KEGG   Mus musculus (house mouse): 15492
Entry
15492             CDS       T01002                                 
Symbol
Hsd3b1, 3-beta-HSD_I, D3Ertd383e
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu01100  Metabolic pathways
mmu04913  Ovarian steroidogenesis
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04934  Cushing syndrome
Module
mmu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mmu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mmu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mmu_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    15492 (Hsd3b1)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    15492 (Hsd3b1)
   04925 Aldosterone synthesis and secretion
    15492 (Hsd3b1)
   04927 Cortisol synthesis and secretion
    15492 (Hsd3b1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    15492 (Hsd3b1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     15492 (Hsd3b1)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     15492 (Hsd3b1)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd NAD_binding_10 Polysacc_synt_2 NmrA KR RmlD_sub_bind Ldh_1_N Ufm1 Sacchrp_dh_NADP DapB_N Polysacc_deac_1 Semialdhyde_dh
Other DBs
NCBI-GeneID: 15492
NCBI-ProteinID: NP_001291729
MGI: 96233
Ensembl: ENSMUSG00000027871
UniProt: P24815 Q3UJ12 Q3UI20
LinkDB
Position
3:complement(98749672..98767110)
AA seq 373 aa
MAGWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETKEEFSKLQTKTKVTVLE
GDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAF
IFCSSVDVAGPNSYKKIVLNGHEEQNHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTL
NTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSIANPVYVENVAWAHILAARGL
RDPKKSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASWSLPLPLLYWLAFLLET
VSFLLRPVYRYRPLFNRHLITLSNSTFTFSYKKAQRDLGYEPLVNWEEAKQKTSEWIGTI
VEQHREILDTKCQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctggatggagctgcctggtgacaggagcaggagggtttgtgggccagaggatcatc
aagatgttggtgcaggagaaagaactgcaggaggtcagagctctggacaaagtattccga
ccagaaaccaaggaggaattctccaagctgcagacaaagaccaaggtgacagtgttggaa
ggagacattctggatgcccagtgcctgaggagagcctgccagggcatctctgttgtcatc
cacactgctgctgtcattgatgtcacaggtgtcattcccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacctattggaggcctgtgttcaagcaagtgtgccagccttc
atcttctgcagctcagttgatgttgcagggcccaactcgtacaagaagatcgtcctgaat
ggccacgaggaacagaatcatgaaagcacatggtctgatccatacccatacagcaaaaag
atggctgagaaggcagtactggcagccaatgggagcatgctgaaaaatggtggcactttg
aatacttgtgccttaagacccatgtacatttatggggagagaagtccattcatttttaat
gcaataattagggccctcaaaaataagggtattctgtgtgttactggcaaattctccata
gccaacccagtatatgtggaaaatgtggcctgggcacacattctggcagccaggggcctt
cgagaccccaagaagtctacaagcatccaaggacagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattacaccctgagtaaggaatgggggctccgccct
aatgccagctggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctacgtccagtctacaggtatagacctctctttaaccgccacttgatc
acactgtcaaatagcacgttcactttttcttacaagaaagctcagcgagatctgggctat
gagccacttgtcaactgggaggaagcaaagcagaaaacctcagagtggatagggacaata
gtggaacagcacagggagatattggacacaaagtgccagtga

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