KEGG   ORTHOLOGY: K04426
Entry
K04426                      KO                                     
Symbol
MAP3K5, ASK1
Name
mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
Pathway
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04071  Sphingolipid signaling pathway
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04214  Apoptosis - fly
map04530  Tight junction
map04668  TNF signaling pathway
map04714  Thermogenesis
map04722  Neurotrophin signaling pathway
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05017  Spinocerebellar ataxia
map05022  Pathways of neurodegeneration - multiple diseases
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04013 MAPK signaling pathway - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04668 TNF signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04071 Sphingolipid signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04214 Apoptosis - fly
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05012 Parkinson disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05014 Amyotrophic lateral sclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05016 Huntington disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05017 Spinocerebellar ataxia
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05022 Pathways of neurodegeneration - multiple diseases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   05418 Fluid shear stress and atherosclerosis
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
   04932 Non-alcoholic fatty liver disease
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5
Other DBs
GO: 0004709
Genes
HSA: 4217(MAP3K5)
PTR: 463023(MAP3K5)
PPS: 100991014(MAP3K5)
GGO: 101147354(MAP3K5)
PON: 100458776(MAP3K5)
NLE: 100587332(MAP3K5)
MCC: 711382(MAP3K5)
MCF: 101925657(MAP3K5)
CSAB: 103240310(MAP3K5)
CATY: 105600400(MAP3K5)
PANU: 101002917(MAP3K5)
TGE: 112623422(MAP3K5)
RRO: 104675014(MAP3K5)
RBB: 108522968(MAP3K5)
TFN: 117097478(MAP3K5)
PTEH: 111525521(MAP3K5)
CJC: 100406322(MAP3K5)
SBQ: 101034123(MAP3K5)
CSYR: 103256327(MAP3K5)
MMUR: 105857227(MAP3K5)
OGA: 100943232(MAP3K5)
MMU: 26408(Map3k5)
MCAL: 110303338(Map3k5)
MPAH: 110337870(Map3k5)
RNO: 365057(Map3k5)
MCOC: 116097922(Map3k5)
CGE: 100752376(Map3k5)
NGI: 103724902(Map3k5)
HGL: 101712051(Map3k5)
CPOC: 100722979(Map3k5)
CCAN: 109697041(Map3k5)
DORD: 105993516(Map3k5)
DSP: 122126135(Map3k5)
NCAR: 124988565
OCU: 100340498(MAP3K5)
OPI: 101530376(MAP3K5)
TUP: 102495244(MAP3K5)
CFA: 476215(MAP3K5)
VVP: 112919386(MAP3K5)
VLG: 121481859(MAP3K5)
AML: 100475304(MAP3K5)
UMR: 103663496(MAP3K5)
UAH: 113259481(MAP3K5)
UAR: 123803353(MAP3K5)
ELK: 111147502
LLV: 125103005
MPUF: 101686402(MAP3K5)
ORO: 101374728(MAP3K5)
EJU: 114222735(MAP3K5)
ZCA: 113927218(MAP3K5)
MLX: 118000829(MAP3K5)
FCA: 101082912(MAP3K5)
PYU: 121013412(MAP3K5)
PBG: 122490389(MAP3K5)
PTG: 102960317(MAP3K5)
PPAD: 109249879(MAP3K5)
AJU: 106983673(MAP3K5)
BTA: 537380(MAP3K5)
BOM: 102276849(MAP3K5)
BIU: 109563980(MAP3K5)
BBUB: 102408502(MAP3K5)
CHX: 102172156(MAP3K5)
OAS: 101121018(MAP3K5)
ODA: 120863070(MAP3K5)
CCAD: 122433913(MAP3K5)
SSC: 100622769(MAP3K5)
CFR: 102522243(MAP3K5)
CBAI: 105077264(MAP3K5)
CDK: 105092037(MAP3K5)
VPC: 102544996(MAP3K5)
BACU: 102999328(MAP3K5)
OOR: 101277232(MAP3K5)
DLE: 111166150(MAP3K5)
PCAD: 102976909(MAP3K5)
PSIU: 116763459(MAP3K5)
ECB: 100073186(MAP3K5)
EPZ: 103556363(MAP3K5)
EAI: 106837192(MAP3K5)
MYB: 102256847(MAP3K5)
MYD: 102771311(MAP3K5)
MMYO: 118659758(MAP3K5)
MLF: 102439932(MAP3K5)
MNA: 107530984(MAP3K5)
PKL: 118705482(MAP3K5)
HAI: 109385622(MAP3K5)
DRO: 112297079(MAP3K5)
SHON: 118986673(MAP3K5)
AJM: 119052787
PDIC: 114494013(MAP3K5)
PHAS: 123821582(MAP3K5)
MMF: 118620900(MAP3K5)
RFQ: 117020789(MAP3K5)
PALE: 102888994(MAP3K5)
PGIG: 120615779(MAP3K5)
PVP: 105289473(MAP3K5)
RAY: 107521291(MAP3K5)
MJV: 108401094(MAP3K5)
TOD: 119252904(MAP3K5)
SARA: 101547499(MAP3K5)
LAV: 100658813(MAP3K5)
TMU: 101346612
DNM: 101411083(MAP3K5)
MDO: 100031527(MAP3K5)
GAS: 123247967(MAP3K5)
SHR: 100917439(MAP3K5)
PCW: 110208922(MAP3K5)
OAA: 100081079(MAP3K5)
GGA: 421688(MAP3K5)
PCOC: 116240569(MAP3K5)
CJO: 107311662(MAP3K5)
NMEL: 110395802(MAP3K5)
APLA: 101799109(MAP3K5)
ACYG: 106032515(MAP3K5)
AFUL: 116487197(MAP3K5)
TGU: 100224192(MAP3K5)
LSR: 110483316(MAP3K5)
SCAN: 103818465(MAP3K5)
PMOA: 120501237(MAP3K5)
OTC: 121346192(MAP3K5)
PRUF: 121354869(MAP3K5)
GFR: 102034507(MAP3K5)
FAB: 101813811(MAP3K5)
PHI: 102104081(MAP3K5)
PMAJ: 107201551(MAP3K5)
CCAE: 111926799(MAP3K5)
CCW: 104689448(MAP3K5)
ETL: 114059498(MAP3K5)
ZAB: 102060991(MAP3K5)
FPG: 101911552(MAP3K5)
FCH: 102057038(MAP3K5)
CLV: 102085051(MAP3K5)
EGZ: 104131143(MAP3K5)
NNI: 104008816(MAP3K5)
ACUN: 113478110(MAP3K5)
TALA: 104366747(MAP3K5)
PADL: 103912745(MAP3K5)
ACHC: 115344983(MAP3K5)
AAM: 106497979(MAP3K5)
AROW: 112977195(MAP3K5)
NPD: 112954904(MAP3K5)
DNE: 112996005(MAP3K5)
ASN: 102375722(MAP3K5)
AMJ: 102573024(MAP3K5)
CPOO: 109320192(MAP3K5)
GGN: 109304590(MAP3K5)
PSS: 102451227(MAP3K5)
CMY: 102936034(MAP3K5)
CPIC: 101943963(MAP3K5)
TST: 117874903(MAP3K5)
CABI: 116818836(MAP3K5)
MRV: 120402164(MAP3K5)
ACS: 100551616(map3k5)
PVT: 110071741(MAP3K5)
SUND: 121932476(MAP3K5)
PBI: 103052010(MAP3K5)
PMUR: 107282238(MAP3K5)
TSR: 106554087(MAP3K5)
PGUT: 117666295(MAP3K5)
VKO: 123020316(MAP3K5) 123026039(MAP3K6)
PMUA: 114594175(MAP3K5)
ZVI: 118082069(MAP3K5)
GJA: 107117647
XLA: 108717885
XTR: 100497692(map3k5)
NPR: 108787404(MAP3K5)
RTEM: 120937349(MAP3K5)
BBUF: 120998524(MAP3K5)
BGAR: 122934291(MAP3K5)
DRE: 100005496(si:ch211-1i11.3) 555703(map3k5)
PPRM: 120475531 120475545 120484263(si:ch211-1i11.3)
IPU: 108257027(map3k5) 108268173(si:ch211-1i11.3) 108271733
PHYP: 113526624 113528943(map3k5)
SMEO: 124384976(si:ch211-1i11.3) 124401148(map3k5)
TFD: 113644595(si:ch211-1i11.3) 113646298(map3k5)
AMEX: 103033000(map3k5) 103038360
EEE: 113572229 113589755(map3k5)
TRU: 101061432(map3k5) 101071039
LCO: 104919600 104926153(map3k5)
NCC: 104941909
CGOB: 115003836(map3k5) 115021489
ELY: 117266425(si:ch211-1i11.3) 117270726(map3k5)
PLEP: 121945592(si:ch211-1i11.3) 121956006(map3k5)
SLUC: 116043308(si:ch211-1i11.3) 116066332(map3k5)
ECRA: 117946066(si:ch211-1i11.3) 117961775(map3k5)
PFLV: 114557214 114572961(map3k5)
GAT: 120807850(map3k5) 120810951(si:ch211-1i11.3)
PPUG: 119194695(map3k5) 119198012(si:ch211-1i11.3)
MSAM: 119897276(si:ch211-1i11.3) 119909551(map3k5)
CUD: 121513660(si:ch211-1i11.3) 121521244(map3k5)
MZE: 101473117(map3k5) 101482122
ONL: 100703888(map3k5) 100704269
OAU: 116311419(map3k5) 116320920(si:ch211-1i11.3)
OLA: 101167985 101175702(map3k5)
OML: 112143789(si:ch211-1i11.3) 112157978(map3k5)
XMA: 102232260 102232771(map3k5)
XCO: 114140993 114158595(map3k5)
XHE: 116717242 116734003(map3k5)
PRET: 103457283(map3k5) 103477798
PFOR: 103141536 103154474(map3k5)
PLAI: 106953170(map3k5) 106954894
PMEI: 106923310 106926889(map3k5)
GAF: 122825130(map3k5) 122831685(si:ch211-1i11.3)
CVG: 107082864(map3k5) 107084615
CTUL: 119778360(map3k5) 119793951(si:ch211-1i11.3)
GMU: 124862290(si:ch211-1i11.3) 124882075(map3k5)
NFU: 107377786(map3k5) 107379353
KMR: 108233483(map3k5) 108240373(si:ch211-1i11.3)
ALIM: 106524693 106528005(map3k5)
NWH: 119409920(si:ch211-1i11.3) 119418611(map3k5)
AOCE: 111572346 111589020(map3k5)
CSEM: 103381109(map3k5) 103388011
POV: 109633076 109635968(map3k5)
SSEN: 122775214(si:ch211-1i11.3) 122783889(map3k5)
HHIP: 117758302(map3k5) 117777402(si:ch211-1i11.3)
LCF: 108888903(map3k5) 108899499
SDU: 111235736 111237351(map3k5)
SLAL: 111661471(map3k5) 111661628
XGL: 120784389(si:ch211-1i11.3) 120789011(map3k5)
HCQ: 109523559 109528311(map3k5)
BPEC: 110172206(map3k5) 110174291
MALB: 109954686 109962300(map3k5)
OMY: 110489000 110517301(si:ch211-1i11.3) 110522164(map3k5) 110529540
ELS: 105017906(map3k5) 105019305
SFM: 108919179 108929292(map3k5)
PKI: 111843026(map3k5) 111848885
AANG: 118222942(si:ch211-1i11.3) 118230513(map3k5)
LOC: 102692342(map3k6) 102695902(map3k5)
LCM: 102352283(MAP3K6)
CMK: 103178324(map3k5) 103187330
SPU: 592507
DME: Dmel_CG4720(Ask1)
DER: 6553939
DSE: 6619027
DSI: Dsimw501_GD19320(Dsim_GD19320)
DAN: 6500408
DSR: 110188207
DPO: Dpse_GA18383(Dpse_Pk92B)
DPE: 6594623
DMN: 108155889
DWI: 6649486
DGR: 6567932
DAZ: 108614318
DNV: 108657357
DHE: 111596705
DVI: 6632503
CCAT: 101449418
BOD: 106627711
MDE: 101891452
SCAC: 106092329
LCQ: 111682647
ACOZ: 120958527
AARA: 120906704
AALB: 115269543
CPII: 120427968
CNS: 116339144
AME: 408533
ACER: 107996343
ALAB: 122712955
BIM: 100742125
BBIF: 117209922
BVK: 117240271
BVAN: 117164525
BTER: 100644945
BPYO: 122575391
CCAL: 108630730
OBB: 114878286
MGEN: 117228365
NMEA: 116432299
CGIG: 122405458
SOC: 105200278
MPHA: 105839067
AEC: 105143801
ACEP: 105626733
PBAR: 105427967
VEM: 105561019
HST: 105181813
DQU: 106744879
CFO: 105257525
FEX: 115233363
LHU: 105675456
PGC: 109857237
OBO: 105279601
PCF: 106784336
PFUC: 122520818
VPS: 122637490
NVI: 100123601
TPRE: 106651350
MDL: 103579352
CGLO: 123264782
FAS: 105266521
DAM: 107048623
AGIF: 122850232
CCIN: 107268205
TCA: 661249
SOY: 115885179
CSET: 123316111
AGB: 108904453
LDC: 111515052
APLN: 108741686
PPYR: 116163906
OTU: 111414313
MSEX: 115443887
BANY: 112058316
PPOT: 106102013
PXU: 106126710
PRAP: 110996751
ZCE: 119834669
SLIU: 111348123
OFU: 114352906
API: 100168328
DNX: 107163715
AGS: 114119051
RMD: 113560014
DCI: 103511857
HHAL: 106686083
NLU: 111046568
FOC: 113204655
ZNE: 110830933
CSEC: 111866348
DMK: 116922300
PVM: 113816913
PJA: 122257438
PCHN: 125029397
HAME: 121859293
PCLA: 123752192
PTRU: 123502841
DSV: 119461475
RSAN: 119396072
RMP: 119174291
VDE: 111246627
VJA: 111270357
DPTE: 113794555
DFR: 124500604
SDM: 118205052
CEL: CELE_F59A6.1(nsy-1)
CBR: CBG_02299(Cbr-nsy-1)
BMY: BM_BM12235(Bma-nsy-1)
BGT: 106060548
GAE: 121370825
HRF: 124118528
HRJ: 124288843
PMAX: 117327071
MMER: 123550860
OSN: 115226339
HMG: 100206765
AQU: 100631731
 » show all
Reference
  Authors
Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H
  Title
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
  Journal
Antioxid Redox Signal 4:415-25 (2002)
DOI:10.1089/15230860260196218
Reference
PMID:8940179
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J Biol Chem 271:31607-11 (1996)
DOI:10.1074/jbc.271.49.31607
  Sequence
[hsa:4217]
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