Mus musculus (house mouse): 270685
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Entry
270685 CDS
T01002
Symbol
Mthfd1l, 2410004L15Rik, Fthfsdc1
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
KO
K13402
monofunctional C1-tetrahydrofolate synthase, mitochondrial [EC:
6.3.4.3
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00670
One carbon pool by folate
mmu01100
Metabolic pathways
mmu01240
Biosynthesis of cofactors
Module
mmu_M00141
C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
270685 (Mthfd1l)
Enzymes [BR:
mmu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.4 Other carbon-nitrogen ligases
6.3.4.3 formate---tetrahydrofolate ligase
270685 (Mthfd1l)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
FTHFS
THF_DHG_CYH
THF_DHG_CYH_C
Motif
Other DBs
NCBI-GeneID:
270685
NCBI-ProteinID:
NP_001164256
MGI:
1924836
Ensembl:
ENSMUSG00000040675
UniProt:
Q3V3R1
Structure
PDB
PDBj
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All DBs
Position
10:3918282..4117081
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AA seq
977 aa
AA seq
DB search
MSVRLPLLLRQLGRQQLPSGPACRLRELCRSGSRSSSSGGGDPEGLRGRRLQDGQTFSSH
GPGNPEAPGMDSIVRDVIHNSKEVLSLLQEKNPAFKPVLVVIQAGDDNLMKDMNQNLAKE
AGLDITHICLPPDSGEDEIIDEILKINEDPRVHGLTLQISEDSLSNKVLNALKPEKDVDG
VTDINLGKLVRGDAPECFVSPLAKAAVELVEKSGITLDGKKVLVVGAHGPLEAALQWLFQ
RKGSMTMSCPWATPQLPDKLREADIVVLGSPKPEEIPAVWIPSGTTILNCFHDFLSGKLS
GGSPGVPVDKLIAEESVSLLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPS
DIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVQLSLLERLKDQTDGKYVLVAGIT
PTPLGEGKSTVTIGLVQALTAHLKVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEF
NLHLTGDIHAITAANNLLAAAIDTRILHESTQTDKALYNRLVPLVNGVREFSEIQLSRLK
KLGIHKTDPSTLTEEEVRKFARLNIDPATITWQRVLDTNDRFLRKITIGQGSTEKGYSRQ
AQFDIAVASEIMAVLALTDSLTDMKERLGRMVVASDKDGQPVTAEDLGVTGALTVLMKDA
IKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGME
KFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNL
QKQIQIAQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSAGGKGSVDL
ARAVREAANKRSRFQFLYDVQLPIVEKIRVIAQTVYGAKDIELSPEAQSKIDRYTQQGFG
NLPICMAKTHLSLSHEPDKKGVPRDFTLPISDVRASIGAGFIYPLVGTMSTMPGLPTRPC
FYDIDLDTETEQVKGLF
NT seq
2934 nt
NT seq
+upstream
nt +downstream
nt
atgagcgtccgcctccctctcctgcttcgccagctcggccgccagcagctgccctcgggc
ccggcgtgtcgcctccgtgagctgtgtcgctcaggcagcagaagcagcagcagcggaggt
ggtgaccccgaggggttacgcgggcggcggctgcaggatggccaaaccttcagcagccat
ggcccaggcaatccggaagcccccgggatggactccatcgtcagagacgtcattcacaat
tccaaggaagtgctgagcttgttgcaagaaaagaaccctgcctttaagccagtgcttgtg
gttattcaggccggtgatgacaatttgatgaaggatatgaaccagaatttggccaaggag
gctggtctggacatcactcacatctgcttgcctccagacagcggagaggatgagatcata
gatgaaatcctgaagattaatgaagaccccagagtgcatggccttacccttcagatctct
gaagattcattgagcaacaaagttctcaatgctttgaaaccagaaaaagatgtggacggg
gtgaccgacatcaatctggggaagctcgtacgaggtgacgctccggagtgttttgtttca
cccttggccaaagctgctgtagaacttgttgaaaagtcagggatcactttggatggaaag
aaggtcttggtcgtaggggcgcacgggcccctggaagctgccctgcagtggcttttccag
agaaaaggatctatgacaatgagctgcccctgggcaacacctcagcttccagacaagctt
cgagaggcagacattgtggtcttaggctcacctaagccagaagagattcctgctgtgtgg
attccatcaggaaccaccattctcaattgcttccatgacttcttgtcagggaagctgagc
ggaggttctcctggggtccccgtggacaaactcattgcagaagagagcgtgagtctcctt
gctgcggctctgcgcattcagaacatggtgagcagcggcaggaggtggctcagagagcag
caacatcgaagatggcgactgcactgcttgaaactgcagcctctctcacctgtgcccagt
gatattgagatttctcgaggacagactccaaaagctgtggatgtccttgccaaggagata
ggattgcttgcagatgaaattgaaatctatggcaagagcaaagccaaagtccaattgtcc
ctgctggagaggttaaaggatcaaacagatggaaaatacgtcttggttgctgggatcacg
cccaccccgctcggagaagggaagagtacagtcaccatcggactagtgcaggcgctgacc
gctcacctgaaagtcaactccttcgcctgtctgaggcagccttctcagggacccactttt
ggagtgaaaggaggagctgcaggaggtggatatgctcaggtcatccccatggaggagttc
aaccttcacctgactggggacatccatgccatcactgccgctaataacttgctggccgca
gccatcgacacgagaattttacatgagagcactcaaacagacaaggctctctacaatcga
ctggttcccttagtgaatggtgtcagagaattttcagaaattcaactttctcggctgaag
aaactggggatacataagactgatccaagcacactgaccgaggaggaagtgaggaagttc
gcccgcctcaacattgaccccgcaaccatcacgtggcagagagtattggacacgaacgac
cgatttctgagaaaaataaccattggacagggaagtacagagaaaggatattcccggcag
gcacagtttgacattgcagtggccagcgagatcatggccgtgctggccttgactgatagc
ctcacagacatgaaagagcggctaggaagaatggtggtggccagtgacaaagacgggcag
cctgtgacagctgaggacttgggggtgaccggcgctctgacagttttgatgaaagacgcc
atcaagccaaatctgatgcagacccttgaaggaacacctgtgtttgtgcacgctggtccc
tttgccaacatcgctcacggcaactcatcagtattagctgataaaatcgcgctgaaattg
gtcggcgaagaagggtttgtggtgactgaagctggctttggggctgatattgggatggag
aaattcttcaatatcaaatgccgagcttctggcctggtgcccaacgttgtcgtgctggta
gccaccgttcgagctctgaagatgcatggaggcgggccgagtgtaactgctggggttcct
ctcaagaaagaatatacagaggagaacattcagctggtagctgatggctgctgcaaccta
cagaagcaaattcagatcgctcagctcttcggggtgccggtggtggtggcactgaatgtc
ttcaagacggacacccgtgcagagattgacttggtgtgtgagctcgctaaacgggccggt
gcctttgatgcggtcccctgctatcactggtcggctggagggaaaggatctgtggacttg
gcccgggctgtgagagaagctgcgaataaaagaagccgcttccagttcctgtatgatgtt
cagcttcccatcgtggaaaagataagagtcattgcccagactgtctatggagccaaggac
attgagctgtctcctgaggcgcagtccaaaatcgatcgctatacgcaacagggttttgga
aatttgcccatttgcatggcgaagacccacctctctctctctcatgaacctgacaaaaag
ggagtgccgagggatttcactctgcccatcagtgatgtccgggccagcatcggggctggg
ttcatttatcctttggtgggaacgatgagcacaatgccaggactgcccacccgaccctgc
ttttatgatatagaccttgacacagaaacggagcaagttaaaggcttgttctaa
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