KEGG   Microcebus murinus (gray mouse lemur): 105881219
Entry
105881219         CDS       T07238                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01521  EGFR tyrosine kinase inhibitor resistance
mmur01522  Endocrine resistance
mmur01524  Platinum drug resistance
mmur04012  ErbB signaling pathway
mmur04014  Ras signaling pathway
mmur04015  Rap1 signaling pathway
mmur04024  cAMP signaling pathway
mmur04062  Chemokine signaling pathway
mmur04066  HIF-1 signaling pathway
mmur04068  FoxO signaling pathway
mmur04070  Phosphatidylinositol signaling system
mmur04071  Sphingolipid signaling pathway
mmur04072  Phospholipase D signaling pathway
mmur04081  Hormone signaling
mmur04140  Autophagy - animal
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04152  AMPK signaling pathway
mmur04210  Apoptosis
mmur04211  Longevity regulating pathway
mmur04213  Longevity regulating pathway - multiple species
mmur04218  Cellular senescence
mmur04360  Axon guidance
mmur04370  VEGF signaling pathway
mmur04380  Osteoclast differentiation
mmur04510  Focal adhesion
mmur04550  Signaling pathways regulating pluripotency of stem cells
mmur04611  Platelet activation
mmur04613  Neutrophil extracellular trap formation
mmur04620  Toll-like receptor signaling pathway
mmur04625  C-type lectin receptor signaling pathway
mmur04630  JAK-STAT signaling pathway
mmur04650  Natural killer cell mediated cytotoxicity
mmur04660  T cell receptor signaling pathway
mmur04662  B cell receptor signaling pathway
mmur04664  Fc epsilon RI signaling pathway
mmur04666  Fc gamma R-mediated phagocytosis
mmur04668  TNF signaling pathway
mmur04670  Leukocyte transendothelial migration
mmur04722  Neurotrophin signaling pathway
mmur04725  Cholinergic synapse
mmur04750  Inflammatory mediator regulation of TRP channels
mmur04810  Regulation of actin cytoskeleton
mmur04910  Insulin signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04915  Estrogen signaling pathway
mmur04917  Prolactin signaling pathway
mmur04919  Thyroid hormone signaling pathway
mmur04923  Regulation of lipolysis in adipocytes
mmur04926  Relaxin signaling pathway
mmur04929  GnRH secretion
mmur04930  Type II diabetes mellitus
mmur04931  Insulin resistance
mmur04932  Non-alcoholic fatty liver disease
mmur04933  AGE-RAGE signaling pathway in diabetic complications
mmur04935  Growth hormone synthesis, secretion and action
mmur04960  Aldosterone-regulated sodium reabsorption
mmur04973  Carbohydrate digestion and absorption
mmur05010  Alzheimer disease
mmur05017  Spinocerebellar ataxia
mmur05020  Prion disease
mmur05100  Bacterial invasion of epithelial cells
mmur05135  Yersinia infection
mmur05142  Chagas disease
mmur05146  Amoebiasis
mmur05160  Hepatitis C
mmur05161  Hepatitis B
mmur05162  Measles
mmur05163  Human cytomegalovirus infection
mmur05164  Influenza A
mmur05165  Human papillomavirus infection
mmur05166  Human T-cell leukemia virus 1 infection
mmur05167  Kaposi sarcoma-associated herpesvirus infection
mmur05168  Herpes simplex virus 1 infection
mmur05169  Epstein-Barr virus infection
mmur05170  Human immunodeficiency virus 1 infection
mmur05171  Coronavirus disease - COVID-19
mmur05200  Pathways in cancer
mmur05203  Viral carcinogenesis
mmur05205  Proteoglycans in cancer
mmur05206  MicroRNAs in cancer
mmur05207  Chemical carcinogenesis - receptor activation
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05210  Colorectal cancer
mmur05211  Renal cell carcinoma
mmur05212  Pancreatic cancer
mmur05213  Endometrial cancer
mmur05214  Glioma
mmur05215  Prostate cancer
mmur05218  Melanoma
mmur05220  Chronic myeloid leukemia
mmur05221  Acute myeloid leukemia
mmur05222  Small cell lung cancer
mmur05223  Non-small cell lung cancer
mmur05224  Breast cancer
mmur05225  Hepatocellular carcinoma
mmur05226  Gastric cancer
mmur05230  Central carbon metabolism in cancer
mmur05231  Choline metabolism in cancer
mmur05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmur05415  Diabetic cardiomyopathy
mmur05417  Lipid and atherosclerosis
mmur05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    105881219 (PIK3R1)
   04015 Rap1 signaling pathway
    105881219 (PIK3R1)
   04630 JAK-STAT signaling pathway
    105881219 (PIK3R1)
   04668 TNF signaling pathway
    105881219 (PIK3R1)
   04066 HIF-1 signaling pathway
    105881219 (PIK3R1)
   04068 FoxO signaling pathway
    105881219 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    105881219 (PIK3R1)
   04072 Phospholipase D signaling pathway
    105881219 (PIK3R1)
   04071 Sphingolipid signaling pathway
    105881219 (PIK3R1)
   04024 cAMP signaling pathway
    105881219 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    105881219 (PIK3R1)
   04152 AMPK signaling pathway
    105881219 (PIK3R1)
   04150 mTOR signaling pathway
    105881219 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105881219 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105881219 (PIK3R1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105881219 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105881219 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    105881219 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    105881219 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    105881219 (PIK3R1)
   04660 T cell receptor signaling pathway
    105881219 (PIK3R1)
   04662 B cell receptor signaling pathway
    105881219 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    105881219 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    105881219 (PIK3R1)
   04670 Leukocyte transendothelial migration
    105881219 (PIK3R1)
   04062 Chemokine signaling pathway
    105881219 (PIK3R1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    105881219 (PIK3R1)
   04929 GnRH secretion
    105881219 (PIK3R1)
   04915 Estrogen signaling pathway
    105881219 (PIK3R1)
   04917 Prolactin signaling pathway
    105881219 (PIK3R1)
   04926 Relaxin signaling pathway
    105881219 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    105881219 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    105881219 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105881219 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105881219 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    105881219 (PIK3R1)
   04722 Neurotrophin signaling pathway
    105881219 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105881219 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    105881219 (PIK3R1)
   04380 Osteoclast differentiation
    105881219 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    105881219 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    105881219 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105881219 (PIK3R1)
   05206 MicroRNAs in cancer
    105881219 (PIK3R1)
   05205 Proteoglycans in cancer
    105881219 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    105881219 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105881219 (PIK3R1)
   05203 Viral carcinogenesis
    105881219 (PIK3R1)
   05230 Central carbon metabolism in cancer
    105881219 (PIK3R1)
   05231 Choline metabolism in cancer
    105881219 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105881219 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105881219 (PIK3R1)
   05212 Pancreatic cancer
    105881219 (PIK3R1)
   05225 Hepatocellular carcinoma
    105881219 (PIK3R1)
   05226 Gastric cancer
    105881219 (PIK3R1)
   05214 Glioma
    105881219 (PIK3R1)
   05221 Acute myeloid leukemia
    105881219 (PIK3R1)
   05220 Chronic myeloid leukemia
    105881219 (PIK3R1)
   05218 Melanoma
    105881219 (PIK3R1)
   05211 Renal cell carcinoma
    105881219 (PIK3R1)
   05215 Prostate cancer
    105881219 (PIK3R1)
   05213 Endometrial cancer
    105881219 (PIK3R1)
   05224 Breast cancer
    105881219 (PIK3R1)
   05222 Small cell lung cancer
    105881219 (PIK3R1)
   05223 Non-small cell lung cancer
    105881219 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105881219 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    105881219 (PIK3R1)
   05161 Hepatitis B
    105881219 (PIK3R1)
   05160 Hepatitis C
    105881219 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    105881219 (PIK3R1)
   05164 Influenza A
    105881219 (PIK3R1)
   05162 Measles
    105881219 (PIK3R1)
   05163 Human cytomegalovirus infection
    105881219 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105881219 (PIK3R1)
   05169 Epstein-Barr virus infection
    105881219 (PIK3R1)
   05165 Human papillomavirus infection
    105881219 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105881219 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    105881219 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105881219 (PIK3R1)
   05142 Chagas disease
    105881219 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105881219 (PIK3R1)
   05017 Spinocerebellar ataxia
    105881219 (PIK3R1)
   05020 Prion disease
    105881219 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105881219 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    105881219 (PIK3R1)
   05415 Diabetic cardiomyopathy
    105881219 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105881219 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    105881219 (PIK3R1)
   04931 Insulin resistance
    105881219 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105881219 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105881219 (PIK3R1)
   01524 Platinum drug resistance
    105881219 (PIK3R1)
   01522 Endocrine resistance
    105881219 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmur04131]
    105881219 (PIK3R1)
Membrane trafficking [BR:mmur04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105881219 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 SH3_9 Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 105881219
NCBI-ProteinID: XP_012638256
Ensembl: ENSMICG00000044724
UniProt: A0A8C5UP55
LinkDB
Position
12:5989095..6071181
AA seq 725 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLSGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADIEQQQALTLPDLA
EQFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSSPAELRQLLDCDTASVDLEMIDV
HVLADAFKRYLLDLPNPVIPVAVYSEMISLAPEVQSSEEYIQLLKKFIRSPNIPHQYWLT
LQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMIFRFPATSSDNTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEII
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgaggggtaccagtacagagcgctgtatgattataaaaaggaaagagaagaa
gatattgacttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgacggacaagaagccaggcctgaagaaattggctggttaagtggctacaat
gaaaccacaggggagaggggggactttccaggaacttacgtagaatatattggaaggaag
aaaatttcgcctcccacaccaaagccccggccacctcggccccttcctgttgcaccaggt
tcttcgaaaactgaagcagacattgagcaacaacaagccttgactctcccggatcttgca
gagcagtttgcgcctcctgacattgccccccctcttcttatcaagcttgtggaagccatc
gaaaagaaaggtctggaatgttcaactctatacagaacacagagctccagcagccccgca
gaattaagacagcttcttgattgtgatacggcctctgtggacttggaaatgatcgatgtg
catgttttagcagacgctttcaaacgctacctgctggacttaccaaatcctgtcattccc
gtagccgtttacagtgaaatgatttctttagccccagaagtacaaagctccgaagaatat
atccagctgttgaagaagttcattaggtcgcctaacatacctcatcagtattggcttacg
cttcagtatttgttaaaacatttcttcaagctctctcaaacctccagcaaaaatctcttg
aatgcaagagtgctctctgaaattttcagccctatgattttcagattcccagcaaccagc
tctgataatactgaacacctcataaaagttatagaaattttaatctcaactgaatggaac
gaacgacagcctgcaccagcactgcctcctaaaccaccaaaacccactactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcg
agggaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagat
gcatcaactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcatcgggatgggaaatatggcttctctgacccattaaccttcaat
tccgtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaa
ttggatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaa
agtcgagaatatgatagattatatgaagaatatacccgtacttcccaggaaatccaaatg
aaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaa
acccaggagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaa
gaaattcaaaggattatgcataattatgataagttaaagtctcgaatcagtgaaattatt
gacagtagaagacgattggaggaagacttgaagaagcaggcagctgagtaccgagagatt
gacaaacgtatgaacagcattaaaccagacctcattcaactaagaaagacgagagaccaa
tacctgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaatgagtggttgggc
aatgaaaacactgaagaccaatattcactggtggaagatgatgaagatctgccccaccac
gatgagaagacgtggaacgtcgggagcagcaaccggaacaaagctgaaaacctgctgcga
gggaagcgggacggcactttcctggtccgggagagcagtaaacagggttgctacgcctgc
tccgtagtggtggatggtgaagtaaagcattgtgtcataaacaagacggccactggctat
ggctttgcagagccctataacttgtacagctctctgaaggaactggtgctacattaccaa
cacacctccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtgtat
gcacagcagaggcgatga

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