Marmota marmota marmota (Alpine marmot): 107138750 Help Entry 107138750         CDS       T09644                                  Symbol Irs1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma04022   cGMP-PKG signaling pathway mmma04068   FoxO signaling pathway mmma04081   Hormone signaling mmma04140   Autophagy - animal mmma04150   mTOR signaling pathway mmma04151   PI3K-Akt signaling pathway mmma04152   AMPK signaling pathway mmma04211   Longevity regulating pathway mmma04213   Longevity regulating pathway - multiple species mmma04722   Neurotrophin signaling pathway mmma04910   Insulin signaling pathway mmma04920   Adipocytokine signaling pathway mmma04923   Regulation of lipolysis in adipocytes mmma04930   Type II diabetes mellitus mmma04931   Insulin resistance mmma04932   Non-alcoholic fatty liver disease mmma04935   Growth hormone synthesis, secretion and action mmma04960   Aldosterone-regulated sodium reabsorption mmma05010   Alzheimer disease mmma05206   MicroRNAs in cancer mmma05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     107138750 (Irs1)    04022 cGMP-PKG signaling pathway     107138750 (Irs1)    04151 PI3K-Akt signaling pathway     107138750 (Irs1)    04152 AMPK signaling pathway     107138750 (Irs1)    04150 mTOR signaling pathway     107138750 (Irs1)   09133 Signaling molecules and interaction    04081 Hormone signaling     107138750 (Irs1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     107138750 (Irs1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     107138750 (Irs1)    04923 Regulation of lipolysis in adipocytes     107138750 (Irs1)    04920 Adipocytokine signaling pathway     107138750 (Irs1)    04935 Growth hormone synthesis, secretion and action     107138750 (Irs1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     107138750 (Irs1)   09156 Nervous system    04722 Neurotrophin signaling pathway     107138750 (Irs1)   09149 Aging    04211 Longevity regulating pathway     107138750 (Irs1)    04213 Longevity regulating pathway - multiple species     107138750 (Irs1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     107138750 (Irs1)   09164 Neurodegenerative disease    05010 Alzheimer disease     107138750 (Irs1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     107138750 (Irs1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     107138750 (Irs1)    04932 Non-alcoholic fatty liver disease     107138750 (Irs1)    04931 Insulin resistance     107138750 (Irs1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  107138750 NCBI-ProteinID:  XP_015336950 Ensembl:  ENSMMMG00000021327 UniProt:  A0A8C6A5W5 LinkDB All DBs Position Unknown AA seq 1242 aa AA seqDB search MASPPDTEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKSH HHEGASAPGAGGSGSCSGSLGLWEAGEDLSYGDGPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILSRGGNGHRYIPGAGLGTSPALLTGDEAASAADLDNRFRKRTHSAGTSPTISHQKT PSQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHALEHRSSHH RPDSSTLHTDDGYMPMSPGVAPVPNSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDP NGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKLWTNGVGGHHSHALSHPKPPVES GGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP EEGARHQHLRLSSSSGRLLYTATAEDSSSSTSSDSLGGGYCGARPEPGLPHPHHHVLQPH LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQPLLHPPEPKSPGEYVNIEF GNDQPGYLSGPMTSRSSPSVRCPSQIQPAPREDETGTEEYMNMDLGPGRRATWQESSGGE MGRVGPAPPGTTSICRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPVSYADMRTGIAA EEVKLPRASAAAPPSASTASSSPAAPQGAAELPAHSSLLGGPQGPGGISAFTRVSLSPNR NQSAKVIRADPQGCRRRHSSETFSSTPTASRGANTVPFGGGAAVGGSGSGGSNSSEDVKR HSSASFENVWLRPGELGGAPKEVAQGCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQ PPPPPPPHQPLGSSESSSTSRSSEDLSTYASISFQKQPEDRQ NT seq 3729 nt NT seq  +upstreamnt  +downstreamnt atggcgagtcctccagataccgaaggtttctcggacgtgcgcaaggtgggctacctgcgc aagcccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggccgggggc cccgcgcgcttggagtactacgagaacgagaagaagtggaggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaaacgtgctgactccaagaac aagcacctggtggctctctatacccgggacgagcactttgccattgctgcggacagtgag gctgagcaagacagctggtaccaggctctcctgcagctgcacaaccgtgccaaaagccac caccacgaaggggcctcagcccctggagcaggaggcagtggtagctgcagtggcagcttg ggcctctgggaggctggagaggacttgagctatggagatgggcccccaggacctgcgttt aaggaggtctggcaggtgatcttgaagcccaagggcctgggtcagacaaagaacctgatt ggcatctaccgcctctgcctgaccagcaagaccattagctttgtgaagctgaactcagag gcagcggctgtggtgctacagctaatgaacatcagacgctgcggccactctgaaaacttc tttttcattgaggtgggccgttctgctgtgacagggcctggggagttctggatgcaggtg gatgactcggtggtggcccagaacatgcatgagactatcttggaggccatgcgggccatg agtgatgagtttcgccctcgaagcaagagccagtcctcatccaactgctccaaccccatc agtgtccccttgcgcaggcaccatctcaacaaccccccgcccagccaggtggggttgacc cgcagatcacgcactgagagcatcactgccacctcccctgccagtatggtaggtgggaag ccaggatccttccgtgtgcgcgcctccagcgatggtgaaggcaccatgtcccgcccagcc tctgtggatggcagccctgtgagtcctagcaccaacagaacccacgcccaccggcatcgg ggcagctcccggctgcatccgcctctcaaccacagtcgctccatccccatgccttcttct cgctgctcgccttcggcaaccagcccagttagtctatcatccagcagcaccagtggccat ggttccacttcggactgtctctttccaaggcggtctagtgcttccgtgtctggttccccc agtgatggcggtttcatctcttcggatgagtatggctctagcccctgcgacttccgaagt tccttccgcagtgtcactccggattccttgggccacaccccaccagcccgaggcgaggag gagctgagcaattatatatgcatgggtggaaagggggcctccactctaacagctcccaat ggtcattacattttgtcccgaggtggtaatggccaccggtacatcccaggagctggcctg ggcaccagcccagcgttgttgactggggatgaagctgccagtgctgctgatctggataat aggttccggaagagaactcactctgcagggacatcccctaccatttcccaccagaagacc ccatcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctatcca ccaggaggtggcagtggaggccgactgcctggctacaggcattctgccttcgtgcccacc cattcctaccctgaggagggtctagagatgcatgccttggagcaccgcagcagccaccat cgcccagatagttctaccctccacactgatgatgggtacatgcccatgtccccaggggtg gccccagtgcccaatagccggaagggcagtggggattatatgcccatgagccccaagagc gtgtctgccccgcagcagatcatcaaccccatcagacgtcatccccagagagtggacccc aatggctacatgatgatgtcccccagtggcagctgctcccctgacattggaggtgggtcc agcagcagcagcagcatcagtgccgccccttctggcagtagctatgggaagctatggaca aatggggttggtgggcaccactctcacgccctgtctcaccccaagccccctgtggagagt gggggtggcaagctcttgccttgtacaggtgactacatgaacatgtcaccagtgggggac tccaacaccagcagcccctctgactgctactatggccctgaggatccccagcacaagcca gtcctttcctactattcattgccaaggtcttttaagcacacccagcgccctggggagcca gaggagggtgcccggcaccagcatctccgcctctcctctagctctggtcgccttctctac actgcaactgcagaagactcttcttcctccaccagcagcgacagcctgggtgggggttac tgtggggctaggccagagcccggcctcccacatccccaccatcatgtcttgcagccccat ttgcctcgaaaagtggacacagctgctcagaccaacagccgcctggctcggcccacaagg ctatctttgggggatcccaaggccagcaccttgcctcgggctcgagaacagcaacagcag cagcccctactgcaccctccagagcccaaaagcccaggggaatatgtgaatattgaattt gggaatgaccagcctggctacttatctggccctatgacttcccgcagctcaccttctgtt cggtgtccatcccagatccagccagctcccagagaggacgagactggcactgaggagtac atgaacatggacttggggccgggcaggagggcaacctggcaggagagtagtgggggggag atgggcagagtgggccctgcacctccagggactactagcatttgcaggcctacccgggca gtgcccagcagccggggtgactacatgaccatgcagatgggttgtccccgtcagagctac gtggacacctcaccagttgcccctgtcagctacgctgacatgcggacaggcattgctgca gaggaggtgaaactgcccagggcctcagcggctgctcctccttcagcctccacagcctct tcttcccctgctgcacctcaaggagcagctgagcttcctgcccactcttcccttttgggg ggcccacagggacctgggggcattagcgccttcacccgggtaagcctcagtcccaaccgc aaccagagtgccaaagtgatccgtgcagatccacaagggtgccggaggaggcatagctca gagaccttttcctcaacacctactgcttccaggggggccaacacggtgccctttggagga ggggctgcagtagggggcagtggcagtggtggcagcaacagcagtgaggatgtcaaacgc cacagctctgcttcctttgagaatgtctggctgagacctggggagcttggcggagccccc aaggaggtggcccaagggtgtggagctgctgggggtttggagaatggtcttaactacata gacctggatttggtcaaggacttcaaacagcgccctcaggagcgcccccctcaaccgcag cctcccccacctccacccccccatcagcccctgggcagtagtgagagcagctccaccagc cgctccagcgaggatttaagcacctatgccagcatcagtttccagaagcagccagaggac cgccagtag

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