Mus musculus (house mouse): 15483
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Entry
15483 CDS
T01002
Symbol
Hsd11b1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00140
Steroid hormone biosynthesis
mmu00980
Metabolism of xenobiotics by cytochrome P450
mmu01100
Metabolic pathways
mmu05204
Chemical carcinogenesis - DNA adducts
Module
mmu_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
15483 (Hsd11b1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
15483 (Hsd11b1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
15483 (Hsd11b1)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
15483 (Hsd11b1)
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Gene cluster
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
DUF1776
THF_DHG_CYH_C
2-Hacid_dh_C
Pyr_redox_2
Motif
Other DBs
NCBI-GeneID:
15483
NCBI-ProteinID:
NP_001038216
MGI:
103562
Ensembl:
ENSMUSG00000016194
UniProt:
P50172
Q4JHD9
Structure
PDB
PDBj
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All DBs
Position
1:complement(192903917..192946345)
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AA seq
292 aa
AA seq
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MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
NT seq
879 nt
NT seq
+upstream
nt +downstream
nt
atggcagttatgaaaaattacctcctcccgatcctggtgctcttcctggcctactactac
tattctacaaatgaagagttcagaccagaaatgctccagggaaagaaagtgattgtcact
ggggccagcaaagggattggaagagaaatggcatatcatctgtcaaaaatgggagcccat
gtggtattgactgccaggtcggaggaaggtctccagaaggtagtgtctcgctgccttgaa
ctcggagcagcctctgctcactacattgctggcactatggaagacatgacatttgcggag
caatttattgtcaaggcgggaaagctcatgggcggactggacatgcttattctaaaccac
atcactcagacctcgctgtctctcttccatgacgacatccactctgtgcgaagagtcatg
gaggtcaacttcctcagctacgtggtcatgagcacagccgccttgcccatgctgaagcag
agcaatggcagcattgccgtcatctcctccttggctgggaaaatgacccagcctatgatt
gctccctactctgcaagcaagtttgctctggatgggttcttttccaccattagaacagaa
ctctacataaccaaggtcaacgtgtccatcactctctgtgtccttggcctcatagacaca
gaaacagctatgaaggaaatctctgggataattaacgcccaagcttctcccaaggaggag
tgcgccctggagatcatcaaaggcacagctctacgcaaaagcgaggtgtactatgacaaa
tcgcctttgactccaatcctgcttgggaacccaggaaggaagatcatggaatttttttca
ttacgatattataataaggacatgtttgtaagtaactag
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