Mus musculus (house mouse): 16396
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Entry
16396 CDS
T01002
Symbol
Itch, 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik
Name
(RefSeq) itchy, E3 ubiquitin protein ligase
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04120
Ubiquitin mediated proteolysis
mmu04144
Endocytosis
mmu04330
Notch signaling pathway
mmu04668
TNF signaling pathway
mmu04932
Non-alcoholic fatty liver disease
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
16396 (Itch)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
16396 (Itch)
04668 TNF signaling pathway
16396 (Itch)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
16396 (Itch)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
16396 (Itch)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mmu04131
]
16396 (Itch)
04121 Ubiquitin system [BR:
mmu04121
]
16396 (Itch)
Enzymes [BR:
mmu01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
16396 (Itch)
Membrane trafficking [BR:
mmu04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
16396 (Itch)
Ubiquitin system [BR:
mmu04121
]
Ubiquitin ligases (E3)
HECT type E3
16396 (Itch)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
16396
NCBI-ProteinID:
NP_001230641
MGI:
1202301
Ensembl:
ENSMUSG00000027598
UniProt:
Q8C863
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:154975401..155068775
Genome browser
AA seq
864 aa
AA seq
DB search
MSDSGPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPTSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTL
QLVGDKEPTETMGDLSVCLDGLQVEAEVVTNGETSCSESTTQNDDGCRTRDDTRVSTNGS
EDPEVAASGENKRANGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSDSD
GSSTGSLPPTNTNVNTSTSEGATSGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQH
GRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQ
WQLQRSQLQGAMQQFNQRFIYGNQDLFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNH
NTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRATTYIDPRTGKSALDNG
PQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWV
IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR
FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC
GLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE
GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEI
DNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPP
YKSYEQLKEKLLFAIEETEGFGQE
NT seq
2595 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggaccacagcttgattccatgggtagtctgaccatgaaatctcaactt
cagatcactgtcatctcagccaaacttaaagaaaataaaaagaattggtttggaccaagt
ccttatgtagaagtcacagtagatggacagtcaaagaagacagaaaaatgcaataataca
aacagtcccaagtggaagcagcccctcacagttattgttacccctacgagtaaattatgt
tttcgtgtgtggagtcaccagaccctgaagtctgatgttttattgggaactgctggatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttatgactttg
cagcttgtaggtgacaaagagccaacagagacgatgggagatttgtcagtttgtcttgat
gggctgcaagtagaagctgaggttgttactaacggtgaaacgtcatgctccgagagtact
acacagaatgatgatggctgcagaaccagagatgatacaagagtgagcacaaatggatca
gaggaccctgaggttgcagcgtcaggggaaaacaagagggccaatgggaacaattctccg
tccctttcaaatggtggttttaagccttctagacctcctagaccttcgagaccacctcca
cccaccccacgaagaccagcttctgtcaatggctcaccatccacgaattctgacagtgat
ggatctagtacaggctccttgccaccaacaaatacaaatgtaaatacaagtacatctgaa
ggagcaacatctggattaataattcctcttactatatctggaggctcgggccctaggcct
ctgaatactgtaagccaagctcccctaccacctgggtgggagcagagagtagaccagcat
gggcgtgtttactatgtagaccatgttgaaaagcgaacaacatgggatagaccagaacct
ctacctcctggctgggaacggcgtgtggacaatatgggacgtatttattatgttgatcat
ttcacaagaaccacaacatggcagaggccaaccttggaatctgtccggaactatgaacag
tggcagctacagcgtagtcagcttcagggagcaatgcagcagtttaaccagagattcatc
tatgggaatcaagatttgtttgctacatcacaaaacaaagaatttgatccgcttggtccg
ttgccccctggatgggagaagagaactgatagcaacggcagagtgtattttgtcaaccac
aacactcggattactcagtgggaagaccccagaagccaaggtcagttaaatgaaaagccc
ttaccagaaggctgggaaatgagattcacagtggatggaattccatattttgtggaccac
aatagaagagcaactacttatatagatccacgaacgggaaaatcagccttagacaatggg
ccccagatagcctatgtgcgggacttcaaggcaaaagttcagtatttccggttctggtgc
cagcaactggccatgccacagcatataaagatcacagtgacaagaaaaacattgtttgag
gattcctttcagcagatcatgagcttcagcccgcaagacctgagaagacgtttgtgggtg
attttcccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttctt
ttgtcacatgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataac
tactgcctgcagataaaccccgcttcttacatcaatccagaccacctgaaatactttcgt
tttattggcagatttattgccatggctctgtttcatgggaaattcatagataccggattt
tctttaccattctataaacgtatcctgaataaaccagttggactgaaggatttagaatct
attgatccagaattttataattcgctcatctgggttaaagaaaacaacattgaagaatgt
ggtttggaaatgtacttctcagttgataaagaaattctaggtgaaattaagagtcatgat
ttgaaacccaatggtggcaatattcttgtgacagaagaaaacaaggaggaatacatcagg
atggtagctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttctttgag
ggctttaatgaaattcttcctcagcaatatttgcaatattttgatgcgaaggaattagag
gttcttctgtgtgggatgcaggagattgatttgaatgactggcagagacatgccatctac
cgccactacaccagaacaagcaagcagatcatgtggttttggcagtttgttaaagaaatt
gataatgagaagaggatgagacttctgcagtttgttactggaacctgccgattgccagtg
ggaggatttgctgaccttatggggagtaatggaccacagaagttctgcatcgaaaaagtt
ggcaaagaaaattggttacccagaagccatacttgttttaaccgcctggacctcccacct
tacaagagctatgagcaactgaaggaaaagctgttatttgccattgaagaaactgaagga
tttggacaagagtaa
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