Mus musculus (house mouse): 26408
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Entry
26408 CDS
T01002
Symbol
Map3k5, 7420452D20Rik, ASK, ASK1, MAPKKK5, Mekk5
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 5
KO
K04426
mitogen-activated protein kinase kinase kinase 5 [EC:
2.7.11.25
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01524
Platinum drug resistance
mmu04010
MAPK signaling pathway
mmu04071
Sphingolipid signaling pathway
mmu04141
Protein processing in endoplasmic reticulum
mmu04210
Apoptosis
mmu04530
Tight junction
mmu04668
TNF signaling pathway
mmu04714
Thermogenesis
mmu04722
Neurotrophin signaling pathway
mmu04932
Non-alcoholic fatty liver disease
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05012
Parkinson disease
mmu05014
Amyotrophic lateral sclerosis
mmu05016
Huntington disease
mmu05017
Spinocerebellar ataxia
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
26408 (Map3k5)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26408 (Map3k5)
04668 TNF signaling pathway
26408 (Map3k5)
04071 Sphingolipid signaling pathway
26408 (Map3k5)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
26408 (Map3k5)
09144 Cellular community - eukaryotes
04530 Tight junction
26408 (Map3k5)
09150 Organismal Systems
09156 Nervous system
04722 Neurotrophin signaling pathway
26408 (Map3k5)
09159 Environmental adaptation
04714 Thermogenesis
26408 (Map3k5)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
26408 (Map3k5)
09164 Neurodegenerative disease
05010 Alzheimer disease
26408 (Map3k5)
05012 Parkinson disease
26408 (Map3k5)
05014 Amyotrophic lateral sclerosis
26408 (Map3k5)
05016 Huntington disease
26408 (Map3k5)
05017 Spinocerebellar ataxia
26408 (Map3k5)
05022 Pathways of neurodegeneration - multiple diseases
26408 (Map3k5)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
26408 (Map3k5)
05418 Fluid shear stress and atherosclerosis
26408 (Map3k5)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
26408 (Map3k5)
04932 Non-alcoholic fatty liver disease
26408 (Map3k5)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
26408 (Map3k5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26408 (Map3k5)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.25 mitogen-activated protein kinase kinase kinase
26408 (Map3k5)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
STE11 family
26408 (Map3k5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MAP3K_TRAF_bd
Pkinase
HisK-N-like
PK_Tyr_Ser-Thr
ASK_PH
TPR-S
DRHyd-ASK
FPP
Pkinase_fungal
Kinase-like
Motif
Other DBs
NCBI-GeneID:
26408
NCBI-ProteinID:
NP_032606
MGI:
1346876
Ensembl:
ENSMUSG00000071369
UniProt:
O35099
LinkDB
All DBs
Position
10:19809847..20018496
Genome browser
AA seq
1380 aa
AA seq
DB search
MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPPPPPPPGS
FWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEAL
QSLREACEAVGATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRE
SFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKG
LTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILSDIRKARNLYTGKELA
AELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKF
HYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRD
HGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQ
SYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPS
AKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLP
DDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTI
TEEKGRGAEDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPE
RDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPL
KDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGIN
PCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFK
VGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLKVSSKKKKTQPKLSA
LSTGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKARAKSCGEKDGKGI
RTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESL
AQGAEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFG
FQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLD
VEDEHEELSSNQTVRRPQAITEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKIETN
RLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPIDIPGFPVCHLNSPGTTTEDSEL
PGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKC
NT seq
4143 nt
NT seq
+upstream
nt +downstream
nt
atgggcaccgaagccggcgagggcatcactttctccgtgccgccctttgcgtccgtgggc
ttttgcaccatcccggagggcggcagctgccggaggggaggaggagcggcgacggcggcg
gagggagagccgagcctgcagcccttgcttgtgccgccgccgccgccaccgccgggcagt
ttctggaacgtggagagcgcggcggctcccggcaccagctgccctaccaccgcccccggg
agcagcgccacccgaggccggggcaactctggcagcgggggcggccggcgtaccaccgtg
gcttatgtgatcaatgaggcgagccaggggcagctggtggtggcggagagcgaggccctg
cagagcctgcgggaggcgtgcgaggcggtgggcgccaccctggagaccctgcatttcggg
aagctggacttcggggaaaccgccgtgctggaccgtttttacaacgcagatattgctgtg
gtggagatgagcgacgccttccggcagccttccttgttttaccatcttggagtgcgagaa
agcttcagtatggccaacaacatcatcctctactgcgatactaattccgattcactccag
tccctgaaggaaattatttgccagaagaatactgtgtgcaccgggaactacaccttcatc
ccctacatggtgacaccacacaacaaggtctactgctgtgacagcagcttcatgaagggc
ctgactgagctcatgcagcctaacttcgagctcctgctggggcccatctgcttacccctc
gtggaccgtttcgttcagcttttgaaggtggcgcaagcgagttccagccagtacttccgg
gaatccatactcagcgatatcaggaaagcacggaacctgtacactggtaaagaattggca
gctgaattggcgaggatccggcaacgggtagacaatattgaagttttgacagcagacatt
gttatcaacctgttgctttcctacagagacatccaggactatgactccatagtgaagctg
gtagagacgttagaaaaacttccaaccttcgacttggcctcgcaccaccacgtgaagttt
cattacgcatttgcactgaacaggagaaatctccctggagacagagcaaaagctcttgac
atcatgatccccatggtacaaagtgaagagcaagttgcttcggatatgtattgtctcgtt
ggccgaatctacaaagatatgtttttggattcaaatttcactgacacggaaagcagggac
catggagcatcttggttcaaaaaggcatttgagtctgagccaacactacagtcaggaatt
aattatgcagttctcttgctggcggctgggcaccagtttgaatcttcttttgagcttcgg
aaagttggagtgaagctgagtagccttctgggtaaaaaggggaacttggaaaaactccag
agctactgggaagtcggattttttctgggagccagtgtcctggccaacgaccacctcagg
gtcattcaggcatccgagaagctgttcagactgaagacaccagcgtggtacctcaagtct
atcgtggagaccattctgatatataaacactttgtgaaactgaccacagagcagccctcg
gctaagcaggaactcgtggacttctggatggatttcctggtcgaggccacaaaaacagat
gttactgttgtcaggttcccagtattaatattagagccaaccaaaatctatcagccttct
tacctgtctatcaataatgaagttgaggagaagacaatatctatttggcatgttctccct
gatgacaagaaaggtatacacgagtggaacttcggtgcttcctctgtcaggggagtgagc
atctctaagtttgaagaacgatgctgtttcctttatgtgcttcacaattctgatgacttc
caaatctacttctgcacagaacttcactgtaaaaggttttttgaaatggtgaataccatc
acggaagagaaggggagaggcgcggaggacggagactgtgagggtgactccctggagtat
gactacgaatacgatgaaaatggagacagagttgtgttagggaagggcacttatgggatc
gtctatgcaggacgagacctgagcaaccaggtcagaattgctattaaggaaatcccagag
agagacagcagatactctcagcccctgcatgaagaaatcgccctgcacaagcatctgaaa
cacaaaaacattgtccagtatctgggctccttcagtgagaacggcttcatcaaaatcttc
atggagcaagtcccaggaggaagcctctctgctctccttcgttcaaaatggggcccatta
aaggacaacgaacagacgattggcttctatacgaagcagatactggaaggattaaaatac
cttcacgacaatcagatagtccaccgggatataaagggtgacaatgtattgattaatacc
tacagtggtgtgctcaagatctctgacttcgggacatccaagaggcttgctggcataaac
ccatgtaccgaaacctttacaggtacccttcagtatatggcgccagaaataatcgataaa
ggaccacgaggctatggaaaggccgccgacatttggtcactgggctgcacaatcatcgaa
atggctactggaaaaccaccattttatgaactaggagagccacaggcagccatgttcaag
gtggggatgtttaaggtccacccggagatcccagagtccatgtcggcggaggccaaggcg
ttcatactgaagtgttttgaaccagaccctgacaagagagcctgtgctaatgacttgctt
attgatgagttcttaaaagtgtccagcaaaaagaaaaagacacaacccaaactttcagct
ctctcgactggatcgaatgagtatcttagaagcatctccctgccggtccctgtcctggta
gaagacaccagcagcagtagcgagtatggctctgtttctcctgatacagagctgaaggcg
gaccccttctccttcaaagccagagctaagtcctgtggagaaaaggacgggaaagggata
cggacattgttcctgggcattccagatgaaaattttgaagatcacagtgcgcccccatct
cctgaagagaaagactcgggcttttttatgctgagaaaggatagtgagaggcgagctacc
cttcacagaatcctgaccgaagaccaggacaaggttgtaaggaacctaatggaatctctg
gcccagggtgctgaagagcctaaactaaagtgggaacacatcacaaccctcatctcgagc
ctcagagagtttgtgaggtccactgaccgaaaaatcatagccactacactgtccaagctc
aagctggagctggacttcgacagccacggcatcagccaggtgcaggtggtcctctttggc
ttccaggatgcggtcaataaagttcttcggaatcataacatcaagccacactggatgttt
gccctggacagcatcatccgaaaggctgtgcagactgcaattaccattctggttccagag
ttgaggccacattttagccttgcatcagagagcgacacagctgatccggaagacctggat
gtcgaagatgaacacgaggaattgtcttcaaatcagacagtccgacggcctcaggccatc
actgaggacgctgtggctacctcgggggtgagcacgctaagctccactgtgtcccatgac
tcccagaatgcacaccggtcgctgaacgtgcagcttggaaggatgaagattgaaactaat
aggttacttgaagagctggttcggaaagagagagagttacaggcactcctccatcaagcc
attgaggaaaaagaccaagaaattaggcacctgaagctcaagtcccagcccatagatatc
cctgggtttcctgtgtgccacctgaactctcctggcacgaccacggaagattctgaactt
cctggctggctgagagaaaatggagctgatgaagacactataagtcggtttctggctgag
gattacacgctagtggatgttctttactacgtcacacgtgatgatctgaagtgcctcaga
ctaaggggcgggatgctgtgcacgctgtggaaggccatcattgactttcggaacaaatgc
tga
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integrated database retrieval system
