Macaca nemestrina (pig-tailed macaque): 105473988 Help Entry 105473988         CDS       T08765                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism mni  Macaca nemestrina (pig-tailed macaque) Pathway mni04022   cGMP-PKG signaling pathway mni04068   FoxO signaling pathway mni04081   Hormone signaling mni04140   Autophagy - animal mni04150   mTOR signaling pathway mni04151   PI3K-Akt signaling pathway mni04152   AMPK signaling pathway mni04211   Longevity regulating pathway mni04213   Longevity regulating pathway - multiple species mni04722   Neurotrophin signaling pathway mni04910   Insulin signaling pathway mni04920   Adipocytokine signaling pathway mni04923   Regulation of lipolysis in adipocytes mni04930   Type II diabetes mellitus mni04931   Insulin resistance mni04932   Non-alcoholic fatty liver disease mni04935   Growth hormone synthesis, secretion and action mni04960   Aldosterone-regulated sodium reabsorption mni05010   Alzheimer disease mni05206   MicroRNAs in cancer mni05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mni00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     105473988 (IRS1)    04022 cGMP-PKG signaling pathway     105473988 (IRS1)    04151 PI3K-Akt signaling pathway     105473988 (IRS1)    04152 AMPK signaling pathway     105473988 (IRS1)    04150 mTOR signaling pathway     105473988 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     105473988 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     105473988 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     105473988 (IRS1)    04923 Regulation of lipolysis in adipocytes     105473988 (IRS1)    04920 Adipocytokine signaling pathway     105473988 (IRS1)    04935 Growth hormone synthesis, secretion and action     105473988 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     105473988 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     105473988 (IRS1)   09149 Aging    04211 Longevity regulating pathway     105473988 (IRS1)    04213 Longevity regulating pathway - multiple species     105473988 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     105473988 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     105473988 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     105473988 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     105473988 (IRS1)    04932 Non-alcoholic fatty liver disease     105473988 (IRS1)    04931 Insulin resistance     105473988 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  105473988 NCBI-ProteinID:  XP_011726616 LinkDB All DBs Position Unknown AA seq 1250 aa AA seqDB search MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAALGAGGGGGSCSGSSGVGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN GHYILSRGGNGHRYTPGTGLGTSPALAGDEASSAADLDNRFRKRTHSAGTSPTITHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR PDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGGCSPDIGGGPSSSSSSAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVESSG GKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEE GARHQHLRLSASSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLP RKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQQQQQQQQQQPLLHPPEPKSP GEYVNIEFGSDQPGYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAA WQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPIAPVSYA DMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQRAAELAAHSSLLGGPQGPGGMSAFT RVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAIGGGGGSSS SSEDVKRHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQRPQ ECTPQPQPPPPPPPHQPLGSSESSSTRRHSSEDLSAYASISFQKQPEDLQ NT seq 3753 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag gcggagcaagacagctggtaccaggctctcctacagctgcacaaccgtgccaagggccac cacgacggagctgcggccctcggggcgggaggtggcgggggcagctgcagtggcagctcc ggcgttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcgttc aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag gcagccgccgtggtgctgcagctgatgaacatcaggcgctgcggccactcggagaacttc ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggctatg agcgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctccaaccccatc agcgtccccctgcgccggcaccatctcaacaaccccccgcccagccaggtggggctgacc cgacgatctcgcactgagagcatcactgccacctccccggccagcatggtgggcgggaaa ccaggctccttccgcgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc tcggtggatggcagccctgtgagtccgagcaccaacagaacccacgcccaccggcatcgg ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccagcttcc cgctgctcgccttcggccaccagccccgtcagtctgtcgtccagcagcaccagcggccat ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttctccc agcgatggcggtttcatctcctcagatgagtatggctccagtccctgcgatttccggagt tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag gagctaagcaactatatctgcatgggcggcaaggggccctccaccctgaccgcccccaac ggtcactacattttgtctcggggtggcaatggccaccgctacaccccaggaacaggcttg ggcacgagtccagccttggctggggatgaagcatccagtgctgcggatctggataatcgc ttccgaaagagaactcactctgcaggcacatcccctaccattacccaccagaagaccccg tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca ggaggtggcagtggaggccgactgccgggacacaggcactctgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc ccagacagctctaccctccacactgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccagcagccgaaagggcagtggagactatatgcccatgagccccaagagcgtg tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc agcagcagcagcagtgccgtcccttctgggagcagctatggaaagctgtggacaaacggg gtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagcagtggt ggcaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggactccaac accagcagcccctctgactgctactatggccctgaggacccccagcacaagccagtcctc tcgtactactcattgccaagatcctttaagcacacccagcgccctggggagccggaggag ggtgcccggcatcagcacctccgcctttctgctagctctggtcgccttctctatgctgca acagcggatgattcttcctcctccaccagcagcgacagcctgggtgggggatactgtggg gctaggctggagcccagccttccacatccccaccatcaggttctgcagccccatctgcct cgaaaggtggacacagctgctcagaccaatagccgcctggcccggcctacgaggctgtcc ctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcagcagcag cagcagcagcaacagcagcaacagcagcccctgctgcaccctccggagcccaagagccca ggagaatatgtgaatattgaatttgggagtgatcagcctggctacttgtctggcccggtg gcttcccgtagctcaccttctgtcaggtgtccatcccagctccagccagctcccagagag gaagagactggcactgaggagtacatgaagatggacctggggccgggccggagggcagcc tggcaggagagcactggggtcgagatgggcagactgggccccgcacctcccggggctgct agcatttgcaggcctacccgggcagtgcccagcagccggggtgactatatgaccatgcag atgagttgtccccgccagagctatgtggacacctcgccaattgcccctgtaagctatgct gacatgcggacaggcattgctgcagaggaggtgagcctgcccagggccaccatggctgct gcctcctcatcctcagcagcctctgcttcccccactgggcctcaaagggcagcagagctg gctgcccactcatccctgctggggggcccacaaggacctgggggcatgagcgccttcacc cgggtgaacctcagtcctaaccgcaaccagagtgccaaagtgatccgtgcagacccacaa gggtgccggaggaggcatagctccgagaccttctcctcaacacccagtgccacccgggtg ggcaacacagtgccctttggagccggggcagcaatagggggtggtggcggtagcagcagc agcagcgaggatgtgaaacgtcacagctctgcttcctttgagaatgtgtggctgaggcct ggggaacttgggggagcccccaaggagccagcccaactgtgtggggctgctgggggtttg gagaatggtcttaactacatagatctggatttggtcaaggacttcaaacagcgccctcag gagtgcacccctcaaccgcagcctcccccacccccaccccctcatcaacccctgggtagc agtgagagcagctccacccgccgccactcaagtgaggatttaagcgcctatgccagcatc agtttccagaagcagccagaggaccttcagtag

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