Mus musculus (house mouse): 26396
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Entry
26396 CDS
T01002
Symbol
Map2k2, MEK2, MK2, Prkmk2
Name
(RefSeq) mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01521
EGFR tyrosine kinase inhibitor resistance
mmu01522
Endocrine resistance
mmu04010
MAPK signaling pathway
mmu04012
ErbB signaling pathway
mmu04014
Ras signaling pathway
mmu04015
Rap1 signaling pathway
mmu04022
cGMP-PKG signaling pathway
mmu04024
cAMP signaling pathway
mmu04066
HIF-1 signaling pathway
mmu04068
FoxO signaling pathway
mmu04071
Sphingolipid signaling pathway
mmu04072
Phospholipase D signaling pathway
mmu04140
Autophagy - animal
mmu04148
Efferocytosis
mmu04150
mTOR signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04218
Cellular senescence
mmu04270
Vascular smooth muscle contraction
mmu04370
VEGF signaling pathway
mmu04371
Apelin signaling pathway
mmu04540
Gap junction
mmu04550
Signaling pathways regulating pluripotency of stem cells
mmu04613
Neutrophil extracellular trap formation
mmu04620
Toll-like receptor signaling pathway
mmu04650
Natural killer cell mediated cytotoxicity
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04720
Long-term potentiation
mmu04722
Neurotrophin signaling pathway
mmu04730
Long-term depression
mmu04810
Regulation of actin cytoskeleton
mmu04910
Insulin signaling pathway
mmu04912
GnRH signaling pathway
mmu04915
Estrogen signaling pathway
mmu04916
Melanogenesis
mmu04917
Prolactin signaling pathway
mmu04919
Thyroid hormone signaling pathway
mmu04921
Oxytocin signaling pathway
mmu04926
Relaxin signaling pathway
mmu04929
GnRH secretion
mmu04934
Cushing syndrome
mmu04935
Growth hormone synthesis, secretion and action
mmu05010
Alzheimer disease
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05200
Pathways in cancer
mmu05205
Proteoglycans in cancer
mmu05206
MicroRNAs in cancer
mmu05207
Chemical carcinogenesis - receptor activation
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05210
Colorectal cancer
mmu05211
Renal cell carcinoma
mmu05213
Endometrial cancer
mmu05214
Glioma
mmu05215
Prostate cancer
mmu05216
Thyroid cancer
mmu05218
Melanoma
mmu05219
Bladder cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05223
Non-small cell lung cancer
mmu05224
Breast cancer
mmu05225
Hepatocellular carcinoma
mmu05226
Gastric cancer
mmu05230
Central carbon metabolism in cancer
mmu05231
Choline metabolism in cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26396 (Map2k2)
04012 ErbB signaling pathway
26396 (Map2k2)
04014 Ras signaling pathway
26396 (Map2k2)
04015 Rap1 signaling pathway
26396 (Map2k2)
04370 VEGF signaling pathway
26396 (Map2k2)
04371 Apelin signaling pathway
26396 (Map2k2)
04066 HIF-1 signaling pathway
26396 (Map2k2)
04068 FoxO signaling pathway
26396 (Map2k2)
04072 Phospholipase D signaling pathway
26396 (Map2k2)
04071 Sphingolipid signaling pathway
26396 (Map2k2)
04024 cAMP signaling pathway
26396 (Map2k2)
04022 cGMP-PKG signaling pathway
26396 (Map2k2)
04151 PI3K-Akt signaling pathway
26396 (Map2k2)
04150 mTOR signaling pathway
26396 (Map2k2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
26396 (Map2k2)
04148 Efferocytosis
26396 (Map2k2)
09143 Cell growth and death
04210 Apoptosis
26396 (Map2k2)
04218 Cellular senescence
26396 (Map2k2)
09144 Cellular community - eukaryotes
04540 Gap junction
26396 (Map2k2)
04550 Signaling pathways regulating pluripotency of stem cells
26396 (Map2k2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
26396 (Map2k2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
26396 (Map2k2)
04620 Toll-like receptor signaling pathway
26396 (Map2k2)
04650 Natural killer cell mediated cytotoxicity
26396 (Map2k2)
04660 T cell receptor signaling pathway
26396 (Map2k2)
04662 B cell receptor signaling pathway
26396 (Map2k2)
04664 Fc epsilon RI signaling pathway
26396 (Map2k2)
09152 Endocrine system
04910 Insulin signaling pathway
26396 (Map2k2)
04929 GnRH secretion
26396 (Map2k2)
04912 GnRH signaling pathway
26396 (Map2k2)
04915 Estrogen signaling pathway
26396 (Map2k2)
04917 Prolactin signaling pathway
26396 (Map2k2)
04921 Oxytocin signaling pathway
26396 (Map2k2)
04926 Relaxin signaling pathway
26396 (Map2k2)
04935 Growth hormone synthesis, secretion and action
26396 (Map2k2)
04919 Thyroid hormone signaling pathway
26396 (Map2k2)
04916 Melanogenesis
26396 (Map2k2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
26396 (Map2k2)
09156 Nervous system
04720 Long-term potentiation
26396 (Map2k2)
04730 Long-term depression
26396 (Map2k2)
04722 Neurotrophin signaling pathway
26396 (Map2k2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
26396 (Map2k2)
05206 MicroRNAs in cancer
26396 (Map2k2)
05205 Proteoglycans in cancer
26396 (Map2k2)
05207 Chemical carcinogenesis - receptor activation
26396 (Map2k2)
05208 Chemical carcinogenesis - reactive oxygen species
26396 (Map2k2)
05230 Central carbon metabolism in cancer
26396 (Map2k2)
05231 Choline metabolism in cancer
26396 (Map2k2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
26396 (Map2k2)
09162 Cancer: specific types
05210 Colorectal cancer
26396 (Map2k2)
05225 Hepatocellular carcinoma
26396 (Map2k2)
05226 Gastric cancer
26396 (Map2k2)
05214 Glioma
26396 (Map2k2)
05216 Thyroid cancer
26396 (Map2k2)
05221 Acute myeloid leukemia
26396 (Map2k2)
05220 Chronic myeloid leukemia
26396 (Map2k2)
05218 Melanoma
26396 (Map2k2)
05211 Renal cell carcinoma
26396 (Map2k2)
05219 Bladder cancer
26396 (Map2k2)
05215 Prostate cancer
26396 (Map2k2)
05213 Endometrial cancer
26396 (Map2k2)
05224 Breast cancer
26396 (Map2k2)
05223 Non-small cell lung cancer
26396 (Map2k2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
26396 (Map2k2)
05170 Human immunodeficiency virus 1 infection
26396 (Map2k2)
05161 Hepatitis B
26396 (Map2k2)
05160 Hepatitis C
26396 (Map2k2)
05164 Influenza A
26396 (Map2k2)
05163 Human cytomegalovirus infection
26396 (Map2k2)
05167 Kaposi sarcoma-associated herpesvirus infection
26396 (Map2k2)
05165 Human papillomavirus infection
26396 (Map2k2)
09171 Infectious disease: bacterial
05132 Salmonella infection
26396 (Map2k2)
05135 Yersinia infection
26396 (Map2k2)
09164 Neurodegenerative disease
05010 Alzheimer disease
26396 (Map2k2)
05022 Pathways of neurodegeneration - multiple diseases
26396 (Map2k2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
26396 (Map2k2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
26396 (Map2k2)
01522 Endocrine resistance
26396 (Map2k2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26396 (Map2k2)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
26396 (Map2k2)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
STE7 family
26396 (Map2k2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
26396
NCBI-ProteinID:
NP_075627
MGI:
1346867
Ensembl:
ENSMUSG00000035027
UniProt:
Q63932
Q8CB46
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:80941749..80960531
Genome browser
AA seq
401 aa
AA seq
DB search
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELDLDEQQRKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRPRP
PGRPISVGHGMDSRPAMAIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERAD
LKLLMNHAFIKRSEGEEVDFAGWLCRTLRLKQPSTPTRTAV
NT seq
1206 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgttaccggcactcactatcaaccctaccatcgccgag
ggcccgtcccccaccagcgagggcgcctctgaggcaaacctggtggacctccagaagaag
ctggaagagctggacctggatgagcagcaaaggaagcggctggaggccttccttacccag
aaggctaaggtcggtgagctcaaggacgacgactttgagaggatctcagagctgggtgcc
ggcaatggcggagtggtcaccaaggcccggcataggccgtcaggcctcatcatggccaga
aagctgatccacctggagatcaaaccggccgtgcgcaaccagatcatccgggagctgcag
gtgctgcacgagtgcaactcgccctacatcgtgggcttctatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggtggctcactggaccaggtactgaag
gaggccaagcggattcctgaagacatcttggggaaggtcagcattgcggtgctccggggc
ctggcctacctccgagagaagcaccagatcatgcacagagatgtgaagccctccaacatc
ctggtgaactctcgcggggagattaagctgtgtgacttcggggtgagcggccagctgatc
gactccatggccaactcgtttgtagggacgcgctcctacatgtccccagagcggctgcag
ggcacccactactctgtgcagtcggacatctggagcatggggctgtcgctggtggagctg
gccatcgggaggtatcccattcccccacctgatgccaaggaactagaggccagctttggc
cggcctgtggtggacggggcagacggagaaccccatagtgtctccccgaggcccaggccc
cctggacgccccatcagtgtaggtcatgggatggacagccgaccggccatggccatcttt
gagctgctggactacatagtgaacgagccacctcccaagctgcccagtggtgtgttcagc
tcagacttccaggagtttgtgaataaatgtctcattaagaacccagcagagcgagcagat
ctgaagctgctgatgaaccacgccttcatcaagcgctctgagggggaggaagtggacttc
gccggctggctgtgcagaaccctgcggctgaagcagcccagcacacccacgcggactgca
gtgtga
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