Marmota marmota marmota (Alpine marmot): 107146314 Help Entry 107146314         CDS       T09644                                  Symbol Adcy2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma00230   Purine metabolism mmma01100   Metabolic pathways mmma01522   Endocrine resistance mmma04015   Rap1 signaling pathway mmma04020   Calcium signaling pathway mmma04022   cGMP-PKG signaling pathway mmma04024   cAMP signaling pathway mmma04062   Chemokine signaling pathway mmma04072   Phospholipase D signaling pathway mmma04081   Hormone signaling mmma04082   Neuroactive ligand signaling mmma04114   Oocyte meiosis mmma04211   Longevity regulating pathway mmma04213   Longevity regulating pathway - multiple species mmma04261   Adrenergic signaling in cardiomyocytes mmma04270   Vascular smooth muscle contraction mmma04371   Apelin signaling pathway mmma04540   Gap junction mmma04611   Platelet activation mmma04713   Circadian entrainment mmma04714   Thermogenesis mmma04723   Retrograde endocannabinoid signaling mmma04724   Glutamatergic synapse mmma04725   Cholinergic synapse mmma04727   GABAergic synapse mmma04750   Inflammatory mediator regulation of TRP channels mmma04911   Insulin secretion mmma04912   GnRH signaling pathway mmma04913   Ovarian steroidogenesis mmma04914   Progesterone-mediated oocyte maturation mmma04915   Estrogen signaling pathway mmma04916   Melanogenesis mmma04918   Thyroid hormone synthesis mmma04921   Oxytocin signaling pathway mmma04922   Glucagon signaling pathway mmma04923   Regulation of lipolysis in adipocytes mmma04925   Aldosterone synthesis and secretion mmma04926   Relaxin signaling pathway mmma04927   Cortisol synthesis and secretion mmma04928   Parathyroid hormone synthesis, secretion and action mmma04934   Cushing syndrome mmma04935   Growth hormone synthesis, secretion and action mmma04970   Salivary secretion mmma04971   Gastric acid secretion mmma04972   Pancreatic secretion mmma04976   Bile secretion mmma05032   Morphine addiction mmma05163   Human cytomegalovirus infection mmma05166   Human T-cell leukemia virus 1 infection mmma05200   Pathways in cancer mmma05207   Chemical carcinogenesis - receptor activation mmma05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:mmma00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     107146314 (Adcy2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     107146314 (Adcy2)    04371 Apelin signaling pathway     107146314 (Adcy2)    04020 Calcium signaling pathway     107146314 (Adcy2)    04072 Phospholipase D signaling pathway     107146314 (Adcy2)    04024 cAMP signaling pathway     107146314 (Adcy2)    04022 cGMP-PKG signaling pathway     107146314 (Adcy2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     107146314 (Adcy2)    04081 Hormone signaling     107146314 (Adcy2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     107146314 (Adcy2)   09144 Cellular community - eukaryotes    04540 Gap junction     107146314 (Adcy2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     107146314 (Adcy2)    04062 Chemokine signaling pathway     107146314 (Adcy2)   09152 Endocrine system    04911 Insulin secretion     107146314 (Adcy2)    04922 Glucagon signaling pathway     107146314 (Adcy2)    04923 Regulation of lipolysis in adipocytes     107146314 (Adcy2)    04912 GnRH signaling pathway     107146314 (Adcy2)    04913 Ovarian steroidogenesis     107146314 (Adcy2)    04915 Estrogen signaling pathway     107146314 (Adcy2)    04914 Progesterone-mediated oocyte maturation     107146314 (Adcy2)    04921 Oxytocin signaling pathway     107146314 (Adcy2)    04926 Relaxin signaling pathway     107146314 (Adcy2)    04935 Growth hormone synthesis, secretion and action     107146314 (Adcy2)    04918 Thyroid hormone synthesis     107146314 (Adcy2)    04928 Parathyroid hormone synthesis, secretion and action     107146314 (Adcy2)    04916 Melanogenesis     107146314 (Adcy2)    04925 Aldosterone synthesis and secretion     107146314 (Adcy2)    04927 Cortisol synthesis and secretion     107146314 (Adcy2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     107146314 (Adcy2)    04270 Vascular smooth muscle contraction     107146314 (Adcy2)   09154 Digestive system    04970 Salivary secretion     107146314 (Adcy2)    04971 Gastric acid secretion     107146314 (Adcy2)    04972 Pancreatic secretion     107146314 (Adcy2)    04976 Bile secretion     107146314 (Adcy2)   09156 Nervous system    04724 Glutamatergic synapse     107146314 (Adcy2)    04727 GABAergic synapse     107146314 (Adcy2)    04725 Cholinergic synapse     107146314 (Adcy2)    04723 Retrograde endocannabinoid signaling     107146314 (Adcy2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     107146314 (Adcy2)   09149 Aging    04211 Longevity regulating pathway     107146314 (Adcy2)    04213 Longevity regulating pathway - multiple species     107146314 (Adcy2)   09159 Environmental adaptation    04713 Circadian entrainment     107146314 (Adcy2)    04714 Thermogenesis     107146314 (Adcy2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     107146314 (Adcy2)    05207 Chemical carcinogenesis - receptor activation     107146314 (Adcy2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     107146314 (Adcy2)    05163 Human cytomegalovirus infection     107146314 (Adcy2)   09165 Substance dependence    05032 Morphine addiction     107146314 (Adcy2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     107146314 (Adcy2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     107146314 (Adcy2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     107146314 (Adcy2) Enzymes [BR:mmma01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      107146314 (Adcy2) SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  107146314 NCBI-ProteinID:  XP_015345880 Ensembl:  ENSMMMG00000016776 LinkDB All DBs Position Unknown AA seq 1024 aa AA seqDB search PPQEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRVFSLVIWMCLVAMGYLFMCF GGTVSPWDQVSFFLFIVFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGAKEHL VWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSL LPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCS PGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCE AIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI SSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAK MRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKK RFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYRATALPAFKYYVTCA CLIFFCIFIVQILVLPKTTVLGVSFGVAFLSLAFILLVCFAGQILQCSKKASASLLWLWK SSGIIANRPWPRISLTVITTAIILTMAVFNMFFLSNSEETILPTANVSNSSFPASNNQAA ILRAQSLFFLPYFIYSCILGLISCSVFLRVNYELKMLLMTVALVGYNTILLHTHAHVLDD YSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIET MENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKEFYTESDVNK EGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQY LHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNV ASRMDSTGVMDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQS NVAS NT seq 3075 nt NT seq  +upstreamnt  +downstreamnt cctcctcaggaagttgaagaccacgtggcctttttaataacagttccaacggcgctggcc attttcttcgcgatattcatcctcgtctgcattgagtctgtgtttaagaagctgctgcgc gtgttctccttggtgatctggatgtgtctcgtggcgatggggtacttgttcatgtgcttc ggaggcactgtctctccctgggaccaggtgtccttcttcctcttcatcgtcttcgtggtg tacaccatgctgcccttcaacatgcgggacgccatcatcgccagcgtcctcacctcctca tcccacaccattgtgctgagcgtctgcctgtctgcgacgcctggggccaaggagcacctg gtctggcagatcctggccaacgtgatcatcttcatctgtgggaacctggcaggtgcctac cacaagcacctcatggaactagctctgcagcagacgtaccaggacacgtgtaactgcatc aagtcccgcatcaagctggaattcgagaagcgccaacaggagcggcttctgctctccctg ctaccagctcacatcgccatggaaatgaaagctgagatcatccagaggctgcaaggcccc aaagcaggccaaatggaaaacacaaacaacttccacaacctgtatgtcaaacggcacacc aacgtgagcatcttgtacgccgacatcgtgggcttcacgcggctggccagcgactgttcc ccgggggagctggtgcacatgctgaatgagctctttgggaagttcgaccagatcgccaag gagaatgagtgcatgaggattaaaattttaggagactgctattactgtgtttccggactt cctatctctctccctaaccatgccaagaattgcgtgaaaatgggactggatatgtgtgaa gccataaagaaagtgagagatgctaccggagtcgacatcaacatgcgtgtgggagtgcat tcagggaacgtcctgtgcggtgtgattggtctgcagaagtggcagtatgacgtgtggtca catgacgtcaccttggccaaccacatggaagctggaggggtccccggacgtgttcacatt tcctctgtcaccttggagcacttgaatggagcttataaagtggaggagggagatggtgac attagggacccctatttaaaacagcacctggtgaaaacctacttcgtaatcaaccccaag ggagagcgacggagtccccagcacctcttcaggcctcgccacaccctggacggagccaag atgagagcctctgtccgcatgacccggtacttggagtcctggggcgcggccaagcccttc gcccatctgcatcacagggatagcatgaccactgagaacggcaagatcagcaccacggac gtaccaatgggtcagcataattttcaaaaccgcactttaagaaccaagtcacaaaagaaa agatttgaagaagaattgaacgaaagaatgatccaagccattgatggaatcaatgcacaa aagcaatggctcaagtctgaagacattcagagaatctcactgcttttctataacaaaatc ctagagaaagaataccgagccacagcactgccggcattcaagtactacgtgacttgcgcc tgcctcatcttcttctgcatcttcatcgtgcagattctcgtgttgccaaagaccacggtc ctcggcgtttcctttggagttgcgttcctgtctctcgccttcatccttttggtctgcttt gctggacagattttgcaatgcagcaaaaaagcctctgcctctctcctgtggctctggaag tcgtcaggcatcatcgccaaccgcccctggccgcggatctccctcacggtcatcaccacg gccatcatactcaccatggccgtgttcaacatgtttttcttgagcaactcagaggaaaca atcctccccactgccaacgtgtcaaactcaagttttcctgcctcaaacaaccaggcagca attctgcgtgcacaaagcttatttttcctgccgtacttcatatacagctgcattctgggg ctgatatcctgctcggtgttcctgagggtgaattacgagttgaagatgctgctcatgacg gtggcgttggtgggctacaacaccatccttctgcacacccacgcccacgtcctggacgac tacagccaggtcttgtttgagagaccaggcatttggaaggacctgaagaccatgggctcc gtgtctctctctatcttcttcatcacgctgctcgttctgggtagacagaatgaatattac tgtaggttagacttcttatggaagaacaagttcaaaaaagagcgggaggagatcgagacc atggagaacctgaaccgcgtgctgctggagaacgtgcttcccgcacacgtggccgagcac ttcctggcccggagcctcaagaacgaggacttgtaccaccagtcgtacgactgtgtctgc gtcatgttcgcctccattccggatttcaaagaattctacacggagtcagatgtgaacaag gagggcttagaatgccttcggctcctgaacgagatcatcgcggactttgatgatctgctg tccaagccaaaattcagcggtgttgaaaaaatcaagaccatcggcagcacctacatggca gccacgggtctgagcgctgtgcccagccaggagcacgcccaggagccggagcggcagtac ctgcacataggcaccatggtggagttcgcctttgccctggtggccaagctggatgccatc aacaagcactccttcaatgacttcaagctgcgagtgggcattaaccatggacctgtaata gctggtgtcatcggagcccagaagccacaatatgatatctggggcaacaccgtcaacgtg gccagcaggatggacagcactggagtcatggacaaaatacaggtcactgaggagaccagc cttgtcctgcagacgctcggatacacctgcacatgtcgggggatcatcaacgtgaaggga aagggggacctgaagacgtactttgtgaacacggaaatgtcccggtccctttcccagagc aatgtggcatcctga

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