEGSAY
EEVPSSVMYSENDISNSIKNGILYLEDPINHEWYPHYFVLTSSKIYYSEETSSDQGNEDE
EEPKEASGSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFV
GDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMR
LSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKI
KHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYG
ALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGD
YGGKKQLWFPSNYVEEMVNPAALEPEREHLDENSPLGDLLRGVVDVPACQIAIRPEGKNN
RLFVFSISLASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALE
LSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIY
PKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDE
AFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVV
DNGLNPVWPAKPFQFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKIGYRAVPL
KNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERCSDASSQLFHGRPREGSFEAR
YQQPFEDFRISQEHLTDHFDSRERRAPRRTRVNGDNRL
NT seq 3537 nt   +upstreamnt  +downstreamnt
atggaattccgcctaaaaaccctgagcctgcaagccacatctgaggatgaagtgaacatg
tggatcaagggcttaacttggttgatggaggacacattaaaggcagccacacccctgcag
attgagaggtggctccgaaaacagttctactcagtggatcggaatcgtgaggatcgtata
tcagccaaggacctgaagaacatgctgtctcaggtcaattaccgggtccccaacatgcgc
ttcctccgagagcggctgacggacctggagcaacgcactggggacatcacctatggacag
tttgctcagctgtaccgcagcctcatgtacagcgcccagaagacgatggacctccccttc
ttggattccagcaccttgaggactggggagcggccagagctctgccgagtgtcccttcct
gagttccagcagttcctccttgagtaccaaggggagctgtgggctgtggaccgcctccag
gtgcaggagttcatgctcagctttctccgagaccccttgcgagagatcgaggagccgtac
ttcttcctggatgagtttgtcaccttcctgttctccaaagaaaacagcgtgtggaactcc
cagctggatgcagtgtccccagacaccatgaacaacccgctctcccactactggatctcc
tcttcgcacaacacgtacctgaccggggaccagttctccagcgagtcctccctggaagcc
tatgctcgctgcctgcggatgggctgtcgctgcatcgagttggactgctgggatggccca
gatgggatgccagtcatttaccatggacacactcttaccaccaagatcaagttctcagat
gtcctacacaccatcaaggagcatgccttcgtggcctcagagtaccctgtcattctgtct
attgaggaccactgcagcattgcccagcagaggaacatggctcagtacttcaagaaggtg
cttggggacacacttctcaccaagcctgtggacatcactgctgatggactcccctcaccc
aaccagctcaagaggaagatccttatcaagcacaagaagctggccgagggcagtgcctat
gaggaggtgcccagctcggtgatgtactctgagaacgacatcagcaactccatcaagaat
ggcatcctctacctggaggatcccataaaccacgagtggtatccccactacttcgttttg
accagcagcaagatctactactctgaggagaccagcagtgaccaaggcaacgaggatgag
gaagagcccaaggaggccagtggtagcacagagctgcactccaatgagaagtggttccat
gggaagctcggcgcagggcgggacgggcggcacattgcagagcgcctgctcactgagtac
tgcattgagactggggctcccgatggctccttcctagtgcgggagagtgagaccttcgtg
ggtgactacacgctgtctttctggcggaacgggaaagtccagcactgccgaatccactcc
cggcaggacgctgggacccccaagttcttcttgacagacaacctcgtctttgattctctc
tatgacctcatcacgcactatcagcaggtgcccctgcgctgcaacgagtttgagatgcgc
ctttcagagcctgtcccacagaccaatgcccacgagagcaaagagtggtaccatgcaagc
ctgaccagagcacaggccgagcacatgctgatgcgtgtgccccgtgatggggccttcttg
gtgcggaaacggagtgagcccaactcatatgccatctccttccgggccgaaggcaagatc
aagcactgccgtgtccagcaggagggccagactgtgatgctggggaactcagagtttgac
agccttgttgacctcatcagctactatgagaagcacccactataccgcaagatgaagctg
cgctaccctatcaatgaggaggcactggagaagataggcacagctgagcctgactatggg
gccctgtacgaaggccgtaaccctggcttctatgtggaggcaaaccctatgccgactttc
aagtgtgcagtgaaagccctctttgactataaggcccagagagaggatgagctgactttc
accaagagcgccatcatccagaatgtggagaaacaagatggaggctggtggcgaggggac
tatggtgggaagaaacagctgtggttcccgtcaaactatgtggaagagatggtcaaccca
gcagccctggagcctgagagggagcacttggacgagaacagcccgctgggggacttattg
cggggggttgtggatgtgcccgcctgtcagattgccatccgtcctgagggcaagaacaac
cggctcttcgtcttctccatcagcctggcatcagtggcccactggtccctggatgttgca
gctgattcccaggaggagctgcaggactgggtgaagaagatccgtgaagtggcccagact
gcagacgccaggctcactgaggggaagatgatggaacggaggaagaagattgcccttgag
ctctctgagcttgtcgtctactgcaggcctgttcccttcgatgaagagaagattggcaca
gaacgtgcctgctaccgggacatgtcgtctttcccggaaaccaaggctgagaaatatgtg
aacaaggccaaaggcaagaagtttctccagtacaatcggctgcagctctcccgcatctac
cccaagggccaacggctggactcctccaattatgatcctttgcccatgtggatctgtggc
agtcaacttgtggccctcaacttccagaccccagacaagcccatgcagatgaaccaggcc
cttttcatggccggtggacactgtggttacgtgctacagccaagcaccatgcgagacgag
gcctttgacccctttgacaagagcagcctccgtggactggagccctgtgccatctgcatt
gaggtgttgggggcccggcacttgccgaagaatggccggggcatcgtgtgtccttttgtg
gagattgaggtggctggagctgagtatgacagtaccaaacagaagaccgagtttgtggtg
gacaatggactgaaccctgtgtggccagccaagcctttccagttccagatcagtaaccct
gaatttgccttccttcgctttgtggtctatgaggaagacatgtttagtgaccagaacttt
ttggctcaggctactttcccagtcaaaggcctgaaaataggatacagagcagtgcctttg
aagaacaactacagtgaggacctggagttggcctccctgctcattaagattgacattttc
cctgccaaggagaatggtgacctcagtcccttcagtggtacatccctgcgggagcggtgc
tcagatgcctccagccagctgtttcatggccggccccgggaaggctcctttgaagcccgc
taccagcagccatttgaggacttccgcatctcccaggagcatctcacagaccactttgac
agtcgggagcgaagggccccaaggaggactcgggtcaatggagacaaccgcctctag

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