Mus musculus (house mouse): 12370 Help Entry 12370             CDS       T01002                                  Symbol Casp8, CASP-8, FLICE, MACH, Mch5 Name (RefSeq) caspase 8   KO K04398   caspase 8 [EC:3.4.22.61] Organism mmu  Mus musculus (house mouse) Pathway mmu01524   Platinum drug resistance mmu04115   p53 signaling pathway mmu04210   Apoptosis mmu04215   Apoptosis - multiple species mmu04217   Necroptosis mmu04620   Toll-like receptor signaling pathway mmu04621   NOD-like receptor signaling pathway mmu04622   RIG-I-like receptor signaling pathway mmu04623   Cytosolic DNA-sensing pathway mmu04625   C-type lectin receptor signaling pathway mmu04657   IL-17 signaling pathway mmu04668   TNF signaling pathway mmu04932   Non-alcoholic fatty liver disease mmu04936   Alcoholic liver disease mmu05010   Alzheimer disease mmu05016   Huntington disease mmu05022   Pathways of neurodegeneration - multiple diseases mmu05132   Salmonella infection mmu05134   Legionellosis mmu05142   Chagas disease mmu05145   Toxoplasmosis mmu05152   Tuberculosis mmu05160   Hepatitis C mmu05161   Hepatitis B mmu05162   Measles mmu05163   Human cytomegalovirus infection mmu05164   Influenza A mmu05165   Human papillomavirus infection mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05169   Epstein-Barr virus infection mmu05170   Human immunodeficiency virus 1 infection mmu05200   Pathways in cancer mmu05203   Viral carcinogenesis mmu05416   Viral myocarditis mmu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     12370 (Casp8)  09140 Cellular Processes   09143 Cell growth and death    04210 Apoptosis     12370 (Casp8)    04215 Apoptosis - multiple species     12370 (Casp8)    04217 Necroptosis     12370 (Casp8)    04115 p53 signaling pathway     12370 (Casp8)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     12370 (Casp8)    04621 NOD-like receptor signaling pathway     12370 (Casp8)    04622 RIG-I-like receptor signaling pathway     12370 (Casp8)    04623 Cytosolic DNA-sensing pathway     12370 (Casp8)    04625 C-type lectin receptor signaling pathway     12370 (Casp8)    04657 IL-17 signaling pathway     12370 (Casp8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     12370 (Casp8)    05203 Viral carcinogenesis     12370 (Casp8)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     12370 (Casp8)    05161 Hepatitis B     12370 (Casp8)    05160 Hepatitis C     12370 (Casp8)    05164 Influenza A     12370 (Casp8)    05162 Measles     12370 (Casp8)    05168 Herpes simplex virus 1 infection     12370 (Casp8)    05163 Human cytomegalovirus infection     12370 (Casp8)    05167 Kaposi sarcoma-associated herpesvirus infection     12370 (Casp8)    05169 Epstein-Barr virus infection     12370 (Casp8)    05165 Human papillomavirus infection     12370 (Casp8)   09171 Infectious disease: bacterial    05132 Salmonella infection     12370 (Casp8)    05134 Legionellosis     12370 (Casp8)    05152 Tuberculosis     12370 (Casp8)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     12370 (Casp8)    05142 Chagas disease     12370 (Casp8)   09164 Neurodegenerative disease    05010 Alzheimer disease     12370 (Casp8)    05016 Huntington disease     12370 (Casp8)    05022 Pathways of neurodegeneration - multiple diseases     12370 (Casp8)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     12370 (Casp8)    05416 Viral myocarditis     12370 (Casp8)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     12370 (Casp8)    04932 Non-alcoholic fatty liver disease     12370 (Casp8)   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     12370 (Casp8)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:mmu01002]     12370 (Casp8) Enzymes [BR:mmu01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.22  Cysteine endopeptidases     3.4.22.61  caspase-8      12370 (Casp8) Peptidases and inhibitors [BR:mmu01002]  Cysteine peptidases   Family C14: caspase family    12370 (Casp8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Peptidase_C14 DED PYRIN Motif Other DBs NCBI-GeneID:  12370 NCBI-ProteinID:  NP_001073595 MGI:  1261423 Ensembl:  ENSMUSG00000026029 UniProt:  O89110 Q3U607 LinkDB All DBs Position 1:58834553..58886663 Genome browser AA seq 480 aa AA seqDB search MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLS FLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSF KFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYER SSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLI INNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEG YQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQ ACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNG TWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP NT seq 1443 nt NT seq  +upstreamnt  +downstreamnt atggatttccagagttgtctttatgctattgctgaagaactgggcagtgaagacctggct gccctcaagttcctgtgcttggactacatcccacacaagaagcaggagaccatcgaggat gcccagaagctatttctgaggctgcgggaaaaggggatgttggaggaaggcaatctgtct ttcctgaaagagctgcttttccacatcagtcggtgggacctgctggtcaacttcctagac tgcaaccgagaggagatggtgagagagctgcgggatccagacaatgcccagatttctccc tacagggtcatgctctttaagctctcagaagaagtgagcgagttggaattgagatctttt aagttccttttgaacaatgagatccccaaatgtaagctggaagatgacttgagcctgctt gaaatttttgtagaaatggagaagaggaccatgctggcagaaaataacttggaaacccta aaatcaatctgtgaccaggtcaacaagagcctgctggggaagatcgaggattatgaaaga tcaagcacagagagaagaatgagccttgaaggaagggaagagttgccaccttcagttttg gatgagatgagcctcaaaatggcggaactgtgtgactcgccaagagaacaagacagtgag tcacggacttcagacaaagtttaccaaatgaagaacaaacctcggggatactgtctgatc atcaacaatcatgatttcagcaaggcccgggaagacataacccaactccgaaaaatgaag gacagaaaaggaacagactgtgataaagaggctctgagtaagacctttaaggagcttcat tttgagatagtatcttacgacgactgcactgcaaatgaaatccacgagattctagaaggc taccaaagcgcagaccacaagaacaaagactgcttcatctgctgtatcctatcccacggt gacaagggtgtcgtctatggaacggatgggaaggaggcctccatctatgacctgacatct tacttcactggttcaaagtgcccttccctgtctgggaaacccaagatctttttcattcag gcttgccaaggaagtaacttccagaaaggagtgcctgatgaggcaggcttcgagcaacag aaccacactttagaagtggattcatcatctcacaagaactatattccggatgaggcagac tttctgctgggaatggctacggtgaagaactgcgtttcctaccgagatcctgtgaatgga acctggtatattcagtcactttgccagagcctgagggaaagatgtcctcaaggagatgac attcttagcatcctgactggcgtgaactatgacgtgagcaataaagacgacaggaggaac aagggaaagcagatgccacagcccaccttcacactacggaagaagctcttcttccctccc taa

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