Mus musculus (house mouse): 384783 Help Entry 384783            CDS       T01002                                  Symbol Irs2, Irs-2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism mmu  Mus musculus (house mouse) Pathway mmu04022   cGMP-PKG signaling pathway mmu04068   FoxO signaling pathway mmu04081   Hormone signaling mmu04140   Autophagy - animal mmu04152   AMPK signaling pathway mmu04211   Longevity regulating pathway mmu04213   Longevity regulating pathway - multiple species mmu04910   Insulin signaling pathway mmu04920   Adipocytokine signaling pathway mmu04923   Regulation of lipolysis in adipocytes mmu04930   Type II diabetes mellitus mmu04931   Insulin resistance mmu04932   Non-alcoholic fatty liver disease mmu04935   Growth hormone synthesis, secretion and action mmu05010   Alzheimer disease mmu05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     384783 (Irs2)    04022 cGMP-PKG signaling pathway     384783 (Irs2)    04152 AMPK signaling pathway     384783 (Irs2)   09133 Signaling molecules and interaction    04081 Hormone signaling     384783 (Irs2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     384783 (Irs2)  09150 Organismal Systems   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     384783 (Irs2)    04935 Growth hormone synthesis, secretion and action     384783 (Irs2)   09149 Aging    04211 Longevity regulating pathway     384783 (Irs2)    04213 Longevity regulating pathway - multiple species     384783 (Irs2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     384783 (Irs2)   09164 Neurodegenerative disease    05010 Alzheimer disease     384783 (Irs2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     384783 (Irs2)    04932 Non-alcoholic fatty liver disease     384783 (Irs2)    04931 Insulin resistance     384783 (Irs2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  384783 NCBI-ProteinID:  NP_001074681 MGI:  109334 Ensembl:  ENSMUSG00000038894 UniProt:  P81122 Structure PDBPDBj LinkDB All DBs Position 8:complement(11034681..11058929) Genome browser AA seq 1321 aa AA seqDB search MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA SAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDN YGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLM NIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPR SKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRT ASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGG ALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSS GSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMS MDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRAT FSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRS GGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYK ASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALR GGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGT FGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYP LPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD SRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSL QQPLPPAPGDLYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPP KPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSET FSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAV PPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQ PGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVK E NT seq 3966 nt NT seq  +upstreamnt  +downstreamnt atggctagcgcgcccctgcctgggccccccgcgtcggcgggcggggacggcccgaacctc aataacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgctttttcgtgttgcgcggccccggcacgggcggcgacgaggca tccgcggctggggggtcgccgccgcagcctccgcggctggagtactacgagagcgagaag aagtggaggagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgtctgaac atcaacaagcgcgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgctgtagcggcggagaacgagcaggagcaggagggctggtaccgcgcactcacc gacttggtcagcgaaggccgctctggcgaggggggctcgggcaccaccggaggctcttgc agcgcctctctcccgggcgtcctgggcggctcagcgggcgccgctggctgcgatgacaac tacgggctcgtgacacccgccacggccgtctaccgcgaggtgtggcaggtgaacctgaaa cctaagggactgggccagagcaagaacctgactggtgtataccgcctatgcctgtctgcg cgcaccatcggcttcgtgaagctcaattgcgaacagccgtcggtgacgctgcagcttatg aacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgttcggcc gtcaccggtcccggggagctgtggatgcaagccgacgactcggtggtggcgcagaacatc catgagaccatcctagaagctatgaaggcactcaaagagctcttcgagttccggcctcgc agcaagagtcagtcgtccgggtcgtcagccacgcatcccatcagcgtgccgggcgcgcgc cgccaccaccacctagtcaacctaccccctagccagaccggcctggtgcgccgctcgcgc actgacagcctggcggccacccccccagcagccaagtgcacttcgtgccgggttcgtacg gccagcgagggcgacggcggcgcggcaggcggggccgggacggcaggaggcaggccgatg tcggtggcagggagccccctgagtcccgggccggtgcgcgcgccccttagccgctcgcac accctgagcgccggctgcggaggccgcccgagcaaagtgactctggcgccggcaggggga gccctgcaacacagccgctccatgtccatgcccgtggcgcactcacctcctgcagccacc agcccaggcagcctgtcctccagcagtgggcacggctcgggctcctacccgctgccacct ggctcccacccgcacctgcctcatccactgcatcacccccaaggccagcgtccgtccagc ggtagtgcctccgcctcgggctcccccagcgacccgggtttcatgtcccttgacgagtat ggctccagccctggcgacctgagagccttcagtagccacaggagcaacacacccgagtca atagcggagaccccgccagccagagatggcagtgggggcgaactctatgggtacatgagc atggatagacccctgagccactgtggccgcccttaccgtagggtctcaggggatggggcc caggacctggatagaggactgaggaagaggacttattccctaaccacgcctgccaggcag cggcaggtacctcagccttcctctgcctctctagatgaatacactctcatgagggccacc ttctctggtagttcaggtcgcctctgcccatccttccctgcgtcctctcccaaagtggcc tacaacccttacccagaggactatggagacattgagattggttctcacaagagttccagc agtaacctgggggcagatgatggctacatgcccatgacccctggggcagcccttaggagt ggtggtcccaatagctgcaagagcgatgactacatgcccatgagccccacaagcgtgtct gctcccaagcagatcctgcagccacgcttggcagcggccttgcccccttccggagcagcc gtgccagcacccccttcaggggtgggcaggaccttcccagtaaacggaggtggctacaaa gccagctccccagcggagagctccccagaagacagtgggtacatgcgaatgtggtgtggc tccaagctgtctatggagaacccagaccctaagctactccccaacggggactacctcaac atgtcccccagcgaggcaggcactgcagggaccccacctgacttctcagcagctttgcgt ggaggcagtgaaggcctcaaaggcatcccgggccactgctacagctctttgccccgctct tataaggctccctgttcctgcagcggagacaatgaccagtatgtgctcatgagctcccct gtgggccggatcttggaagaggagagactggagccccaggccaccccaggggctggcacc tttggggcagctggtggtagtcatacccagcctcatcactcagcagtgccttcctccatg aggccgagtgccatcggtggccgccctgagggcttcctgggccagcgatgtcgggcagtg cggcctacacgcctatcgctagagggactgcagacccttcccagcatgcaagagtaccct ctacccacagagcccaagagccctggcgagtacatcaacattgactttggtgaggcaggt acccgtctgtctccgcctgcccccccactactggcatccgcggcctcatcttcttcactg ctctcagctagtagtcctgcttcatccctgggttcaggaaccccaggcaccagcagcgac agccggcagcgctctccactctctgactatatgaacctggacttcagttctcccaagtcc cccaagcctagcacccgcagtggggacacagtaggctccatggatggccttctctctcca gaggcttcatccccatacccaccactgcccccacgtccttccacttccccttcctcctta cagcagcctctgccacctgccccgggagacctataccgcctgcctccagcatcagctgcc acttcccagggtcccactgctggctcctcaatgtcctccgagcctggggataatggtgac tataccgagatggcctttggtgtggctgcaaccccgccacaacctatcgtggcacctcca aagccagaaggtgcccgagtggccagtcccacatcgggcttgaagcggctaagtctcatg gatcaggtatctggggtggaggctttccttcaagtcagccagccccctgacccccaccgg ggtgctaaggtcatccgtgcagacccacaggggggacgtcgtcgccacagttcagagacc ttttcctctaccaccaccgtcaccccagtgtccccatcctttgcccacaattccaagcgc cacaattcggcctctgtggaaaatgtctcactcaggaaaagcagtgaaggcagcagtacc ctgggaggaggtgatgagccgcccacatccccaggacaggcacagcccttggtggctgtg cccccagtgccacaggctaggccgtggaaccccggtcagcccggagctttgattggctgt cctggaggcagcagttctcccatgcgcagagagacctccgtgggtttccagaacggcctc aactatatcgccatcgatgtgagaggcgagcaggggtccttggcgcagtctcagccgcag ccaggagacaagaactcctggagccggacccgtagccttggggggctcctcggcaccgtc ggaggctctggcgccagcggagtgtgtgggggtccaggcactggagctttgccctctgcc agcacctatgcaagcatcgacttcctgtcccatcacttgaaggaagccacagtcgtgaaa gagtga

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