Mus musculus (house mouse): 22637
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Entry
22637 CDS
T01002
Symbol
Zap70, Srk, ZAP-70, mrtle, mur
Name
(RefSeq) zeta-chain (TCR) associated protein kinase
KO
K07360
tyrosine-protein kinase ZAP-70 [EC:
2.7.10.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04014
Ras signaling pathway
mmu04064
NF-kappa B signaling pathway
mmu04650
Natural killer cell mediated cytotoxicity
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu05135
Yersinia infection
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05340
Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
22637 (Zap70)
04064 NF-kappa B signaling pathway
22637 (Zap70)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
22637 (Zap70)
04660 T cell receptor signaling pathway
22637 (Zap70)
04658 Th1 and Th2 cell differentiation
22637 (Zap70)
04659 Th17 cell differentiation
22637 (Zap70)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
22637 (Zap70)
09171 Infectious disease: bacterial
05135 Yersinia infection
22637 (Zap70)
09163 Immune disease
05340 Primary immunodeficiency
22637 (Zap70)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
22637 (Zap70)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
22637 (Zap70)
Protein kinases [BR:
mmu01001
]
Non-receptor tyrosine kinases
SYK family
22637 (Zap70)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
DUF7063
DUF7145
ABC1
SH2_1
Haspin_kinase
Kdo
Motif
Other DBs
NCBI-GeneID:
22637
NCBI-ProteinID:
NP_001276694
MGI:
99613
Ensembl:
ENSMUSG00000026117
UniProt:
P43404
LinkDB
All DBs
Position
1:36800912..36821899
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AA seq
618 aa
AA seq
DB search
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
QQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGYTPEPARLASS
TDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRK
KQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGP
LHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG
LSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYK
KMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLA
SRAEGPPQCEQVAEAACG
NT seq
1857 nt
NT seq
+upstream
nt +downstream
nt
atgcccgatcccgcggcgcacctgccattcttctatggcagcatctcgcgggctgaggcc
gaggagcacctgaagctggcaggcatggccgacgggctgttcctcctgcgccagtgtttg
cgctccctgggcggctacgtgctgtcgttggtgcacgacgtgcgcttccaccatttcccc
atcgagcgccaactcaacggcacgtacgccatcgcgggcgggaaggcgcactgcggcccg
gccgagctctgccagttctactctcaggaccccgacgggctgccctgcaacctgcgtaag
ccgtgtaaccggccgcccggactggagccacagcccggggtcttcgactgcctgcgtgat
gctatggtgcgcgactacgtgcgccagacctggaagctggagggcgatgcactagagcag
gccatcatcagccaggccccacaggtggagaagctcattgctaccacagcccacgagcga
atgccctggtatcacagcagcctgactcgtgaggaggccgagcgcaaactctattccggc
cagcagaccgacggcaagttcctgctgaggccccggaaggagcagggcacatatgcactg
tccctggtctatgggaaaactgtataccactatctcatcagccaggacaaggctggcaag
tactgcatccccgaaggcaccaagtttgacacgctctggcagctggtggagtacctgaag
ctgaaggcggatggactaatttaccgcttgaaggaggtctgtcccaacagcagcgccagc
gcggcagttgctgcacccaccctcccagcccacccatccacattcactcagcctcagaga
cgagtggacaccctgaactcggacggatacacccctgaaccagcacgcttagcgtcatcg
acagacaagccccggccgatgcccatggacacaagtgtgtacgagagtccctacagcgac
cctgaggaactcaaagacaagaagctcttcctgaagcgagagaatctcctcgtggcggac
atcgagcttggctgtggcaactttggctccgtgcgccagggagtctatcgcatgcgcaag
aagcagattgacgtggccatcaaggtgctgaagcagggcacagagaaggccgacaaagat
gagatgatgcgagaggcccagatcatgcaccagctcgacaacccctacatcgtgcggctc
atcggcgtgtgccaggcagaagcactcatgctggtcatggagatggcgggaggcgggccc
ctgcacaagttcctgctgggaaagaaggaggagatccctgtgagcaatgtggctgaactg
ctgcaccaggtggccatgggcatgaagtatttggaggagaaaaactttgtgcaccgcgac
ctggcagcccgcaatgttctactggtcaatcggcactatgccaagatcagcgactttggc
ctgtccaaagccctgggtgctgacgacagctattacacagcccggtctgcagggaagtgg
cctctgaagtggtacgcgccagagtgcatcaactttcggaagttctccagccgcagtgac
gtctggagctatggggtcaccatgtgggaggccttctcctatggccagaagccctacaag
aaaatgaagggccccgaggtcctggacttcatcaagcagggtaagaggatggaatgtccg
ccggagtgtcctcctgagatgtatgcacttatgagtgactgctggatctacaagtgggag
gatcgccccgacttcctgactgtggaacaacgtatgcggaactattactacagcctggcc
agccgggccgagggacccccacagtgtgaacaggtggccgaggctgcatgtggctga
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