KEGG   Mus musculus (house mouse): 15495
Entry
15495             CDS       T01002                                 
Symbol
Hsd3b4
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu01100  Metabolic pathways
mmu04913  Ovarian steroidogenesis
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04934  Cushing syndrome
Module
mmu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mmu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mmu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mmu_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    15495 (Hsd3b4)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    15495 (Hsd3b4)
   04925 Aldosterone synthesis and secretion
    15495 (Hsd3b4)
   04927 Cortisol synthesis and secretion
    15495 (Hsd3b4)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    15495 (Hsd3b4)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     15495 (Hsd3b4)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     15495 (Hsd3b4)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 NAD_binding_10 NmrA GDP_Man_Dehyd Polysacc_synt_2 RmlD_sub_bind KR Sacchrp_dh_NADP Semialdhyde_dh Ldh_1_N
Other DBs
NCBI-GeneID: 15495
NCBI-ProteinID: NP_001104806
MGI: 96236
Ensembl: ENSMUSG00000095143
UniProt: Q61767 Q3UIU9
LinkDB
Position
3:complement(98406387..98417895)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKQEEELSKLQTKTKVTVLK
GDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNLKGTQLLLDACVEANVPTF
IYSSSVLVAGPNSYKEIILNAHEEEHHESTWSNPYPYSKKMAEKAVLAANGSILKNGGTL
HTCALRLSFIYGEECQVTSTTVKTALKNNSIIKKNATFSIANPVYVGNAAWAHILAARSL
QDPKKSPSIQGQFYYITDDTPHQSYDDLKCTLSKEWGLRLDTSWSLPLPLLYWLAFLLET
VSFLLRPVYNYRPPFNRLLITVLNSVFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTL
VMQHREIGNKKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgacaggagcaggagggtttcttggccagaggattgtc
cgaatgttggtgcaggaggaagagctgcaggagatcagagccctgttcaggaccttcggt
cgaaaacaggaagaggaattgtccaagctgcagacaaagaccaaggtgacagtactgaag
ggagacattctggatgcccagtgcctgaagagagcctgccagggcatgtctgctgtcatc
cacaccgctgctgctattgacccccttggtgccgcttccagacagaccatcctagatgtc
aatctgaaaggtactcagctcctactggatgcttgtgtggaagccaacgtgccaacattc
atctacagcagctcagtgcttgtggctggaccaaattcctacaaggagatcatcctgaat
gcccatgaggaggagcatcatgaaagcacatggtctaacccatacccatacagcaaaaag
atggctgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcactttg
catacttgtgccttaagactctctttcatctatggggaagaatgccaagtcacttcaacc
actgtgaaaacagcactgaagaacaacagcataattaagaaaaatgccacattctccatc
gccaacccagtgtatgtgggcaatgcagcctgggctcacattctggctgccaggagccta
caggaccctaagaagtccccaagcatccaaggacagttctattacattacagatgacacc
cctcaccaaagctatgatgacttaaaatgcaccctgagcaaggagtggggcctccgcctt
gataccagctggagtcttcctctgcccctgctctactggcttgccttcctcctggaaact
gtgagcttcctgctacgtccagtctacaactatagaccaccatttaaccgcctcttgatc
acagtgctaaatagtgtattcaccttctcctacaagaaggctcagcgagatctgggctat
gagccacttgtcagctgggaggaagccaagcagaaaacctcagagtggatcggaacacta
gtgatgcagcacagggagattggaaacaaaaagtcacagtga

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